Recombinant Human PPM1G, His-tagged

• Cat.No.: PPM1G-31050TH
• Product Overview: Recombinant fragment, corresponding to amino acids 25-420 of Human PPM1G fused to His-tag at N-terminus, 27 kDa.

Specification

• Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Widely expressed. Most abundant in testis, skeletal muscle, and heart.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 25mM Tris, 2mM Beta mercaptoethanol, 1mM DTT, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MEGKEEPGSD SGTTAVVALI RGKQLIVANA GDSRCVVSEA GKALDMSYDH KPEDEVELAR IKNAGGKVTM DGRVNGGLNL SRAIGDHFYK RNKNLPPEEQ MISALPDIKV LTLTDDHEFM VIACDGIWNV MSSQEVVDFI QSKISQRDEN GELRLLSSIV EELLDQCLAP DTSGDGTGCD NMTCIIICFK PRNTAELQPE SGKRKLEEVL STEGAEENGN SDKKKKAKRD
• Sequence Similarities: Belongs to the PP2C family.

Gene Information

• Gene Name: PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G [ Homo sapiens ]
• Official Symbol: PPM1G
• Synonyms: PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform
• Gene ID: 5496
• mRNA Refseq: NM_177983
• Protein Refseq: NP_817092
• MIM: 605119
• Uniprot ID: O15355
• Chromosome Location: 2p23.3
• Pathway: mRNA processing, organism-specific biosystem
• Function: hydrolase activity; metal ion binding; protein serine/threonine phosphatase activity