PRG2

  • Official Full Name

    proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

  • Overview

    The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PRG2; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein); MBP; BMPG; MBP1; bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein; prg-2; Piwi (fruitfly) Related Gene; Piwi (fruitfly) Related Gene family member (prg-2); 4H292; tag-292;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His|GST
  • His|MBP
  • SUMO
  • N/A
  • N
  • ABP
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRG2-1745H Recombinant Human PRG2 protein, His & MBP-tagged E.coli His/MBP Gln105~Tyr222
Human PRG2-45H Recombinant Human PRG2, GST-tagged Wheat Germ GST
Human PRG2-44H Recombinant Human PRG2, His-tagged HEK293 His
Human PRG2-46H Recombinant Human PRG2, StrepII-tagged Human Cell Strep II
Human PRG2-2872HCL Recombinant Human PRG2 293 Cell Lysate HEK293 N/A
Human PRG2-19H Recombinant Human PRG2 Protein (Leu17-End), N-His-ABP tagged E.coli N-His-ABP Leu17-End
Human PRG2-2390H Recombinant Human PRG2 protein, His-SUMO-tagged E.coli His-SUMO 106-222aa
Human PRG2-1749H Recombinant Human PRG2 Protein, His-GST-tagged E.coli His/GST
Human PRG2-4492H Recombinant Human PRG2 protein, His-GST-tagged E.coli His/GST 17-104aa
Human PRG2-13H Recombinant Human PRG2 Protein (Leu17-End), N-His-ABP tagged E.coli N-His-ABP Leu17-End
Human PRG2-1264H Recombinant Human PRG2 Protein (Leu17-Tyr222), C-His tagged Mammalian cells C-His Leu17-Tyr222
Human PRG2-5978H Recombinant Human PRG2 Protein (Thr106-Tyr222), N-His tagged E.coli N-His Thr106-Tyr222
Mouse Prg2-1746M Recombinant Mouse Prg2 protein, His & GST-tagged E.coli His/GST Arg37~Lys215 (Accession # Q61878)
Rat Prg2-1747R Recombinant Rat Prg2 protein, His & GST-tagged E.coli His/GST Gly80~Lys219 (Accession # Q63189)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PRG2 involved in several pathways and played different roles in them. We selected most pathways PRG2 participated on our site, such as Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AsthmaIL4;HLA-DMB;HLA-DRB3;H2-AB1;IL9;HLA-DRB5;EPX;FCER1G;FCER1A

PRG2 has several biochemical functions, for example, carbohydrate binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRG2 itself. We selected most functions PRG2 had, and list some proteins which have the same functions with PRG2. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingReg2;SIGLEC6;Fcer2a;KLRC3;ILLR4;KLRB1A;CLEC6A;Clec4n;CD302
heparin bindingCOL20A1;ELANE;FGF9;CCL15;THBS1;REG4;RPL29;FGF1;HSD17B12

PRG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRG2.

CHD3; RBM48

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