SMAD4 Protein

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SMAD4

Official Full Name	SMAD family member 4
Background	SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms	SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS

Species :
Human
Mouse
Rat
Rhesus Macaque

Source :
E.coli
HEK293
HEK293T
Mammalian Cell

Tag :
GST
His
T7
Myc/DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag
Human	SMAD4-1095H	Recombinant Human SMAD Family Member 4, GST-tagged	E.coli	GST
Human	SMAD4-217H	Recombinant Human SMAD4 protein, His-tagged	E.coli	His
Human	SMAD4-31192TH	Recombinant Human SMAD4, His-tagged	E.coli	His
Human	SMAD4-31193TH	Recombinant Human SMAD4	E.coli	N/A
Human	SMAD4-386H	Recombinant Human SMAD Family Member 4, His-tagged	E.coli	His
Mouse	SMAD4-15587M	Recombinant Mouse SMAD4 Protein	Mammalian Cell	His
Mouse	Smad4-1978M	Recombinant Mouse Smad4 protein, His & T7-tagged	E.coli	His/T7
Rat	SMAD4-5609R	Recombinant Rat SMAD4 Protein	Mammalian Cell	His
Rhesus Macaque	SMAD4-4332R	Recombinant Rhesus monkey SMAD4 Protein, His-tagged	Mammalian Cell	His
Human	SMAD4-1676HCL	Recombinant Human SMAD4 293 Cell Lysate	HEK293	N/A
Human	SMAD4-1778H	Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK
Mouse	Smad4-5952M	Recombinant Mouse Smad4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK

Involved Pathway Protein Function Interacting Protein SMAD4 Related Gene Family

SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	FBXO32; TNFSF10; PRMT1; MAPK3; GADD45BB; NLK2; PTEN; TGFB1A; G6PCA.1; HOMER1
Cell cycle	PLK4; TUBGCP5; HIST4H4; PRKDC; TGFB1A; DNA2; SPO11; THRSP; PDS5B; RAD9
Wnt signaling pathway	PPP3CCA; CCND3; MAPK8B; PORCNL; EP300; NLK2; NFATC2; PPP3R1; BTRC; SFRP1A
TGF-beta signaling pathway	INHBC; SMAD3; BMPR1AA; ID3; BMP8A; FST; SMURF1; TGFBR1A; SMAD4; CHRD
Hippo signaling pathway	FZD9; PPP1CB; PPP1CA; LEF1; INADL; APC2; ACTG1; AXIN2; ACTB; CRB2
Adherens junction	SSX2IP; FER; WAS; SNAI2; PVRL1; ACTN4; FYN; NLK2; TGFBR1A; PVRL4
Signaling pathways regulating pluripotency of stem cells	PIK3CG; JARID2; DLX5; FZD9; HESX1; MEIS1; FZD2; MAP2K1; FZD8; IGF1R
Hepatitis B	IFNA10; TGFB3; FAS; ATP6AP1; NRAS; MAPK1; STAT2; STAT1; TLR2; IFNA14
HTLV-I infection	SMAD4; MAP3K14; CRTC1; VCAM1; HLA-DQB1; ZFP36; ATF3; IL1R2; FZD2; ETS2
Pathways in cancer	PLCB3; ERBB2; NFKBIA; SMO; ROCK2; Kitl; BIRC7; TGFB2; LAMA3; PLEKHG5
Colorectal cancer	GSK3B; AKT2; RHOA; PIK3CA; FOS; PIK3CD; APC2; LEF1; MSH2; PIK3CB
Pancreatic cancer	CCND1; RALBP1; SMAD2; CDC42; ARHGEF6; KRAS; PIK3R3; RB1; MAPK1; ARAF
Chronic myeloid leukemia	CCND1; RAF1; TP53; SHC1; PIK3CD; CBLC; MDM2; BAD; HDAC2; GAB2

SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

Function	Related Protein
contributes_to DNA binding	MRE11A; FOXH1; RFC3; ARNTL1A; SMAD4; NFE2L2A; GTF3C2; GTF3C6; MLXIPL; MAFGB
I-SMAD binding	AXIN2; SMAD2; TGFBR1; SMAD7; CTNNB1; SMAD6; TGFB1I1; SMAD4; SMURF1; SMAD1
R-SMAD binding	ZC3H3; RANBP3; PMEPA1; ANKRD1; MEN1; MYOCD; CTNNB1; FOXH1; PPM1A; FOS
RNA polymerase II core promoter proximal region sequence-specific DNA binding	BATF2; TGIF1; PAXBP1; TFAP2E; CEBPZ; NFIC; FOXJ2; STAT3; MEOX2; EGR2
RNA polymerase II transcription factor binding	SFPI1; GATA2A; TBX3; MTDH; KDM1A; GATA1A; GATA2B; TRP53; WWP2; NFATC1
chromatin binding	RELB; SOX10; PRKAA2; PRKCB; CREBBP; MAZ; PSIP1; HDGF2; CENPB; GATA2B
collagen binding	SPARC; SERPINH1; CTSL1; FN1; PCOLCE2; MMP9; Itga10&Itgb1; VWF; ITGA1; PDGFA
core promoter proximal region sequence-specific DNA binding	CREBBP; PAX2; TFAP2A; KLF1; DMRT2; KLF4; DMRTA1; UHRF1; DMRTC1C2; SMAD3
identical protein binding	RASSF3; DVL1; NEFL; TRIM39; Serpina1c; CALHM1; CD74; UBQLN1; DCP1A; ATXN3
metal ion binding	ADPRHL2; TRIM35-24; ZNF691; GMPR2; PLEKHF2; NUDT12; ZRANB1B; JAZF1; ACAP2; CMC1
protein binding	PAK6; KHDRBS2; FAM46C; IL18R1; HOXB6; LRRC4; MTMR2; EIF6; FOXO1; CLN6
protein heterodimerization activity	HIST3H3; ADD1; PPP3CB; AGTR1A; KCNK3; HIST1H2AC; PDGFA; ABTB2; MAFA; CXorf15
protein homodimerization activity	SYT6; CEACAM1; AOC3; NETO2; DMRT2A; KIAA0947; GSTM1; SNX2; PVRL4; MTMR2
contributes_to sequence-specific DNA binding	FIGLA; HNRNPAB; TRIM28; TCF3; HIF1A; ARNT; HDAC4; NEUROD1; EPAS1; SMAD4
transcription factor activity, RNA polymerase II transcription factor binding	ATF4; GTF2E1; YAP1; GATA4; TWIST2; SMAD4; MYOCD; MAMSTR; LHX2; THRAA
contributes_to transcription factor activity, protein binding	SMAD3; SMAD4
contributes_to transcription factor activity, sequence-specific DNA binding	MAFGA; SOX19B; SOX19A; SMAD3; NKX2-5; GATA4; VDRA; SOX1B; HNRNPAB; SOX1A
transcription regulatory region DNA binding	TOMM20A; ZFP639; NKX3; ZNF649; SALL1; BCL11B; BCOR; RFX3; TAF2; SALL1A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	MYOG; RAX; IRF4; TFAP2C; BSX; HIF1A; KCNA3; IRF1; KLF15; SOX1
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	SMAD4

SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

SMAD3; SMAD2

SMAD4

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SMAD4

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