SMAD4

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SMAD4

Official Full Name SMAD family member 4
Background SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli GST
    Human SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 N/A
    Human SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli His
    Human SMAD4-31192TH Recombinant Human SMAD4, His-tagged E.coli His
    Human SMAD4-31193TH Recombinant Human SMAD4 E.coli N/A
    Human SMAD4-386H Recombinant Human SMAD Family Member 4, His-tagged E.coli His
    Mouse SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cell His
    Mouse Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli His/T7
    Mouse Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cell His
    Rhesus Macaque SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cell His

    SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway CDKN2B; AKT1; PRKAG3; SGK2; RAG1; KLF2B; PDPK1B; HRASB; ARAF; MAPK12B
    Cell cycle NEDD1; MSH4; GADD45BA; CDC25A; NCAPH; CENPK; CDT1; PLK1; TBC1D8; DULLARD
    Wnt signaling pathway NFATC4; WNT7B; RHOAB; WNT11B; PRKCBB; CCND1; SFRP5; LEF1; SKP1; WNT11R
    TGF-beta signaling pathway LFT2; SMAD3A; BAMBI; SMAD2; IFNG1-2; SMAD7; LEFTY1; ACVR1C; BMPR1BB; BMP7
    Hippo signaling pathway FZD8; PARD6B; WNT6; BMPR2; CRB1; SMAD7; TGFB1; TGFB2; APC2; YWHAE
    Adherens junction ACTG1; MAPK3; WASB; TJP1; CREBBP; FARP2; SMAD4; RAC1B; WASF1; ACP1
    Signaling pathways regulating pluripotency of stem cells FZD5; FZD3; MEIS1; AXIN2; LIF; HRAS; SMAD9; MAP2K2; FZD9; INHBE
    Hepatitis B YWHAB; AKT2; ATF4; BAX; SRC; CASP10; DDX58; STAT2; NFATC3; IFNA12
    HTLV-I infection MAP3K3; ATF4; ELK1; FOS; MAPK8; RB1; TGFB2; CD40; TGFBR1; POLE
    Pathways in cancer RAC3; CDH1; GNGT1; GNA11; BIRC2; MAPK1; PLCB4; Fzd4; PIK3CB; WNT1
    Colorectal cancer AKT2; PIK3R2; TP53; MSH6; ARAF; TGFB3; PIK3CA; RAC2; RHOA; TGFB1
    Pancreatic cancer MAPK10; IKBKG; VEGFA; STAT3; TGFA; MAPK1; CASP9; TGFB1; MAPK3; IKBKB
    Chronic myeloid leukemia ARAF; NFKB1; TGFB1; AKT1; RUNX1; TGFB2; BCR; MAPK3; SHC3; PIK3R1

    SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding MRE11A; GTF3C2; TCF3; SMAD2; FOXH1; GTF3C5; ARNTL1A; CLOCKA; SMAD4; MAFGB
    I-SMAD binding TGFB1I1; AXIN2; SMAD1; TGFBR1; SMAD4; SMAD6; AXIN1; SMURF1; SMAD7; SMAD2
    R-SMAD binding PMEPA1; MEN1; FOS; SMAD6; JUN; SMAD4; SMAD2; TRIM33; PAX6; PPM1A
    RNA polymerase II core promoter proximal region sequence-specific DNA binding HOXA7; KCNA3; OTX2; RBPJ; TP73; MYPOP; TCF3B; MIXL1; PITX1; ETV2
    RNA polymerase II transcription factor binding GATA1; GATA6; ANKRD1; GSC; MIXL1; TRP53; GSK3B; GATA2B; SFPI1; MEF2A
    chromatin binding SP3; POU1F1; TRP63; MSL1A; SHMT2; ACTL6A; TCF3; HOXD13; CHAF1B; ANKRD2
    collagen binding SMAD3; SMAD4; COMP; FN1; CD44; Itga10&Itgb1; PCOLCE; SPARC; DCN; CTSB
    core promoter proximal region sequence-specific DNA binding DMRTC1C2; KLF4; DMRTC2; SMAD3; MEF2C; DMRT3A; SP3A; CREBBP; DMRT2A; UHRF1
    identical protein binding DAPK2; DNMT3A; BIRC5; PKD2; RABAC1; GOT2; ALDOB; GLE1; PON2; SOD2
    metal ion binding UBA5; ZNF625; ZFY1; GFI1B; PLEKHF1; MTL5; HBB-Y; KIT; APEX1; STEAP2
    protein binding MFAP4; NHEJ1; CUL4B; THEMIS2; AACS; Tnfrsf23; RCC1; MOS; EGR2; RBM39
    protein heterodimerization activity MAP3K7; PDGFA; ATF2; NR2C2; VEGFB; NR4A2; MYF5; AHR; BTBD11; DMRT3
    protein homodimerization activity NR2F2; GZMA; GSTM4; IRF3; GIPC1; BHLHE40; ODZ4; MAP3K12; CDH13; STOM
    contributes_to sequence-specific DNA binding HIF1A; HNRNPAB; PPARG; NEUROD1; FIGLA; EPAS1; TCF3; HDAC4; SMAD4; TRIM28
    transcription factor activity, RNA polymerase II transcription factor binding THRAA; ATF4; YAP1; TWIST2; ATF2; GATA4; MYOCD; ZNF296; SRF; GTF2E1
    contributes_to transcription factor activity, protein binding SMAD3; SMAD4
    contributes_to transcription factor activity, sequence-specific DNA binding VDRA; NKX2-5; TAF10; SOX1A; HNRNPAB; MAFGA; TAF6; SMAD4; SOX19B; MAFGB
    transcription regulatory region DNA binding KDM1A; SALL4; HIVEP3; SERPINB1A; KLF1; XRCC5; ZFP746; TAF7; NFKB1; CALCOCO1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MEOX1; TCF12; TCF4; FOSL1; GMEB1; ATF4; SRF; SP1; ALS2CR8; FOXA1
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity SMAD4

    SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

    SMAD3; SMAD2

    TGF

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