SMAD4 Protein


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Official Full Name SMAD family member 4
Background SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli GST Inquiry
    Human SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli His Inquiry
    Human SMAD4-31192TH Recombinant Human SMAD4, His-tagged E.coli His Inquiry
    Human SMAD4-31193TH Recombinant Human SMAD4 E.coli N/A Inquiry
    Human SMAD4-386H Recombinant Human SMAD Family Member 4, His-tagged E.coli His Inquiry
    Mouse SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cell His Inquiry
    Mouse Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cell His Inquiry
    Rhesus Macaque SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cell His Inquiry
    Human SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 N/A Inquiry
    Human SMAD4-2042H Recombinant Human SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human SMAD4-288HFL Recombinant Full Length Human SMAD4 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Rhesus Macaque SMAD4-4148R Recombinant Rhesus Macaque SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rat SMAD4-5268R Recombinant Rat SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Mouse SMAD4-8457M Recombinant Mouse SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway MAPK3; PTEN; MAPK11; PIK3CB; PRMT1; GADD45AA; MAPK13; BCL6A; MDM2; RBL2
    Cell cycle CEP76; ORC5; CDK7; GADD45BA; BRCC3; INCENP; DBF4; RB1; CSNK1D; SPO11
    Wnt signaling pathway WNT1; PRKACG; FZD1; TCF7L2; WNT8B; PRKACAB; Fzd4; PLCB4; PRKACBA; FZD5
    TGF-beta signaling pathway TFDP1; ID2; ACVR1C; ROCK2B; ACVR1B; CUL1; TGFB3; ACVR2B; CHD; NOG2
    Hippo signaling pathway FZD6; TGFB2; SMAD7; APC2; FZD7; PPP2R1B; TCF7; SERPINE1; BMP8B; MOB1A
    Adherens junction ACTN3; FYN; MLLT4; BAIAP2; CSNK2A1; TCF7L1A; CSNK2A2A; MAP3K7; SMAD4; ACTB1
    Signaling pathways regulating pluripotency of stem cells STAT3; ESRRB; WNT2B; BMPR2; WNT8B; MAPK12; MAPK11; PCGF5; FZD6; INHBB
    Hepatitis B TGFB1; RB1; IKBKG; MAPK3; Fasl; FASLG; NFATC2; PRKCB; CXCL8; Ifna15
    HTLV-I infection WNT11; SMAD4; FOS; RANBP3; TP53; MAPK8; POLE; TNF; POLE3; HLA-DQA2
    Pathways in cancer BIRC2; GNG5; MAP2K2; ARAF; F2RL3; ARNT; RAC3; FH1; TRAF4; FGFR3
    Colorectal cancer PIK3CB; PIK3R5; TGFBR1; TGFB2; PIK3CA; RAC1; BCL2; BAX; TGFB1; AXIN2
    Pancreatic cancer NFKB1; BCL2L1; PIK3CB; RALGDS; MAPK8; SMAD2; PIK3CD; RAF1; MAPK3; BAD
    Chronic myeloid leukemia KRAS; BAD; SHC4; CBLB; PIK3R2; CBL; SHC2; RB1; SHC1; PIK3CA

    SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding CLOCKA; GTF3C2; MRE11A; FOXH1; SMAD4; SMAD2; GTF3C4; MAFGA; TCF3; RFC3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding HOXC11; SOX10; ZNF713; MED8; ZNF395; PITX2; ZFP639; ESR1; NR4A3; ONECUT2
    RNA polymerase II transcription factor binding PITX2; TOX2; SPI1; SMAD4; MIXL1; TRP53; GATA1A; ZFPM2A; Ar; GATA5
    chromatin binding TGIF1; HIST2H3C1; MBD1; PBX2; ZMYND11; SUPT5H; CSNK2B; RUNX2; REST; FOSL2
    collagen binding CTSB; CTSS; FN1; ABI3BP; ANTXR1; DCN; TGFBI; SMAD7; CD44; NID1
    core promoter proximal region sequence-specific DNA binding SP3A; DMRT2B; MEF2C; PAX2; SMAD4; DMRTA1; ZFP516; MIXL1; DMRTC1B; DMRT2
    identical protein binding TLR3; ZDHHC17; DYNLT1B; CRYAA; RASSF3; LYZ1; SFRP1; FHOD1; MBIP; AGXT2L2
    metal ion binding CARS; ZBTB10; OVOL2; CACNA2D3; SIVA1; THAP4; MOBKL2B; AGBL1; ZNF496; SFTPBB
    protein binding CAMP; C19orf73; SAC3D1; SDHB; NME5; DRG2; PAG1; ZFP64; NEDD4; DTD2
    protein heterodimerization activity HIST1H2AG; BIRC5; TLR1; OSTB; TIMELESS; FZD1; TAF4B; UBXN6; BCL2A; KCNH5
    protein homodimerization activity DHDPSL; BAX; NTRK1; IGJ; AXIN1; SIAH1A; ERBB4; BMP2B; UGT1A9; ANXA6
    contributes_to sequence-specific DNA binding HIF1A; NEUROD1; TRIM28; HNRNPAB; SMAD4; PPARG; ARNT; TCF3; EPAS1; FIGLA
    transcription factor activity, RNA polymerase II transcription factor binding ATF4; MYOCD; HIF1A; GATA4; MAMSTR; GTF2E1; THRAA; TWIST2; YAP1; NACC2
    contributes_to transcription factor activity, protein binding SMAD4; SMAD3
    contributes_to transcription factor activity, sequence-specific DNA binding GATA4; SOX19B; SOX1A; TAF12; TAF6; NKX2-5; VDR; NKX2; SMAD4; TRIM28
    transcription regulatory region DNA binding RFX3; SALL2; TCF7L2; GLIS2; SOX17; CEBPA; HIVEP3; MLL1; XBP1; KLF1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding AKNA; MEIS3; TP53; NEUROG3; NFIA; RFX4; JUNB; BARHL2; WT1; EBF3A
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity SMAD4

    SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

    SMAD3; SMAD2

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