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Official Full Name SMAD family member 4
Background SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli GST
    Human SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 N/A
    Human SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli His
    Human SMAD4-31192TH Recombinant Human SMAD4, His-tagged E.coli His
    Human SMAD4-31193TH Recombinant Human SMAD4 E.coli N/A
    Human SMAD4-386H Recombinant Human SMAD Family Member 4, His-tagged E.coli His
    Mouse SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cell His
    Mouse Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli His/T7
    Mouse Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cell His
    Rhesus Macaque SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cell His

    SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway RBL2; CAT; STK4; GABARAPL1; RAG1; PRKAB1B; MAPK3; IL7R; GADD45AA; PRKAG3
    Cell cycle SMC3; SKA1; HDAC2; KIF2C; DYRK1A; MAD2L1; PCM1; ORC1; MCM10; MCM8
    Wnt signaling pathway NLK; FZD9; FZD2; CCND2; DKK1; SMAD4; CAMK2G1; PPARD; BTRC; PRKCG
    TGF-beta signaling pathway BMPR2B; SMAD7; SMAD5; LEFTY1; SMAD3A; MYCB; BMP8B; SMAD1; BAMBIB; ACVR2AA
    Hippo signaling pathway PRKCI; WNT6; APC2; SCRIB; DVL3; BMP4; BBC3; CTNNA3; LLGL1; BMP5
    Adherens junction CTNNB1; WASF3B; PTPRFB; SMAD3; MAP3K7; ACTN2B; EP300; PTPRJA; CSNK2A2A; LMO7A
    Signaling pathways regulating pluripotency of stem cells MAPK3; PAX6; SMAD9; REST; SMAD3; WNT3A; PCGF6; NEUROG1; WNT7A; INHBC
    Pathways in cancer TCEB2; HSP90AB1; FLT3LG; BRAF; HIF1A; TFG; MAP2K1; PRKCG; FGFR2; FGF11
    Colorectal cancer BRAF; RALGDS; RAC2; AKT1; TCF7L2; RAC3; TCF7; TP53; TGFBR2; SMAD2
    Pancreatic cancer RAC2; TGFB1; TGFBR1; ARAF; TGFB3; TGFA; STAT3; PIK3R2; SMAD4; MAPK3
    Chronic myeloid leukemia TGFB2; AKT1; SMAD4; ABL1; CTBP1; SHC2; CTBP2; MECOM; SHC4; RUNX1

    SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding ARNTL1A; TCF3; GTF3C4; SMAD2; MRE11A; MCM7; MLXIPL; ARNTL1B; FOXH1; MAFGB
    R-SMAD binding TRIM33; RANBP3; PAX6; SMAD3; SMAD2; PMEPA1; PARP1; FOXH1; C18orf1; SMURF1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CREB3L2; PAX8; ELF1; MITFA; JUNB; IFI203; PHOX2B; TBX20; PYDC3; ZIC3
    RNA polymerase II transcription factor binding TP53; TBX6; CHST13; MIXL1; GSK3B; SFPI1; XBP1; TEAD3; ATF4; SPI1
    chromatin binding SMC1A; APBB1; NEUROG1; HIF1AB; NSD1; STAG2; FLI1; TLE4; OST4; MEIOB
    collagen binding MMP9; SMAD3; GP6; LRRC15; PDGFA; NID2; SERPINH2; ITGA10; PODN; PCOLCE2
    core promoter proximal region sequence-specific DNA binding MEF2C; PAX2; DMRTA2; CREBBP; SMAD4; KLF4; DMRTC1B; UHRF1; TFAP2A; DMRT2B
    identical protein binding PPP5C; LCK; USP2; VWA1; MYD88; C1QL2; S100B; ACADM; MTSS1; CLDN7
    metal ion binding ATP8A1; CYP21A1; NME3; EGR1; GMPR; DBR1; KLF10; PEG3; ZFP511; ZNFL1
    protein binding CDK13; CDC42BPA; SYCP1; TGFB1I1; FCGR2A; NTHL1; NMRK2; ZBTB7B; TMEM100; CD99L2
    protein heterodimerization activity PAFAH1B3; ITGB1A; TAS1R3; CENPW; HIST1H2BK; SMC4; SOS1; TAF8; THRA; NEUROD1
    protein homodimerization activity PON1; APOA4; KCNK3; TESC; ACTN1; CAMK2D; NBL1; DMRT3A; IRAK2; BMP7A
    contributes_to sequence-specific DNA binding TRIM28; HIF1A; PPARG; NEUROD1; FIGLA; EPAS1; HNRNPAB; TCF3; ARNT; SMAD4
    transcription factor activity, RNA polymerase II transcription factor binding LHX2; THRAA; MYOCD; ATF4; TWIST2; ZNF296; GTF2E1; HIF1A; YAP1; SMAD4
    contributes_to transcription factor activity, protein binding SMAD3; SMAD4
    contributes_to transcription factor activity, sequence-specific DNA binding NFE2L2A; TRIM28; SOX19A; NKX2-5; TAF10; SMAD3; VDRB; FOXH1; GATA4; HNRNPAB
    transcription regulatory region DNA binding ARID4A; ZFP513; ZNF649; GATA6; ATF5; SERPINB1A; EGR2; PRDM5; TCF7L2; BCL11AB
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ELF3; DBP; CREB3L1; GCM1; ZFAT; NR1H4; MYBL2; Ar; ISL1; ZIC1
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity SMAD4

    SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

    SMAD3; SMAD2


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