SMAD4 Protein

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SMAD4

Official Full Name	SMAD family member 4
Background	SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms	SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS

Species :
Human
Mouse
Rat
Rhesus Macaque

Source :
E.coli
HEK293
HEK293T
Mammalian Cell

Tag :
GST
His
T7
Myc/DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag
Human	SMAD4-1095H	Recombinant Human SMAD Family Member 4, GST-tagged	E.coli	GST
Human	SMAD4-217H	Recombinant Human SMAD4 protein, His-tagged	E.coli	His
Human	SMAD4-31192TH	Recombinant Human SMAD4, His-tagged	E.coli	His
Human	SMAD4-31193TH	Recombinant Human SMAD4	E.coli	N/A
Human	SMAD4-386H	Recombinant Human SMAD Family Member 4, His-tagged	E.coli	His
Mouse	SMAD4-15587M	Recombinant Mouse SMAD4 Protein	Mammalian Cell	His
Mouse	Smad4-1978M	Recombinant Mouse Smad4 protein, His & T7-tagged	E.coli	His/T7
Rat	SMAD4-5609R	Recombinant Rat SMAD4 Protein	Mammalian Cell	His
Rhesus Macaque	SMAD4-4332R	Recombinant Rhesus monkey SMAD4 Protein, His-tagged	Mammalian Cell	His
Human	SMAD4-1676HCL	Recombinant Human SMAD4 293 Cell Lysate	HEK293	N/A
Human	SMAD4-1778H	Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK
Mouse	Smad4-5952M	Recombinant Mouse Smad4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK

Involved Pathway Protein Function Interacting Protein SMAD4 Related Gene Family

SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	PRMT1; HRAS; SGK3; FBXO32; CDKN2D; PRKAG1; FOXG1A; INSRA; FOXO3A; PTEN
Cell cycle	E2F5; ORC2L; CENPN; DCTN1; CDK1; WEE2; ANAPC5; CSNK1D; CDKN1BB; CDCA8
Wnt signaling pathway	RHOAD; AXIN1; PORCNL; SIAH2L; PORCN; FZD7A; WNT11; WNT2BA; PRKACAA; WNT6
TGF-beta signaling pathway	PPP2R1B; BMPR2B; FST; ACVR2A; TGFB1A; TFDP1A; RHOA; IFNG1-2; NDR1; ZFYVE9
Hippo signaling pathway	FZD8; PPP2R2A; AREG; LEF1; Fzd4; WNT6; BIRC2; DLG1; BMP6; ACTB
Adherens junction	IGF1R; MAPK3; PTPN1; TCF7L1A; SSX2IP; PTPRF; EGFR; ACP1; MAPK1; CSNK2A1
Signaling pathways regulating pluripotency of stem cells	AXIN2; SMAD5; ONECUT1; WNT1; ZIC3; ACVR2B; BMPR1B; ESRRB; PCGF3; ID4
Hepatitis B	IKBKG; PIK3R1; IFNA12; IFIH1; CREB3L1; HSPG2; PIK3CA; IFNA6; Fasl; PIK3R2
HTLV-I infection	HLA-G; WNT9A; WNT11; PIK3R5; SPI1; TGFBR2; WNT6; MYB; TP53INP1; LCK
Pathways in cancer	FGF14; PLD1; FADD; WNT7B; PIK3CB; LAMA3; SFPI1; GNAI3; PIK3CA; TRAF4
Colorectal cancer	ARAF; PIK3R1; RAC2; APPL1; SMAD3; APC; PIK3CB; TCF7; CYCS; RAC3
Pancreatic cancer	TGFBR1; RAC2; NFKB1; PIK3CG; MAPK1; STAT3; IKBKG; PIK3CA; ARAF; RAD51
Chronic myeloid leukemia	TGFBR2; PIK3CA; MAPK1; ARAF; STAT5A; MDM2; TGFB1; KRAS; NRAS; PTPN11

SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

Function	Related Protein
contributes_to DNA binding	GTF3C3; GTF3C4; MAFGB; AHR2; CLOCKA; NFE2L2A; GTF3C5; GTF3C2; MAFGA; MCM7
I-SMAD binding	TGFB1I1; SMAD1; SMAD4; CTNNB1; SMURF1; TGFBR1; AXIN2; AXIN1; SMAD2; SMAD7
R-SMAD binding	FOXH1; MYOCD; MEN1; PAX6; PPM1A; PMEPA1; C18orf1; ANKRD1; JUN; SMAD3
RNA polymerase II core promoter proximal region sequence-specific DNA binding	POU1F1; NEUROG3; CEBPG; MIXL1; HLTF; FOSL2; ZNF100; SMAD4; MYBL1; TBX20
RNA polymerase II transcription factor binding	MIXL1; TRP53; SPI1; ZFPM2A; TOX2; MEF2A; TP53; WWP2; DHX9; SPOP
chromatin binding	TCF7L1A; RERE; PRDM13; KLF14; SOD3; ANKRD2; MED12; ARID5A; CHAF1B; TOX4
collagen binding	CCBE1; MMP13; Itga10&Itgb1; COMP; SRGN; MMP9; GPR56; ITGA9; GP5; PDGFB
core promoter proximal region sequence-specific DNA binding	MEF2C; DMRT1; DMRTC2; DMRT2B; CXXC1; DMRT3A; DMRTA1; DMRT2A; SP3A; DMRTA2
identical protein binding	CLDN14; MAP3K13; APOE; SH3GL1; GRASP; PCNA; ETNPPL; CNTN2; G6PD; TRADD
metal ion binding	QTRT1; ZDHHC20A; ING5B; ITPK1A; ZNF280D; ICN2; GNAT2; NR2F1B; TNK2; ACVR2A
protein binding	ZC3H18; NEURL1B; C10orf46; ARFGAP1; ACLY; LRRC29; ZFAND5; RBBP5; KCNE1L; BFAR
protein heterodimerization activity	TAS1R3; HIST1H2AK; Defa-rs7; TOP2B; CAV2; GRIN1; HIST1H4I; SCUBE1; DRD1; FZD1
protein homodimerization activity	CHEK2; TYRP1; CAT; BCL11A; UGT1A6B; SFTPC; TRIM9; ASNS; TCF3; Anks6
contributes_to sequence-specific DNA binding	FIGLA; HNRNPAB; SMAD4; HIF1A; NEUROD1; TCF3; EPAS1; TRIM28; PPARG; HDAC4
transcription factor activity, RNA polymerase II transcription factor binding	GATA4; NACC2; LHX2; MYOCD; SMAD4; SRF; TWIST2; ZNF296; ATF4; ATF2
contributes_to transcription factor activity, protein binding	SMAD3; SMAD4
contributes_to transcription factor activity, sequence-specific DNA binding	SMAD4; TRIM28; VDRA; MAFGB; VDR; TAF7; TAF6; HNRNPAB; SMAD2; SOX1B
transcription regulatory region DNA binding	SMAD4; RBBP5; CDK5RAP2; HMGB2; ZNF821; THRA; ZNF649; SMAD3; NCOR1; ATMIN
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	FOXD1; HLTF; CEBPE; TP63; ELF4; EBF4; HOXD13; PITX3; ZNF750; NDN
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	SMAD4

SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

SMAD3; SMAD2

SMAD4

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SMAD4

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