SMAD4 Protein

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SMAD4

Official Full Name	SMAD family member 4
Background	SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms	SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS;

Species :
Human
Mouse
Rat
Rhesus Macaque

Source :
E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag :
Flag
GST
His
His (Fc)-Avi
T7
Myc/DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SMAD4-1095H	Recombinant Human SMAD Family Member 4, GST-tagged	E.coli	GST	Inquiry
Human	SMAD4-217H	Recombinant Human SMAD4 protein, His-tagged	E.coli	His	Inquiry
Human	SMAD4-31192TH	Recombinant Human SMAD4, His-tagged	E.coli	His	Inquiry
Human	SMAD4-31193TH	Recombinant Human SMAD4	E.coli	N/A	Inquiry
Human	SMAD4-386H	Recombinant Human SMAD Family Member 4, His-tagged	E.coli	His	Inquiry
Mouse	SMAD4-15587M	Recombinant Mouse SMAD4 Protein	Mammalian Cell	His	Inquiry
Mouse	Smad4-1978M	Recombinant Mouse Smad4 protein, His & T7-tagged	E.coli	His/T7	Inquiry
Rat	SMAD4-5609R	Recombinant Rat SMAD4 Protein	Mammalian Cell	His	Inquiry
Rhesus Macaque	SMAD4-4332R	Recombinant Rhesus monkey SMAD4 Protein, His-tagged	Mammalian Cell	His	Inquiry
Human	SMAD4-1676HCL	Recombinant Human SMAD4 293 Cell Lysate	HEK293	N/A	Inquiry
Human	SMAD4-2042H	Recombinant Human SMAD4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Human	SMAD4-288HFL	Recombinant Full Length Human SMAD4 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Rhesus Macaque	SMAD4-4148R	Recombinant Rhesus Macaque SMAD4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	SMAD4-5268R	Recombinant Rat SMAD4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SMAD4-8457M	Recombinant Mouse SMAD4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Human	SMAD4-1778H	Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	Smad4-5952M	Recombinant Mouse Smad4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry

Involved Pathway Protein Function Interacting Protein SMAD4 Related Gene Family

SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	MAPK3; PTEN; MAPK11; PIK3CB; PRMT1; GADD45AA; MAPK13; BCL6A; MDM2; RBL2
Cell cycle	CEP76; ORC5; CDK7; GADD45BA; BRCC3; INCENP; DBF4; RB1; CSNK1D; SPO11
Wnt signaling pathway	WNT1; PRKACG; FZD1; TCF7L2; WNT8B; PRKACAB; Fzd4; PLCB4; PRKACBA; FZD5
TGF-beta signaling pathway	TFDP1; ID2; ACVR1C; ROCK2B; ACVR1B; CUL1; TGFB3; ACVR2B; CHD; NOG2
Hippo signaling pathway	FZD6; TGFB2; SMAD7; APC2; FZD7; PPP2R1B; TCF7; SERPINE1; BMP8B; MOB1A
Adherens junction	ACTN3; FYN; MLLT4; BAIAP2; CSNK2A1; TCF7L1A; CSNK2A2A; MAP3K7; SMAD4; ACTB1
Signaling pathways regulating pluripotency of stem cells	STAT3; ESRRB; WNT2B; BMPR2; WNT8B; MAPK12; MAPK11; PCGF5; FZD6; INHBB
Hepatitis B	TGFB1; RB1; IKBKG; MAPK3; Fasl; FASLG; NFATC2; PRKCB; CXCL8; Ifna15
HTLV-I infection	WNT11; SMAD4; FOS; RANBP3; TP53; MAPK8; POLE; TNF; POLE3; HLA-DQA2
Pathways in cancer	BIRC2; GNG5; MAP2K2; ARAF; F2RL3; ARNT; RAC3; FH1; TRAF4; FGFR3
Colorectal cancer	PIK3CB; PIK3R5; TGFBR1; TGFB2; PIK3CA; RAC1; BCL2; BAX; TGFB1; AXIN2
Pancreatic cancer	NFKB1; BCL2L1; PIK3CB; RALGDS; MAPK8; SMAD2; PIK3CD; RAF1; MAPK3; BAD
Chronic myeloid leukemia	KRAS; BAD; SHC4; CBLB; PIK3R2; CBL; SHC2; RB1; SHC1; PIK3CA

SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

Function	Related Protein
contributes_to DNA binding	CLOCKA; GTF3C2; MRE11A; FOXH1; SMAD4; SMAD2; GTF3C4; MAFGA; TCF3; RFC3
I-SMAD binding	SMAD6; TGFBR1; SMURF1; SMAD1; AXIN2; CTNNB1; SMAD2; SMAD7; TGFB1I1; AXIN1
R-SMAD binding	PPM1A; PARP1; SMAD3; RANBP3; TRIM33; SMAD4; ANKRD1; FOS; ZC3H3; PMEPA1
RNA polymerase II core promoter proximal region sequence-specific DNA binding	HOXC11; SOX10; ZNF713; MED8; ZNF395; PITX2; ZFP639; ESR1; NR4A3; ONECUT2
RNA polymerase II transcription factor binding	PITX2; TOX2; SPI1; SMAD4; MIXL1; TRP53; GATA1A; ZFPM2A; Ar; GATA5
chromatin binding	TGIF1; HIST2H3C1; MBD1; PBX2; ZMYND11; SUPT5H; CSNK2B; RUNX2; REST; FOSL2
collagen binding	CTSB; CTSS; FN1; ABI3BP; ANTXR1; DCN; TGFBI; SMAD7; CD44; NID1
core promoter proximal region sequence-specific DNA binding	SP3A; DMRT2B; MEF2C; PAX2; SMAD4; DMRTA1; ZFP516; MIXL1; DMRTC1B; DMRT2
identical protein binding	TLR3; ZDHHC17; DYNLT1B; CRYAA; RASSF3; LYZ1; SFRP1; FHOD1; MBIP; AGXT2L2
metal ion binding	CARS; ZBTB10; OVOL2; CACNA2D3; SIVA1; THAP4; MOBKL2B; AGBL1; ZNF496; SFTPBB
protein binding	CAMP; C19orf73; SAC3D1; SDHB; NME5; DRG2; PAG1; ZFP64; NEDD4; DTD2
protein heterodimerization activity	HIST1H2AG; BIRC5; TLR1; OSTB; TIMELESS; FZD1; TAF4B; UBXN6; BCL2A; KCNH5
protein homodimerization activity	DHDPSL; BAX; NTRK1; IGJ; AXIN1; SIAH1A; ERBB4; BMP2B; UGT1A9; ANXA6
contributes_to sequence-specific DNA binding	HIF1A; NEUROD1; TRIM28; HNRNPAB; SMAD4; PPARG; ARNT; TCF3; EPAS1; FIGLA
transcription factor activity, RNA polymerase II transcription factor binding	ATF4; MYOCD; HIF1A; GATA4; MAMSTR; GTF2E1; THRAA; TWIST2; YAP1; NACC2
contributes_to transcription factor activity, protein binding	SMAD4; SMAD3
contributes_to transcription factor activity, sequence-specific DNA binding	GATA4; SOX19B; SOX1A; TAF12; TAF6; NKX2-5; VDR; NKX2; SMAD4; TRIM28
transcription regulatory region DNA binding	RFX3; SALL2; TCF7L2; GLIS2; SOX17; CEBPA; HIVEP3; MLL1; XBP1; KLF1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	AKNA; MEIS3; TP53; NEUROG3; NFIA; RFX4; JUNB; BARHL2; WT1; EBF3A
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	SMAD4

SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

SMAD3; SMAD2

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SMAD4 Protein

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