SMAD4 Protein

SMAD4

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SMAD4

Official Full Name SMAD family member 4
Background SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli GST
    Human SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli His
    Human SMAD4-31192TH Recombinant Human SMAD4, His-tagged E.coli His
    Human SMAD4-31193TH Recombinant Human SMAD4 E.coli N/A
    Human SMAD4-386H Recombinant Human SMAD Family Member 4, His-tagged E.coli His
    Mouse SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cell His
    Mouse Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli His/T7
    Rat SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cell His
    Rhesus Macaque SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cell His
    Human SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 N/A
    Human SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PRMT1; HRAS; SGK3; FBXO32; CDKN2D; PRKAG1; FOXG1A; INSRA; FOXO3A; PTEN
    Cell cycle E2F5; ORC2L; CENPN; DCTN1; CDK1; WEE2; ANAPC5; CSNK1D; CDKN1BB; CDCA8
    Wnt signaling pathway RHOAD; AXIN1; PORCNL; SIAH2L; PORCN; FZD7A; WNT11; WNT2BA; PRKACAA; WNT6
    TGF-beta signaling pathway PPP2R1B; BMPR2B; FST; ACVR2A; TGFB1A; TFDP1A; RHOA; IFNG1-2; NDR1; ZFYVE9
    Hippo signaling pathway FZD8; PPP2R2A; AREG; LEF1; Fzd4; WNT6; BIRC2; DLG1; BMP6; ACTB
    Adherens junction IGF1R; MAPK3; PTPN1; TCF7L1A; SSX2IP; PTPRF; EGFR; ACP1; MAPK1; CSNK2A1
    Signaling pathways regulating pluripotency of stem cells AXIN2; SMAD5; ONECUT1; WNT1; ZIC3; ACVR2B; BMPR1B; ESRRB; PCGF3; ID4
    Hepatitis B IKBKG; PIK3R1; IFNA12; IFIH1; CREB3L1; HSPG2; PIK3CA; IFNA6; Fasl; PIK3R2
    HTLV-I infection HLA-G; WNT9A; WNT11; PIK3R5; SPI1; TGFBR2; WNT6; MYB; TP53INP1; LCK
    Pathways in cancer FGF14; PLD1; FADD; WNT7B; PIK3CB; LAMA3; SFPI1; GNAI3; PIK3CA; TRAF4
    Colorectal cancer ARAF; PIK3R1; RAC2; APPL1; SMAD3; APC; PIK3CB; TCF7; CYCS; RAC3
    Pancreatic cancer TGFBR1; RAC2; NFKB1; PIK3CG; MAPK1; STAT3; IKBKG; PIK3CA; ARAF; RAD51
    Chronic myeloid leukemia TGFBR2; PIK3CA; MAPK1; ARAF; STAT5A; MDM2; TGFB1; KRAS; NRAS; PTPN11

    SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding GTF3C3; GTF3C4; MAFGB; AHR2; CLOCKA; NFE2L2A; GTF3C5; GTF3C2; MAFGA; MCM7
    I-SMAD binding TGFB1I1; SMAD1; SMAD4; CTNNB1; SMURF1; TGFBR1; AXIN2; AXIN1; SMAD2; SMAD7
    R-SMAD binding FOXH1; MYOCD; MEN1; PAX6; PPM1A; PMEPA1; C18orf1; ANKRD1; JUN; SMAD3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding POU1F1; NEUROG3; CEBPG; MIXL1; HLTF; FOSL2; ZNF100; SMAD4; MYBL1; TBX20
    RNA polymerase II transcription factor binding MIXL1; TRP53; SPI1; ZFPM2A; TOX2; MEF2A; TP53; WWP2; DHX9; SPOP
    chromatin binding TCF7L1A; RERE; PRDM13; KLF14; SOD3; ANKRD2; MED12; ARID5A; CHAF1B; TOX4
    collagen binding CCBE1; MMP13; Itga10&Itgb1; COMP; SRGN; MMP9; GPR56; ITGA9; GP5; PDGFB
    core promoter proximal region sequence-specific DNA binding MEF2C; DMRT1; DMRTC2; DMRT2B; CXXC1; DMRT3A; DMRTA1; DMRT2A; SP3A; DMRTA2
    identical protein binding CLDN14; MAP3K13; APOE; SH3GL1; GRASP; PCNA; ETNPPL; CNTN2; G6PD; TRADD
    metal ion binding QTRT1; ZDHHC20A; ING5B; ITPK1A; ZNF280D; ICN2; GNAT2; NR2F1B; TNK2; ACVR2A
    protein binding ZC3H18; NEURL1B; C10orf46; ARFGAP1; ACLY; LRRC29; ZFAND5; RBBP5; KCNE1L; BFAR
    protein heterodimerization activity TAS1R3; HIST1H2AK; Defa-rs7; TOP2B; CAV2; GRIN1; HIST1H4I; SCUBE1; DRD1; FZD1
    protein homodimerization activity CHEK2; TYRP1; CAT; BCL11A; UGT1A6B; SFTPC; TRIM9; ASNS; TCF3; Anks6
    contributes_to sequence-specific DNA binding FIGLA; HNRNPAB; SMAD4; HIF1A; NEUROD1; TCF3; EPAS1; TRIM28; PPARG; HDAC4
    transcription factor activity, RNA polymerase II transcription factor binding GATA4; NACC2; LHX2; MYOCD; SMAD4; SRF; TWIST2; ZNF296; ATF4; ATF2
    contributes_to transcription factor activity, protein binding SMAD3; SMAD4
    contributes_to transcription factor activity, sequence-specific DNA binding SMAD4; TRIM28; VDRA; MAFGB; VDR; TAF7; TAF6; HNRNPAB; SMAD2; SOX1B
    transcription regulatory region DNA binding SMAD4; RBBP5; CDK5RAP2; HMGB2; ZNF821; THRA; ZNF649; SMAD3; NCOR1; ATMIN
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding FOXD1; HLTF; CEBPE; TP63; ELF4; EBF4; HOXD13; PITX3; ZNF750; NDN
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity SMAD4

    SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

    SMAD3; SMAD2

    TGF

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