SMAD4

  • Official Full Name

    SMAD family member 4
  • Overview

    SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
  • Synonyms

    SMAD4;SMAD family member 4;MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila);mothers against decapentaplegic homolog 4;DPC4;MAD homolog 4;SMAD, mothers against DPP homolog 4;deleted in pancreatic carcinoma locus 4;deletion target in pancreatic carcinoma 4;mothers against decapentaplegic, Drosophila, homolog of, 4;JIP;MADH4;MYHRS

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • Mammalian Cells
  • E.coli
  • HEK293
  • Flag
  • GST
  • His
  • T7
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SMAD4-288HFL Active Recombinant Full Length Human SMAD4 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli Human GST
SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cells Mouse His
Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli Mouse His&T7 Thr9~Ser231
SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli Human His
SMAD4-386H Recombinant Full Length Human SMAD Family Member 4, His-tagged E.coli Human His Full L. 1-552 a.a.
SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cells Rhesus macaque His
SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cells Rat His
SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 Human Non
SMAD4-03HFL Recombinant Full length Human SMAD4 Protein, His tagged HEK293 Human His Full L.
SMAD4-12HML Recombinant Full length Human SMAD4 Protein, R361H mutant, His tagged HEK293 Human His Full L.
SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
SMAD4-2042H Recombinant Human SMAD4 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
SMAD4-2042H-B Recombinant Human SMAD4 Protein Pre-coupled Magnetic Beads HEK293 Human
SMAD4-2544H Recombinant Human SMAD4 protein, His-tagged E.coli Human His 567aa(including fusion tag)
SMAD4-4148R Recombinant Rhesus Macaque SMAD4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SMAD4-4148R-B Recombinant Rhesus Macaque SMAD4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SMAD4-5268R Recombinant Rat SMAD4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
SMAD4-5268R-B Recombinant Rat SMAD4 Protein Pre-coupled Magnetic Beads HEK293 Rat
SMAD4-5868H Recombinant Human SMAD4 Protein (Met1-Asp552), C-His tagged E.coli Human His Met1-Asp552
SMAD4-5869H Recombinant Human SMAD4 Protein (Pro139-Asp332), N-His tagged E.coli Human His Pro139-Asp332
Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
SMAD4-8457M Recombinant Mouse SMAD4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SMAD4-8457M-B Recombinant Mouse SMAD4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway,Cell cycle,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Colorectal cancer MSH2,PIK3R3,SMAD2,MAP2K1,APPL1,APC2,TCF7L2,AKT1,MSH6,BCL2
    Wnt signaling pathway CCND2A,SOST,PLCB3,WNT4A,LRP6,PPARDB,TCF7L2,PRKCG,LRP5,SFRP1
    TGF-beta signaling pathway BMP5,BMPR2B,RHOAB,ACVR1,THBS1,ACVR2B,CHD,RHOAC,ZFYVE16,ID4
    HTLV-I infection MSX1,PPP3CC,CD40,FZD8,CCND3,FZD7,PRKACA,HLA-DMA,FZD6,AKT2
    Pancreatic cancer PIK3R3,RAC1,PIK3CB,KRAS,ARHGEF6,TRP53,SMAD3,BRCA2,RALB,PIK3R1
    Cell cycle SFN,BUB3,MAD1L1,CEP63,CEP135,RCC2,LEMD3,ORC2,BRE,NDE1
    Adherens junction SSX2IPA,TCF7,WASF2,ERBB2,MAP3K7,ACTB2,RHOAD,INSRB,NLK,IGF1R
    Chronic myeloid leukemia HRAS,MAPK1,TGFBR2,TGFB1,IKBKG,CCND1,NFKBIA,BCR,ARAF,MDM2
    FoxO signaling pathway PRKAB1B,SMAD3,CAT,INSB,PRKAB1,KLF2A,AGAP2,SGK2,AKT2L,GABARAP

    Protein Function

    SMAD4 has several biochemical functions, for example, contributes_to DNA binding,I-SMAD binding,R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding SERPINH1,ADAM9,CCBE1,Itga10&Itgb1,LRRC15,SERPINH1B,PDGFA,ITGA9,GPR56,USH2A
    I-SMAD binding SMAD7,SMAD2,TGFBR1,CTNNB1,AXIN1,TGFB1I1,SMURF1,AXIN2,SMAD1,SMAD6
    contributes_to transcription factor activity, protein binding SMAD3
    R-SMAD binding CTNNB1,SMAD2,PPM1A,SMURF1,PMEPA1,TRIM33,SMAD3,PAX6,PARP1,SMAD6
    protein heterodimerization activity HIST1H3H,SRY,HIST1H3C,SCUBE1,FLOT1,HOMER1,TAF8,TLR1,ODZ4,TAP1
    identical protein binding CSK,SOD1,SCHIP1,ALDOB,SFRP1,SNRNP200,SMAD1,PHC2,GAPDH,TARDBP
    protein homodimerization activity OXA1L,SRF,SYT16,CIDEA,TCF3,PKD2,ZBTB4,RIPK2,PRMT2,KIAA0947
    RNA polymerase II transcription factor binding ZFPM1,CHST13,MIXL1,MTA2,GFI1B,TRP53,GATA3,TP53,TRPS1,TBX3
    chromatin binding DNAJC2,CREB3,AIRE,TOX,EWSR1A,SMAD6,CCNT1,ARNTL1B,Ar,TADA2A

    Interacting Protein

    SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.

    SMAD3;SMAD2

    SMAD4 Related Signal Pathway

    Resources

    References

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