smad4

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smad4

Official Full Name SMAD family member 4
Background SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
Synonyms SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli GST
    Human SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 N/A
    Human SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli His
    Human SMAD4-31192TH Recombinant Human SMAD4, His-tagged E.coli His
    Human SMAD4-31193TH Recombinant Human SMAD4 E.coli N/A
    Human SMAD4-386H Recombinant Human SMAD Family Member 4, His-tagged E.coli His
    Mouse SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cell His
    Mouse Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli His/T7
    Rat SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cell His
    Rhesus Macaque SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cell His

    smad4 involved in several pathways and played different roles in them. We selected most pathways smad4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with smad4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway BNIP4; INSRB; MAPK14A; CDKN2D; CAT; INSB; SGK2A; GABARAPL2; IRS2; CDKN1BB
    Cell cycle NDE1; MCPH1; RBL2; ANKLE2; DYNC1I2; ESCO2; CCNE1; CDC14B; B9D2; CCDC99
    Wnt signaling pathway PRKCG; GPC4; PRKACAB; SERPINF1; CCND1; MAP3K7; SMAD3; ROCK2; DKK2; MAPK10
    TGF-beta signaling pathway SMAD4; RPS6KB2; ACVR2AA; BMP2B; INHBC; SPAW; MAPK3; BMPR2; SMAD1; LEFTY2
    Hippo signaling pathway PARD3; PPP2R2C; AXIN1; CRB2; YWHAB; DVL3; YWHAG; WWC1; PARD6A; SMAD4
    Adherens junction AASS; PVRL4; RAC1; PVRL3; CSNK2A2A; VCL; PARD3; ACTB; TCF7L1A; INSRA
    Signaling pathways regulating pluripotency of stem cells HNF1A; FZD9; SMAD1; FGFR2; WNT6; FZD1; WNT10B; AKT2; WNT2B; AKT1
    Hepatitis B SMAD4; BAD; NFATC1; MAPK1; TLR2; IKBKE; CCND1; IFNA1; HSPG2; NFKBIA
    HTLV-I infection NRP1; MAPK8; NFKB2; LTBR; HLA-DRB5; CD40; RB1; IL1R1; CD3E; CD3D; HLA-DMA
    Pathways in cancer BIRC3; VEGFA; FGF16; PTK2; NRAS; TRAF4; FZD3; FGF12; WNT1; IGF1R
    Colorectal cancer GSK3B; TP53; MLH1; AKT1; APC; RAC3; PIK3CA; RAC1; SMAD2; TGFB3
    Pancreatic cancer RAC3; TGFB1; RAD51; RAF1; ARAF; SMAD2; CCND1; PIK3R2; MAP2K1; ARHGEF6
    Chronic myeloid leukemia PIK3R3; GAB2; MAPK1; CCND1; TGFB3; NFKBIA; PTPN11; MAP2K1; CTBP2; MECOM

    smad4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by smad4 itself. We selected most functions smad4 had, and list some proteins which have the same functions with smad4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding MCM7; MRE11A; SMAD4; ARNTL1A; GTF3C6; TCF3; MAFGB; MLXIPL; MAFGA; FOXH1
    I-SMAD binding TGFBR1; SMAD6; TGFB1I1; CTNNB1; SMAD7; SMAD1; SMAD2; AXIN1; AXIN2; SMURF1
    R-SMAD binding MEN1; PMEPA1; AXIN1; ANKRD1; FOXH1; SMAD6; RANBP3; MYOCD; ZEB2; TRIM33
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CEBPG; ELF1; GATA1; NFIB; PBX1; FEZF1; NKX2; KLF13; JUN; AGO1
    RNA polymerase II transcription factor binding XBP1; CHST13; TBX20; GATA3; KDM1A; GATA4; GATA1; DHX9; CREBBP; NFATC1
    chromatin binding SUV39H1; UXT; SIN3A; PATZ1; TCF7; PRKAA2; CITED2; ERCC6; CBX5; GLI2
    collagen binding ASPN; PDGFA; CTSB; LRRC15; PAK1; DCN; SMAD7; MMP13; CCBE1; CTSK
    core promoter proximal region sequence-specific DNA binding CREBBP; DMRTC1C2; ZFP516; TFAP2A; DMRTC1B; CXXC1; DMRT2A; DMRTC2; MIXL1; KLF4
    identical protein binding C10orf88; GOT1; ACTN2; BNIP2; SEPHS1; IGF2R; ORAI1; PYCARD; TRIP10; NCAM1
    metal ion binding ZBTB6; METAP2; CYP2P8; PPARAB; MKNK2; ZNF395B; TRMT1L; SHHA; ZNF670; USP2
    protein binding RPS28; XIAP; ENPP1; RPP25L; GPSM1; R3HDM2; LCMT1; WDR18; CRKL; STAC3
    protein heterodimerization activity TAL1; ATF3; BCL2L2; HIST1H4I; TAS1R1; HIST1H2BB; SPNA1; ANO9A; PPP1CBL; CRLF1
    protein homodimerization activity GSTM1; RAP1GAP; SRM; Fzd4; FBXO4; TDG; MAP3K13; GPD1L; BCL2L10; CEACAM5
    contributes_to sequence-specific DNA binding HIF1A; TRIM28; HDAC4; SMAD4; ARNT; PPARG; EPAS1; NEUROD1; HNRNPAB; FIGLA
    transcription factor activity, RNA polymerase II transcription factor binding ZNF296; NACC2; HIF1A; YAP1; ATF2; MAMSTR; LHX2; THRAA; SRF; SMAD4
    contributes_to transcription factor activity, protein binding SMAD4; SMAD3
    contributes_to transcription factor activity, sequence-specific DNA binding SMAD4; TAF10; GATA4; VDRA; TAF6; SOX1A; VDR; SMAD2; MAFGA; TAF12
    transcription regulatory region DNA binding WNT1; WNT11; SOX2; MTERFD1; MTERFD3; ZFP513; NFKB1; GATA3; PAX2; CITED1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GLI2; JUNB; MITFA; NR4A3; MEOX2; MYOCD; TFE3; NFKB2; IRF4; MYB
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity SMAD4

    smad4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with smad4 here. Most of them are supplied by our site. Hope this information will be useful for your research of smad4.

    SMAD3; SMAD2

    TGF

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