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  • Official Full Name

    SMAD family member 4

  • Overview

    SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
  • Synonyms

    SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMAD4-288HFL Active Recombinant Full Length Human SMAD4 Protein, C-Flag-tagged Mammalian cells Flag
Human SMAD4-31192TH Recombinant Human SMAD4, His-tagged E.coli His
Human SMAD4-31193TH Recombinant Human SMAD4 E.coli N/A
Human SMAD4-217H Recombinant Human SMAD4 protein, His-tagged E.coli His
Human SMAD4-1095H Recombinant Human SMAD Family Member 4, GST-tagged E.coli GST
Human SMAD4-386H Recombinant Human SMAD Family Member 4, His-tagged E.coli His
Human SMAD4-1676HCL Recombinant Human SMAD4 293 Cell Lysate HEK293 N/A
Human SMAD4-5868H Recombinant Human SMAD4 Protein (Met1-Asp552), C-His tagged E.coli C-His Met1-Asp552
Human SMAD4-1778H Recombinant Human SMAD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SMAD4-2042H Recombinant Human SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SMAD4-5869H Recombinant Human SMAD4 Protein (Pro139-Asp332), N-His tagged E.coli N-His Pro139-Asp332
Human SMAD4-2042H-B Recombinant Human SMAD4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Smad4-1978M Recombinant Mouse Smad4 protein, His & T7-tagged E.coli His/T7 Thr9~Ser231 (Accession # P97471)
Mouse SMAD4-15587M Recombinant Mouse SMAD4 Protein Mammalian Cell His
Mouse Smad4-5952M Recombinant Mouse Smad4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SMAD4-8457M Recombinant Mouse SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMAD4-8457M-B Recombinant Mouse SMAD4 Protein Pre-coupled Magnetic Beads HEK293
Rat SMAD4-5609R Recombinant Rat SMAD4 Protein Mammalian Cell His
Rat SMAD4-5268R Recombinant Rat SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SMAD4-5268R-B Recombinant Rat SMAD4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SMAD4-4332R Recombinant Rhesus monkey SMAD4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SMAD4-4148R Recombinant Rhesus Macaque SMAD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SMAD4-4148R-B Recombinant Rhesus Macaque SMAD4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMAD4 Related Gene Family
  • SMAD4 Related Research Area
  • SMAD4 Related Signal Pathway

SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayCAMK2D;MAPK9;RAC2;FZD7B;WNT6;DAAM2;WNT11B;MMP7;WNT7AA
Hippo signaling pathwayFZD3;SMAD2;GDF5;PARD6B;WNT6;FRMD6;TEAD3;WNT3;PRKCI
Signaling pathways regulating pluripotency of stem cellsINHBA;FGFR3;WNT8A;INHBC;WNT1;HESX1;HAND1;FZD2;PCGF6
Pathways in cancerBIRC3;LAMA5;RXRB;GNG5;PLD1;MMP1;GLI1;PIK3R2;PIK3CG
Colorectal cancerRAF1;AXIN1;TGFB2;RAC1;TCF7;RHOA;TP53;PIK3CA;BAX
Chronic myeloid leukemiaTRP53;PTPN11;RUNX1;KRAS;CRKL;CRK;PIK3CD;SMAD4;CTBP2

SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.

Function Related Protein
contributes_to DNA bindingCLOCKA;SMAD2;RFC3;SMAD4;MAFGA;GTF3C3;GTF3C5;GTF3C6;GTF3C4
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTCF7L2;KLF17;FIGLA;MYPOP;ESRRA;ETV2;TGIF1;GMEB2;RFX1
RNA polymerase II transcription factor bindingMEF2A;T;ZFPM2;GATA6;ZGLP1;ZFPM1;GSK3B;KDM1A;TP53
chromatin bindingHDAC7A;NSD1;KIAA0101;MED12;NKX6;CITED1;PAX3;MORF4L1;MBD1
collagen bindingITGA2;TLL1;USH2A;MMP9;SMAD3;ITGA3;CTSS;CD44;SMAD7
core promoter proximal region sequence-specific DNA bindingDMRTC2;KLF4;DMRTC1C2;SMAD3;MIXL1;SP3;GATA3;TFAP2A;MEF2C
identical protein bindingADORA2A;TLR3;SCAND1;LZTFL1;CRYAB;NQO1;DNM1L;PRKD1;PRMT8
protein bindingCLU;BCL11A;SCNN1D;CARD9;KLHL3;ATP6V1B2;FAM111A;FAM54A;PSMB10
protein heterodimerization activityRXRA;CHRAC1;HIST1H4C;UGT1A6A;DMRT3A;IKBKB;SCGB2A1;STX1A;MAFGB
protein homodimerization activityBMPR1A;NR4A3;ERBB4;GREM2;CISD2;TERF1;APOA2;DPYD;MYH9
contributes_to sequence-specific DNA bindingNEUROD1;FIGLA;PPARG;HDAC4;SMAD4;EPAS1;TRIM28;ARNT;TCF3
transcription factor activity, RNA polymerase II transcription factor bindingNACC2;SMAD4;YAP1;ATF2;HIF1A;ZNF296;MAMSTR;SRF;THRAA
contributes_to transcription factor activity, protein bindingSMAD3;SMAD4
contributes_to transcription factor activity, sequence-specific DNA bindingSMAD3;TAF12;SOX19B;TAF6;TAF7;FOXH1;RXRA;SOX1A;VDRB
transcription regulatory region DNA bindingTFEB;XBP1;DHX36;CTCF;AIRE;XRCC5;ZNF174;SALL1A;ATF4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNR4A2;CEBPG;TFE3;JUN;ETV2;MYBL2;FOXD1;NR2E1;NR4A1
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.


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