Recombinant Human SMAD4
Cat.No. : | SMAD4-31193TH |
Product Overview : | Recombinant full length human Smad4 with N-terminal proprietary tag; amino acids 1-552, 95kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the dwarfin/SMAD family.Contains 1 MH1 (MAD homology 1) domain.Contains 1 MH2 (MAD homology 2) domain. |
Gene Name : | SMAD4 SMAD family member 4 [ Homo sapiens ] |
Official Symbol : | SMAD4 |
Synonyms : | SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; |
Gene ID : | 4089 |
mRNA Refseq : | NM_005359 |
Protein Refseq : | NP_005350 |
MIM : | 600993 |
Uniprot ID : | Q13485 |
Chromosome Location : | 18q21.1 |
Pathway : | ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; |
Function : | contributes_to DNA binding; DNA binding; I-SMAD binding; R-SMAD binding; SMAD binding; |
Products Types
◆ Recombinant Protein | ||
SMAD4-5268R | Recombinant Rat SMAD4 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMAD4-8457M | Recombinant Mouse SMAD4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Smad4-5952M | Recombinant Mouse Smad4 Protein, Myc/DDK-tagged | +Inquiry |
SMAD4-2042H | Recombinant Human SMAD4 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMAD4-4148R | Recombinant Rhesus Macaque SMAD4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SMAD4-1676HCL | Recombinant Human SMAD4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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