SOCS3

  • Official Full Name

    suppressor of cytokine signaling 3

  • Overview

    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOCS3; suppressor of cytokine signaling 3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Trx
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOCS3-5093H Recombinant Human SOCS3, His-tagged E.coli His
Human SOCS3-6940H Recombinant Human Suppressor Of Cytokine Signaling 3, Myc-DDK-tagged HEK293 Myc/DDK
Human SOCS3-3895H Recombinant Human SOCS3 protein(Met1-Leu225), His&Trx-tagged E.coli N-His&Trx Met1-Leu225
Human SOCS3-6938H Recombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged E.coli GST
Human SOCS3-6941H Recombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged Wheat Germ GST
Human SOCS3-1580HCL Recombinant Human SOCS3 293 Cell Lysate HEK293 N/A
Human SOCS3-1315H Recombinant Human SOCS3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOCS3-2068H Recombinant Human SOCS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SOCS3-2068H-B Recombinant Human SOCS3 Protein Pre-coupled Magnetic Beads HEK293
Human SOCS3-1793HFL Recombinant Full Length Human SOCS3 Protein, C-Flag-tagged Mammalian cells Flag
Human SOCS3-6682H Recombinant Human SOCS3 Protein (Met1-Leu225), N-His tagged E.coli N-His Met1-Leu225
Mouse Socs3-26M Recombinant Mouse Socs3 protein, His-tagged E.coli His
Mouse Socs3-892M Recombinant Mouse Socs3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Socs3-1797R Recombinant Rat Socs3 protein, His-tagged E.coli His Met1~Leu225 (Accession # O88583)
Rat SOCS3-5665R Recombinant Rat SOCS3 Protein Mammalian Cell His
Rat SOCS3-5324R Recombinant Rat SOCS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Socs3-3515R Recombinant Rat Socs3 protein, His-SUMO-tagged E.coli His-SUMO 1-225aa
Rat SOCS3-1526R Recombinant Rat SOCS3 Protein (1-225 aa), His-tagged Yeast His 1-225 aa
Rat SOCS3-5324R-B Recombinant Rat SOCS3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SOCS3-4402R Recombinant Rhesus monkey SOCS3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SOCS3-4218R-B Recombinant Rhesus Macaque SOCS3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SOCS3-4218R Recombinant Rhesus Macaque SOCS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken SOCS3-6168C Recombinant Chicken SOCS3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • SOCS3 Related Signal Pathway

SOCS3 involved in several pathways and played different roles in them. We selected most pathways SOCS3 participated on our site, such as Ubiquitin mediated proteolysis, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisITCH;ANAPC7;HERC3;UBA6;UBE2W;TCEB1B;TCEB2;TCEB1;XIAP
Osteoclast differentiationBTK;STAT1;FCGR3;FCGR1;MAPK13;MAP3K7;TYROBP;FYN;ACP5
Jak-STAT signaling pathwayGh;MCL1;IFNB;IL6;PIK3CG;OSMR;IL4R;IL2RGB;IFNB1
TNF signaling pathwayBIRC3;MAPK8;DNM1L;MAP3K7IP3;MLKL;LTA;MAPK3;CASP8;LIF
Insulin signaling pathwaySOCS1;PTPRF;INPP5K;RAF1A;FBP1A;PHKG1B;PHKG1;SH2B2;TRIP10
Prolactin signaling pathwaySOCS1;SHC3;RELA;SHC1;PIK3CG;RAF1;SOS1;AKT2;PRL
Adipocytokine signaling pathwayPPARGC1A;POMCA;ADIPOR1;ADIPOQB;ACSL4;CHUK;PRKAB1;RXRG;RXRGB
Type II diabetes mellitusCACNA1G;MTOR;PIK3R3;INSR;MAPK9;PIK3R1;PIK3R5;PRKCE;IKBKB
Insulin resistanceNR1H3;AKT2L;PRKCQ;PIK3R3B;SLC27A5;PPARGC1A;PRKAG2;PPP1CB;PTPN1
Non-alcoholic fatty liver disease (NAFLD)EIF2AK3;TGFB1;COX6A2;NDUFB5;SDHA;NDUFV1;PIK3R3;NDUFA4;PIK3CA
Hepatitis CCD81;IKBKG;OSTN;STAT1;PPP2R2A;NFKB1;CLDN7;PPARA;TBK1
Influenza ANXF3;IFNB1;EIF2AK4;HSPA8;HSPA2;TMPRSS13;NXT2;PIK3CA;OAS1B
Herpes simplex infectionPKZ;TLR9;PILRA;THOC4;POU2F3;DAXX;H2-Q10;IL1B;MAP3K7

SOCS3 has several biochemical functions, for example, protein binding, protein kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS3 itself. We selected most functions SOCS3 had, and list some proteins which have the same functions with SOCS3. You can find most of the proteins on our site.

Function Related Protein
protein bindingALOX12;JAG2;LGALS13;RHOXF2;HDAC6;P2RX7;NLGN4X;POLL;STAT6
protein kinase inhibitor activitySOCS5B;WNK1;CAMK2N1A;CISHB;PRKRIP1;SOCS1;TSACC;CHP1;GMFG

SOCS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS3.

PTK2; YES1; KIAA1958; MAP1S; TRDN; SH2D2A; RASA1

Research Area

Related articles

Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).
Cianciulli, A; Dragone, T; et al. IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. INTERNATIONAL IMMUNOPHARMACOLOGY 24:369-376(2015).
  • Q&As
  • Reviews

Q&As (6)

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What are the treatment strategies for SOCS3? 06/05/2023

Therapeutic strategies for SOCS3 can include regulating its expression level, blocking its interaction with other proteins, or regulating its associated signal transduction pathways. These approaches may have potential applications in the treatment of autoimmune diseases, inflammatory diseases, and certain cancers.

How about the relationship between the structure and function of SOCS3? 10/03/2022

The structure of SOCS3 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

What is the specific role of SOCS3 in inflammatory diseases? 02/21/2022

In inflammatory diseases, SOCS3 may reduce the inflammatory response by inhibiting the production and release of pro-inflammatory cytokines and promoting the expression of anti-inflammatory factors. It could be a potential target for the treatment of inflammatory diseases.

Does there have interactions of SOCS3 with other proteins? 01/13/2022

This protein can interact with a variety of other proteins, including JAK kinase, STAT transcription factors, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.

What factors should be considered in drug development for SOCS3? 12/15/2021

Drug development for SOCS3 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

What is the main function of SOCS3 in the immune system? 10/23/2020

SOCS3 is primarily involved in immunosuppressive and anti-inflammatory responses in the immune system. It can inhibit the production and release of pro-inflammatory cytokines and promote the expression of anti-inflammatory factors, thereby reducing the inflammatory response.

Customer Reviews (3)

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Reviews
11/30/2022

    SOCS3 is very stable in Western blot, and its performance will not be affected even if it is stored for a long time.

    03/22/2022

      SOCS3 has long-lasting effects and sustained release performance.

      08/28/2020

        This synthesis cost and application cost are moderate, and it is cost-effective for production.

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