Recombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged

• Cat.No.: SOCS3-6941H
• Product Overview: RecombinantHuman SOCS3 protein wasexpressed as GST-tagged fusion protein by vitro wheatgerm.

Specification

• Cat. No.: SOCS3-6941H
• Description: SOCS3is a protein that in humans is encoded by the SOCS3 gene. This gene encodes amember of the STAT-induced STAT inhibitor (SSI), also known as suppressor ofcytokine signaling (SOCS), family. SSI family members are cytokine-induciblenegative regulators of cytokine signaling. The expression of this gene isinduced by various cytokines, including IL6, IL10, and interferon(IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, andinhibit the activity of JAK2 kinase.
• Species: Human
• Quality ControlTesting: 12.5%SDS-PAGE Stained with Coomassie Blue.
• Sequence: MVTHSKFPAAGMSRPLDTSLRLKTF SSKSEYQLVVNAVRKLQESGFYWSA VTGGEANLLLSAEPAGTFLIRDSSD QRHFFTLSVKTQSGTKNLRIQCEGG SFSLQSDPRSTQPVPRFDCVLKLVH HYMPPPGAPSFPSPPTEPSSEVPEQ PSAQPLPGSPPRRAYYIYSGGEKIP LVLSRPLSSNVATLQHLCRKTVNGH LDSYEKVTQLPGPIREFLDQYDAPL
• Preparation Method: in vitro wheatgerm expression system
• Molecular Weight: 50.49 kDa
• Purification: GlutathioneSepharose 4 Fast Flow.
• Buffer: 50 mMTris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Storage: Storeat -80°C. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: SOCS3 suppressor of cytokine signaling 3 [ Homosapiens ]
• Official Symbol: SOCS3
• Synonyms: SOCS3;suppressor of cytokine signaling 3; CIS3; SSI3; ATOD4; Cish3;SSI-3; SOCS-3; MGC71791; CIS-3; STAT-induced STAT inhibitor 3; cytokine-inducedSH2 protein 3; cytokine-inducible SH2 protein 3
• Gene ID: 9021
• mRNA Refseq: NM_003955
• Protein Refseq: NP_003946
• MIM: 604176
• UniProt ID: O14543
• Chromosome Location: 17q25.3
• Pathway: ATF-2 transcription factor network; Adipocytokinesignaling pathway; Class I MHC mediated antigen processing & presentation;Cytokine Signaling in Immune system; ECS complex; EGFR1 Signaling Pathway; EPOsignaling pathway; Growth hormone receptor signaling; Herpes simplexinfection; IL-2 Signaling Pathway; IL-3 Signaling Pathway; IL-4 SignalingPathway; IL-6 Signaling Pathway; IL-9 Signaling Pathway
• Function: protein kinase inhibitor activity

Reviews

11/30/2022

SOCS3 is very stable in Western blot, and its performance will not be affected even if it is stored for a long time.

03/22/2022

SOCS3 has long-lasting effects and sustained release performance.

08/28/2020

This synthesis cost and application cost are moderate, and it is cost-effective for production.

Q&As

What are the treatment strategies for SOCS3?

Therapeutic strategies for SOCS3 can include regulating its expression level, blocking its interaction with other proteins, or regulating its associated signal transduction pathways. These approaches may have potential applications in the treatment of autoimmune diseases, inflammatory diseases, and certain cancers.

How about the relationship between the structure and function of SOCS3?

The structure of SOCS3 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

What is the specific role of SOCS3 in inflammatory diseases?

In inflammatory diseases, SOCS3 may reduce the inflammatory response by inhibiting the production and release of pro-inflammatory cytokines and promoting the expression of anti-inflammatory factors. It could be a potential target for the treatment of inflammatory diseases.

Does there have interactions of SOCS3 with other proteins?

This protein can interact with a variety of other proteins, including JAK kinase, STAT transcription factors, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.

What factors should be considered in drug development for SOCS3?

Drug development for SOCS3 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

What is the main function of SOCS3 in the immune system?

SOCS3 is primarily involved in immunosuppressive and anti-inflammatory responses in the immune system. It can inhibit the production and release of pro-inflammatory cytokines and promote the expression of anti-inflammatory factors, thereby reducing the inflammatory response.