"TIMP2" Related Products

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Recombinant Human TIMP2 Protein, His-tagged

Cat.No.: TIMP2-37H
Product Overview: Recombinant human TIMP2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description: TIMP2, also known as metalloproteinase inhibitor 2, belongs to the tissue inhibitors of metalloproteinases family. The TIMP family inhibit most MMPs by forming non-covalent binary complex. TIMP2 plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors.
Source: Insect cell
Species: Human
Tag: His
Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass: 22.5kDa (200aa)18-28KDa (SDS–PAGE under reducing conditions.)
AA Sequence: CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKAEGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRGAAPPKQEFLD IEDPHHHHHH
Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity: >95% by SDS – PAGE
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.25mg/ml (determined by Absorbance at 280nm)
Gene Name: TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
Official Symbol: TIMP2
Synonyms: TIMP2; TIMP metallopeptidase inhibitor 2; tissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; CSC 21K; TIMP-2; tissue inhibitor of metalloproteinases 2; CSC-21K;
Gene ID: 7077
mRNA Refseq: NM_003255
Protein Refseq: NP_003246
MIM: 188825
UniProt ID: P16035
Chromosome Location: 17q25
Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem;
Function: enzyme activator activity; enzyme inhibitor activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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