TRAF6

  • Official Full Name

    TNF receptor-associated factor 6, E3 ubiquitin protein ligase

  • Overview

    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
  • Synonyms

    TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; RNF85; MGC:3310; TNF receptor-associated factor 6; RING finger protein 85; interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRAF6-31603TH Recombinant Human TRAF6 protein, GST-tagged Wheat Germ GST
Human TRAF6-591H Recombinant Human TRAF6 Mammalian Cell His
Human TRAF6-817HCL Recombinant Human TRAF6 293 Cell Lysate HEK293 N/A
Human TRAF6-818HCL Recombinant Human TRAF6 293 Cell Lysate HEK293 N/A
Human TRAF6-3143H Recombinant Human TRAF6 Protein, GST-tagged E.coli GST
Human TRAF6-3146H Recombinant Human TRAF6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TRAF6-2249H Recombinant Human TRAF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TRAF6-3618H Recombinant Human TRAF6 protein E.coli N/A
Human TRAF6-3144H Recombinant Human TRAF6 protein, His-tagged E.coli His
Human TRAF6-105HFL Active Recombinant Full Length Human TRAF6 Protein, C-Flag-tagged Mammalian cells Flag
Human TRAF6-555H Recombinant Human TRAF6 Protein, His-tagged E.coli His
Human TRAF6-6512H Recombinant Human TRAF6 Protein (Gln348-Asp504), N-His tagged E.coli N-His
Human TRAF6-3147H Recombinant Human TRAF6 Protein, His-SUMO-tagged E.coli His/SUMO
Human TRAF6-3521H Recombinant Human TRAF6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TRAF6-607HF Recombinant Full Length Human TRAF6 Protein, GST-tagged In Vitro Cell Free System GST
Human TRAF6-2249H-B Recombinant Human TRAF6 Protein Pre-coupled Magnetic Beads HEK293
Mouse TRAF6-17291M Recombinant Mouse TRAF6 Protein Mammalian Cell His
Mouse Traf6-6621M Recombinant Mouse Traf6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TRAF6-9560M Recombinant Mouse TRAF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TRAF6-9560M-B Recombinant Mouse TRAF6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Traf6-556M Recombinant Mouse Traf6 Protein, His-tagged E.coli His
Rat TRAF6-6257R Recombinant Rat TRAF6 Protein Mammalian Cell His
Rat TRAF6-5914R Recombinant Rat TRAF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TRAF6-5914R-B Recombinant Rat TRAF6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TRAF6-4934R Recombinant Rhesus monkey TRAF6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TRAF6-4748R-B Recombinant Rhesus Macaque TRAF6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TRAF6-4748R Recombinant Rhesus Macaque TRAF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TRAF6-3905Z Recombinant Zebrafish TRAF6 Mammalian Cell His
Chicken TRAF6-481C Recombinant Chicken TRAF6 Protein, His-tagged E.coli N-His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRAF6 Related Research Area
  • TRAF6 Related Signal Pathway

TRAF6 involved in several pathways and played different roles in them. We selected most pathways TRAF6 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayRELB;CACNA1SB;ELK1;IKBKB;FGF13A;PRKACBA;PLA2G4F;RPS6KA3A;PLA2G4C
NF-kappa B signaling pathwayPLCG2;LBP;GADD45B;BIRC2;CCL21B;IRAK4;TLR4;PIAS4;UBE2I
Ubiquitin mediated proteolysisUBE2U;UBE2G1;PIAS4B;NEDD4;UBE2M;UBE2G2;KEAP1B;MDM2;UBE2IA
EndocytosisVPS26B;EHD1B;SMAD3;HRASB;CHMP4B;ADRB3;HRASA;SH3GL1;STAM
Osteoclast differentiationGAB2;MAPK3;NFKB2;MAP2K1;SQSTM1;PPARG;MAPK11;TNFRSF11B;FCGR4
Toll-like receptor signaling pathwayRAC1;MAP2K4A;IFNA14;MAPK13;PIK3R3A;LY96;CXCL8B.3;PIK3R2;IRF5
NOD-like receptor signaling pathwayNFKB1;CASP8;PYDC1;MAPK13;MAPK9;MAPK12A;HSP90B1;HSP90AA1;MAPK8B
RIG-I-like receptor signaling pathwayIFNA10;IFNA12;IKBKE;TRAF3;IKBKG;NLRX1;CASP8;MAPK12A;SIKE1
Neurotrophin signaling pathwayMAP2K1;CAMK4;MAPK12;SHC2;MAP2K2;NFKBIB;NTRK2;PIK3R2;NFKB1
PertussisGM5077;RHOA;IL-8;MAPK11;C4BP;TICAM2;RELA;IRAK1;PYCARD
LeishmaniasisHLA-DMB;HLA-DRB3;Itgam&Itgb2;STAT1;PTGS2;IL1B;FCGR2A;TRAF6;HLA-DPB1
Chagas disease (American trypanosomiasis)MAPK9;CFLAR;AKT1;TLR6;IL6;IFNGR2;Fasl;CD247;PPP2R1A
ToxoplasmosisTGFB1;ITGA6;MAPK13;BAD;LAMB4;HLA-DQA2;HSPA1B;HLA-DRB1;PIK3CA
TuberculosisITGAM;MAPK3;CD209B;NFKB1;PPP3CB;FCGR2B;AKT2;PPP3CA;HLA-DRB4
Hepatitis CCLDN10;RIPK1;NRAS;PPP2R2C;OAS1B;IFNA10;CLDN5;MAPK8;ARAF
MeaslesCD3E; CD3D;EIF2AK1;TNFRSF10C;TAB2;CD28;OAS2;MX1;MAVS;Ifna15
Herpes simplex infectionOAS3;CASP3B;HLA-DMB;HCFC1;MAPK10;HLA-DOB;SRSF5B;SRSF1A;NXF2
Epstein-Barr virus infectionPSMD3;PSMC6;CD19;TBK1;POLR2C;RIPK1;VIM;SPI1;IKBKB
Pathways in cancerARHGEF1;CCNE1;GNA11;BIRC5;BAX;HIF1A;FN1;CYCS;RELA
Small cell lung cancerBCL2;BIRC3;LAMA4;TRAF2;NOS2;APAF1;AKT1;AKT2;LAMA3

TRAF6 has several biochemical functions, for example, histone deacetylase binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF6 itself. We selected most functions TRAF6 had, and list some proteins which have the same functions with TRAF6. You can find most of the proteins on our site.

Function Related Protein
histone deacetylase bindingSFPQ;TOP2B;HDAC1;CCND1;RUNX2;NUDT21;CDC20;NKX2-5;HEY2
identical protein bindingLRRK2;SMN1;WAS;STAT2;KCTD13;MVK;CCDC91;SCHIP1;PYDC3
ligase activityRNF170;GLULB;CNOT4;HERC6;GLULA;ACSM2;RNF111;TRIM21;RING1
mitogen-activated protein kinase kinase kinase bindingDUSP19;MAP2K1;MAPK1;MAP4K2;CDC37;TRAF6;STK38;PPEF2;MAP3K11
protein N-terminus bindingSNCA;ZWINT;RPA2;KCNB1;GTF2H2;ERCC5;SNF8;STXBP1;ALG2
protein bindingPHF19;KIR2DL3;NUP62L;TTK;CIZ1;RNF180;TCTN2;BFAR;LGALS3
protein kinase B bindingBAD;BCL10;TRAF6;APPL1;CCDC88A;ANKRD2;PDE3B;CDC37;PINK1
protein kinase bindingADAM10;PIH1D1;STXBP1;CAMK2N1A;MAP2K6;PARN;CDKN2C;PDCD10;AKAP5
thioesterase bindingTRAF3;TRAF6;TRAF4;TRAF5;CALM1;ARF6;CALM2;CDC42;HAUS7
tumor necrosis factor receptor bindingLTB;TNF;CD70;TNFSF14;TRADD;ERAP1;TNFSF13;TRAF4;CD40LG
ubiquitin conjugating enzyme bindingRNF217;RNF14;UBE2V1;ARIH1L;FOXL2;RNF144B;RNF19B;ZMYM2;ANKIB1A
ubiquitin protein ligase activityLRSAM1;TRIM2;UHRF2;TOPORS;RNF180;RNF144A;UBE2N;RFWD2;WWP2
ubiquitin protein ligase bindingUBE2A;IKBKE;SUMO1;AICDA;XRCC5;TRAF6;YOD1;SMAD6;CBS
ubiquitin-protein transferase activityRNF187;BIRC5B;FBXL14B;RNF144AB;FBXO2;TRAF5;CDC34;PEX2;ZYG11B
zinc ion bindingZCWPW2;ZFAND5A;ZSWIM1;TRIM55A;S100B;BPTF;ZDHHC20A;CHORDC1;ZCCHC6

TRAF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF6.

TRAF2; TAX1BP1; TRAF5

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What role does TRAF6 protein play in cancer development and progression? 01/28/2022

TRAF6 has been implicated in promoting the survival, proliferation, and metastasis of cancer cells, and its overexpression has been linked to poor prognosis in various types of cancer.

Are there any potential therapeutic strategies targeting TRAF6 protein in clinical practice? 12/01/2020

Research is underway to develop small molecule inhibitors and antibodies targeting TRAF6 for the treatment of inflammatory and autoimmune diseases, as well as cancer.

What are the biomarkers associated with TRAF6 protein expression in clinical diagnostics? 07/17/2019

Elevated levels of TRAF6 expression have been detected in the blood and tissue samples of patients with autoimmune diseases and certain types of cancer, making it a potential biomarker for disease diagnosis and prognosis.

How does TRAF6 protein interact with other signaling molecules in the cell? 01/05/2018

TRAF6 interacts with various receptors and adaptor proteins to activate downstream signaling pathways, including the NF-κB, MAPK, and JNK pathways, which are critical for immune and inflammatory responses.

How does TRAF6 protein contribute to bone metabolism? 12/25/2017

TRAF6 is involved in the regulation of osteoclast differentiation and bone resorption, making it a potential target for the treatment of bone-related diseases such as osteoporosis.

Customer Reviews (3)

Write a review
Reviews
04/26/2023

    The TRAF6 protein comes highly recommended due to its exceptional performance in ELISA assays.

    10/06/2017

      I am genuinely excited to embark on this scientific journey, empowered by the superior TRAF6 protein and the manufacturer's unwavering commitment to ensuring my success.

      05/10/2017

        The TRAF6 protein's superior performance in ELISA paves the way for robust and precise data analysis, providing invaluable insights into various biological processes.

        Ask a Question for All TRAF6 Products

        Required fields are marked with *

        My Review for All TRAF6 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends