UGT1A6
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A6 -
Overview
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants. -
Synonyms
UGT1A6;UDP glucuronosyltransferase 1 family, polypeptide A6;UDP glycosyltransferase 1 family, polypeptide A6;UDP-glucuronosyltransferase 1-6;GNT1;HLUGP;UGT1F;HLUGP1;Phenol metabolizing UDP glucuronosyltransferase;Phenol-metabolizing UDP-glucuronosyltransferase;UD16_HUMAN;UDP glucuronosyltransferase 1 family polypeptide A6;UDP glucuronosyltransferase 1A6;UDP glycosyltransferase 1 family polypeptide A6;UDP-glucuronosyltransferase 1-F;UDP-glucuronosyltransferase 1A6;UDPGT;UDPGT 1-6;UGT 1F;UGT-1F;UGT1;UGT1 06;UGT1*6;UGT1-06;UGT1.6;UDP-glucuronosyltransferase 1 family polypeptide A6s;UGT1A6S
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mus musculus
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- Insect cells
- His
- DDK
- Myc
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT1A6-2517H | Recombinant Human UGT1A6 protein, His-tagged | E.coli | Human | His | 176-488 aa | |
| UGT1A6-12H | Recombinant Human UGT1A6 protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| UGT1A6-208H | Recombinant Human UGT1A6, GST-tagged | Wheat Germ | Human | GST |
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| UGT1A6-31663TH | Recombinant Human UGT1A6 | Human | Non | Full L. |
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| UGT1A6-6432R | Recombinant Rat UGT1A6 Protein | Mammalian Cells | Rat | His |
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| UGT1A6-7719Z | Recombinant Zebrafish UGT1A6 | Mammalian Cells | Zebrafish | His |
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| UGT1A6-511HCL | Recombinant Human UGT1A6 293 Cell Lysate | HEK293 | Human | Non |
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| RFL3207MF | Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (27-531) |
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| RFL32553RF | Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-6(Ugt1) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length of Mature Protein (26-529) |
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| RFL7834HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (27-532) |
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| UGT1A6-540HF | Recombinant Full Length Human UGT1A6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 532 amino acids |
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| UGT1A6-6088R | Recombinant Rat UGT1A6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| UGT1A6-6088R-B | Recombinant Rat UGT1A6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| UGT1A6-96H | Recombinant Human UGT1A6 Protein | Insect cells | Human |
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Involved Pathway
UGT1A6 involved in several pathways and played different roles in them. We selected most pathways UGT1A6 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | GSTP1,AKR1C2,CYP2C54,ARNT,MGST2,CYP3A43,SULT1A3,ALDH3B2,GSTP2,ALDH1A3 |
| Steroid hormone biosynthesis | UGT1A9,CYP7B1,CYP2C45,UGT2A1,CYP3A7,UGT2B7,CYP2C38,SRD5A2A,CYP3A7-CYP3AP1,UGT2A2 |
| Drug metabolism - cytochrome P | GSTM5,UGT1AB,UGT2A3,GSTAL,GSTT1B,UGT2A1,ALDH3B2,MGST1.1,UGT1A1,GSTT1 |
| Metabolic pathways | HMGCS1,HIBADH,POLE2,ALDH9A1A.1,MTMR6,NME7,ALDOAA,GALNT18A,PLA2G5,GMPPAA |
| Drug metabolism - other enzymes | DPYDB,ITPA,IMPDH1,PNAT10,UGT2A1,DPYD,NAT,UGT2A3,IMPDH1A,PNAT3 |
| Starch and sucrose metabolism | PYGM,PGM2,UGT2B15,UGT1AB,AMY1A,UGP2A,GUSB,AMY2B,HKDC1,GPI1 |
| Metabolism of xenobiotics by cytochrome P | DHDH,UGT2A1,UGT1AB,GSTM7,GSTP1,GSTA4,CBR1L,CBR3,GSTAL,GSTA2 |
| Porphyrin and chlorophyll metabolism | UROS,FXN,UGT1A9,UGT1A7,HCCS,HCCSA.1,HCCSB,COX10,HMOX2A,UGT2A1 |
| Pentose and glucuronate interconversions | GKUP,DHDHL,UGP2,ALDH2.2,OXSR1,UGT1A9,AKR1B8,ALDH2.1,AKR1B10,ALDH3A2 |
Protein Function
UGT1A6 has several biochemical functions, for example, enzyme binding,glucuronosyltransferase activity,NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A6 itself. We selected most functions UGT1A6 had, and list some proteins which have the same functions with UGT1A6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucuronosyltransferase activity | UGT3A1,UGT1B2,UGT1A2,UGT5G1,UGT5B4,UGT5G2,UGT2A6,GYLTL1B,UGT5A3,UGT5A5 |
| enzyme binding | SCN5A,CASP2,TRIO,HSPA8,PCCA,YWHAE,GSTM2,UGT1A4,FAM84B,PTEN |
| protein heterodimerization activity | DRD2,MAFG,TAF6,H3F3C,PDGFA,NR4A2,BIK,HIST1H2AA,MYF5,NKX2-5 |
| protein homodimerization activity | SNRPC,UGT1A9,ASNSD1,RRAGA,MVD,CD8A,GRM6,ANXA9,BLOC1S6,BOKA |
| NOT retinoic acid binding | UGT1A4,UGT2B15,UGT2B7 |
| NOT glucuronosyltransferase activity | UGT1A3,UGT1A9,UGT1A4,UGT1A7,UGT1A1 |
Interacting Protein
UGT1A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A6.
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References
- Uchihashi, S; Nishikawa, M; et al. The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. JOURNAL OF BIOCHEMISTRY 152:331-340(2012).
- Milne, AM; Burchell, B; et al. A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue. DRUG METABOLISM AND DISPOSITION 39:2258-2263(2011).
