UGT1A6

  • Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A6

  • Overview

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.
  • Synonyms

    UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; GNT1; HLUGP; UGT1F; HLUGP1; Phenol metabolizing UDP glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UD16_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family polypeptide A6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT 1F; UGT-1F; UGT1; UGT1 06; UGT1*6; UGT1-06; UGT1.6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UGT1A6S;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Insect cells
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UGT1A6-208H Recombinant Human UGT1A6, GST-tagged Wheat Germ GST
Human UGT1A6-31663TH Recombinant Human UGT1A6 N/A
Human UGT1A6-12H Recombinant Human UGT1A6 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human UGT1A6-511HCL Recombinant Human UGT1A6 293 Cell Lysate HEK293 N/A
Human UGT1A6-96H Recombinant Human UGT1A6 Protein Insect cells
Human UGT1A6-2517H Recombinant Human UGT1A6 protein, His-tagged E.coli His 176-488 aa
Human UGT1A6-540HF Recombinant Full Length Human UGT1A6 Protein, GST-tagged In Vitro Cell Free System GST 532 amino acids
Rat UGT1A6-6432R Recombinant Rat UGT1A6 Protein Mammalian Cell His
Rat UGT1A6-6088R Recombinant Rat UGT1A6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UGT1A6-6088R-B Recombinant Rat UGT1A6 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL7834HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-532)
Mus musculus (Mouse) RFL3207MF Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-531)
Rattus norvegicus (Rat) RFL32553RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-6(Ugt1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-529)
Zebrafish UGT1A6-7719Z Recombinant Zebrafish UGT1A6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UGT1A6 involved in several pathways and played different roles in them. We selected most pathways UGT1A6 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsGUSB;AKR1B10;XYLB;AKR1B7;DCXR;OXSR1;UGT2B7;UGT1A3;ALDH2.2
Ascorbate and aldarate metabolismUGT1A9;UGT1A7C;UGT1A7;UGT1A2;UGT2A2;UGT2A1;UGT1A6A;GKUP;UGT1A1
Steroid hormone biosynthesisSRD5A2;HSD3B2;HSD17B12A;UGT2B7;COMTA;HSD17B2;CYP2C54;UGT1A4;SULT2B1
Starch and sucrose metabolismG6PCA.1;UGDH;UGT1A2;UGT1A6A;PYGMA;AMY2A3;GYS1;G6PC;GANC
Retinol metabolismALDH1A1;UGT1A6;RDH10;CYP3A7-CYP3AP1;CYP2C18;DHRS9;AOX3;Aldh1a7;RDH8A
Porphyrin and chlorophyll metabolismUGT1A6A;UGT5G1;UGT1A6;UGT1A2;HMBSB;HMOX2;UGT2A2;GUSB;UGT1A3
Metabolism of xenobiotics by cytochrome PDHDHL;GSTM3;ALDH3B2;CBR1L;MGST1.2;UGT1A1;UGT2A1;UGT1A4;SULT2A1
Drug metabolism - cytochrome PGSTM6;GSTT1;MGST1.1;MAOA;AOX3L1;GSTA1;UGT2B7;GSTM3;ALDH3B1
Drug metabolism - other enzymesUGT1A1;UGT1A7C;ITPA;CDA;UPB1;UPP1;CES1C;UCKL1;UGT1A6B
Metabolic pathwaysBHMT;NME4;ATP5F1;ATPV0E2;PI4KA;HPSE;POLR2B;LIPC;PANK4
Chemical carcinogenesisALDH1A3;GSTM2;CYP3A7;CYP2C50;ADH1A;AHA-1;GSTP2;UGT2A3;SULT1A3

UGT1A6 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A6 itself. We selected most functions UGT1A6 had, and list some proteins which have the same functions with UGT1A6. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingDYM;STC2;ZFP346;YWHAH;UGT1A6A;ACAT1;JUND;PTPLAD2;CABYR
glucuronosyltransferase activityUGT5E1;UGT5C3;UGT1B1;UGT2B5;UGT1A3;UGT3A1;UGT2B15;UGT5A5;UGT1A5
NOT glucuronosyltransferase activityUGT1A7;UGT1A1;UGT1A4;UGT1A6;UGT1A3;UGT1A9
protein heterodimerization activityHOMER2;ERBB2;KCNIP1;ZHX2;GCLM;IKZF4;HIST1H2AA;ANO2;NR4A2
protein homodimerization activityATF3;ADSSL1;ANXA9;NR2C1;TOP2A;SLC16A1;MAP3K9;COMMD1;ANO2
NOT retinoic acid bindingUGT1A6;UGT2B15;UGT1A4;UGT2B7

UGT1A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A6.

Research Area

Related articles

Uchihashi, S; Nishikawa, M; et al. The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. JOURNAL OF BIOCHEMISTRY 152:331-340(2012).
Milne, AM; Burchell, B; et al. A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue. DRUG METABOLISM AND DISPOSITION 39:2258-2263(2011).
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