UGT1A6 Protein


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Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A6
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.
Synonyms UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; GNT1; HLUGP; UGT1F; HLUGP1; Phenol metabolizing UDP glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UD16_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family polypeptide A6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT 1F; UGT-1F; UGT1; UGT1 06; UGT1*6; UGT1-06; UGT1.6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UGT1A6S
    • Species :
    • Homo sapiens (Human)
    • Human
    • Rat
    • Rattus norvegicus (Rat)
    • Zebrafish
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • In Vitro Cell Free System
    • Insect cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A6-12H Recombinant Human UGT1A6 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A6-208H Recombinant Human UGT1A6, GST-tagged Wheat Germ GST
    Human UGT1A6-31663TH Recombinant Human UGT1A6 N/A
    Rat UGT1A6-6432R Recombinant Rat UGT1A6 Protein Mammalian Cell His
    Zebrafish UGT1A6-7719Z Recombinant Zebrafish UGT1A6 Mammalian Cell His
    Human UGT1A6-511HCL Recombinant Human UGT1A6 293 Cell Lysate HEK293 N/A
    Rattus norvegicus (Rat) RFL32553RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-6(Ugt1) Protein, His-Tagged E.coli expression system His
    Homo sapiens (Human) RFL7834HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged E.coli expression system His
    Human UGT1A6-2517H Recombinant Human UGT1A6 protein, His-tagged E.coli His
    Human UGT1A6-540HF Recombinant Full Length Human UGT1A6 Protein, GST-tagged In Vitro Cell Free System GST
    Human UGT1A6-96H Recombinant Human UGT1A6 Protein Insect cells

    UGT1A6 involved in several pathways and played different roles in them. We selected most pathways UGT1A6 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions Akr1b3; UGT1A4; AKR1B1; AKR1B8; DHDHL; UGT1A7; DHDH; UGT1AB; OXSR1; SORD
    Ascorbate and aldarate metabolism UGDH; ALDH7A1; ALDH3A2; UGT1A3; UGT2B7; ALDH9A1B; GKUP; ALDH9A1; RGN; ALDH2.1
    Steroid hormone biosynthesis CYP2D26; HSD17B12; AKR1C3; UGT1A1; CYP3A7-CYP3AP1; CYP1A; CYP19A1B; H2-KE6; UGT2A1; CYP2C37
    Starch and sucrose metabolism PGM2L1; GBE1; UGT1A7C; PYGM; UGT1A6A; HKDC1; GPI1; PYGL; UXS1; G6PC2
    Retinol metabolism CYP3A7-CYP3AP1; CYP2C54; RDH10A; DGAT1A; UGT5G1; RDH11; CYP26C1; CYP2A4; CYP2C18; RETSATL
    Porphyrin and chlorophyll metabolism MMAB; CP; UGT1A6; UGT2A1; CPOX; PPOX; UROS; UGT2B7; GUSB; UGT1A6B
    Metabolism of xenobiotics by cytochrome P GSTM7; UGT1A6; GSTP1; GSTT2; AKR7A3; UGT2B7; UGT2A1; AKR7A5; MGST3; GSTO1
    Drug metabolism - cytochrome P UGT2A2; GSTT2B; GSTM7; AOX3L1; MAOA; FMO6P; MGST1.1; GSTA4; UGT1A9; MGST3
    Drug metabolism - other enzymes UGT1A6B; IMPDH1A; UCKL1; Nat3; CDA; UGT2B7; UMPS; UPP1; TYMP; TPMT.1
    Metabolic pathways DHCR7; UGT1A1; CES1D; PLA2G1B; ATP5B; ATP6V1G1; CYP1A; LPCAT4; ALPI; ACOT5
    Chemical carcinogenesis GSTM5; SULT2A1; UGT1A2; UGT1A7; ADH5; FAM84B; CYP2C70; ADH6; EPHX1; GSTO2

    UGT1A6 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A6 itself. We selected most functions UGT1A6 had, and list some proteins which have the same functions with UGT1A6. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding UBE4B; KAT8; BLZF1; CABYR; UGT1A2; SCN5A; U2AF2; DNMT3L; ESR1; NOXO1
    glucuronosyltransferase activity LARGE; GYLTL1B; UGT5E1; UGT1A2; UGT5F1; UGT1B3; UGT8A; UGT1AB; B3GNT1; UGT1B1
    NOT glucuronosyltransferase activity UGT1A7; UGT1A6; UGT1A4; UGT1A1; UGT1A9; UGT1A3
    protein heterodimerization activity NR4A2; ITGB1B; BCL2L2; DMBX1; PPP1CBL; POLA1; NEUROD2; MYO5A; SOX17; PAFAH1B3
    protein homodimerization activity TPR; ANO6; PDGFB; NADKD1; SOD1; ZFP423; RENBP; CAMK2B; TWIST1; PON3
    NOT retinoic acid binding UGT1A4; UGT1A6; UGT2B15; UGT2B7

    UGT1A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A6.

    Uchihashi, S; Nishikawa, M; et al. The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. JOURNAL OF BIOCHEMISTRY 152:331-340(2012).
    Milne, AM; Burchell, B; et al. A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue. DRUG METABOLISM AND DISPOSITION 39:2258-2263(2011).

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