||This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.
|Molecular Mass :
|AA Sequence :
||MACLLRSFQRISAGVFFLALWGMVV GDKLLVVPQDGSHWLSMKDIVEVLS DRGHEIVVVVPEVNLLLKESKYYTR KIYPVPYDQEELKNRYQSFGNNHFA ERSFLTAPQTEYRNNMIVIGLYFIN CQSLLQDRDTLNFFKESKFDALFTD PALPCGVILAEYLGLPSVYLFRGFP CSLEHTFSRSPDPVSYIPRCYTKFS DHMTFSQRVANFLVNLLEPYLFYCL FSKYEELASAVLKRDVDIITLYQKV SVWLLRYDFVLEYPRPVMPNMVFIG GINCKKRKDLSQEFEAYINASGEHG IVVFSLGSMVSEIPEKKAMATADAL GKIPQTVLWRYTGTRPSNLANNTIL VKWLPQNDLLGHPMTRAFITHAGSH GVYESICNGVPMVMMPLFGDQMDNA KRMETKGAGVTLNVLEMTSEDLENA LKAVINDKSYKENIMRLSSLHKDRP VEPLDLAVFWVEFVMRHKGAPHLRP AAHDLTWYQYHSLDVIGFLLAVVLT VAFITFKCCAYGYRKCLGKKGRVKK AHKSKTH
||ELISA; WB-Re; AP; Array
||Best use within three months from the date of receipt of this protein.
||Store at -80°C. Aliquot to avoid repeated freezing and thawing.
|Storage Buffer :
||50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.