Recombinant Human UGT1A6 Protein

• Cat.No.: UGT1A6-96H
• Product Overview: Recombinant human UGT1A6 protein without tag was expressed in insect cells.

Specification

• Species: Human
• Source: Insect cells
• Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

Gene Information

• Gene Name: UGT1A6 UDP glucuronosyltransferase family 1 member A6 [ Homo sapiens (human) ]
• Official Symbol: UGT1A6
• Synonyms: UGT1A6; UDP glucuronosyltransferase family 1 member A6; GNT1; UGT1; HLUGP; UDPGT; UGT1A; UGT1C; UGT1E; UGT1F; HLUGP1; UGT-1A; UGT-1C; UGT-1E; UGT1.1; UGT1.3; UGT1.5; UGT1A1; UGT1A3; UGT1A5; UGT1-01; UGT1-03; UGT1-05; UGT1A6S; hUG-BR1; UDPGT 1-6; UDP-glucuronosyltransferase 1-6; Bilirubin-specific UDPGT isozyme 1; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-5; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A3; UDP-glucuronosyltransferase 1A5; UDP-glucuronosyltransferase 1A6; UDPGT 1-1; UDPGT 1-3; UDPGT 1-5; UGT-1FUGT1*6; UGT1-06; UGT1.6; phenol-metabolizing UDP-glucuronosyltransferase
• Gene ID: 54578
• mRNA Refseq: NM_001072
• Protein Refseq: NP_001063
• MIM: 606431
• UniProt ID: P19224