Recombinant Human UGT1A6

• Cat.No.: UGT1A6-31663TH
• Product Overview: Recombinant full length UGT1A6 protein (Human)

Specification

• Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.
• Tissue specificity: Expressed in skin, kidney and liver.
• Biological activity: Vial Content: 5 mg protein.concentration: 2-20 mg/mL protein
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 100mM Potassium phosphate, 1mM DTT, 0.1mM EDTA, pH 7.4
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: DKLL VVPQDGSHWL SMKDIVEVLS DRGHEIVVVV PEVNLLLKES KYYTRKIYPV PYDQEELKNR YQSFGNNHFA ERSFLTAPQT EYRNNMIVIG LYFINCQSLL QDRDTLNFFK ESKFDALFTD PALPCGVILA EYLGLPSVYL FRGFPCSLEH TFSRSPDPVS YIPRCYTKFS DHMTFSQRVA NFLVNLLEPY LFYCLFSKYE ELASAVLKRD VDIITLYQKV SVWLLRYDFV LEYPRPVMPN MVFIGGINCK KRKDLSQEFE AYINASGEHG IVVFSLGSMV SEIPEKKAMA IADALGKIPQ TVLWRYTGTR PSNLANNTIL VKWLPQNDLL GHPMTRAFIT HAGSHGVYES ICNGVPMVMM PLFGDQMDNA KRMETKGAGV TLNVLEMTSE DLENALKAVI NDKSYKENIM RLSSLHKDRP VEPLDLAVFW VEFVMRHKGA PHLRPAAHDL TWYQYHSLDV IGFLLAVVLT VAFITFKCCA YGYRKCLGKK GRVKKAHKSK TH
• Sequence Similarities: Belongs to the UDP-glycosyltransferase family.
• Tag: Non

Gene Information

• Gene Name: UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 [ Homo sapiens ]
• Official Symbol: UGT1A6
• Synonyms: UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; GNT1; HLUGP; UGT1F
• Gene ID: 54578
• mRNA Refseq: NM_001072
• Protein Refseq: NP_001063
• MIM: 606431
• Uniprot ID: P19224
• Chromosome Location: 2q37
• Pathway: Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P =>
• Function: enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; NOT retinoic acid binding