Usp16 involved in several pathways and played different roles in them. We selected most pathways Usp16 participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Usp16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Integrated Breast Cancer Pathway |
DHTKD1; GRN; LGALS13; GDI1; C21orf7; ERAL1; NOXA1; USP16; PLK3; EDAR |
Usp16 has several biochemical functions, for example, cysteine-type endopeptidase activity, histone binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Usp16 itself. We selected most functions Usp16 had, and list some proteins which have the same functions with Usp16. You can find most of the proteins on our site.
| Function |
Related Protein |
| cysteine-type endopeptidase activity |
USP9; USP18; CASPC; USP44; USP20; Casp3; CTSO; USP15; CASPB; CTSSB.1 |
| histone binding |
ELP2; ATRX; HJURP; HIST1H4J; HIST1H3G; UHRF1; NPM2; HIST1H3I; TONSL; TBL1X |
| transcription coactivator activity |
KDM5A; ZSCAN1; TFDP1A; NR2C2; PRPF6; PRDM16; EP300; CTNNB1; MAX; PSMC3 |
| ubiquitin binding |
USP25; CXCR4; UBE2N; USP5; TNFAIP3; OTUB1B; TSG101; SMAD3; SHRPRBCK1R; UBAP1 |
| ubiquitin-specific protease activity |
UCHL1; USP2A; OTUB1A; USP31; OTUD3; OTUB1; USP42; OTUD5B; USP25; USP8 |
| zinc ion binding |
INTS12; MYLIPB; AMFR; NR2C2; LIN28B; CIZ1; ZCRB1; BPTF; SIVA1; ZFYVE20 |
Usp16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Usp16 here. Most of them are supplied by our site. Hope this information will be useful for your research of Usp16.
a6nck6_human; HERC2; FOS; DBT; HIST1H2BL
Zhang, Z; Yang, HR; et al. The Histone H2A Deubiquitinase USP16 Interacts with HERC2 and Fine-tunes Cellular Response to DNA Damage. JOURNAL OF BIOLOGICAL CHEMISTRY 289:-(2014).
Yang, W; Lee, YH; et al. The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. NATURE COMMUNICATIONS 5:-(2014).
