Recombinant Human USP16 Protein (G2-L823), His tagged

• Cat.No.: USP16-1218H
• Product Overview: Recombinant Human 8His-TEV-GG-USP16(G2-L823 end) Protein was expressed in Insect cell.

Specification

• Description: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: G2-L823
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: USP16 ubiquitin specific peptidase 16 [ Homo sapiens (human) ]
• Official Symbol: USP16
• Synonyms: USP16; ubiquitin specific peptidase 16; UBPM; UBP-M; ubiquitin carboxyl-terminal hydrolase 16; deubiquitinating enzyme 16; ubiquitin specific protease 16; ubiquitin thioesterase 16; ubiquitin thiolesterase 16; ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; EC 3.4.19.12
• Gene ID: 10600
• mRNA Refseq: NM_006447
• Protein Refseq: NP_006438
• MIM: 604735
• UniProt ID: Q9Y5T5