Active Recombinant human USP16 protein, GST-tagged

• Cat.No.: USP16-212H
• Product Overview: Recombinant human USP16 (187-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: USP16 (ubiquitin carboxyl-terminal hydrolase 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and is involved in transcriptional regulation that controls cell differentiation, cell cycle and apoptosis through modulations with p16 Ink4a and p19 Arf. Downregulation of USP16 by truncated HBx may contribute to the growth of hepatocellular carcinoma cells. USP16 may also play a crucial role in provoking the self-renewal and/or senescence pathways in Down syndrome through the removal of ubiquitin from H2AK119, a critical mark for the maintenance of several somatic tissues.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Bio-activity: ≥24nmol/min/mg
• Molecular Mass: 110 kDa
• Purity: >85%
• Stability: 1 year at –70 centigrade from date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL

Gene Information

• Gene Name: USP16
• Official Symbol: USP16
• Synonyms: UBPM; UBP-M
• Gene ID: 10600
• mRNA Refseq: NM_006447.3
• Protein Refseq: NP_006438.1
• MIM: 604735
• UniProt ID: Q9Y5T5