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AKR1B10

  • Official Full Name

    aldo-keto reductase family 1, member B10 (aldose reductase)

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
  • Synonyms

    AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase); HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; aldo-keto reductase family 1 member B10; ARP; hARP; SI reductase; aldose reductase-like 1; small intestine reductase; aldose reductase-like peptide; aldose reductase-related protein; aldo-keto reductase family 1, member B11 (aldose reductase-like);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf21 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His|T7
  • Met|His
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKR1B10-406H Active Recombinant Human AKR1B10 protein E.coli N/A
Human AKR1B10-995H Active Recombinant Human AKR1B10 Protein, Met & His-tagged Sf21 Insect Cell Met/His Ala2-Tyr316
Human AKR1B10-2764H Recombinant Human AKR1B10, His-tagged E.coli His
Human AKR1B10-27154TH Recombinant Human AKR1B10 E.coli N/A 316 amino acids
Human AKR1B10-410H Recombinant Human AKR1B10 Protein, GST-tagged Wheat Germ GST
Human AKR1B10-27155TH Recombinant Human AKR1B10 E.coli N/A
Human AKR1B10-8931HCL Recombinant Human AKR1B10 293 Cell Lysate HEK293 N/A
Human AKR1B10-1533H Recombinant Human AKR1B10 protein, His & T7-tagged E.coli His/T7 Met1~Tyr316 (Accession # O60218)
Human AKR1B10-0254H Recombinant Human AKR1B10 Protein (M1-Y316), Tag Free E.coli No tag M1-Y316
Human AKR1B10-301110H Recombinant Human AKR1B10 protein, GST-tagged E.coli GST Met1-Tyr316
Human AKR1B10-0255H Recombinant Human AKR1B10 Protein (M1-Y316), His tagged E.coli His M1-Y316
Human AKR1B10-1365HF Recombinant Full Length Human AKR1B10 Protein, GST-tagged In Vitro Cell Free System GST 316 amino acids
Human AKR1B10-0093H Recombinant Human AKR1B10 Protein (Met1-Tyr316), N-His-tagged E.coli N-His Met1-Tyr316
Chicken AKR1B10-6197C Recombinant Chicken AKR1B10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKR1B10 involved in several pathways and played different roles in them. We selected most pathways AKR1B10 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsSORD;ALDH1B1;ALDH2;DCXR;UGT1A6;UGT1A9;Akr1b3;ALDH2.1;UGT1A4
Fructose and mannose metabolismPFKFB4;FBP1B;HK1;HK3;DHRS13L1;AKR1B1L;GMDS;PFKM;GMPPB
Galactose metabolismGLB1;GALT;GALE;UGP2;PFKM;AKR1B1;B4GALT2;GALM;AKR1B7
Glycerolipid metabolismAGPAT6;AGPAT3;PPAP2B;PPAP2A;ALDH3A2A;DGAT2;LIPG;LIPCA;AGPAT9L
Metabolic pathwaysPFAS;PRDX6;AUH;ACSL3;ACLY;EXT1A;GANC;PIP5K1BA;MTHFD2L

AKR1B10 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, geranylgeranyl reductase activity, indanol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B10 itself. We selected most functions AKR1B10 had, and list some proteins which have the same functions with AKR1B10. You can find most of the proteins on our site.

Function Related Protein
aldo-keto reductase (NADP) activityHSD3B5;AKR1C21;SPR;KCNAB1;AKR1C3;AKR1B1;AKR1C4;AKR1C6;H2-KE6
geranylgeranyl reductase activityAKR1C3;AKR1B10;AKR1B8
indanol dehydrogenase activityAKR1B8;AKR1C3;AKR1B10
protein bindingTBC1D1;SSX3;PPHLN1;KLF6;PDGFRB;UBE2V1;CCNA2;SGTB;GPS1
retinal dehydrogenase activityAKR1C6;ALDH8A1;AKR1B8;ALDH1A1;ALDH1A3;AKR1C4;AKR1C3;Aldh1a7;AKR1B10

AKR1B10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B10 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B10.

ACACA; TERF2IP; Nedd1; Jup; Slain1; TSNAX

  • Q&As
  • Reviews

Q&As (15)

Ask a question
What are the methods for laboratory detection of AKR1B10 protein? 03/25/2023

AKR1B10 protein is mainly detected in laboratory by enzyme-linked immunosorbent assay, fluorescence quantitative PCR and other methods.

Which cell signaling pathways does AKR1B10 protein participate in? 09/10/2022

AKR1B10 is involved in a variety of cell signaling pathways, such as NF-κB, WNT/ β-catenin signaling pathways, and thus plays a role in cell proliferation, differentiation and apoptosis.

How does AKR1B10 play a role in neuroprotective mechanisms? 06/03/2022

This protein is involved in the NADP/NADPH metabolic pathway, plays an antioxidant and neuroprotective role, and thus has a promising application in the prevention and treatment of central nervous system diseases.

AKR1B10 has the potential to be used in the early diagnosis and prevention of which cancers? 02/06/2022

AKR1B10 has a certain application prospect in the early diagnosis and prognosis evaluation of lung cancer, colorectal cancer, liver cancer and other cancers.

How is AKR1B10 protein distributed in the human body 01/24/2022

The AKR1B10 protein is an alcohol contraction enzyme that is associated with a variety of diseases and is mainly found in tissues such as liver, lung, stomach, breast, kidney, pancreas and intestine.

Does AKR1B10 have potential applications in the treatment of inflammatory diseases? 08/31/2021

AKR1B10 inhibitors can be used to prevent and treat a variety of inflammatory diseases, such as rheumatoid arthritis and hepatitis B.

How does AKR1B10 function in lung cancer? 08/28/2021

AKR1B10 protein is associated with cell proliferation, angiogenesis and malignant metastasis in lung cancer

In what diseases do AKR1B10 inhibitors have potential applications? 06/18/2021

AKR1B10 inhibitors have potential anti-tumor and anti-inflammatory therapeutic effects and can be used in the treatment of lung cancer, breast cancer, diabetes and other diseases.

Whether AKR1B10 protein is involved in tumorigenesis? 05/03/2021

The expression level of AKR1B10 protein in tumor cells is increased, which is related to tumor proliferation, invasion and metastasis, and is a new tumor biomarker.

What is the role of AKR1B10 protein in metabolic diseases? 04/01/2021

AKR1B10 is involved in the occurrence and development of metabolic diseases, such as diabetes and obesity, and is a possible therapeutic target.

Whether AKR1B10 protein has a function in the human body 07/18/2020

AKR1B10 protein is involved in various metabolic processes and cell proliferation and growth, such as steroid hormone metabolism, fatty acid synthesis, cell cycle regulation and so on.

Does there any steroid hormone metabolic pathways involved in AKR1B10? 08/18/2019

The metabolic pathways of steroid hormones involved in AKR1B10 include oxidative metabolism and reductive metabolism of steroid hormones.

Is AKR1B10 protein associated with hepatotoxicity? 07/16/2019

AKR1B10 protein is involved in the metabolism of some drugs and may be related to hepatotoxicity, which is a hot molecule in the study of drug metabolism and toxicity.

What diseases is AKR1B10 associated with? 04/24/2019

AKR1B10 protein is associated with a variety of diseases, such as tumors, lung diseases, metabolic diseases, and neurological diseases.

In what retinal diseases is AKR1B10 associated? 04/14/2019

AKR1B10 protein is involved in the metabolism of retinal glycoglycation end products, which is associated with diabetic retinopathy and other diseases.

Customer Reviews (4)

Write a review
Reviews
09/20/2022

    Has therapeutic effects on specific disease models and is a promising candidate for new drugs.

    03/31/2022

      The laboratory personnel feedback that the protein is easy to operate, can meet the experimental needs, and has a good cost performance.

      05/30/2019

        It has been found to increase yield and purity and improve production efficiency in biotechnology production.

        09/30/2018

          Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.

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