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Recombinant Human AKR1B10 protein, His & T7-tagged

Cat.No. : AKR1B10-1533H
Product Overview : Recombinant Human AKR1B10 aa. (Met1~Tyr316 (Accession # O60218)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Source : E. coli
Species : Human
Tag : His&T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 39.8kDa
Protein length : Met1~Tyr316 (Accession # O60218)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 8.2
Gene Name : AKR1B10 aldo-keto reductase family 1 member B10 [ Homo sapiens (human) ]
Official Symbol : AKR1B10
Synonyms : AKR1B10; aldo-keto reductase family 1 member B10; HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; aldo-keto reductase family 1 member B10; ARP; SI reductase; aldo-keto reductase family 1, member B10 (aldose reductase); aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like 1; aldose reductase-like peptide; aldose reductase-related protein; hARP; small intestine reductase
Gene ID : 57016
mRNA Refseq : NM_020299.4
Protein Refseq : NP_064695.3
UniProt ID : O60218

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (4)

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Reviews
09/20/2022

    Has therapeutic effects on specific disease models and is a promising candidate for new drugs.

    03/31/2022

      The laboratory personnel feedback that the protein is easy to operate, can meet the experimental needs, and has a good cost performance.

      05/30/2019

        It has been found to increase yield and purity and improve production efficiency in biotechnology production.

        09/30/2018

          Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.

          Q&As (15)

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          What are the methods for laboratory detection of AKR1B10 protein? 03/25/2023

          AKR1B10 protein is mainly detected in laboratory by enzyme-linked immunosorbent assay, fluorescence quantitative PCR and other methods.

          Which cell signaling pathways does AKR1B10 protein participate in? 09/10/2022

          AKR1B10 is involved in a variety of cell signaling pathways, such as NF-κB, WNT/ β-catenin signaling pathways, and thus plays a role in cell proliferation, differentiation and apoptosis.

          How does AKR1B10 play a role in neuroprotective mechanisms? 06/03/2022

          This protein is involved in the NADP/NADPH metabolic pathway, plays an antioxidant and neuroprotective role, and thus has a promising application in the prevention and treatment of central nervous system diseases.

          AKR1B10 has the potential to be used in the early diagnosis and prevention of which cancers? 02/06/2022

          AKR1B10 has a certain application prospect in the early diagnosis and prognosis evaluation of lung cancer, colorectal cancer, liver cancer and other cancers.

          How is AKR1B10 protein distributed in the human body 01/24/2022

          The AKR1B10 protein is an alcohol contraction enzyme that is associated with a variety of diseases and is mainly found in tissues such as liver, lung, stomach, breast, kidney, pancreas and intestine.

          Does AKR1B10 have potential applications in the treatment of inflammatory diseases? 08/31/2021

          AKR1B10 inhibitors can be used to prevent and treat a variety of inflammatory diseases, such as rheumatoid arthritis and hepatitis B.

          How does AKR1B10 function in lung cancer? 08/28/2021

          AKR1B10 protein is associated with cell proliferation, angiogenesis and malignant metastasis in lung cancer

          In what diseases do AKR1B10 inhibitors have potential applications? 06/18/2021

          AKR1B10 inhibitors have potential anti-tumor and anti-inflammatory therapeutic effects and can be used in the treatment of lung cancer, breast cancer, diabetes and other diseases.

          Whether AKR1B10 protein is involved in tumorigenesis? 05/03/2021

          The expression level of AKR1B10 protein in tumor cells is increased, which is related to tumor proliferation, invasion and metastasis, and is a new tumor biomarker.

          What is the role of AKR1B10 protein in metabolic diseases? 04/01/2021

          AKR1B10 is involved in the occurrence and development of metabolic diseases, such as diabetes and obesity, and is a possible therapeutic target.

          Whether AKR1B10 protein has a function in the human body 07/18/2020

          AKR1B10 protein is involved in various metabolic processes and cell proliferation and growth, such as steroid hormone metabolism, fatty acid synthesis, cell cycle regulation and so on.

          Does there any steroid hormone metabolic pathways involved in AKR1B10? 08/18/2019

          The metabolic pathways of steroid hormones involved in AKR1B10 include oxidative metabolism and reductive metabolism of steroid hormones.

          Is AKR1B10 protein associated with hepatotoxicity? 07/16/2019

          AKR1B10 protein is involved in the metabolism of some drugs and may be related to hepatotoxicity, which is a hot molecule in the study of drug metabolism and toxicity.

          What diseases is AKR1B10 associated with? 04/24/2019

          AKR1B10 protein is associated with a variety of diseases, such as tumors, lung diseases, metabolic diseases, and neurological diseases.

          In what retinal diseases is AKR1B10 associated? 04/14/2019

          AKR1B10 protein is involved in the metabolism of retinal glycoglycation end products, which is associated with diabetic retinopathy and other diseases.

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