akt1
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  • Official Full Name
  • RAC-alpha serine/threonine-protein kinase
  • Background
  • Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
  • Synonyms
  • AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1
Cat.#:AKT1-14HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-336HTag:His|Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 Protein, His & Strep-tagged
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Cat.#:AKT1-427HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-2521HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged, Active
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Cat.#:AKT1-101HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged
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Cat.#:AKT1-1516HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein
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Cat.#:AKT1-155HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-156HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-259HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-307HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His/MBP-tagged
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Cat.#:AKT1-30HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT1 protein, Flag-tagged, Biotinylated
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Cat.#:AKT1-3920HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-420HTag:GST|His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-His tagged
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Cat.#:AKT1-421HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-422HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-tagged
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Cat.#:AKT1-47HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-50HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-56HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Actived
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Cat.#:AKT1-57HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Inactived
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Cat.#:AKT1-786HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1, His tagged
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Cat.#:AKT1-1507MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKT1 Protein
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Cat.#:AKT1-605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT1 Protein
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Cat.#:AKT1-296RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT1 Protein, His-tagged
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Cat.#:AKT1-6612CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKT1
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Cat.#:AKT1-8342ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT1
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Cat.#:AKT1-1363HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 (Active), GST-tagged
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Cat.#:AKT1-677HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1 cell lysate
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Involved Pathway

AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FASLG; FGF8; PLA2G4A; LAMTOR3; RPS6KA4; RAC3A; IKBKB; RASA1; MRAS; TGFB2
ErbB signaling pathway
CAMK2G1; NCK2A; PAK2B; SHC3; PIK3R3; CBLB; TGFA; ARAF; ERBB3B; NCK1
Ras signaling pathway
HGF; NGF; PLA2G6; CSF1; KSR2; PDGFC; PAK6; PIK3R3; ZAP70; PDGFA
Rap signaling pathway
PRKCI; FGF10; VEGFC; MAGI2; ITGB2; IGF1; PIK3CB; KIT; TLN1; PARD6A
cGMP-PKG signaling pathway
PPIF; ATP1B3; KCNMB4; LOC100328615; NFATC2; RHOA; ROCK1; NFATC3; BAD; ITPR1
cAMP signaling pathway
GRIN3A; CAMK2G; ATP1B4; CAMK4; CREB3L2; ATP1A1; GRIA4; FSHR; VAV1; GLP1R
Chemokine signaling pathway
RAP1A; CXCL16; CX3CR1; LOC100033925; GNG7; CXCL13; PIK3CD; GNAI3; SHC2; PRKCB
HIF- signaling pathway
PIK3CB; NOS3; INS; INSR; MKNK1; TEK; PIK3R2; IFNGR2; CAMK2G; VHL
FoxO signaling pathway
FBXO25; G6PC2; SKP2; GABARAPL1; MAPK10; HOMER3; IRS4; GADD45AB; PTEN; AGAP2
Sphingolipid signaling pathway
GNAI2; NOS3; SPHK1; LASS1; PPP2R2D; BDKRB2; PPP2R2C; TRAF2; SGPP1; MAPK8
Phospholipase D signaling pathway
PIP5K1C; AVP; AKT1; LPAR6; GRB2; MAPK3; LPAR5; MAP2K2; RHEB; PIK3CD
mTOR signaling pathway
STRADA; PIK3R5; PIK3CD; RPS6KB2; PIK3CB; RPS6KB1; ULK2; PRKCBB; HIF1AB; MAPK1
PIK-Akt signaling pathway
FGFR1; IFNA7; VWF; PDGFRB; SPP1; PPP2R2B; CCND3; PHLPP2; VTN; LAMB3
AMPK signaling pathway
PPP2R2B; GYS2; RPS6KB2; PFKFB1; MAP3K7; PRKAG1; ELAVL1; PPP2R2C; PIK3R2; CPT1B
Apoptosis
BIRC3; TRAF2; BCAP31; NFKBIAA; DYNLL2; PRKACAA; IL3RA; PANK1A; NGF; PIK3CD
Adrenergic signaling in cardiomyocytes
CACNG3; CACNB1; CACNA1D; ATP1B3B; ADCY8; CREB3L3L; PPP2R2B; CACNG4; TPM4A; VMHCL
VEGF signaling pathway
AKT2L; PIK3R3B; RAC2; SHC2; PTGS2A; MAP2K2; CDC42L; HRASB; NOS3; PIK3CA
Osteoclast differentiation
TREM2; NCF4; MAP3K14; NFKB2; LILRB1; SOCS3; MAP2K1; PIK3R3; MAPK10; MAPK3
Focal adhesion
PPP1R12C; ITGA7; STYK1; PAK6B; PDGFRA; THBS4B; LAMB3; RAC1A; PPP1CA; VTNB
Tight junction
SHROOM2; PRKCBA; LLGL1; JAM3B; CLDNF; PRKCG; PPP2R2CA; EPB41L3; CLDNH; ACTN3
Signaling pathways regulating pluripotency of stem cells
ESX1; OTX1; MAPK13; ISL1; BMPR2; WNT8B; KLF4; AKT1; WNT5B; ACVR1
Platelet activation
GNAS; PLA2G4F; GP9; PLCG2; PRKG1; ARHGEF1; F2R; LYN; FERMT3; PIK3R3
Toll-like receptor signaling pathway
RELA; IL8L2; CCL3L3; CCL3L1; CCL4L2; STAT1B; MAP2K3; AKT2; IFNA13; IFNA3
Jak-STAT signaling pathway
IFNA12; IL13RA1; CCND2A; Ifnl2; TP-1; IL9; RAF1B; AKT2; SOCS4; EP300
T cell receptor signaling pathway
NFKB1; NRAS; IL5; CDC42; DEF6A; KRAS; RAF1; NFKBIB; CARD11; SHB
B cell receptor signaling pathway
GRB2; PPP3R1; MAPK1; DAPP1; PPP3R2; RAC2; PTPN6; INPP5D; PIK3R1; PIK3CA
Fc epsilon RI signaling pathway
IL3; MAPK3; GRB2; IL13; MAPK11; MAP2K1; RAC3; PIK3CB; PLA2G4A; BTK
Fc gamma R-mediated phagocytosis
MARCKSL1; FCGR1A; PIK3R2; PAK1; PPAP2A; LIMK1; PLA2G4A; VAV3; RPS6KB2; PPAP2B
TNF signaling pathway
MAP2K1; VCAM1; TNFAIP3; FADD; MMP14; MAPK11; AKT2; CREB3L3; TNFRSF1B; LIF
Neurotrophin signaling pathway
MAPKAPK2; NGF; PIK3R2; GSK3B; IRAK1; NTRK2; RELA; PIK3R5; AKT2; PLCG2
Cholinergic synapse
CAMK2B; KCNQ3; KCNJ12; GNG11; GNAO1; KCNJ6; CHRM1; KCNQ5; PRKCA; ACHE
Dopaminergic synapse
GNG2; PPP1CB; PPP3CC; PPP2R5E; PPP1CA; GNG10; SLC18A1; PRKCA; GNG4; PPP2R2B
Insulin signaling pathway
FBP1B; HK1; CALM4; HK2; PTPRFB; PHKA2; FBP1; INSRA; PDPK1B; PPP1CAB
Progesterone-mediated oocyte maturation
CDC25B; ANAPC4; CPEB1B; GNAI1; MAPK9; IGF1RB; CDC16; MAD2L1; CDH1-A; CDC23
Estrogen signaling pathway
MMP2; SOS1; ESR1; CALM1; CALM3; CALML3; KCNJ5; PLCB1; HSPA1B; MAPK1
Prolactin signaling pathway
LHCGR; PIK3CB; SRC; MAPK10; STAT5B; HRAS; CSN2; MAP2K2; LHB; RELA
Thyroid hormone signaling pathway
AKT1; PLN; PLCG1; MED30; EP300; MED13L; PFKP; HDAC1; PRKACB; MED24
Adipocytokine signaling pathway
MAPK8; RXRA; LEPR; ACSL4; NFKB1; POMCA; G6PC; PRKAG3; CPT1B; ACACB
Glucagon signaling pathway
CAMK2A; FBP1; PLCB2; PKM2; SIK2; FOXO1; LDHB; PDHA2; GYS2; PYGB
Regulation of lipolysis in adipocytes
PRKACB; IRS4; PNPLA2; PLIN1; PIK3CD; PTGER3; GNAS; PRKACA; AKT2; FABP4
Insulin resistance
CREB3L3A; NFKB1; RPS6KA1; AKT2; SLC2A2; G6PC; PIK3R3B; PRKAB1A; NFKBIA; PRKCE
Non-alcoholic fatty liver disease (NAFLD)
UQCRB; COX7A2L; NDUFA12; IL-8; NDUFB1; RELA; IRS1; MAPK8; GSK3B; NDUFA2
Carbohydrate digestion and absorption
AMY2A3; ATP1A1; TAS1R3; HK1; GNAT3; PIK3R1; Amy1; ATP1B1; G6PC2; AKT2
Chagas disease (American trypanosomiasis)
SMAD3; TICAM1; PIK3CG; CD3G; CCL2; IL1B; CD3E; CD3D; LOC100033925; C1QB; FADD
Toxoplasmosis
MAPK11; CASP9; HLA-DPB1; IKBKB; PDPK1; PIK3R2; PIK3R5; LAMA1; MAP2K3; STAT3
Tuberculosis
CD209A; Pla2r1; IRAK2; CALML3; MAPK10; TRAF6; CAMK2D; IFNG; HLA-DPB1; NFKB1
Hepatitis C
IFNA2; PPP2R2C; PPP2R2D; BRAF; CLDN8; PPP2CB; RNASEL; IFNA21; NR1H3; MAPK13
Hepatitis B
IRF3; IFN-a; DDB2; CCND1; TLR4; EP300; PIK3CD; PIK3R3; IL6; STAT4
Measles
DDX58; PRKCQ; DOK1; IFNA13; TLR7; CLEC4M; STAT5B; CD3E; CD3D; FAS; HSPA8
Influenza A
NFKBIA; TMPRSS2; IFNA6; IFNA21; KPNA1; PIK3CB; RAF1; TNF; MAPK9; OAS1
HTLV-I infection
MAP3K14; MYBL1; FDPS; POLD4; EGR1; ETS2; PTTG1; TBPL2; CRTC1; WNT7A
Epstein-Barr virus infection
PSMD3; HLA-E; NEDD4; TYK2; PIK3R5; CD38; MAP3K14; HLA-G; POLR2J3; TRAF2
Pathways in cancer
PRKACB; FGF14; F2RL3; SMO; LAMB1; PIK3R2; IGF1; PIK3CG; NKX3; LAMA2
Proteoglycans in cancer
TWIST2; MET; WNT3A; ELK1; AKT2; ARHGEF1; ERBB2; ITGA2; ARHGEF12; MMP2
Colorectal cancer
TGFB3; MSH2; MAPK1; MAPK3; SMAD4; TGFBR1; APC2; RAC1; TGFB1; MAPK8
Renal cell carcinoma
RAC1; GAB1; MAPK1; RBX1; ARNT2; PAK3; EGLN1; VHL; ETS1; ARAF
Pancreatic cancer
RAF1; ARHGEF6; STAT3; CASP9; PIK3CD; PIK3CB; RAC1; PIK3R5; MAPK1; MAPK9
Endometrial cancer
TCF7; MLH1; LEF1; MAP2K1; PTEN; MAPK3; RAF1; CTNNA3; AXIN1; MAP2K2
Glioma
PIK3R2; PDGFRB; RB1; Pdgfa&Pdgfb; AKT1; PIK3R1; PRKCB; PTEN; MAP2K1; TGFA
Prostate cancer
SRD5A2; GSK3B; NKX3; INSRR; MAP2K2; FGFR2; GRB2; HRAS; CREB5; NRAS
Melanoma
PDGFD; AKT1; FGF11; MAPK3; NRAS; PIK3R3; PIK3CB; FGF4; PDGFB; PIK3CD
Chronic myeloid leukemia
IKBKB; PTPN11; BCL2L1; CRK; CBLC; HDAC2; TGFBR1; MAP2K2; TP53; CDK6
Acute myeloid leukemia
SFPI1; GRB2; PIK3R2; STAT5B; RPS6KB1; PIK3R3; CEBPA; IKBKG; STAT5A; ARAF
Small cell lung cancer
LAMB4; ITGA6; PIK3CB; LAMA4; NFKBIA; NOS2; LAMC1; LAMB3; TP53; CYCS
Non-small cell lung cancer
RXRA; AKT1; ERBB2; BAD; BRAF; RXRB; MAPK1; CASP9; PLCG2; PRKCB
Central carbon metabolism in cancer
PIK3R5; PIK3CD; SIRT3; IDH1; KRAS; GLS; PFKL; SLC7A5; PDHA1; NTRK1
Choline metabolism in cancer
SLC22A1; PPAP2C; DGKD; PDGFRB; PDGFC; DGKG; PLD2; SOS1; RPS6KB1; SLC22A5

Protein Function

AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein AANAT; KCNH1; HDAC7; TSC2; ZFP36; YWHAQ; HDAC7A; KIF13B; ARRB2; IRS2
Function ATP binding
Related Protein UBE2L3; UBE2R2; ERN1; FICD; DHX36; OASL; SHPRH; Acsm2a; STK24; XRCC6
Function enzyme binding
Related Protein RARA; NPC2; HLCS; TTN; CAT; WWOX; SLC12A3; U2AF2; HDAC10; SORT1
Function identical protein binding
Related Protein ITGB3; IRF3; CCL3; CLDN23; ATG16L1; RIPK1; LRRK1; GOT1; PRC1; DYNLRB1
Function kinase activity
Related Protein AGPHD1; MAPK12A; PDXKB; CAMK2N1A; PRKCHA; EPHB4A; MAP3K4; SBK1; NTRK3A; LMTK3
Function nitric-oxide synthase regulator activity
Related Protein CALM2; HSP90AA1; CALM1; ESR1; AKT1; HSP90AA1.1; HSP90AB1; CALM3
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein MYO1G; ARAP2; PARD3; GAB2; COMMD1; ARAP3; CYTH3; NRGN; FERMT2; GBF1
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein FAM21C; D6WSU116E; TTPA; NCF1; MAPKAP1; ADAP2; ZFYVE1; ARAP3; GAB2; DAPP1
Function protein binding
Related Protein KIAA1279; VPS37A; FGFR3; SLC30A8; PRPF4B; F8; CIT; POU3F2; FUS; WDR92
Function protein kinase C binding
Related Protein ADAM9; PRKCB; HINT1; HAND2; GRK5; PKN1; PDLIM5; DACT3; TOP2B; HDAC9
Function protein kinase activity
Related Protein CCL8; CDK5R1; CAMK2D2; NRBP1; TNIK; GSG2; EPHB4B; CSNK1A1; RBM4.3; BMPR1AB
Function protein phosphatase 2A binding
Related Protein ENSAA; AKT1; MASTL; CPD; SMG7; SHC1; RPS6KB1; IGBP1; CTTNBP2NL; SMG5
Function protein serine/threonine kinase activity
Related Protein PKN1; SGK2A; NIM1; TAF1L; TSSK4; SQSTM1; SYK; PRKCB; HUNK; MAP3K12
Function protein serine/threonine/tyrosine kinase activity
Related Protein AURKB; DSTYK; PRKAA2; CLK3; DYRK3; CLK1; DYRK2; AURKC; DYRK4; PRKACA

Interacting Protein

AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.
MDM2; N/A; PPP2CA

AKT1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).

AKT1 Related Gene Family

TGF