akt1
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  • Official Full Name
  • RAC-alpha serine/threonine-protein kinase
  • Background
  • Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
  • Synonyms
  • AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1
Cat.#:AKT1-14HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-336HTag:His & Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 Protein, His & Strep-tagged
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Cat.#:AKT1-427HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-2521HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged, Active
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Cat.#:AKT1-101HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged
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Cat.#:AKT1-1516HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human AKT1 protein
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Cat.#:AKT1-155HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-156HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-259HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-307HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His/MBP-tagged
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Cat.#:AKT1-30HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT1 protein, Flag-tagged, Biotinylated
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Cat.#:AKT1-3920HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-420HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-His tagged
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Cat.#:AKT1-421HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-422HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-tagged
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Cat.#:AKT1-47HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-50HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-56HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Actived
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Cat.#:AKT1-57HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Inactived
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Cat.#:AKT1-786HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1, His tagged
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Cat.#:AKT1-1507MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKT1 Protein
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Cat.#:AKT1-605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT1 Protein
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Cat.#:AKT1-296RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT1 Protein, His-tagged
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Cat.#:AKT1-6612CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKT1
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Cat.#:AKT1-8342ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT1
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Cat.#:AKT1-1363HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 (Active), GST-tagged
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Cat.#:AKT1-677HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1 cell lysate
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Involved Pathway

AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
JIP1; RPS6KA2; PPP3R2; Pdgfa&Pdgfb; RPS6KA3B; PRKCA; FGF17; CACNG1; NF1; MAPK9
ErbB signaling pathway
CBLC; PAK3; MAP2K4; RAF1; PAK2B; SHC4; SHC1; CAMK2A; CAMK2G1; MAPK9
Ras signaling pathway
PLA2G4C; RAF1; CALM3; PAK2; PIK3CB; GRIN2B; STK4; PDGFRA; GRIN1; FGF3
Rap signaling pathway
PLCB3; FGF5; FIGF; Fgf15; PRKCG; Itgam&Itgb2; ITGB2; FGF20; RAPGEF6; RASGRP3
cGMP-PKG signaling pathway
ATP1A3; IRS2; CALM4; PRKCE; PLCB3; MYLK; CALML3; ATP2B1; ATP1B2; NPR1
cAMP signaling pathway
MAPK9; TSHR; SOX9; GLI1; BDNF; ATP2B4; ACOX3; MC2R; PTGER3; MAPK1
Chemokine signaling pathway
PTK2B; CXCL12; KRAS; ROCK1; CDC42; Ccl9; IKBKB; PF4; CCL14; GNGT1
HIF- signaling pathway
PIK3R3; TF; LDHA; IL6R; GAPDH; BCL2; PIK3CB; ANGPT2; ERBB2; CAMK2B
FoxO signaling pathway
USP7; PDPK1; PLK3; AKT2; FOXO3; HRAS; FOXO3A; MDM2; MAPK3; TGFBR1
Sphingolipid signaling pathway
OPRD1; PIK3CB; ROCK2; TRAF2; CERS4; CERS2; PIK3CA; BAX; TRADD; PPP2R2B
Phospholipase D signaling pathway
SHC3; AVPR1B; MRAS; FYN; IL-8; PLCB2; INS1; PLCG1; LPAR6; PLCB4
mTOR signaling pathway
PRKAA1; PRKCG; PIK3R3; RB1CC1; ULK1; MLST8; RPS6; AKT2L; HIF1A; RPS6KA2
PIK-Akt signaling pathway
LAMA3; MCL1; GNB3; ITGA9; Kitl; IKBKG; FGF7; IL7; ITGA4; PPP2R5B
AMPK signaling pathway
STK11; INS; HMGCR; PPP2R3A; G6PC3; CREB5; FBP2; PRKAA2; PIK3R1; TSC2
Apoptosis
PIK3R5; Fasl; PLEC; DFFA; XIAP; CAPN1B; PIK3R3B; IL3; CDKN2A; IKBKG
Adrenergic signaling in cardiomyocytes
ADRB2; ADRA1B; CACNA1DA; TPM4; AKT2; CACNB4A; PRKACA; CACNA2D2; PPP2CA; CACNB3A
VEGF signaling pathway
AKT2L; PRKCB; NRAS; PPP3R2; PRKCBB; MAPK14B; PIK3CG; RAF1B; MAPKAPK2; SRC
Osteoclast differentiation
FHL2; BTK; SPI1; PLCG2; MAP3K7; FCGR3B; MAP2K7; SIRP-BETA; RELA; TNF
Focal adhesion
LAMA5; VAV2; RHOAB; MYL2B; PIK3R3; PRKCG; ACTG1; RAP1A; MET; RHOA
Tight junction
MAGI1B; GNAI1; OCLNB; TJP2; MYH3; MYLPFB; MYLPFA; HRASA; ACTN2B; MYH1C
Signaling pathways regulating pluripotency of stem cells
KLF4; KRAS; SMARCAD1; ID4; FGFR4; WNT2; WNT7A; BMPR1A; PAX6; IGF1
Platelet activation
ORAI1; MYL12B; ITPR3; ROCK2; RAP1A; ARHGAP35; ROCK1; FYN; PPP1R12A; AKT2
Toll-like receptor signaling pathway
MAP2K4; IL8L1; NFKBIAB; TLR3; IRAK4; MYD88; FOS; TLR1LB; MAPK8; TLR7
Jak-STAT signaling pathway
IL17D; BCL2L1; IL27RA; IL4; M17; IL12RB2; PIAS4B; IFNA5; PIM1; CISHB
T cell receptor signaling pathway
PPP3CB; MAP3K7; CD8B; PIK3CB; CD3E; RAF1; NCK2; LAT; EVLB; ZAP70
B cell receptor signaling pathway
NFKB1; ARPC1B; RASGRP3; CDK7; IGHM; PIK3R3; PLEKHA1; VAV2; CD79A; PPP3CA
Fc epsilon RI signaling pathway
VAV1; HRAS; PIK3CG; PLCG1; GM-CSF; RAC2; IL4; FYN; IL3; PRKCA
Fc gamma R-mediated phagocytosis
INPPL1; CFL1; LYN; BIN1; PIK3CA; PRKCB; MARCKS; PPAP2B; ASAP1; FCGR2B
TNF signaling pathway
PIK3CB; CREB5; VCAM1; MAP3K5; Casp3; CXCL2; TNFRSF1A; MLKL; IL1B; BAG4
Neurotrophin signaling pathway
ARHGDIA; HRAS; CAMK2G; PIK3R5; BAX; PIK3CB; FASLG; CALM2; NTRK2; SHC4
Cholinergic synapse
CAMK2D; GNG12; GNG5; PIK3R2; PRKACB; FYN; KCNQ4; PRKCA; PRKACG; CHRNA3
Dopaminergic synapse
PPP2R5B; GNGT1; PLCB1; ATF6B; GNG3; CALM4; PPP2CB; GRIA3; CALM3; SLC6A3
Insulin signaling pathway
RAPGEF1B; MKNK2; PIK3R5; PIK3CA; PPP1R3CA; RPTOR; PRKACAB; FOXO1; PYGMA; FLOT2
Progesterone-mediated oocyte maturation
CCNA2; MAPK8B; PRKACAA; KRAS; RPS6KAL; MAPK3; ADCY1A; INSB; MAPK13; CDC23
Estrogen signaling pathway
PRKACA; GNAS; MAP2K1; CALM3; PLCB4; CREB3L1; SHC3; ITPR1; HSPA2; HSPA1B
Prolactin signaling pathway
PIK3CD; TNFSF11; MAPK1; PRLR; PRL; STAT5A; INS; PIK3CA; PIK3CB; NRAS
Thyroid hormone signaling pathway
HIF1A; PLCG1; AKT2; RHEB; ATP1B1; NCOA3; TRP53; DIO2; TBC1D4; ITGAV
Adipocytokine signaling pathway
PRKAB1A; MAPK8; LEP; G6PCA.2; RXRBA; PRKAG3B; IRS2; PRKAG2A; SLC2A1A; TNFRSF1B
Glucagon signaling pathway
CREB5; CRTC2; PPP3CC; PDE3B; PLCB2; PYGB; CALM3; PHKA2; CALM4; PHKB
Regulation of lipolysis in adipocytes
ABHD5; INSR; PRKG2; LOC100328615; PRKACB; IRS2; PTGER3; INS; PNPLA2; PTGS1
Insulin resistance
OGT.1; PCK1; SLC2A4; PRKCDA; NFKB1; CRTC2; RPS6KB1; CREB3L3; MAPK9; AKT2
Non-alcoholic fatty liver disease (NAFLD)
NDUFS7; COX4I2; RAC1; XBP1; LEP; NDUFB9; COX7B; ADIPOR1; NDUFA1; INS2
Carbohydrate digestion and absorption
PIK3CA; PIK3R1; Amy1; ATP1B3; GNAT3; PIK3R5; AKT1; TAS1R3; PIK3R2; HK3
Chagas disease (American trypanosomiasis)
PPP2R2B; FAS; CCL5; CXCL8; C1QB; ACE; PIK3CB; MAPK13; TICAM1; IL12B
Toxoplasmosis
PIK3CG; NFKBIB; HSPA6; LAMA4; CD40LG; BAD; LAMB2; LAMA1; HSPA1A; LDLR
Tuberculosis
Il23a; IFNA10; CALM3; CARD9; CAMP; LSP1; Itgam&Itgb2; FCGR3; KSR1; MRC1
Hepatitis C
CLDN3; SOCS3; TRAF6; RAF1; AKT2; OAS1; OCLN; PPP2CB; NFKB1; TP53
Hepatitis B
CCND1; IFNA8; RB1; STAT6; FAS; MAVS; NFATC4; STAT3; VDAC3; BAD
Measles
IFNA12; IFNGR2; IFNA5; STAT1; STAT5B; TBK1; FASLG; IFNA1; IFNA17; CD46
Influenza A
CPSF4; GSK3B; CXCL8; IFNA8; MAPK9; BMA2; IL1B; PIK3R2; CCL2; RSAD2
HTLV-I infection
DVL3; APC2; SLC25A6; MSX2; RANBP3; WNT9B; EGR1; HLA-DQB1; TGFBR2; FZD1
Epstein-Barr virus infection
GTF2E2; DDX58; ENTPD3; FGR; GSK3B; PSMC6; TBP; POLR2A; HLA-DRB5; IL10RB
Pathways in cancer
Shh; SKP2; FH1; TGFB1; WNT7B; SMAD2; FZD9; RET; CTNNA3; CCNA1
Proteoglycans in cancer
PTCH1; WNT3A; Casp3; CBLB; CAV1; PRKCA; ARHGEF12; RAC1; PAK1; ERBB3
Colorectal cancer
TGFBR1; RHOA; TP53; PIK3R2; GSK3B; BRAF; ARAF; RALGDS; MAPK1; MAP2K1
Renal cell carcinoma
TCEB2; MAP2K1; GAB1; RAPGEF1; MET; PIK3R2; TGFB1; PAK1; TGFB2; PAK3
Pancreatic cancer
AKT2; PLD1; KRAS; ARAF; CASP9; IKBKG; IKBKB; PIK3CD; VEGFA; RALBP1
Endometrial cancer
PIK3CG; MLH1; FOXO3; GRB2; PIK3R3; TCF7L2; BRAF; TCF7; PIK3CA; PIK3CB
Glioma
MTOR; CALM1; PRKCA; RB1; SOS1; CALML5; CALM4; MAP2K2; BRAF; AKT2
Prostate cancer
NKX3; LEF1; PDGFA; MAP2K1; FGFR2; HSP90AB1; CREB3L2; BCL2; Pdgfa&Pdgfb; MDM2
Melanoma
PIK3R5; PDGFRB; PDGFC; Fgf15; FGF3; FGF5; TP53; Pdgfa&Pdgfb; FGF17; RB1
Chronic myeloid leukemia
MAP2K1; NFKB1; TGFBR2; AKT2; STAT5B; CBLB; CCND1; KRAS; GAB2; CDK6
Acute myeloid leukemia
PIK3CA; SFPI1; NFKB1; AKT1; PIM1; TCF7L2; EIF4EBP1; RPS6KB1; ARAF; RARA
Small cell lung cancer
XIAP; CASP9; COL4A1; BIRC3; TRAF6; TRAF1; LAMA5; LAMB2; APAF1; AKT2
Non-small cell lung cancer
KRAS; GRB2; FHIT; NRAS; SOS1; PLCG2; RXRG; PIK3R3; ERBB2; RAF1
Central carbon metabolism in cancer
KIT; SLC16A3; PDHA1; G6PDX; AKT2; PDHA2; C12orf5; GLS2; SLC2A2; SLC2A1
Choline metabolism in cancer
PRKCB; PLD2; PDGFB; MAP2K1; WASL; CHKB; TSC2; SP1; RAF1; CHKA

Protein Function

AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein IRS2; TSC2; AKT1; SRPK2; PPP1R12A; HDAC7; KCNH1; ZFP36; RPTOR; ARRB2
Function ATP binding
Related Protein CHD1L; TRIOA; HSP90B1; MAPK4; KIF14; UBE2G1A; PIP5K1B; DDX24; ITPKA; ROR2
Function enzyme binding
Related Protein MSH2; PRKCA; HDAC1; EGFR; CYP2A6; UBE2I; SELS; LGALS9; BACE1; CBX1
Function identical protein binding
Related Protein GPSM2; PRPF3; BAX; UGP2; DDX58; PRC1; MTSS1; COL18A1; TNPO3; MSTN
Function kinase activity
Related Protein PRKACAB; ADKB; SBK1; BMPR2A; CDK5; MKNK2A; Aatk; MAP2K4A; cka1; PIK3CA
Function nitric-oxide synthase regulator activity
Related Protein HSP90AA1.1; HSP90AA1; CALM3; ESR1; AKT1; CALM1; HSP90AB1; CALM2
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein ANXA8; ARAP2; INPPL1; ARAP3; OGT; FAM21C; MYO1G; GAB2; CYTH3; KIF16B
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein GAB2; COMMD1; NCF1; AKT1; D6WSU116E; RS1; PLEK; RAG2; PLEKHA1; KIF16B
Function protein binding
Related Protein MAGEC2; PYGB; IGFBP5; DAB1; CARHSP1; NANOS2; HTATIP2; SPINK7; RAP1B; AP2S1
Function protein kinase C binding
Related Protein HDAC7; FEZ1; PKP2; GRK5; HAND2; GNB2L1; DACT1; PRKCSH; TWF2; PDLIM5
Function protein kinase activity
Related Protein PRKG2; CCL5; TBCK; MAP3K4; PRKCI; PRKDC; ADRBK2; CDKL5; CDC7; BMPR1AA
Function protein phosphatase 2A binding
Related Protein SPHK1; TP53; HMGCR; EIF4EBP1; TRP53; ARPP19; PPP2R4; PTPN1; ENSAA; CPD
Function protein serine/threonine kinase activity
Related Protein SRPK1; PRKCQ; WNK2; TNIK; MAP4K4; MAP4K5; MAP4K6; TNK2; OXSR1A; VRK2
Function protein serine/threonine/tyrosine kinase activity
Related Protein AURKB; CLK2; RPS6KA1; AURKA; DYRK1AA; TESK1; CLK4; PRKACA; TTK; DYRK2

Interacting Protein

AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.
MDM2; N/A; PPP2CA

AKT1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).

AKT1 Related Gene Family

TGF