akt1
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  • Official Full Name
  • RAC-alpha serine/threonine-protein kinase
  • Background
  • Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
  • Synonyms
  • AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1
Cat.#:AKT1-14HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-336HTag:His & Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 Protein, His & Strep-tagged
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Cat.#:AKT1-427HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-2521HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged, Active
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Cat.#:AKT1-101HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged
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Cat.#:AKT1-1516HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human AKT1 protein
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Cat.#:AKT1-155HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-156HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-259HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-307HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His/MBP-tagged
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Cat.#:AKT1-30HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT1 protein, Flag-tagged, Biotinylated
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Cat.#:AKT1-3920HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-420HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-His tagged
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Cat.#:AKT1-421HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-422HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-tagged
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Cat.#:AKT1-47HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-50HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-56HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Actived
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Cat.#:AKT1-57HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Inactived
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Cat.#:AKT1-786HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1, His tagged
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Cat.#:AKT1-1507MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKT1 Protein
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Cat.#:AKT1-605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT1 Protein
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Cat.#:AKT1-296RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT1 Protein, His-tagged
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Cat.#:AKT1-6612CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKT1
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Cat.#:AKT1-8342ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT1
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Cat.#:AKT1-1363HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 (Active), GST-tagged
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Cat.#:AKT1-677HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1 cell lysate
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Involved Pathway

AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNB3; RAC1; DUSP16; ARR3B; MAPK8IP2; CASP3A; RAC1A; PPP3R1; MINK1; PAK2
ErbB signaling pathway
BRAF; PLCG2; PRKCB; SHC1; PRKCA; MAPK8A; NRG2; GAB1; ARAF; SRC
Ras signaling pathway
FGF8; PIK3R5; IGF1R; PLA1A; CALM3; REL; PIK3CB; RASAL2; FGFR4; FGF14
Rap signaling pathway
PLCB2; ACTB; RAC1; ACTG1; FGF22; FGF3; MAPK12; FGF7; FGF4; FGF13
cGMP-PKG signaling pathway
INS1; GNAI2; IRS2; MYLK; RAF1; PDE5A; ATP1A1; PPP3CB; AGTR1B; VDAC3
cAMP signaling pathway
MC2R; NFATC1; GNAI1; HTR1E; CALM1; PIK3R5; VAV2; CALML5; MAP2K1; DRD1A
Chemokine signaling pathway
GNB3; GM2506; CXCL11; GNGT2; VAV2; CCL20; SHC3; PRKACB; GNG8; ROCK1
HIF- signaling pathway
PIK3R2; GM5506; Il6ra; PRKCB; MAPK1; PFKL; AKT1; TIMP1; PGK1; EP300
FoxO signaling pathway
SMAD3A; IRS2; PRKAG2A; INSB; G6PCA.1; PRKAA2; FOXO3A; FOXG1A; HOMER1B; PRKAG3B
Sphingolipid signaling pathway
RAC1; SPHK2; PIK3R1; DEGS2; FYN; CERS4; S1PR5; PIK3R5; PPP2R2C; PPP2CB
Phospholipase D signaling pathway
PIK3CG; PTGFR; LPAR4; DGKZ; MAP2K2; PIK3R3; PTPN11; CYTH4; DNM3; PLA2G4A
mTOR signaling pathway
RPS6KA3B; TSC1A; PRKCA; DEPDC6; IGF1; POLDIP3; RHEB; RPS6KA6; PIK3CB; PIK3R3B
PIK-Akt signaling pathway
LAMA5; FGF22; TLR4; FGFR1; IL4R; HRAS; FOXO3; ITGA2; FGF12; PDGFA
AMPK signaling pathway
INS2; PFKFB1; RPS6KB1; IRS1; FBP2; PIK3R1; CCNA1; RPTOR; PFKM; IRS2
Apoptosis
DBNL; STK26; IRF2A; BCL2L11; BAX; IRF4; STK24A; CLSPN; PIK3CB; RELA
Adrenergic signaling in cardiomyocytes
SLC9A1; ADRB2; CAMK2B; CREB5; ATP1B3A; MAPK12A; ADCY1A; CACNG2A; SCN1BB; TPM4B
VEGF signaling pathway
PTGS2; AKT1; PTK2; PLA2G4A; HRASA; MAP2K2; PIK3R5; PPP3R1B; CDC42; VEGFA
Osteoclast differentiation
LILRA4; TNF; SOCS1; FOSL2; MAP2K1; PIK3CD; IL1B; FCGR4; IKBKG; NFKB1
Focal adhesion
ACTN2; PPP1R12B; PRKCA; THBS4A; VAV2; CCND2A; RAC2; VEGFC; ITGA2; PARVA
Tight junction
CLDN9; CLDN7A; PTENA; PARD6GA; MYL7; RRAS; CASK; CLDN4; PRKCD; EPB41L1
Signaling pathways regulating pluripotency of stem cells
BMPR1A; FZD6; FZD5; BMPR2; MAP2K1; MAPK3; Fzd4; WNT9A; SETDB1; FGFR3
Platelet activation
PLA2G4A; FERMT3; MYLK2; COL24A1; APBB1IP; MYLK4; PRKCI; PIK3CA; PLA2G4F; GP1BB
Toll-like receptor signaling pathway
TRAF6; TRAF3; CCL5; Ifna15; MAPK12B; IL8L1; TLR5B; MAP3K7; NFKB1; CXCL11
Jak-STAT signaling pathway
BCL2A; IL2RGA; STAT6; IL2RGB; GRB2A; PTPN11; Il23a; TP-1; IL23R; HRAS
T cell receptor signaling pathway
PPP3CA; CD4; PDCD1; PIK3CG; Il2; SLA1; IFNG; LCP2; CABIN1; PIK3R5
B cell receptor signaling pathway
DUSP4; RAC3; KRAS; BTK; LIME1; CD79A; DUSP6; HRAS; NFKBIA; AKT2
Fc epsilon RI signaling pathway
VAV1; PRKCA; INPP5D; PLA2G4A; FYN; PIK3R1; MAPK12; MAP2K6; RAC3; MAPK1
Fc gamma R-mediated phagocytosis
MAP2K1; PLA2G4F; RAC2; BIN1; DOCK2; LIMK1; WASF1; ASAP1; CFL2; ARF6
TNF signaling pathway
TRAF3; BIRC3; CASP7; MAP3K7; FADD; RIPK1; IKBKG; CREB3L1; MAP2K1; PIK3R3
Neurotrophin signaling pathway
GAB1; MAP2K1; PSEN1; ARHGDIG; MAP3K5; PSEN2; MAPK3; PIK3R1; PIK3R2; CAMK2G
Cholinergic synapse
FOS; PIK3R5; KCNQ4; CHRNA4; KCNQ1; ATF4; GNG13; CHRNB2; CREB3L2; AKT1
Dopaminergic synapse
CREB5; GNB4; ITPR3; PPP2R5B; ATF6B; DDC; GSK3A; TH; GNAL; SLC6A3
Insulin signaling pathway
PRKAA1; INPPL1; SOCS2; TSC1A; PRKAG3; FLOT2A; PIK3CB; MAP2K2; PPP1CAB; PHKA1
Progesterone-mediated oocyte maturation
PRKACB; SPDYB; MAPK12; PIK3R2; RPS6KA3A; MAPK9; PIK3R3B; HSP90AA1.1; CDC25B; PIK3R3A
Estrogen signaling pathway
PIK3CD; PIK3CB; HRAS; MAP2K1; CALML3; FKBP5; GABBR2; NRAS; PLCB2; ATF6B
Prolactin signaling pathway
MAPK13; IRF1; ESR2; SLC2A2; HRAS; PIK3CG; PIK3R5; NEK3; MAPK12; SHC4
Thyroid hormone signaling pathway
PFKP; PRKCB; ATP1A2; NCOA3; ESR1; ATP1B1; BMP4; THRB; PLN; PRKCA
Adipocytokine signaling pathway
SOCS3B; AKT2L; IRS1; NFKBIAB; NFKB1; PPARAB; CAMKK1; SLC2A1; RXRA; CD36
Glucagon signaling pathway
PLCB4; PRKAG2; PYGM; PRKAB1; CAMK2D; PHKA1; FOXO1; CAMK2A; FBP1; PCK1
Regulation of lipolysis in adipocytes
INSR; PRKG2; GNAI2; PIK3CD; GNAS; PNPLA2; GNAI1; FABP4; PTGS2; PIK3R2
Insulin resistance
SOCS3B; PPP1R3DA; PYGL; MAPK8; TRIB3; CD36; PIK3CD; PRKCD; SLC2A4; RPS6KA6
Non-alcoholic fatty liver disease (NAFLD)
PIK3R2; KCNA3; RELA; GSK3B; TNFRSF1A; IL1B; PRKAG1; UQCRH; PRKAA2; NDUFA2
Carbohydrate digestion and absorption
AMY2A; SLC5A1; SLC2A5; ATP1A4; FXYD2; AKT1; AMY2A3; AKT2; PRKCB; G6PC
Chagas disease (American trypanosomiasis)
CD247; GNA15; FADD; IL1B; MAPK13; FAS; PPP2R1A; PLCB4; IFNGR2; CD3E; CD3D
Toxoplasmosis
LAMA3; HLA-DMB; AKT2; IRAK4; MAP2K3; HLA-DPA1; TNFRSF1A; TLR4; CYCS; H2-AB1
Tuberculosis
HLA-DOA; IFNA14; MAPK3; ATP6V0B; ATP6V1H; FCER1G; LBP; IL6; IRAK4; Ifna11
Hepatitis C
BRAF; TRAF2; SOCS3; CLDN10; PIK3R2; OCLN; CLDN2; IFIT1; TBK1; TNFRSF1A
Hepatitis B
Fasl; TIRAP; IKBKG; PRKCA; TNF; OSTN; PRKCG; STAT6; IFNA7; IFNA2
Measles
IFNG; TAB2; EIF3H; PIK3R2; IFNA13; OAS3; PIK3R5; BBC3; CD3E; CD3D; IL2RA
Influenza A
PRKCA; PLG; HLA-DQA1; CASP1; OAS2; TNF; TNFRSF10A; HSPA8; MAPK11; IFNA4
HTLV-I infection
CRTC3; FZD3; PRKACG; MSX2; CDC16; TGFB2; HLA-DMA; CD3E; HLA-F; ATF4
Epstein-Barr virus infection
MAP3K7; CD44; GSK3B; PIK3CB; EIF2AK4; CCNA1; PRKACB; NFKBIB; POLR2C; TRADD
Pathways in cancer
ARHGEF1; PPARG; FGF9; LEF1; DAPK2; MMP2; ITGB1; BRCA2; RXRG; CDC42
Proteoglycans in cancer
TGFB1; PPP1R12C; TNF; PAK1; ERBB3; SDC4; PRKCB; SDC2; STAT3; FZD6
Colorectal cancer
BAD; TGFB1; MAPK1; CCND1; PIK3CB; ARAF; AKT2; KRAS; RAF1; LEF1
Renal cell carcinoma
HGF; MAP2K1; CUL2; TCEB1; RAC1; RAP1A; FH; AKT2; TGFB1; CDC42
Pancreatic cancer
AKT2; IKBKB; RAF1; BCL2L1; STAT1; SMAD2; BRCA2; PIK3CA; KRAS; TGFB3
Endometrial cancer
APC; SOS1; PIK3R1; MAPK3; PIK3CG; BAD; CTNNA2; CDH1; TCF7; LEF1
Glioma
PIK3R3; PRKCG; Pdgfa&Pdgfb; CALML3; NRAS; CAMK2D; PDGFRB; CAMK2G; TP53; AKT2
Prostate cancer
AKT1; BRAF; PIK3CB; CCND1; ARID1A; HRAS; TCF7; CCNE1; MAP2K1; GSK3B
Melanoma
FGF6; PIK3R3; IGF1; Pdgfa&Pdgfb; PDGFRB; CDH1; FGF4; RAF1; FGF11; FGF19
Chronic myeloid leukemia
CDK6; CTBP2; BRAF; SHC3; GRB2; BAD; PIK3CG; NFKBIA; PIK3R1; MAPK3
Acute myeloid leukemia
PIM2; PIM1; RPS6KB2; RAF1; MAP2K2; TCF7; CHUK; IKBKB; RARA; PIK3R5
Small cell lung cancer
ITGA6; LAMA4; LAMB3; BCL2L1; CCND1; BCL2; BIRC3; XIAP; ITGA2B; LAMA1
Non-small cell lung cancer
MAP2K2; FOXO3; RXRB; RXRA; TP53; SOS1; AKT1; EML4; MAP2K1; CCND1
Central carbon metabolism in cancer
MTOR; PIK3CD; MAPK1; PFKP; SIRT6; RAF1; HK3; HIF1A; FLT3; PTEN
Choline metabolism in cancer
PDGFD; TSC2; SLC22A1; PRKCB; DGKD; PLD2; PRKCG; RAC1; PDGFRB; RHEB

Protein Function

AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein IRS2; KCNH1; AANAT; HDAC7; RPTOR; AKT1; TSC2; PRKCZ; ZFP36; ARRB2
Function ATP binding
Related Protein ACTA1; MAP2K4A; AFG3L2; UBE2Q1; BLM; GRK1A; MCM7; MST1R; UBE2I; STK16
Function enzyme binding
Related Protein HIST1H2AM; PRKDC; ZNF346; EGLN1; BIRC5; HIST1H2AE; PICK1; KDM4C; APOA1; TSPAN10
Function identical protein binding
Related Protein NDC80; CLDN14; EPHA4; MUL1A; BTK; UBE4A; BCL2L1; GSTM3; RNF4; GRIN3A
Function kinase activity
Related Protein BSK146; EK1; CDK5R1A; PFKMB; KALRN; RPS6KB1B; TPK1; MAP2K4A; CDK5R1B; ROCK2A
Function nitric-oxide synthase regulator activity
Related Protein HSP90AA1.1; CALM1; HSP90AA1; CALM2; AKT1; HSP90AB1; ESR1; CALM3
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein INPPL1; DAPP1; ASAP1; ARAP2; ARHGAP9; ZFYVE16; RACGAP1; COMMD1; BTK; CYTH3
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein PLEK; GAB2; NCF1; ADAP2; ARAP3; PLEKHA1; FAM21C; MYO1G; DAPP1; AKT1
Function protein binding
Related Protein C14orf104; GPX7; CYP1A1; EPB41L1; APOO; HMBOX1; IL6; MBP; IRF6; C19orf60
Function protein kinase C binding
Related Protein YWHAG; IRS1; HAND2; DSP; PARD6A; PKP2; SDPRB; PRKCB; GRK5; CASQ2
Function protein kinase activity
Related Protein CDK5; NRBP2; MAP4K6; RIPK3; BRAF; PDK2; IRAK4; EK1; NAT1; PRKCA
Function protein phosphatase 2A binding
Related Protein PTPN1; SPHK1; RPS6KB1; HMGCR; ARPP19; AKT1; STRN4; MAPT; TRP53; CTTNBP2NL
Function protein serine/threonine kinase activity
Related Protein TSSK2; TLK2; AKT2; MARK2; MAPKAPK2; BMPR1B; GRK7A; MAP2K3; ULK2; MARK1
Function protein serine/threonine/tyrosine kinase activity
Related Protein AURKC; CLK3; ACVR2B; PRKACA; SGK1; TESK2; MAP2K1; CLK4; DYRK3; TESK1

Interacting Protein

AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.
MDM2; N/A; PPP2CA

AKT1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).

AKT1 Related Gene Family

TGF