akt1
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  • Official Full Name
  • RAC-alpha serine/threonine-protein kinase
  • Background
  • Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
  • Synonyms
  • AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1
Cat.#:AKT1-14HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-336HTag:His & Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 Protein, His & Strep-tagged
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Cat.#:AKT1-427HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-2521HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged, Active
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Cat.#:AKT1-101HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, GST-tagged
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Cat.#:AKT1-1516HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human AKT1 protein
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Cat.#:AKT1-155HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-156HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKT1 protein, MYC/DDK-tagged
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Cat.#:AKT1-259HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-307HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His/MBP-tagged
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Cat.#:AKT1-30HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT1 protein, Flag-tagged, Biotinylated
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Cat.#:AKT1-3920HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-420HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-His tagged
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Cat.#:AKT1-421HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT1 Protein, His-tagged
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Cat.#:AKT1-422HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKT1 Protein, GST-tagged
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Cat.#:AKT1-47HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT1 protein, His-tagged
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Cat.#:AKT1-50HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 protein, GST-tagged
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Cat.#:AKT1-56HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Actived
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Cat.#:AKT1-57HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1, Inactived
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Cat.#:AKT1-786HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1, His tagged
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Cat.#:AKT1-1507MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKT1 Protein
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Cat.#:AKT1-605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT1 Protein
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Cat.#:AKT1-296RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT1 Protein, His-tagged
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Cat.#:AKT1-6612CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKT1
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Cat.#:AKT1-8342ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT1
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Cat.#:AKT1-1363HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT1 (Active), GST-tagged
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Cat.#:AKT1-677HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT1 cell lysate
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Involved Pathway

AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RAC2; FGFR2; MAP3K3; MAPKAPK2A; PRKACBA; BRAF; GADD45AB; TRAF2; PPP3R2; PAK2B
ErbB signaling pathway
AKT2L; PAK2B; HRASB; GRB2; CAMK2G; MAP2K2; PAK6B; RAF1; RPS6KB2; RPS6KB1
Ras signaling pathway
PLCE1; MRAS; PIK3CD; HRAS; FGF3; GAB2; KSR2; RRAS2; RAC2; Kitl
Rap signaling pathway
PIK3R2; Pdgfa&Pdgfb; FGF13; KITLG; PFN2; LPAR2; FGF20; FGF1; PDGFA; ITGAM
cGMP-PKG signaling pathway
ITPR1; SLC8A1; ATP1B2; PLCB2; ATP2A1; SLC25A5; CALM4; INS1; PLN; ATP1B3
cAMP signaling pathway
MAPK9; GLI1; PIK3R2; GRIN2A; HTR1B; ACOX1; PTGER3; RAC2; SLC9A1; GRIN1
Chemokine signaling pathway
CCL14; XCL2; CCR1; IKBKB; IKBKG; CXCR1; CCL21; ARRB2; GNB3; Adcy4
HIF- signaling pathway
EGLN1; IL6; IFNGR2; PDHA2; CUL2; PIK3R1; HK1; IFNG; PIK3CG; FLT1
FoxO signaling pathway
HOMER1; EGFRA; SGK2A; CCNB3; SOS1; IRS4; NLK2; GADD45BB; INS2; PRKAB2
Sphingolipid signaling pathway
PLCB4; MAPK9; S1PR5; PPP2R5A; MAPK11; NFKB1; PLCB1; PRKCZ; AKT1; PLD1
Phospholipase D signaling pathway
CYTH4; SPHK1; SHC2; CXCR1; PIK3CG; PLCB4; LPAR3; PIK3CD; MS4A2; NRAS
mTOR signaling pathway
PRKCA; PIK3CG; INS; TNF; RPS6KB1; PTEN; RRAGC; EIF4BB; VEGFAB; PIK3R3B
PIK-Akt signaling pathway
PKN1; ATF4; GNG7; GNB2; RAF1; INS2; IBSP; VEGFC; NR4A1; ANGPT4
AMPK signaling pathway
CREB3; AKT3; ADIPOR1; CPT1A; AKT1S1; ADIPOR2; PFKFB4; CREB3L2; IGF1; LEPR
Apoptosis
NFKBIAA; DAPK1; BNIP3LB; XIAP; NGF; CTNNB1; PRKAR2AB; RELA; BCL2; TNFRSF10A
Adrenergic signaling in cardiomyocytes
CREB3L3A; PPP1CA; CAMK2B; ADRA1BB; PPP2R5B; CACNB4A; ACTC1B; PPP2R3A; RYR2; TNNT2A
VEGF signaling pathway
MAPK13; HRASA; MAP2K2; PIK3CB; AKT1; PRKCBB; SRC; VEGFA; PIK3CG; HRAS
Osteoclast differentiation
SYK; SIRP-BETA; NCF4; MITF; MAPK11; SOCS3; NFKB1; SQSTM1; PPP3R1; MAP3K7
Focal adhesion
COL1A1B; MYL2; Reln; ROCK2; CCND3; MYLK; AKT2L; MET; THBS4A; PGF
Tight junction
ACTB1; CDC42L; SHROOM2; CLDN14; HRASA; CLDN7A; PPP2CB; RHOAD; CLDN5A; PRKCZ
Signaling pathways regulating pluripotency of stem cells
LHX5; ESX1; NRAS; WNT11; ID1; APC; OTX1; PCGF1; PIK3R3; FZD5
Platelet activation
MAPK13; COL24A1; TBXAS1; PRKG1; VAMP8; ITPR1; MAPK3; MAPK11; PPP1R12A; APBB1IP
Toll-like receptor signaling pathway
MAP2K4B; CCL4L1; IL8L1; IFNA1; CD14; IFNAR2; CCL5; STAT1; TLR2-2; MAP2K2A
Jak-STAT signaling pathway
IL3; SOCS5B; IFNA21; STAT5B; IFNGR2; PTPN2A; EPOR; AKT2L; IL13; CSF3
T cell receptor signaling pathway
PTPN6; MAPK9; PLCG1; CD4; CD8B; IKBKB; CD3D; PPP3R2; RELA; NRAS
B cell receptor signaling pathway
ACTR2; CDK7; NFKBIE; CD79B; PIK3CB; SYK; LAT2; DOK3; NRAS; DOK1
Fc epsilon RI signaling pathway
PLCG2; RAC1; GM-CSF; INPP5D; IL4; RAC2; PLA2G4C; MAPK3; PIK3CG; MAPK13
Fc gamma R-mediated phagocytosis
MARCKSL1; PLA2G6; MARCKS; INPPL1; PLA2G4F; CFL1; ARPC5L; AKT2; VAV2; DOCK2
TNF signaling pathway
BIRC3; CREB3L1; CCL20; TNFAIP3; MAP2K4; MLKL; CXCL10; IL18R1; CFLAR; BCL3
Neurotrophin signaling pathway
RAP1A; BDNF; IRS1; HRAS; MAPK13; PSEN1; RHOA; NGFR; MAPK10; RPS6KA3
Cholinergic synapse
GNG7; PIK3CB; ITPR3; GNB1; ATF4; CREB5; KCNJ2; CHRNA6; CHAT; KCNQ3
Dopaminergic synapse
MAPK12; GNAI3; CALM3; PLCB3; GNAO1; CREB3L4; GSK3B; KIF5A; CALM4; CALML5
Insulin signaling pathway
INS2; MAP2K2; G6PCA.2; MAPK9; PRKACBA; PHKG1; PRKACAB; G6PC; PRKAR1A; PIK3R2
Progesterone-mediated oocyte maturation
GNAI1; MAPK9; ADCY1A; PIK3CG; ANAPC7; MAD2L2; AKT2; MAD1L1; PPP1R2P9; PIK3R3
Estrogen signaling pathway
ITPR1; ATF4; HSPA1L; PIK3CB; GNAI3; HSPA1B; RAF1; PRKACB; GNAI2; CALM2
Prolactin signaling pathway
FOS; MAPK1; SHC3; SOCS1; SHC1; INS2; MAPK3; ESR1; GALT; TNFSF11
Thyroid hormone signaling pathway
RHEB; PLCD4; ITGB3; ACTG1; NCOA3; ATP1A3; KAT2B; PRKACA; PRKACB; DIO2
Adipocytokine signaling pathway
MTOR; ACSBG1; ADIPOR2; CAMKK1A; PRKAG1; ACACB; RXRB; G6PCA.1; LEPB; SLC2A1
Glucagon signaling pathway
ITPR3; CALM2; CRTC2; PDHB; CREB3L3; GCG; CREB3L2; AKT1; CAMK2G; GNAQ
Regulation of lipolysis in adipocytes
Adcy4; INS2; PIK3R2; GNAI2; PDE3B; PRKG1; INS1; AKT1; INSR; INS
Insulin resistance
PRKAB1B; INS2; PPP1R3D; PIK3R3; PTPRF; GFPT1; MAPK8B; RPS6KA3A; RPS6KB1B; PIK3CD
Non-alcoholic fatty liver disease (NAFLD)
IKBKB; MAP3K11; NDUFV1; MAP3K5; NDUFA1; ITCH; ATF4; PIK3R2; MAPK10; NDUFS8
Carbohydrate digestion and absorption
PIK3R1; AKT2; ATP1B3; G6PC2; SLC5A1; ATP1A3; ATP1B2; TAS1R2; AMY2A; ATP1A1
Chagas disease (American trypanosomiasis)
RELA; CD3E; CD3D; CXCL8; IL1B2; GNAL; PPP2R2C; C1QB; FASLG; CCL5; NFKB1
Toxoplasmosis
IL10RB; NFKB1; ITGB1; LAMA2; PIK3R5; LAMA1; LAMB2; LAMB1; HLA-DRB4; HLA-DOB
Tuberculosis
cgr2b; PPP3CB; FCGR3A; MAPK10; IFNA12; KSR1; RFXANK; CAMP; CD209B; HLA-DRB5
Hepatitis C
IFNA2; IFNA13; PIK3CG; EIF2AK1; CLDN3; NR1H3; IFNA8; PDPK1; PPP2R2D; BAD
Hepatitis B
ATP6AP1; TLR2; IFNA8; MYD88; PIK3CD; CASP10; TGFB2; MAPK8; CASP9; PIK3R3
Measles
TBK1; STAT3; CLEC4M; PIK3R1; SH2D1A; IL1A; TLR7; CCND1; IFNA2; TRAF6
Influenza A
IFNGR2; TMPRSS2; MAP2K2; MAPK3; PIK3R5; IFIH1; PML; FDPS; IL1B; NXT2
HTLV-I infection
WNT4; TNF; IL15RA; FDPS; WNT11; SMAD4; VAC14; RANBP1; MSX2; HLA-DRB1
Epstein-Barr virus infection
MAPK8; AKAP8L; AKT2; IRF3; CD38; Fcer2a; POLR2E; HLA-DRB5; VIM; PSMD13
Pathways in cancer
GRB2; MAPK9; LAMB3; SMAD2; GSTP1; RAC3; TRP53; PIK3R2; CASP8; CDH1
Proteoglycans in cancer
RDX; SDC1; ERBB2; ARHGEF1; PIK3CG; HPSE2; MRAS; MET; WNT2; WNT10B
Colorectal cancer
PIK3CA; PIK3R1; MAPK1; APC2; LEF1; AXIN2; BAX; Casp3; MLH1; PIK3CB
Renal cell carcinoma
AKT2; MAP2K2; PIK3CA; TCEB2; PAK2; FH1; EP300; GAB1; FLCN; SLC2A1
Pancreatic cancer
ARAF; RAD51; RALBP1; RAC3; RAC1; PIK3CA; PIK3R5; CASP9; TGFBR2; STAT1
Endometrial cancer
PIK3CA; BRAF; ERBB2; SOS1; CDH1; TCF7L2; AKT1; MAPK1; ELK1; PIK3R5
Glioma
CALML3; CALM4; SHC1; PRKCG; MTOR; ARAF; PDGFB; CAMK2A; PDGFA; PIK3R1
Prostate cancer
IGF1R; PDGFRB; MAPK1; PDGFA; CCNE2; HSP90AB1; CREB3L2; LEF1; TP53; AKT1
Melanoma
FGF20; TRP53; FGF11; BRAF; FGF17; MAPK1; MAP2K1; PTEN; PIK3R3; AKT1
Chronic myeloid leukemia
PIK3R5; GRB2; SHC4; MAP2K2; SMAD4; AKT1; PIK3CD; TRP53; TP53; SHC1
Acute myeloid leukemia
PIK3CD; FLT3; PIK3R3; HRAS; SFPI1; PIK3R2; CCNA1; RARA; RUNX1; LEF1
Small cell lung cancer
TRAF6; LAMA4; BCL2; AKT1; NFKBIA; PIK3R3; LAMB2; CASP9; TRAF4; ITGA2
Non-small cell lung cancer
CASP9; RASSF1; RXRG; PIK3CD; TP53; PLCG2; KRAS; PIK3R2; PDPK1; TRP53
Central carbon metabolism in cancer
KRAS; MTOR; FLT3; SLC2A2; NTRK3; PGAM1; TRP53; PDHB; PTEN; LDHA
Choline metabolism in cancer
DGKZ; TSC1; DGKE; PIP5K1B; PDGFC; RAC3; NRAS; PDGFA; MAPK8; WASF3

Protein Function

AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein DDIT4; ZFP36; KCNH1; PRKCE; AANAT; KIF13B; PPP1R12A; ARRB2; AKT1; TSC2
Function ATP binding
Related Protein ATP2A1L; Acsm2a; RAD17; MYHC4; GTF2F2B; PAPSS1; CLCN5; MSH5; CDC42BPA; P2RX6
Function enzyme binding
Related Protein NOP14; CTNNBL1; ESR2; ESR1; UGT1A1; CA; HIF1A; N4BP2L2; HDAC1; SUDS3
Function identical protein binding
Related Protein DESI1; ACY3; DNMT3A; DYNLT3; EIF2AK3; REG3B; RUNX1T1; NOD1; G6PDX; CCT7
Function kinase activity
Related Protein AKT2L; TRIO; BCKDK; PRKACAB; RPS6KAL; CAMK1GB; HYKK.2; PI4KAA; SMG1; CAMK2D2
Function nitric-oxide synthase regulator activity
Related Protein CALM2; HSP90AA1; ESR1; CALM3; HSP90AB1; HSP90AA1.1; AKT1; CALM1
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein GAB2; CYTH3; D6WSU116E; DAPP1; PHLDA3; ANXA8; ARAP1; PIRT; COMMD1; PARD3
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein KIF16B; ZFYVE1; TTPA; PLEK; AKT1; PHLDA3; RS1; MYO1G; ADAP2; RAG2
Function protein binding
Related Protein KCNE1L; CDK20; EGR1; ABTB1; MYO7A; TLE3A; DDX58; GSG2; EIF2B2; MUSK
Function protein kinase C binding
Related Protein HSPB1; HAND2; HINT1; PEA15A; SDC4; PICK1; AKT2; IRS1; SDPRB; LDB3
Function protein kinase activity
Related Protein TRIM28; ERBB3B; PRKACAB; PRKAA2; ZNF143B; PRKACBB; DCKL1B; PRKCHB; DCLK3; CDK12
Function protein phosphatase 2A binding
Related Protein ARPP19; BCL2; IGBP1; SMG5; TP53; PPP2R2A; PPME1; CPD; STRN; CTTNBP2NL
Function protein serine/threonine kinase activity
Related Protein STK38; MAP4K4; RPS6KA3B; NEK11; STK33; PKN2; IRAK3; PRKD2; LATS1; NEK6
Function protein serine/threonine/tyrosine kinase activity
Related Protein AURKB; SGK1; PRKAA2; TESK1; DYRK3; AURKC; PRKACA; TNK2; TTK; ACVR2B

Interacting Protein

AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.
MDM2; N/A; PPP2CA

AKT1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).

AKT1 Related Gene Family

TGF