AKT1 Protein, RAC-alpha serine/threonine-protein kinase

AKT1

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AKT1

Official Full Name RAC-alpha serine/threonine-protein kinase
Background Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
Synonyms AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Rabbit
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • 6xHis-GST
    • Flag
    • GST
    • His
    • MBP
    • Strep
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKT1-14H Recombinant Human AKT1 Protein, His-tagged Insect Cell His
    Human AKT1-001H Recombinant Human AKT1 Protein, His-GST-tagged E.coli 6xHis-GST
    Human AKT1-336H Recombinant Human AKT1 protein, His/Strep-tagged HEK293 His/Strep
    Human AKT1-101H Recombinant Human AKT1, GST-tagged Sf9 Insect Cell GST
    Human AKT1-1363H Recombinant Human AKT1 (Active), GST-tagged Sf9 Insect Cell GST
    Human AKT1-1516H Recombinant Human AKT1 protein E.coli N/A
    Human AKT1-155H Recombinant Human AKT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1-156H Recombinant Human AKT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1-2521H Recombinant Human AKT1, GST-tagged, Active E.coli GST
    Human AKT1-259H Recombinant Human AKT1 protein, His-tagged Insect Cell His
    Human AKT1-307H Recombinant Human AKT1 protein, His/MBP-tagged E.coli His/MBP
    Human AKT1-30H Recombinant Human AKT1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human AKT1-3920H Recombinant Human AKT1 protein, GST-tagged E.coli GST
    Human AKT1-420H Recombinant Human AKT1 Protein, GST-His tagged Insect Cell GST/His
    Human AKT1-421H Recombinant Human AKT1 Protein, His-tagged Insect Cell His
    Human AKT1-422H Recombinant Human AKT1 Protein, GST-tagged Wheat Germ GST
    Human AKT1-427H Recombinant Human AKT1 Protein, His-tagged E.coli His
    Human AKT1-47H Recombinant Human AKT1 protein, His-tagged E.coli His
    Human AKT1-50H Recombinant Human AKT1 protein, GST-tagged Insect Cell GST
    Human AKT1-56H Recombinant Human AKT1, Actived Sf9 Insect Cell N/A
    Human AKT1-57H Recombinant Human AKT1, Inactived Sf9 Insect Cell N/A
    Human AKT1-677HCL Recombinant Human AKT1 cell lysate Insect Cell N/A
    Human AKT1-786H Recombinant Human AKT1, His tagged Insect Cell His
    Human CAB-2492MH Mouse Anti-Human AKT1 Monoclonal Antibody, DyLight 649 Mouse N/A
    Human CPBTT-30930RH Rabbit Anti-Human AKT Polyclonal Antibody Rabbit N/A
    Mouse AKT1-1507M Recombinant Mouse AKT1 Protein Mammalian Cell His
    Rat AKT1-605R Recombinant Rat AKT1 Protein Mammalian Cell His
    Rhesus Macaque AKT1-296R Recombinant Rhesus monkey AKT1 Protein, His-tagged Mammalian Cell His
    Chicken AKT1-6612C Recombinant Chicken AKT1 Mammalian Cell His
    Zebrafish AKT1-8342Z Recombinant Zebrafish AKT1 Mammalian Cell His

    AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNG1A; ELK4; PPP3R2; FGF7; FGF12; RAC3A; GADD45AA; FLNB; CACNB4A; PPP3R1
    ErbB signaling pathway CAMK2D2; GSK3B; PAK6B; MTOR; PAK6; MAPK8; AKT1; AKT3A; AKT2; HBEGFA
    Ras signaling pathway PLCG2; FGFR3; RALB; HGF; ANGPT1; GAB2; MET; GNG4; PRKACB; GNB1
    Rap signaling pathway LPAR3; PRKCI; CALML3; INS1; FGFR4; RALGDS; HRAS; Pdgfa&Pdgfb; LPAR2; FLT4
    cGMP-PKG signaling pathway CALM2; MAPK3; ATP1B1; ATP1B3; MEF2D; AGTR1A; BDKRB2; CREB3L2; GNAI2; GNAI3
    cAMP signaling pathway TNNI3; GLI3; HCN2; RAC2; MAPK1; GNAI3; VAV2; MAP2K1; TSHR; Adcy4
    Chemokine signaling pathway CXCL13; AKT1; AMCF-II; GNB2; CCL21B; GRK7; MAPK3; GRK5; PRKACG; LOC100033925
    HIF- signaling pathway PDK1; MKNK2; VHL; NOS2; ANGPT2; TIMP1; FLT1; MAP2K2; PDHA1; HKDC1
    FoxO signaling pathway SMAD2; INSB; NRAS; KRAS; GABARAPL1; CDKN2B; PRKAA2; BCL6; FOXO4; MAPK1
    Sphingolipid signaling pathway NOS3; SPHK1; PPP2R2C; LASS2; MAPK8; SGMS1; PIK3R1; OPRD1; PPP2R5B; GNAI3
    Phospholipase D signaling pathway PDGFC; PIK3CG; AGPAT3; PDGFD; PTPN11; PLCB4; MTOR; PDGFB; FYN; MAP2K1
    mTOR signaling pathway RPS6KA3A; PIK3CD; TSC1; DEPDC6; CAB39; BRAF; IRS1; CAB39L1; EIF4BA; PTEN
    PIK-Akt signaling pathway PDGFB; TCL1B; PRKAA1; TRP53; BCL2; RXRA; GRB2; LAMB1; TNN; FGF5
    AMPK signaling pathway CREB5; PIK3R3; LEP; PPP2R3C; LIPE; PRKAA1; RAB2A; PRKAG1; PDPK1; PPP2R2D
    Apoptosis RNF8; MAP3K14; PKP1; NTRK1; PRKAR1B; PIK3CG; PRKAR2AB; CASP2; CASP8; CTNNB1
    Adrenergic signaling in cardiomyocytes CALM1; CACNA1D; CACNB2; PIK3R2; CAMK2B; ATF6B; CALML5; ATP2B3B; TNNT2A; BCL2A
    VEGF signaling pathway PIK3R1; MAPK11; PIK3R3; SRC; KRAS; RAC1B; PIK3CA; MAPK14B; AKT3A; SHC2
    Osteoclast differentiation OSCAR; NFATC2; FCGR2C; LILRA2; TEC; TGFBR2; PIK3R2; IFNG; STAT1; SQSTM1
    Focal adhesion BRAF; PRKCG; PIK3CG; THBS2; COL6A4; COL24A1; MYL7; LAMB1; PAK4; PPP1CAA
    Tight junction MRAS; CLDN8; CLDND; CDC42L; ZAK; SHROOM3; GNAIA; MYH1; CLDN7; PARD6A
    Signaling pathways regulating pluripotency of stem cells PIK3CA; NEUROG1; WNT2B; KLF4; MAP2K2; BMP4; MAPK11; PCGF1; APC; GRB2
    Platelet activation FGA; PPP1CB; AKT2; SYK; ITPR3; PLCB1; PIK3CD; ITGB3; PRKCI; MYL12A
    Toll-like receptor signaling pathway IFNA12; NFKB1; MAP2K2B; RIPK1; MAP2K7; TLR3; IL6; IFNA3; TAB2; AKT2L
    Jak-STAT signaling pathway IL23R; IFNA7; IFNG; RAF1B; IL13RA1; IL11RA2; FHL1B; CSH2; STAM2; IL20RB
    T cell receptor signaling pathway SOS1; PIK3R2; PPP3CA; PPP3R1; RELA; NFKBIA; CD247; PLCG1; LCP2; PIK3R5
    B cell receptor signaling pathway GSK3B; CARD11; LCP2A; ACTR2; NFKBIE; CD81; DUSP4; CRKL; PIK3CD; CDK6
    Fc epsilon RI signaling pathway KRAS; PLA2G4F; PLA2G4D; PLCG1; NRAS; PIK3CD; PIK3R5; MAPK8; PIK3CA; MAPK3
    Fc gamma R-mediated phagocytosis PIP5K1C; FCGR1A; PIK3CD; PIK3CG; PRKCA; WASF3; MAPK3; cgr2b; AKT1; PLCG1
    TNF signaling pathway TRAF1; TNF; MMP9; PIK3CG; RIPK1; NFKBIA; LTA; CASP7; MAP2K4; IL15
    Neurotrophin signaling pathway FASLG; RPS6KA5; ARHGDIA; ZFP110; PSEN2; MAPKAPK2; CALM4; PIK3CG; RPS6KA3; NFKBIA
    Cholinergic synapse GNB4; CHRM2; GNG11; KCNJ6; CAMK4; KCNQ3; GNG7; GNG13; PLCB1; CHRM1
    Dopaminergic synapse GRIN2B; KCNJ6; PPP2R2C; DRD1A; PRKACG; PPP2R2B; CREB3L1; PPP2R1B; PPP1CB; CAMK2A
    Insulin signaling pathway AKT3A; PRKAB1B; PIK3R5; PPP1CBL; MAP2K2; PPARGC1A; CALM3B; RPS6KB2; INSR; NRAS
    Progesterone-mediated oocyte maturation CDH1-A; MAPK12B; GNAI2B; MAPK3; RPS6KA2; HSP90AA1; RPS6KA6; ANAPC1; INSB; ADCY1B
    Estrogen signaling pathway MAP2K2; GNAI1; KCNJ9; HSP90AA1; HSP90B1; ESR1; SP1; PRKACG; PIK3R3; ITPR3
    Prolactin signaling pathway ESR1; MAPK13; MAPK10; PRLR; IRF1; PIK3R3; MAPK12; INS1; SHC4; ELF5
    Thyroid hormone signaling pathway RAF1; MED12; PIK3R1; GATA4; PIK3R3; SLC16A10; RXRA; PRKCB; ATP2A2; THRA
    Adipocytokine signaling pathway JAK2A; G6PCA.2; ACSL4B; CPT1B; MAPK8; RXRG; CAMKK2; TRADD; PCK1; PRKAB1
    Glucagon signaling pathway PKM; PPP3CC; LDHAL6B; PRKAG3; PCK2; PPP3R2; PYGM; CREB3L3; PRKAB2; CALM2
    Regulation of lipolysis in adipocytes NPY1R; PIK3CD; PIK3CA; IRS2; NPY; PIK3R1; FABP4; INS2; PTGER3; PRKACA
    Insulin resistance PTENB; AKT2L; IL6; INSB; NFKBIA; G6PC2; PIK3R3B; SOCS3B; PIK3R3A; PPP1R3C
    Non-alcoholic fatty liver disease (NAFLD) PIK3CG; NDUFAB1; PIK3CB; PRKAG1; NDUFA13; MAPK8; NDUFB6; Fasl; COX7A2L; RAC1
    Carbohydrate digestion and absorption HKDC1; ATP1B3; G6PC; PIK3CG; TAS1R2; FXYD2; AMY1A; ATP1A1; AKT2; PIK3R2
    Chagas disease (American trypanosomiasis) PIK3CB; CD3D; MAPK1; IL1B; CD247; TGFBR2; PPP2R2C; BDKRB2; CD3G; GNA15
    Toxoplasmosis ITGB1; TGFB3; LAMB1; HSPA1B; PIK3R1; PIK3CD; AKT2; HLA-DOA; IFNG; LAMC1
    Tuberculosis FCGR4; BCL2; MAPK11; IFNB1; SRC; FCGR1; MAPK13; PPP3R2; TRADD; MYD88
    Hepatitis C MAPK8; IFNA10; IRF1; RIPK1; RNASEL; STAT3; RELA; IFN-a; IFNA14; Ifna11
    Hepatitis B TLR2; IKBKG; FADD; IFNB1; IFNA6; BCL2; STAT5B; IFNA4; IFNA14; EGR3
    Measles EIF2AK1; AKT1; TRAF6; IL1B; IFNAR2; STAT5B; IL2RB; TNFRSF10D; HSPA1A; IFNA12
    Influenza A MAPK11; ADAR; H2-AB1; STAT2; NLRP3; IL1B; IL18; OAS2; MAP2K7; PABPN1L
    HTLV-I infection CALR; NFATC4; DLG1; DVL1; AKT2; ATF4; MAP3K1; CRTC3; RB1; CDC27
    Epstein-Barr virus infection NFKBIB; CSNK2B; RAN; ENTPD1; HDAC4; CD44; HDAC1; TAB2; NCOR2; POLR1C
    Pathways in cancer FGF11; CTNNA3; FGF13; BDKRB1; PGF; Kitl; DAPK3; FN1; MMP2; CCNA1
    Proteoglycans in cancer PIK3R3; Fzd4; CCND1; WNT8B; PIK3R1; TRP53; FZD7; FN1; PIK3R5; MMP2
    Colorectal cancer RALGDS; MAPK10; MSH2; PIK3CA; RAF1; BAD; CYCS; BRAF; TCF7; PIK3R5
    Renal cell carcinoma RAPGEF1; FH; PIK3CA; MAPK1; CUL2; KRAS; TCEB1; SOS1; PAK1; TGFB3
    Pancreatic cancer BRCA2; TGFBR1; TRP53; TGFA; TGFB2; RAC3; STAT3; PIK3CD; TGFB1; MAPK8
    Endometrial cancer PIK3R3; TCF7; AKT1; PDPK1; PIK3CB; PIK3R1; AXIN2; PIK3R2; CTNNA3; ELK1
    Glioma PDGFRB; CAMK2D; PLCG1; TRP53; IGF1; PLCG2; Pdgfa&Pdgfb; PDGFB; GRB2; TP53
    Prostate cancer CREB3L3; FGFR1; PIK3R2; SMARCD1; PDGFD; MAP2K1; NOXA1; SRD5A2; PDGFA; SMARCC2
    Melanoma FGF13; FGF5; PDGFB; MITF; MET; BAD; IGF1R; HGF; FGF8; RB1
    Chronic myeloid leukemia CBL; ABL1; AKT2; SHC4; NRAS; HDAC2; RB1; PTPN11; PIK3R5; NFKBIA
    Acute myeloid leukemia CCND1; MYC; IKBKG; ARAF; MAP2K2; CHUK; GRB2; STAT3; PIK3CG; NFKB1
    Small cell lung cancer LAMA1; XIAP; LAMA4; PTGS2; CCNE1; FHIT; LAMA3; BIRC8; ITGA2; AKT1
    Non-small cell lung cancer PRKCA; RB1; KRAS; MAP2K2; MAP2K1; CCND1; PIK3R1; TRP53; PIK3R5; TP53
    Central carbon metabolism in cancer PKM2; SIRT6; PGAM2; TP53; PIK3CB; MAP2K1; PGAM1; PFKM; MTOR; SIRT3
    Choline metabolism in cancer PLD2; MAP2K2; PIK3CG; DGKG; AKT2; PPAP2A; DGKB; KRAS; GPCPD1; CHKB

    AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding HDAC7; ZFP36; TSC2; AKT1; KCNH1; IRS2; HDAC7A; DDIT4; KIF13B; YWHAQ
    ATP binding MCM5; ABCG2B; ERCC6L2; FIGNL2; SPHK1; FAM120B; PANK1A; IDE; GUCY2C; GC2
    enzyme binding SIRT1; ZFP36; EHHADH; PEX7; NCOA1; CDC20; CASC3; HDAC1; CYP2C19; ANK1
    identical protein binding AMOTL2; BTK; HSP90AA1; CEP57L1; RASSF1; COMMD1; SH2B2; FZD1; LEPR; RGMB
    kinase activity PKN2; PRKCDA; DCLK2; PTK2BB; FYNA; TSSK1; CAMK2A; CKMB; EPHA4A; PIK3R3B
    nitric-oxide synthase regulator activity CALM1; HSP90AA1.1; HSP90AA1; AKT1; HSP90AB1; ESR1; CALM2; CALM3
    phosphatidylinositol-3,4,5-trisphosphate binding OGT; D6WSU116E; FAM21C; ARAP1; JPH2; ARHGAP9; ARAP3; ZFYVE16; MAPKAP1; CYTH3
    phosphatidylinositol-3,4-bisphosphate binding DAPP1; ZFYVE1; GAB2; FAM21C; KIF16B; PLEK; TTPA; ADAP2; MYO1G; RAG2
    protein binding PXN; REG3A; CC10; KIT; HOXB7; EGLN1; CDA; BLOC1S3; EDNRB; TFDP1
    protein kinase C binding AVPR1A; ADAM9; HAND2; SDPR; C1QBP; FEZ1; HDAC7A; GNB2L1; ADD3; AKT2
    protein kinase activity TSSK1; CAD; TBRG4; MAPK14B; DYRK3; STK24; MAP2K1; SIK2A; MAP3K1; MAP3K12
    protein phosphatase 2A binding STRN4; PTPN1; CTTNBP2NL; BCL2; CPD; PPME1; TRP53; SMG5; MASTL; SMG7
    protein serine/threonine kinase activity HIPK2; LATS1; STK32B; RAF1B; CSNK1DA; ACVR2B; BSK146; TAF1; CAMK1GA; MAPK8
    protein serine/threonine/tyrosine kinase activity DYRK3; TESK2; TESK1; MAP2K1; DSTYK; AURKC; CLK3; SGK1; ACVR2B; AKT1

    AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.

    MDM2; N/A; PPP2CA

    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
    Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).

    TGF

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