ATP1B1 Protein, ATPase, Na+/K+ transporting, beta 1 polypeptide


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Official Full Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Background The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
Synonyms ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide; ATP1B; sodium/potassium-transporting ATPase subunit beta-1; adenosinetriphosphatase; Na, K-ATPase beta-1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; sodium/potassium-dependent ATPase beta-1 su
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP1B1-10007H Recombinant Human ATP1B1, GST-tagged E.coli GST
    Human ATP1B1-2279H Recombinant Human ATP1B1 protein, His-tagged E.coli His
    Human ATP1B1-246H Recombinant Human ATP1B1, His tagged Human Cell Fc
    Human ATP1B1-919HCL Recombinant Human ATP1B1 cell lysate Human Cell N/A
    Human ATP1B1-965H Recombinant Human ATP1B1 protein, GST-tagged Wheat Germ GST
    Mouse ATP1B1-2116M Recombinant Mouse ATP1B1 Protein Mammalian Cell His
    Mouse ATP1b1-3766M Recombinant Mouse ATP1b1, His-tagged E.coli His
    Mouse Atp1b1-462M Recombinant Mouse Atp1b1 Protein, His-tagged E.coli His
    Rat ATP1B1-856R Recombinant Rat ATP1B1 Protein Mammalian Cell His
    Cynomolgus Monkey ATP1B1-321C Recombinant Cynomolgus ATP1B1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ATP1B1-449R Recombinant Rhesus monkey ATP1B1 Protein, His-tagged Mammalian Cell His
    Chicken ATP1B1-7069C Recombinant Chicken ATP1B1 Mammalian Cell His

    ATP1B1 involved in several pathways and played different roles in them. We selected most pathways ATP1B1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway MAPK3; NFATC1; MEF2B; FXYD2; IRS1; RGS2; AKT2; SLC25A5; NOS3; CREB3L1
    cAMP signaling pathway RAC2; PPP1CA; PRKACA; AKT1; PDE3A; SLC9A1; BAD; BDNF; ATP1A3; VIPR2
    Cardiac muscle contraction TNNT2; CACNB2A; TNNC1; CACNG3; MYL4; COX7A1; ATP1B2; ATP1B1; UQCRC2; COX7A2A
    Adrenergic signaling in cardiomyocytes ATP1A2A; PRKACA; AGTR2; ADCY3; AKT2; VMHC; GNAIA; RPS6KA5; KCNE1; ADCY6
    Insulin secretion CREB3L3; PCLO; KCNN3; GNAS; CCKAR; CAMK2B; ATF4; ATP1A3; KCNMB1; ATP1A2
    Thyroid hormone synthesis PLCB4; Adcy4; GPX6; PLCB1; DUOX2; SLC5A5; PDIA4; PRKACG; GNAS; CREB3L2
    Thyroid hormone signaling pathway MED4; DIO3; GATA4; PIK3R5; PRKCA; PLCG1; MED14; NCOR1; ATP1A4; ATP1B1
    Aldosterone-regulated sodium reabsorption HSD11B2; NEDD4L; PRKCG; PDPK1; ATP1B3; PRKCA; SCNN1G; IRS1; ATP1A1; FXYD4
    Endocrine and other factor-regulated calcium reabsorption ATP1B4; RAB11A; BDKRB2; GNAS; GNAQ; ESR1; KLK1B1; PLCB3; KLK1; TRPV5
    Proximal tubule bicarbonate reclamation SLC9A3; GLUD2; ATP1B4; ATP1A2; CA4; ATP1A4; SLC38A3; SLC4A4; PCK2; ATP1B1
    Salivary secretion GNAS; ITPR3; MUC5B; AMY1A; PRKACG; VAMP2; DMBT1; CALM2; PRKACA; ATP1B3
    Gastric acid secretion PLCB4; KCNE2; KCNQ1; CAMK2B; ATP1B4; GNAI1; CALM2; CA2; CAMK2A; GNAQ
    Pancreatic secretion CD38; ATP2A3; CPA1; ATP2A2; CLCA2; PLA2G2E; PLCB1; BST1; CLCA4; PRSS1
    Carbohydrate digestion and absorption AMY2A2; ATP1A1; AKT2; PIK3R2; ATP1B4; SLC37A4; TAS1R2; ATP1B1; SI; ATP1B2
    Protein digestion and absorption ATP1B3; MEP1A; ATP1A1; FXYD2; SLC7A8; CELA2B; COL6A6; SLC8A2; ATP1B2; CELA3B
    Bile secretion SLC22A8; ABCG2; SLC5A1; SLC22A7; SLCO1A2; BAAT; NR0B2; ATP1B2; ABCC3; SLCO1A4
    Mineral absorption SLC11A1; SLC26A6; SLC8A1; FTL; VDR; S100G; TRPV6; ATP7A; STEAP1; Trf

    ATP1B1 has several biochemical functions, for example, contributes_to ATP binding, ATPase activator activity, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B1 itself. We selected most functions ATP1B1 had, and list some proteins which have the same functions with ATP1B1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ATP binding ATP1B1; MSH2; MSH6; SFRP5; ABCG8; ATP1A2; ATP5D
    ATPase activator activity AHSA1L; DNAJC10; RAB4A; ATP1B3; MYBPC3; ATP1B2; DNAJC15; AHSA1; TOR1AIP2; AHSA2
    contributes_to ATPase activity ATP1B1; ATP5L; MSH6; ABCG8; PPP2R4; ATP5B; ATP5I; ATP5D; MSH2; ATP5C1
    ATPase binding RAB4A; TOR1AIP2; NUFIP1; LCK; WFS1; TAF9; FBL; PGR; NHP2L1; ATP6V0A2
    MHC class II protein complex binding ATP1B1; PKM2; CD81; ANXA11; YWHAE; HLA-DMA; PKM; CD74; HSP90AB1; HLA-DOB
    contributes_to drug binding PGGT1B; ATP1A2; ATP1B1
    contributes_to potassium ion binding ATP1A2; ATP1B1
    protein C-terminus binding MED12; SLC9A3R2; VPS36; CTGF; SHANK2; KCNK3; ITGB3BP; PPP1R9B; HPCAL4; IFT52
    protein binding MTA1; MXD4; APOBEC1; PTBP3; UBE3A; MKNK1; LDB3; WTIP; Icosl; KRT80
    contributes_to sodium ion binding ATP1A2; ATP1B1
    contributes_to sodium:potassium-exchanging ATPase activity ATP1B1; ATP1A1; ATP1A2; ATP1B3; ATP1B2

    ATP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B1.

    SLC4A1; MLC1; NR3C1; SMAD2; DDAH2; CRIP2; PSME1; EZH2; RIF1; TRMT2A; KMT2B; ouabain

    Willmsa, K; Shoemaker, CB; et al. Cloning and expression of a Na+, K+-ATPase alpha-subunit from Taenia solium (TNaK1 alpha). MOLECULAR AND BIOCHEMICAL PARASITOLOGY 138:79-82(2004).
    Therien, AG; Goldshleger, R; et al. Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase. JOURNAL OF BIOLOGICAL CHEMISTRY 272:32628-32634(1997).

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