ATP1B1

  • Official Full Name

    ATPase, Na+/K+ transporting, beta 1 polypeptide
  • Overview

    The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
  • Synonyms

    ATP1B1;ATPase, Na+/K+ transporting, beta 1 polypeptide;ATP1B;sodium/potassium-transporting ATPase subunit beta-1;adenosinetriphosphatase;Na, K-ATPase beta-1 polypeptide;Beta 1-subunit of Na(+),K(+)-ATPase;sodium/potassium-dependent ATPase beta-1 su

Recombinant Proteins

  • Human
  • Mouse
  • Cynomolgus
  • Rhesus macaque
  • Chicken
  • Rat
  • Mus musculus
  • Sus scrofa (Pig)
  • Dog
  • Tetronarce Californica
  • Pan troglodytes
  • Anguilla anguilla
  • Sheep
  • E.coli
  • Insect Cells
  • Mammalian Cells
  • Human Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Fc
  • Non
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATP1B1-10007H Recombinant Human ATP1B1, GST-tagged E.coli Human GST 59-303a.a.
Atp1b1-462M Recombinant Mouse Atp1b1 Protein, His-tagged E.coli Mouse His Thr53~Ser304
ATP1B1-17H Active Recombinant Human ATP1B1 Protein (63-303aa), C-His tagged Insect Cells Human His 63-303aa
ATP1B1-2116M Recombinant Mouse ATP1B1 Protein Mammalian Cells Mouse His
ATP1B1-2279H Recombinant Human ATP1B1 protein, His-tagged E.coli Human His 63-303 a.a.
ATP1B1-246H Recombinant Human ATP1B1, His tagged Human Cells Human Fc 63-303 a.a.
ATP1B1-321C Recombinant Cynomolgus ATP1B1 Protein, His-tagged Mammalian Cells Cynomolgus His
ATP1b1-3766M Recombinant Mouse ATP1b1, His-tagged E.coli Mouse His 304
ATP1B1-449R Recombinant Rhesus monkey ATP1B1 Protein, His-tagged Mammalian Cells Rhesus macaque His
ATP1B1-7069C Recombinant Chicken ATP1B1 Mammalian Cells Chicken His
ATP1B1-856R Recombinant Rat ATP1B1 Protein Mammalian Cells Rat His
ATP1B1-965H Recombinant Human ATP1B1 protein, GST-tagged Wheat Germ Human GST
ATP1B1-919HCL Recombinant Human ATP1B1 cell lysate Human Cells Human Non
ATP1B1-1071H Recombinant Human ATP1B1 protein(Glu63-Ser303), His-tagged HEK293 Human His Glu63-Ser303
ATP1B1-1131HF Recombinant Full Length Human ATP1B1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 303 amino acids
Atp1b1-1309M Recombinant Mouse Atp1b1 Full Length Transmembrane protein, His-tagged E.coli Mouse His Full L. 1-304aa
ATP1B1-2550H Recombinant Human ATP1B1 protein(101-170 aa), C-His-tagged E.coli Human His 101-170 aa
ATP1B1-278R Recombinant Rhesus Macaque ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
ATP1B1-278R-B Recombinant Rhesus Macaque ATP1B1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ATP1B1-512R Recombinant Rat ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ATP1B1-512R-B Recombinant Rat ATP1B1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ATP1B1-71C Recombinant Cynomolgus Monkey ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
ATP1B1-71C-B Recombinant Cynomolgus Monkey ATP1B1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
ATP1B1-850M Recombinant Mouse ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ATP1B1-850M-B Recombinant Mouse ATP1B1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL-1006MF Recombinant Full Length Mouse Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-304)
RFL-11617SF Recombinant Full Length Pig Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Sus scrofa (Pig) His Full L. Full Length (1-303)
RFL-11841CF Recombinant Full Length Dog Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Dog His Full L. Full Length (1-303)
RFL-15257RF Recombinant Full Length Rat Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Rat His Full L. Full Length (1-304)
RFL-19609TF Recombinant Full Length Torpedo Californica Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Tetronarce Californica His Full L. Full Length (1-305)
RFL-33534GF Recombinant Full Length Chicken Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Chicken His Full L. Full Length (1-305)
RFL-36188PF Recombinant Full Length Pan Troglodytes Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Pan troglodytes His Full L. Full Length (1-303)
RFL-36303AF Recombinant Full Length Anguilla Anguilla Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Anguilla anguilla His Full L. Full Length (1-303)
RFL-7504HF Recombinant Full Length Human Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Human His Full L. Full Length (1-303)
RFL-7919OF Recombinant Full Length Sheep Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli Sheep His Full L. Full Length (1-303)

    Involved Pathway

    ATP1B1 involved in several pathways and played different roles in them. We selected most pathways ATP1B1 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mineral absorption FTH1,MT1X,MT1G,SLC26A6,ATP1A4,Trf,MT1E,CYBRD1,SLC46A1,MT1M
    Thyroid hormone signaling pathway STAT1,MTOR,SLC2A1,BMP4,HDAC2,MED24,FOXO1,PLCB3,RCAN2,NOTCH2
    Proximal tubule bicarbonate reclamation SLC4A4,GLS2,ATP1A1,PCK1,GLUD2,FXYD2,ATP1A3,Car4,SLC38A3,MDH1
    Insulin secretion FFAR1,SNAP25,PRKCB,KCNN1,KCNN2,PCLO,INS1,PLCB1,RIMS2,KCNJ11
    Cardiac muscle contraction COX7B,ATP1A1B,CACNA2D1A,CACNA2D2,UQCRH,ATP1A3A,MYH15,COX6A1,COX6B1,ATP1A4
    Aldosterone-regulated sodium reabsorption ATP1B3,PRKCB,PIK3CA,KRAS,HSD11B2,ATP1A1,ATP1B4,INSR,FXYD2,ATP1A2
    Endocrine and other factor-regulated calcium reabsorption PLCB2,KLK1B26,PLCB3,KLK1B8,PTH1R,BDKRB2,CALB1,PRKACB,SLC8A1,PRKACG
    Gastric acid secretion ITPR1,GNAQ,CALM3,HRH2,CALM4,ATP1B4,KCNK2,PLCB1,GNAI3,ATP1A2
    Bile secretion SLCO1B1,SLCO1A5,AQP8,ADCY8,SLC51A,SCTR,SLCO1B2,ABCC2,CFTR,ATP1A2

    Protein Function

    ATP1B1 has several biochemical functions, for example, contributes_to ATP binding,ATPase activator activity,contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B1 itself. We selected most functions ATP1B1 had, and list some proteins which have the same functions with ATP1B1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding EIF2B5,FSCN1,DPPA4,CLSTN2,RHOBTB3,PMM1,TBCA,AGGF1,ZNF263,BCL2L10
    ATPase binding TCIRG1,ATP6V1G1,ATPIF1A,ANK2,DNAJC10,CHRNA7,ATP6V0A4,ATP1B2,SDF2L1,DERL1
    contributes_to ATPase activity ATP5J2,ATP5L,ATP5I,RFC3,ATP5F1,MSH2,ABCG8,ATP5E,ATP1A2,ATP5O
    contributes_to ATP binding ABCG8,MSH6,SFRP5,ATP5D,MSH2,ATP1A2
    MHC class II protein complex binding HSP90AB1,PKM2,HLA-DRB1,MS4A1,YWHAE,HLA-DMA,HLA-DOB,HSPA8,CD74,HSP90AA1
    contributes_to drug binding ATP1A2,PGGT1B
    contributes_to potassium ion binding ATP1A2
    protein C-terminus binding CDC37,STIP1,HSPG2,PCGF1,YEATS4,AGO2,KSR1,TERF2,PPP2CA,PEX12
    ATPase activator activity ATP1B2,TOR1AIP2,ATP1B3,DNAJC19,DNAJB6,DNAJC24,DNAJC10,RAB4A,AHSA1,AHSA2

    Interacting Protein

    ATP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B1.

    SLC4A1;MLC1;NR3C1;SMAD2;DDAH2;CRIP2;PSME1;EZH2;RIF1;TRMT2A;KMT2B;ouabain

    Resources

    References

    • Willmsa, K; Shoemaker, CB; et al. Cloning and expression of a Na+, K+-ATPase alpha-subunit from Taenia solium (TNaK1 alpha). MOLECULAR AND BIOCHEMICAL PARASITOLOGY 138:79-82(2004).
    • Therien, AG; Goldshleger, R; et al. Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase. JOURNAL OF BIOLOGICAL CHEMISTRY 272:32628-32634(1997).

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