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Active Recombinant Human ATP1B1 Protein (63-303aa), C-His tagged

Cat.No. : ATP1B1-17H
Product Overview : Recombinant human ATP1B1 protein (63-303aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
Source : Baculovirus
Species : Human
Tag : C-His
Form : Liquid
Bio-activity : > 3,000 pmol/min/μg, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of Adenosine 5-triphosphate to phosphate per minute per minute at pH 7.5 at 25 centigrade.
Molecular Mass : 29 kDa (250aa)
Protein Length : 63-303aa
AA Sequence : EFKPTYQDRVAPPGLTQIPQIQKTE ISFRPNDPKSYEAYVLNIVRFLEKY KDSAQRDDMIFEDCGDVPSEPKERG DFNHERGERKVCRFKLEWLGNCSGL NDETYGYKEGKPCIIIKLNRVLGFK PKPPKNESLETYPVMKYNPNVLPVQ CTGKRDEDKDKVGNVEYFGLGNSPG FPLQYYPYYGKLLQPKYLQPLLAVQ FTNLTMDTEIRIECKAYGENIGYSE KDRFQGRFDVKIEVKS
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE, Enzyme Activity
Notes : For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Name : ATP1B1 ATPase Na+/K+ transporting subunit beta 1 [ Homo sapiens (human) ]
Official Symbol : ATP1B1
Synonyms : ATP1B1; ATPase Na+/K+ transporting subunit beta 1; ATP1B; sodium/potassium-transporting ATPase subunit beta-1; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; Na, K-ATPase beta-1 polypeptide; adenosinetriphosphatase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium-dependent ATPase beta-1 subunit; sodium/potassium-transporting ATPase beta-1 chain; EC 3.6.1.3
Gene ID : 481
mRNA Refseq : NM_001677
Protein Refseq : NP_001668
MIM : 182330
UniProt ID : P05026

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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