ccl15
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  • Official Full Name
  • chemokine (C-C motif) ligand 15
  • Background
  • Chemokine CC-2 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3. The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14.
  • Synonyms
  • LKN1; NCC3; SY15; HCC-2; Lkn-1; MIP-5; NCC-3; SCYL3; MIP-1d; SCYA15; HMRP-2B; chemokine (C-C motif) ligand 15; CCL15_HUMAN; MIP5; C-C motif chemokine 15 [Precursor]; Small-inducible cytokine A15; Macrophage inflammatory protein 5; Chemokine CC-2; MIP-1delta; Leukotactin-1; Mrp-2b; small inducible cytokine subfamily A (Cys-Cys), member 15; CCL15
Cat.#:CCL15-0611HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL15 Protein, GST-Tagged
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Cat.#:CCL15-107HTag:
Source (Host):Species:Human
Product nameHuman CCL15
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Cat.#:CCL15-10837HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL15, GST-tagged
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Cat.#:CCL15-197HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL15, His tagged
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Cat.#:CCL15-256HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL15 Protein, His-tagged
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Cat.#:CCL15-30165THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL15
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Cat.#:CCL15-7731HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCL15 293 Cell Lysate
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Involved Pathway

CCL15 involved in several pathways and played different roles in them. We selected most pathways CCL15 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFRSF10A; LEPR; IFNAR2; BMPR1AA; CCL14; IL9; BMP7; IL10RB; EPOR; CXCL11
Chemokine signaling pathway
CXCL1; PIK3CA; Ccl21c; CRKL; PTK2; DOCK2; ELMO1; PF4V1; PRKCB; CXCR6

Protein Function

CCL15 has several biochemical functions, for example, CCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL15 itself. We selected most functions CCL15 had, and list some proteins which have the same functions with CCL15. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL35.1; CCL21; CCL24; XCL2; CCL26; CCL25B; CCL3L1; CCL38.1; CXCL32B.1; CCRL2
Function chemoattractant activity
Related Protein SAA1; FGF7; HMGB2; CCL3; BMP4; CCL16; SAA4; HGF; CXCL12A; MIF
Function chemokine activity
Related Protein CCL17; CCL3L1; PPBP; CXCL12B; Ccl21a; CCL3L3; CCL38.1; CCL21B; IL8L2; CCL15
Function heparin binding
Related Protein CRISPLD2; FGF7; KNG1; THBS1; SFRP1; LIPC; SERPINE2; PCOLCE2; PLA2G2D; AAMP
Function receptor binding
Related Protein WNT7A; LAMA4; TNFSF10; PARK7; HSPA1A; CCL2; KNG1; TNFSF9; PSPN; IL29

CCL15 Related Articles

Ahlberg, V; Bengtsson, KL; et al. Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38:17-26(2012).
Lechner, CJ; Gantin, RG; et al. Chemokines and cytokines in patients with an occult Onchocerca volvulus infection. MICROBES AND INFECTION 14:438-446(2012).

CCL15 Related Gene Family

Chemokines Cytokines