Active Recombinant Human CCL15 Protein (92 aa)
Cat.No. : | CCL15-326C |
Product Overview : | Recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) produced in E. coli is a single non-glycosylated polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhMIP-5/CCL15 has a molecular mass of 10.2 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | Macrophage Inflammatory Protein-5 (MIP-5/CCL15) is a chemokine originally identified in the human hemofiltrate, thus it is also named Hemofiltrate CC Chemokine-2 (HCC-2). MIP-5 belongs to the CCL chemokine family, and its receptors are G-protein coupled receptors CCR1 and CCR3, with CCR1 being the major one. MIP-5 is mainly expressed in heart and skeletal muscle, and CCR1 is expressed on Th1 and Th2 cells in human cord blood lymphocytes. In vivo, MIP-5 promotes the accumulation of immature myeloid cells and the expansion of metastatic foci in the lever. MIP-5 contributes to severe asthma, sarcoidosis, and atherosclerosis;however, MIP-5 can also inhibit stem cell proliferation, implicating its therapeutic potential as an alternative to high dose chemotherapy. |
Source : | E. coli |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 2 μg/mL, measured by the FLIPR assay using CHO cells transfected with human CCR1, the receptor of human CCL15, corresponding to a specific activity of > 500 units/mg. |
Molecular Mass : | 10.2 kDa, observed by reducing SDS-PAGE. |
Protein Length : | 92 |
AA Sequence : | QFTNDAETELMMSKLPLENPVVLNS FHFAADCCTSYISQSIPCSLMKSYF ETSSECSKPGVIFLTKKGRQVCAKP SGPGVQDCMKKLKPYSI |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% by SDS-PAGE analysis. |
Storage : | Lyophilized recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhMIP-5/CCL15 remains stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/mL. |
Gene Name : | CCL15 chemokine (C-C motif) ligand 15 [ Homo sapiens ] |
Official Symbol : | CCL15 |
Synonyms : | CCL15; chemokine (C-C motif) ligand 15; SCYA15, small inducible cytokine subfamily A (Cys Cys), member 15; C-C motif chemokine 15; CC chemokine 3; chemokine CC 2; HCC 2; HMRP 2B; leukotactin 1; Lkn 1; macrophage inflammatory protein 5; MIP 1 delta; MIP 1d; MIP 5; NCC 3; SCYL3; MIP-1 delta; chemokine CC-2; new CC chemokine 3; small-inducible cytokine A15; small inducible cytokine subfamily A (Cys-Cys), member 15; LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; MIP-1D; MRP-2B; SCYA15; HMRP-2B; |
Gene ID : | 6359 |
mRNA Refseq : | NM_032965 |
Protein Refseq : | NP_116741 |
MIM : | 601393 |
UniProt ID : | Q16663 |
Products Types
◆ Recombinant Protein | ||
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CCL15-197H | Recombinant Human CCL15 protein(Gln22-Ile113), His-tagged | +Inquiry |
CCL15-0611H | Recombinant Human CCL15 Protein, GST-Tagged | +Inquiry |
CCL15-070C | Active Recombinant Human CCL15 Protein (92 aa) | +Inquiry |
CCL15-10837H | Recombinant Human CCL15, GST-tagged | +Inquiry |
◆ Lysates | ||
CCL15-7731HCL | Recombinant Human CCL15 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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