• Official Full Name
  • chemokine (C-C motif) receptor 4
  • Background
  • High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
  • Synonyms
  • CCR4; chemokine (C-C motif) receptor 4; LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4; C-C chemokine receptor type 4; fusin; chemokine (C-C) receptor 4; leukocyte-expressed seven-transmembrane-domain receptor;
Source (Host):E. coli Cell FreeSpecies:Human
Product nameRecombinant Human CCR4 Protein (1-360 aa), His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR4 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCR4 Protein, His-tagged
Source (Host):Species:
Product nameCCR4 Total GPCR Internalization Assay Kit
Source (Host):Species:
Product nameCCR4 CHO-K1 β-Arrestin GPCR Assay Kit
Source (Host):Species:
Product nameD-Lactate Assay Kit

CCR4 Related Articles

Yamauchi, J; Coler-Reilly, A; et al. Mogamulizumab, an Anti-CCR4 Antibody, Targets Human T-Lymphotropic Virus Type 1-infected CD8(+) and CD4(+) T Cells to Treat Associated Myelopathy. JOURNAL OF INFECTIOUS DISEASES 211:238-248(2015).
Ni, X; Jorgensen, JL; et al. Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome. CLINICAL CANCER RESEARCH 21:274-285(2015).

CCR4 Related Gene Family

Chemokines Cytokines