col2a1
Share
  • Official Full Name
  • collagen, type II, alpha 1
  • Background
  • Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage.
  • Synonyms
  • ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1
Cat.#:COL2A1-1649HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL2A1 Protein, GST-tagged
+Inquiry
Cat.#:COL2A1-11432HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL2A1, His-tagged
+Inquiry
Cat.#:COL2A1-181HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human COL2A1
+Inquiry
Cat.#:COL2A1-26HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human COL2A1 protein, His-tagged
+Inquiry
Cat.#:COL2A1-3929HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL2A1, His tagged
+Inquiry
Cat.#:Col2a1-36MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Col2a1 protein, His-tagged
+Inquiry
Cat.#:COL2A1-3733MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL2A1 Protein
+Inquiry
Cat.#:Col2a1-7924MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Col2a1 protein, His-tagged
+Inquiry
Cat.#:COL2A1-1521RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COL2A1 Protein
+Inquiry
Cat.#:Col2a1-7925RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Col2a1 protein, His-tagged
+Inquiry
Cat.#:COL2A1-5996CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COL2A1
+Inquiry
Cat.#:COL2A1-7926RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit COL2A1 protein, His & GST-tagged
+Inquiry
Cat.#:COL2A1-1647HTag:
Source (Host):Human jointSpecies:Human
Product nameNative Human COL2A1 Protein
+Inquiry
Cat.#:COL2A1-1648HTag:
Source (Host):Human nasal septumSpecies:Human
Product nameNative Human COL2A1 Protein
+Inquiry
Cat.#:COL2A1-2063HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL2A1 cell lysate
+Inquiry

Involved Pathway

COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amoebiasis
SERPINB1C; PTK2; RELA; ARG1; TGFB3; PIK3R5; PIK3CB; RAB7A; COL24A1; PLCB3
Assembly of collagen fibrils and other multimeric structures
DST; LOXL4; TLL2; COL10A1A; COL5A2; COL6A2; BMP1B; PLEC; COL4A5; COL2A1
Collagen biosynthesis and modifying enzymes
TLL2; COL10A1A; PCOLCE2; PPIB; TLDC2; SERPINH1; BMP1B; COL8A2; COL4A3; ADAMTS3
Collagen formation
EMID2; LOXL3; COL3A1; SERPINH1; COL10A1; PCOLCEB; CTSS; COL4A3; COL28A1D; COL4A6
ECM-receptor interaction
THBS4A; COMP; THBS4; COL4A4; ITGA1; LAMC2; GP1BB; LAMB1; ITGA8; COL5A2A
Endochondral Ossification
COL10A1; CDKN1C; NKX3.2; COL10A1A; PTHLH; FRZB; PTHLHA; RUNX3; SOX5; SERPINH1
Extracellular matrix organization
MUSK; FBLN1; NID1; COL10A1; MMP10; FAM49BA; MFAP4; COL28A1A; COL19A1; TLL2
Focal Adhesion
ITGA9; PPP1R12B; COL5A2A; VAV3; PXNA; LAMB4; SRC; COL4A2; PAK2; TNN

Protein Function

COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent conferring tensile strength
Related Protein COL9A1; COL9A3; COL2A1
Function identical protein binding
Related Protein RIPK3; PDCD6; C; MPZL2B; SORD; C1QTNF9; SDK2; COL18A1; TRIP10; SNRNP200
Function metal ion binding
Related Protein ZFP30; TPP1; TAX1BP1; ING5B; MMP25; THAP7; NUBPL; CYP8B3; FAHD1; OLA1
Function platelet-derived growth factor binding
Related Protein Pdgfa&Pdgfb; COL2A1; PDGFRB; COL1A2; COL6A1; PDGFRA; COL4A1; COL3A1; PDGFB; COL5A1

Interacting Protein

COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.
COCH; RELA; HYAL1

COL2A1 Related Articles

Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).