col2a1
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  • Official Full Name
  • collagen, type II, alpha 1
  • Background
  • Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage.
  • Synonyms
  • ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1
Cat.#:COL2A1-1649HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL2A1 Protein, GST-tagged
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Cat.#:COL2A1-11432HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL2A1, His-tagged
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Cat.#:COL2A1-181HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human COL2A1
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Cat.#:COL2A1-26HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human COL2A1 protein, His-tagged
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Cat.#:COL2A1-3929HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL2A1, His tagged
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Cat.#:Col2a1-36MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Col2a1 protein, His-tagged
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Cat.#:COL2A1-3733MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL2A1 Protein
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Cat.#:Col2a1-7924MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Col2a1 protein, His-tagged
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Cat.#:COL2A1-1521RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COL2A1 Protein
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Cat.#:Col2a1-7925RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Col2a1 protein, His-tagged
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Cat.#:COL2A1-5996CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COL2A1
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Cat.#:COL2A1-7926RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit COL2A1 protein, His & GST-tagged
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Cat.#:COL2A1-1647HTag:
Source (Host):Human jointSpecies:Human
Product nameNative Human COL2A1 Protein
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Cat.#:COL2A1-1648HTag:
Source (Host):Human nasal septumSpecies:Human
Product nameNative Human COL2A1 Protein
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Cat.#:COL2A1-2063HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL2A1 cell lysate
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Involved Pathway

COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amoebiasis
SERPINB1B; COL5A1; ADCY1; LAMB2; Casp3; TGFB1; IL12A; SERPINB13; COL4A6; LAMA2
Assembly of collagen fibrils and other multimeric structures
COL10A1; COL6A3; COL6A1; PCOLCE; COL3A1; COL1A2; LOXL2; COL5A3A; CTSS; LOXL4
Collagen biosynthesis and modifying enzymes
COL9A1; COL9A3; COL3A1; COL4A5; COL5A3A; COL15A1B; COL23A1; P3H2; COL25A1; COL28A1D
Collagen formation
P3H2; COL19A1; COL10A1; LOX; COL4A4; COL4A3; LOXL3; COL28A1D; ADAMTS2; BMP1B
ECM-receptor interaction
LAMA5; COL24A1; VTNB; TNR; ITGA9; COMP; ITGB1B.2; VWF; LAMC1; LAMB3
Endochondral Ossification
RUNX3; KIF3A; ADAMTS4; FRZB; COL2A1; ADAMTS1; IFT88; ADAMTS5; NKX3.2; CTSL2
Extracellular matrix organization
ADAMTS1; COL28A1A; COL5A3A; COL10A1; CTSD; DAG1; CTSG; MATN3B; LRP4; COL25A1
Focal Adhesion
PAK1; PPP1CBL; GSK3AA; THBS4A; CDC42L; VWF; ACTN1; COL11A2; VASPA; MAPK9

Protein Function

COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent conferring tensile strength
Related Protein COL9A3; COL9A1; COL2A1
Function identical protein binding
Related Protein DAAM1; GAPDH; C1QTNF9; PRMT1; FHOD1; VIM; LCK; SH3GL3; SERPINB1A; IIGP1
Function metal ion binding
Related Protein MTMR4; PRKCBA; TRIM35-24; ATF7; TGFBR2; FBXO30B; ZNFL2A; NRXN2; HE1A; OSGEP
Function platelet-derived growth factor binding
Related Protein COL1A1; COL3A1; COL5A1; COL2A1; PDGFRA; COL4A1; COL1A2; COL6A1; Pdgfa&Pdgfb; PDGFRB

Interacting Protein

COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.
COCH; RELA; HYAL1

COL2A1 Related Articles

Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).