COL2A1 Protein, collagen, type II, alpha 1


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Official Full Name collagen, type II, alpha 1
Background Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage.
Synonyms ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Human joint
    • Human Nasal Septum
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL2A1-11432H Recombinant Human COL2A1, His-tagged E.coli His
    Human COL2A1-1647H Native Human COL2A1 Protein Human joint N/A
    Human COL2A1-1648H Native Human COL2A1 Protein Human Nasal Septum N/A
    Human COL2A1-1649H Recombinant Human COL2A1 Protein, GST-tagged Wheat Germ GST
    Human COL2A1-181H Recombinant Human COL2A1 Mammalian Cell His
    Human COL2A1-2063HCL Recombinant Human COL2A1 cell lysate Human Cell N/A
    Human COL2A1-26H Recombinant Human COL2A1 protein, His-tagged CHO His
    Human COL2A1-3929H Recombinant Human COL2A1, His tagged Human Cell His
    Mouse Col2a1-36M Recombinant Mouse Col2a1 protein, His-tagged HEK293 His
    Mouse COL2A1-3733M Recombinant Mouse COL2A1 Protein Mammalian Cell His
    Mouse Col2a1-7924M Recombinant Mouse Col2a1 protein, His-tagged E.coli His
    Rat COL2A1-1521R Recombinant Rat COL2A1 Protein Mammalian Cell His
    Rat Col2a1-7925R Recombinant Rat Col2a1 protein, His-tagged E.coli His
    Chicken COL2A1-5996C Recombinant Chicken COL2A1 Mammalian Cell His
    Rabbit COL2A1-7926R Recombinant Rabbit COL2A1 protein, His & GST-tagged E.coli His/GST

    COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amoebiasis IL12B; CD1d1; LAMC3; AASS; PIK3R1; COL5A1; SERPINB6; SERPINB2; NFKB1; COL4A5
    Assembly of collagen fibrils and other multimeric structures COL5A3B; COL10A1A; COL4A3; COL4A4; COL6A2; LOXL4; COL8A1; COL1A1; TLL1; COL11A1B
    Collagen biosynthesis and modifying enzymes PRP; TLL2; COL16A1; CRTAP; COL15A1B; COL5A3B; COL5A1; COL4A4; COL28A1; COL25A1
    Collagen formation COL16A1; MMP13; MMP20; PCOLCE2; COL5A2; COL9A1A; PCOLCE2B; LEPREL1; LEPRE1; CTSB
    ECM-receptor interaction COL5A1; HMMR; COL2A1B; VWF; COL6A5; Itga10&Itgb1; COL3A1; GP1BB; ITGA6; LAMA2
    Endochondral Ossification CST5; NKX3.2; MMP13; DDR2; CDKN1C; PTH; MGP; SERPINH1; ADAMTS4; PTHLHA
    Extracellular matrix organization TIMP2B; BGNB; BMP1B; COL6A2; COL17A1A; CTSK; COMP; COL9A1B; MMP12; TLL2
    Focal Adhesion TESK2; ITGA4; ITGB1B.2; PIK3CD; VWF; ITGB7; SPP1; BADB; RAPGEF1B; FLT4

    COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix structural constituent conferring tensile strength COL9A3; COL2A1; COL9A1
    identical protein binding NUDT16; KCNJ10; CALCA; CRYBB2; ALDOB; TYROBP; TRIP13; NELL2; DYNLT1F; VCP
    metal ion binding SNAI2; CYP51; FYCO1; CYBRD1; MTMR4; LIMS2; ZNF703; ZNF500; GALNTL5; NUAK1
    platelet-derived growth factor binding COL1A2; COL5A1; Pdgfa&Pdgfb; COL6A1; PDGFB; PDGFA; PDGFRB; COL4A1; COL1A1; PDGFRA

    COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.


    Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
    Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).

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