Active Recombinant Human COL2A1 protein, His-tagged
Cat.No. : | COL2A1-26H |
Product Overview : | Recombinant Human COL2A1(Gln26-Arg266 & Gly957-Leu1487) fused with His tag at N-terminal was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | Type II collagen is an essential component of cartilage. It is essential for skeletal development and for the ability of cartilage to resist compressive forces. Type II collagen is a homotrimer of a1(II) chains. Defects in Type II collagen are the cause of numerous diseases, including chondrodysplasias and arthritis. This recombinant mini pro-a1(II) collagen consists of the N‑terminal propeptide, 108 Gly-X-Y repeats, and the C‑terminal propeptide. Proteolytic processing of the C‑terminal propeptide by the procollagen C-proteinase (BMP-1) releases chondrocalcin, a calcium binding protein. |
Source : | CHO |
Species : | Human |
Tag : | His |
Predicted N Terminal : | His & Asp1242 |
Form : | Supplied as a 0.2 μm filtered solution in Tris and NaCl. |
Bio-activity : | Measured by the cleavage of its C-terminal propeptide by Recombinant Human BMP‑1/PCP. >50% of full-length Pro-Collagen II is cleaved by Recombinant Human BMP‑1/PCP. |
Molecular Mass : | Predicted Molecular Mass: 78 kDa;SDS-PAGE: 92-100 kDa, 65-70 kDa, 36 kDa, reducing conditions. |
Endotoxin : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >85%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain |
Storage : | Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 centigrade as supplied.3 months, -70 centigrade under sterile conditions after opening. |
Gene Name : | COL2A1 collagen, type II, alpha 1 [ Homo sapiens ] |
Official Symbol : | COL2A1 |
Synonyms : | COL2A1; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) , SEDC; collagen alpha-1(II) chain; chondrocalcin; cartilage collagen; alpha-1 type II collagen; collagen II, alpha-1 polypeptide; AOM; ANFH; SEDC; COL11A3; MGC131516; |
Gene ID : | 1280 |
mRNA Refseq : | NM_001844 |
Protein Refseq : | NP_001835 |
UniProt ID : | P02458 |
Chromosome Location : | 12q12-q13.2 |
Pathway : | Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; |
Function : | extracellular matrix structural constituent conferring tensile strength; identical protein binding; platelet-derived growth factor binding; |
Products Types
◆ Recombinant Protein | ||
COL2A1-2156H | Recombinant Human COL2A1 Protein, His-tagged | +Inquiry |
Col2a1-1279M | Recombinant Mouse Col2a1 Protein, His-tagged | +Inquiry |
COL2A1-2712H | Recombinant Human COL2A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
COL2A1-1178R | Recombinant Rat COL2A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
COL2A1-3929H | Recombinant Human COL2A1 protein(Asp1242-Leu1487), His-tagged | +Inquiry |
◆ Native Protein | ||
COL2A1-16C | Native Chicken COL2A1 Protein | +Inquiry |
COL2A1-13B | Native Bovine COL2A1 Protein | +Inquiry |
COL2A1-14B | Native Bovine COL2A1 Protein | +Inquiry |
◆ Lysates | ||
COL2A1-2063HCL | Recombinant Human COL2A1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket