Recombinant Human COL2A1 Protein, GST-tagged

• Cat.No.: COL2A1-1649H
• Product Overview: Human COL2A1 full-length ORF ( AAH07252, 1 a.a. - 268 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 55.22 kDa
• AA Sequence: MSAFAGLGPREKGPDPLQYMRADQA AGGLRQHDAEVDATLKSLNNQIESI RSPEGSRKNPARTCRDLKLCHPEWK SGDYWIDPNQGCTLDAMKVFCNMET GETCVYPNPANVPKKNWWSSKSKEK KHIWFGETINGGFHFSYGDDNLAPN TANVQMTFLRLLSTEGSQNITYHCK NSIAYLDEAAGNLKKALLIQGSNDV EIRAEGNSRFTYTALKDGCTKHTGK WGKTVIEYRSQKTSRLPIIDIAPMD IGGPEQEFGVDIGPVCFL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: COL2A1 collagen, type II, alpha 1 [ Homo sapiens ]
• Official Symbol: COL2A1
• Synonyms: COL2A1; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) , SEDC; collagen alpha-1(II) chain; chondrocalcin; cartilage collagen; alpha-1 type II collagen; collagen II, alpha-1 polypeptide; AOM; ANFH; SEDC; COL11A3; MGC131516
• Gene ID: 1280
• mRNA Refseq: NM_001844
• Protein Refseq: NP_001835
• MIM: 120140
• UniProt ID: P02458