gp1ba
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  • Official Full Name
  • glycoprotein Ib (platelet), alpha polypeptide
  • Background
  • Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
  • Synonyms
  • BSS; GP1B; CD42B; mgC34595; CD42b-alpha; GP1BA; platelet glycoprotein Ib alpha chain; GPIbA GP-Ib alpha antigen CD42b-alpha platelet membrane glycoprotein 1b-alpha subunit
Cat.#:GP1BA-1401HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GP1BA Protein (17-531 aa), His-tagged
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Cat.#:GP1BA-531HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GP1BA Protein (17-505 aa), His-tagged
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Cat.#:GP1BA-16HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GP1BA Protein, His-tagged
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Cat.#:GP1BA-5130HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GP1BA Protein, GST-tagged
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Cat.#:GP1BA-1511HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GP1BA protein, His & T7-tagged
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Cat.#:GP1BA-17HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human glycoprotein Ibα, His-tagged, double sulfated
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Cat.#:GP1BA-1832HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GP1BA protein, His-tagged
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Cat.#:GP1BA-18HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human glycoprotein Ibα, His-tagged, fully sulfated
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Cat.#:GP1BA-19HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human glycoprotein Ibα, His-tagged, non-sulfated
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Cat.#:GP1BA-21HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GP1BA, His-tagged, Single-sulfated
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Cat.#:Gp1ba-1512MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gp1ba protein, His & T7-tagged
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Cat.#:GP1BA-5823HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GP1BA 293 Cell Lysate
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Involved Pathway

GP1BA involved in several pathways and played different roles in them. We selected most pathways GP1BA participated on our site, such as ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP1BA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ECM-receptor interaction
VWF; COL4A6; LAMB1A; COL6A6; LAMA4; SV2A; GP9; LAMB3; COL3A1; COL1A1A
Platelet activation
PPP1R12A; PIK3CG; AKT2; MYLK3; MAPK11; PRKCI; BTK; TBXA2R; MAPK12; ACTG1
Hematopoietic cell lineage
CD33; IL11RA2; CSF3; CD2; CD3E; CD3D; CD3D; IL11RA; EPO; CD34; CD38

Protein Function

GP1BA has several biochemical functions, for example, protein binding, thrombin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP1BA itself. We selected most functions GP1BA had, and list some proteins which have the same functions with GP1BA. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TNPO3; CRP; SDHA; CDK5RAP3; PPP1R2P9; GATAD2B; THY1; APOB; NPHP1; MUSK
Function thrombin receptor activity
Related Protein GP1BA; F2R; F2RL2; F2RL1.2; F2RL1; F2RL1.1

Interacting Protein

GP1BA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP1BA here. Most of them are supplied by our site. Hope this information will be useful for your research of GP1BA.
VWF; GP9; YWHAZ; F2; F12; GP1BB; FLNA; YWHAQ; YWHAB; YWHAG; YWHAE; YWHAH

GP1BA Related Articles

Bragadottir, G; Birgisdottir, ER; et al. Clinical phenotype in heterozygote and biallelic Bernard-Soulier syndrome-A case control study. AMERICAN JOURNAL OF HEMATOLOGY 90:149-155(2015).
Biguzzi, E; Franchi, F; et al. Genetic background and risk of postpartum haemorrhage: results from an Italian cohort of 3219 women. HAEMOPHILIA 20:E377-E383(2014).