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Recombinant Human GP1BA Protein (17-531 aa), His-tagged

Cat.No. : GP1BA-1401H
Product Overview : Recombinant Human GP1BA Protein (17-531 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Partial.
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  • Gene Information
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Description : GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 58.9 kDa
Protein length : 17-531 aa
AA Sequence : HPICEVSKVASHLEVNCDKRNLTAL PPDLPKDTTILHLSENLLYTFSLAT LMPYTRLTQLNLDRCELTKLQVDGT LPVLGTLDLSHNQLQSLPLLGQTLP ALTVLDVSFNRLTSLPLGALRGLGE LQELYLKGNELKTLPPGLLTPTPKL EKLSLANNNLTELPAGLLNGLENLD TLLLQENSLYTIPKGFFGSHLLPFA FLHGNPWLCNCEILYFRRWLQDNAE NVYVWKQGVDVKAMTSNVASVQCDN SDKFPVYKYPGKGCPTLGDEGDTDL YDYYPEEDTEGDKVRATRTVVKFPT KAHTTPWGLFYSWSTASLDSQMPSS LHPTQESTKEQTTFPPRWTPNFTLH MESITFSKTPKSTTEPTPSPTTSEP VPEPAPNMTTLEPTPSPTTPEPTSE PAPSPTTPEPTPIPTIATSPTILVS ATSLITPKSTFLTTTKPVSLLESTK KTIPELDQPPKLRGVLQGHLESSRN DPFLHPDFCCLLPLGFYVLGLFWLL FASVVLILLLSWVGH
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : GP1BA glycoprotein Ib (platelet), alpha polypeptide [ Homo sapiens ]
Official Symbol : GP1BA
Synonyms : GP1BA; GP1B; CD42b; GP-Ib alpha; BSS; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; MGC34595;
Gene ID : 2811
mRNA Refseq : NM_000173
Protein Refseq : NP_000164
MIM : 606672
UniProt ID : BC027955

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of Glycoprotein Ib platelet subunit alpha (GP1BA) in platelet physiology and hemostasis? 05/05/2022

Glycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.

What diseases or conditions are associated with dysregulation or abnormal expression of GP1BA? 11/24/2021

Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.

How does GP1BA contribute to platelet adhesion and the formation of platelet plugs at sites of vascular injury? 12/03/2020

GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.

What are the interactions or binding partners of GP1BA, and how do they influence platelet function? 08/13/2020

Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.

How does GP1BA participate in the regulation of blood clotting and coagulation cascades? 01/06/2019

GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.

In which cellular compartments is GP1BA predominantly localized, especially within platelets? 08/24/2018

GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.

Are there therapeutic implications or potential targets related to GP1BA in diseases involving platelet disorders? 03/06/2018

There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.

Customer Reviews (3)

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Reviews
11/04/2022

    Its compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.

    04/12/2022

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      06/24/2016

        The product's track record of being featured in influential publications positively influenced our decision to use it.

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