mapk12
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  • Official Full Name
  • mitogen-activated protein kinase 12
  • Background
  • Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
  • Synonyms
  • MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitoge
Cat.#:MAPK12-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK12 Protein, His-tagged
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Cat.#:MAPK12-264HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12, Gly & Pro tagged
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Cat.#:MAPK12-279HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12, His-GST tagged
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Cat.#:MAPK12-27HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAPK12 protein, GST-tagged
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Cat.#:MAPK12-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK12, His-tagged
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Cat.#:MAPK12-31377THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK12
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Cat.#:MAPK12-31378THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK12, His-tagged
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Cat.#:MAPK12-375HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK12, GST-tagged, Active
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Cat.#:MAPK12-738HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 12
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Cat.#:MAPK12-9528MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK12 Protein
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Cat.#:MAPK12-3572RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK12 Protein
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Cat.#:MAPK12-1264HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 12, His-tagged
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Cat.#:MAPK12-1343HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 12, His-tagged
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Cat.#:MAPK12-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12 cell lysate
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Involved Pathway

MAPK12 involved in several pathways and played different roles in them. We selected most pathways MAPK12 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PPP3CCB; NFATC3; FGF6A; RAF1; RPS6KA2; MAPK3; MAP2K5; TAOK3; MAPT; MAP3K4
Rap signaling pathway
MRAS; SRC; ANGPT2; MAP2K6; FGF8; ITGAM; VASP; GRIN2A; ACTB; MAPK3
FoxO signaling pathway
PLK2; PIK3R3A; IGF1; INS2; PRMT1; MAPK14A; PTENB; PIK3R3B; BCL6; SGK2B
Sphingolipid signaling pathway
PLCB3; PPP2R5B; TRADD; MAPK13; PTEN; RHOA; SPTLC1; S1PR5; MAPK9; PIK3R5
Oocyte meiosis
PPP2CA; CUL1; MAPK12B; PRKACBA; SPDYA; ANAPC4; CAMK2G1; PPP2R5C; BUB1; CAMK2B
Adrenergic signaling in cardiomyocytes
MAPK1; ATP2B4; RAPGEF4; CALM1A; PPP2R1B; CALM4; PPP2R5C; MYH7; GNA15.4; CAMK2B1
VEGF signaling pathway
PIK3R3B; PLA2G4A; SRC; CDC42L; PIK3R1; PPP3R1B; SHC2; MAPK3; SPHK2; VEGFAA
Osteoclast differentiation
MAPK8; CSF1R; FCGR1; LILRA4; IFNG; SFPI1; IL1R1; IL1A; NFATC1; FCGR2C
Signaling pathways regulating pluripotency of stem cells
DLX5; WNT5B; WNT16; INHBC; PIK3CB; AKT1; INHBA; PCGF5; JARID2; ESRRB
Platelet activation
PLCB2; VWF; MAPK3; TLN1; PLCB1; P2RY12; ACTB; PPP1CA; LYN; STIM1
Toll-like receptor signaling pathway
IFNA8; PIK3R5; MAPK8; CASP8; IL12A; PIK3R3B; IFNAR2; MAP2K3; TLR7; TLR4
NOD-like receptor signaling pathway
NAIP7; HSP90AB1; TRIP6; TRAF6; NFKBIA; NLRP3; SUGT1; RIPK2; HSP90AA1.2; MAP3K7IP3
RIG-I-like receptor signaling pathway
IFNB1; IFNA5; PL10; CXCL8B.3; DDX58; IFNA7; IRF7; IFNA17; IFNA4; DDX3X
T cell receptor signaling pathway
MAPK12; CBLB; LAT; PIK3R5; PAK1; OXSR1A; LCP2; CD3E; PPP3CA; FYN
Fc epsilon RI signaling pathway
PIK3CB; MAPK1; RAC3; PLA2G4A; LAT; MAP2K7; PRKCA; MAPK12; HRAS; PLA2G4D
TNF signaling pathway
CREB3L1; LIF; MAPK13; PTGS2; AKT2; FAS; PIK3CD; BIRC2; CX3CL1; RPS6KA5
Leukocyte transendothelial migration
MLLT4; GNAI3; CLDN4; NOX1; PLCG1; ITGB2L; MYL2; CLDN17; MAPK12; JAM2
Neurotrophin signaling pathway
RAP1B; MAGED1; ARHGDIG; CAMK2A; MAP3K5; RAP1A; BDNF; PLCG1; KRAS; CALM2
Retrograde endocannabinoid signaling
GABRD; SLC17A6; GRIA3; GABRA1; GRIA4; GABRG3; GABRQ; MAPK10; GABRR1; GNG11
Dopaminergic synapse
CALM1; ATF4; GRIN2B; KIF5B; GNGT1; GNGT2; DRD1; GNB2; DRD4; PLCB3
Inflammatory mediator regulation of TRP channels
CALML3; KLK1B4; NGF; HRH1; HTR2B; ACCN3; PLA2G4C; PLCG1; PPP1CB; ACCN4
GnRH signaling pathway
RAF1; GNA11A; CALM2A; EGFRA; FSHB; CALM1B; GNA15.1; MAPK14A; MAPK12B; MAPK8A
Progesterone-mediated oocyte maturation
MAD2L2; MAPK9; RAF1B; ADCY1B; MAD2L1; MAD1L1; MAPK8A; AKT1; FZR1; GNAI2A
Prolactin signaling pathway
INS2; STAT1; SOCS1; AKT2; GALT; MAPK8; FOS; TNFRSF11A; PIK3R3; PRP2
Amyotrophic lateral sclerosis (ALS)
BID; TP53; GRIN2C; PPP3R1; BCL2; MAPK13; MAP3K5; SLC1A2; MAPK12; PPP3R2
Epithelial cell signaling in Helicobacter pylori infection
ADAM17; MAPK10; IKBKB; ATP6V1E1; NFKBIA; ATP6V1D; MAPK9; GIT1; CXCR1; ATP6V1G2
Shigellosis
HCLS1; WASF1; ITGA5; U2AF1; MAPK11; SRC; ATG5; RELA; RAC1; CDC42
Salmonella infection
CDC42L2; MAPK14B; RAB7B; MAPK12A; PFN4; RILP; DYNC1LI2; PLEKHM2; CCL3L1; NLRC4
Pertussis
C1QC; TLR4; MAPK11; MAPK13; CALML3; IRF8; RELA; GNAI2; TRAF6; PYCARD
Leishmaniasis
H2-AB1; TLR2; NFKB1; STAT1; IRAK1; FCGR3; HLA-DOB; HLA-DMB; IRAK4; ELK1
Chagas disease (American trypanosomiasis)
TLR4; TLR2; GNA15; NFKB1; IL1B2; GNAO1; IFNG; TGFBR2; GNAS; PIK3CG
Toxoplasmosis
PIK3CB; IRGM1; PIK3R3; IKBKG; MAP2K6; BIRC3; TYK2; HLA-DMB; IL12B; IFNGR2
Tuberculosis
CLEC7A; BCL10; CALM4; ITGB2; IL18; ATP6AP1; MAPK3; RFX5; SRC; LSP1
Hepatitis C
STAT2; PPP2R2A; CLDN3; IFNAR2; STAT3; NFKB1; IKBKG; RIPK1; MAPK12; TRAF3
Influenza A
IL12B; IFNG; MAPK13; MAP2K6; DDX39B; Fasl; PIK3CA; Ifna15; LOC780933; HLA-DRB3
Epstein-Barr virus infection
YWHAB; IL10RB; POLR2J; POLR2I; TRAF5; FCER2; AKAP8L; SPI1; CSNK2A2; MAP3K14
Proteoglycans in cancer
WNT3; SDC2; ACTG1; HRAS; PRKACB; SDC4; ELK1; CAMK2B; FZD3; MTOR

Protein Function

MAPK12 has several biochemical functions, for example, ATP binding, MAP kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK12 itself. We selected most functions MAPK12 had, and list some proteins which have the same functions with MAPK12. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACSM5; KIF4A; CKMT2A; EPHB4B; SRPK1B; SETX; KIT; TOR1B; MAPK12B; ACTA1A
Function MAP kinase activity
Related Protein MAPK14B; MAPK12; NLK2; MAPK11; NLK; MAPK6; MAPK12A; MAPK14A; NLK1; MAPK15
Function magnesium ion binding
Related Protein PKMB; TSSK1; PTEN; PKM2; MAP3K8; PRPSAP1; MAPK12; FAN1; ATP8B3; DYRK3
Function protein binding
Related Protein MIS12; LRDD; SLC19A2; THBD; E2F6; GUCY2C; RGMA; PHIP; C6orf130; TP73
Function protein serine/threonine kinase activity
Related Protein TRPM6; RPS6KAL; NIM1K; MAP3K14; PLK4; MAPK8; STK40; ULK4; TTK; ULK3

Interacting Protein

MAPK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK12.
SIAH1; saicar; PKM; PTPN4; SRPK1; DUSP1; DLG1; PKN1; TERF1; GTF2I; PDGFRL; MAPK1; PRPF4B; MAPK15