mapk12
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  • Official Full Name
  • mitogen-activated protein kinase 12
  • Background
  • Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
  • Synonyms
  • MAPK12; mitogen-activated protein kinase 12; SAPK3; ERK6; p38gamma; PRKM12; SAPK 3; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitoge
Cat.#:MAPK12-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK12 Protein, His-tagged
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Cat.#:MAPK12-264HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12, Gly & Pro tagged
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Cat.#:MAPK12-279HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12, His-GST tagged
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Cat.#:MAPK12-27HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAPK12 protein, GST-tagged
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Cat.#:MAPK12-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK12, His-tagged
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Cat.#:MAPK12-31377THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK12
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Cat.#:MAPK12-31378THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK12, His-tagged
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Cat.#:MAPK12-375HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK12, GST-tagged, Active
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Cat.#:MAPK12-738HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 12
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Cat.#:MAPK12-9528MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK12 Protein
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Cat.#:MAPK12-3572RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK12 Protein
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Cat.#:MAPK12-1264HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 12, His-tagged
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Cat.#:MAPK12-1343HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 12, His-tagged
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Cat.#:MAPK12-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK12 cell lysate
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Involved Pathway

MAPK12 involved in several pathways and played different roles in them. We selected most pathways MAPK12 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF2; TNFRSF1A; RAC1A; PLA2G4A; GADD45B; ZAK; FGF6B; CACNA2D2; MAPK14A; TMEM37
Rap signaling pathway
FGF18; FGFR4; FLT1; PLCB4; PIK3R2; GNAO1; GNAQ; PRKCI; NGF; PIK3R5
FoxO signaling pathway
IRS4; STAT3; IGF1; MAPK3; HRAS; PRMT1; MAPK12B; TGFBR2; KLF2A; SGK2
Sphingolipid signaling pathway
OPRD1; TRAF2; SGMS1; SPHK1; ROCK1; PPP2R5D; TP53; PLD2; PPP2R5C; RAC2
Oocyte meiosis
PPP1CAB; CALM4; SLK; Ar; ESPL1; AURKA; PPP1CA; ANAPC4; PPP2R5CB; SPDYB
Adrenergic signaling in cardiomyocytes
CAMK2D; AGTR1; PPP2CA; ATP1A3A; MYH15; CREB3; ADRa1A; TNNC1; CACNB4A; PIK3CA
VEGF signaling pathway
MAPK12B; NFATC2; PXNA; PLCG1; PTK2AA; RAC1; AKT3A; RAF1A; PTGS2; PPP3CCA
Osteoclast differentiation
GRB2; NOX1; PPP3CC; IFNG; CSF1R; SIRPA; RELA; MAPK8; FCGR4; FHL2
Signaling pathways regulating pluripotency of stem cells
WNT2B; WNT6; BMPR1A; FZD5; FZD3; BMP4; INHBA; MAPK12; LEFTY2; JARID2
Platelet activation
ITPR1; PLA2G4A; FCER1G; PIK3CA; ITGB1; PLCB3; FERMT3; MYLK4; MAPK1; SNAP23
Toll-like receptor signaling pathway
MAP2K7; MAPK8B; PIK3R1; CD80; IFNA10; TMED7-TICAM2; CCL4L2; MAPK12A; CCL3; CCL4
NOD-like receptor signaling pathway
CASPA; IL1B; CASP1; IKBKG; IKBKB; TNF; CCL2; CXCL1; TRAF6; NFKBIB
RIG-I-like receptor signaling pathway
DAK; PIN1; PL10; TRADD; OTUD5A; ATG12; CASP10; DHX58; TRAF6; IFNA14
T cell receptor signaling pathway
TNF; MAP3K14; PTPN6; CD3D; IL4; PAK2; CD3E; CD8A; PAK3; PPP3R1
Fc epsilon RI signaling pathway
MAP2K2; RAC3; AKT1; HRAS; RAF1; PLCG1; RAC1; MAP2K7; MAPK1; SYK
TNF signaling pathway
PIK3R2; ITCH; CFLAR; MAP3K14; FADD; FOS; CASP10; MAPK10; TRAF1; IKBKG
Leukocyte transendothelial migration
ITGB2; MYL2; ITGA4; PIK3R5; VASP; THY1; VCAM1; ACTN1; VAV3; CLDN10
Neurotrophin signaling pathway
MAPK12; RAC1; RPS6KA6; PIK3CG; MAPK3; MAPK8; BDNF; MAPK7; RPS6KA3; RHOA
Retrograde endocannabinoid signaling
PRKCA; GABRA4; MAPK8; GNGT2; FAAH; GABRR3; GNAI3; GNAO1; GNG7; GNB2
Dopaminergic synapse
CALM1; GRIA1; PPP2R1B; MAPK13; GNG12; GSK3A; PPP1CC; DRD2; GNG5; GNB4
Inflammatory mediator regulation of TRP channels
NTRK1; TRPV1; CYP2J2; CALM4; TRPV2; PRKACA; ALOX12E; ACCN5; MAPK9; TRPV3
GnRH signaling pathway
CALM3; ADCY1A; MAP3K2; CAMK2G; HRASA; MMP14B; PRKACBA; CALM1A; GNA11; CAMK2D2
Progesterone-mediated oocyte maturation
AKT2; MAPK10; AKT2L; CCNB3; HSP90AA1; CPEB1; CDC23; CPEB3; MAPK14B; PRKACBB
Prolactin signaling pathway
PIK3R3; SOCS4; PIK3R5; RAF1; SIRPA; INS1; SOCS6; ELF5; SOCS5; SOCS7
Amyotrophic lateral sclerosis (ALS)
MAPK13; MAPK14; MAPK12; PPP3CC; GRIN2A; MAP3K5; BID; PPP3CA; BCL2L1; GRIN2D
Epithelial cell signaling in Helicobacter pylori infection
MAP3K14; ATP6V1C1; ATP6V1D; CXCR2; ATP6V1E1; ATP6V0A1; CXCR1; SRC; F11R; MAPK12
Shigellosis
WASL; RHOG; PFN1; ACTB; VCL; MAPK12; CDC42; NFKB1; HCLS1; ITGB1
Salmonella infection
DYNC1LI2; RAB7; CCL4L2; ARPC5L; TLR4BA; PKN1; IFNGR2; DYNC2H1; LBP; IFNGR1
Pertussis
CALM2; C3; SERPING1; CALML5; MYD88; C5; C1RA; AMCF-II; IL1A; ITGAM
Leishmaniasis
MAPK1; FCGR3; HLA-DQA1; HLA-DQB1; IRAK4; CR1; NFKB1; FCGR1; PRKCB; IL4
Chagas disease (American trypanosomiasis)
TGFBR2; ACE; AKT2; PPP2R2C; TNF; PPP2R2A; MAPK8; C1QB; PIK3CD; GNAI3
Toxoplasmosis
HLA-DRA; PIK3CG; HLA-DRB4; IKBKG; HLA-DRB5; IFNGR2; NFKBIB; CASP9; LAMB2; HLA-DRB1
Tuberculosis
ITGAX; CAMP; Ifna11; TGFB2; PMAP-36; IFNA14; Ifna15; CD74; HLA-DMB; HLA-DQB1
Hepatitis C
MAPK1; PPP2R1A; IFNA1; PPP2R1B; AKT2; IFNAR2; NFKB1; OAS3; HRAS; TNFRSF1A
Influenza A
HLA-DQA1; TNFRSF1A; NXF1; EP300; IKBKB; LOC100033925; DDX39B; EIF2AK1; HLA-DPA1; GSK3B
Epstein-Barr virus infection
HLA-DQA2; PSMD1; TAB2; EIF2AK1; PSMD11; POLR1D; YWHAG; PSMC4; MAPK13; PRKACA
Proteoglycans in cancer
PRKCG; HPSE2; HSPG2; ROCK1; WNT9B; MET; PXN; TGFB2; PRKACG; PDPK1

Protein Function

MAPK12 has several biochemical functions, for example, ATP binding, MAP kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK12 itself. We selected most functions MAPK12 had, and list some proteins which have the same functions with MAPK12. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MCM3; RIPK3; DDX39AA; CCT2; ACACB; XRCC5; SMYHC2; CAMK2B1; MAP3K9; PLK5
Function MAP kinase activity
Related Protein MAPK14; MAPK11; MAPK14B; MAPK8B; NLK1; MAPK12A; MAPK13; MAPK15; MAPK12; MAPK12B
Function magnesium ion binding
Related Protein EYA2; SRPK2; PDXK; TDP2; PRPS2; ENOSF1; NT5C1AA; MAST2; ABL1; FAN1
Function protein binding
Related Protein CLK4; PAK1IP1; LGALS1; PFKM; FOXL2; TACR2; ACAT2; KIF14; SYCE1; TRIM74
Function protein serine/threonine kinase activity
Related Protein LRRK2; MAP2K5; ZAK; CAMK2G1; MAP2K7; CAMK1GA; CSNK1DB; SRPK1; TLK1B; STRC

Interacting Protein

MAPK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK12.
SIAH1; saicar; PKM; PTPN4; SRPK1; DUSP1; DLG1; PKN1; TERF1; GTF2I; PDGFRL; MAPK1; PRPF4B; MAPK15