map2k1
Share
  • Official Full Name
  • mitogen-activated protein kinase kinase 1
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Cat.#:MAP2K1-175HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1, GST-tagged
+Inquiry
Cat.#:MAP2K1-167HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human v protein, MYC/DDK-tagged
+Inquiry
Cat.#:MAP2K1-2568HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K1, His-tagged
+Inquiry
Cat.#:MAP2K1-299HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His/MBP-tagged
+Inquiry
Cat.#:MAP2K1-300HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His/MBP-tagged
+Inquiry
Cat.#:MAP2K1-343HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAP2K1
+Inquiry
Cat.#:MAP2K1-596HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP2K1, His-tagged
+Inquiry
Cat.#:MAP2K1-62HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MAP2K1 protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:MAP2K1-639HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His-tagged
+Inquiry
Cat.#:Map2k1-1032MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k1 protein, GST-tagged
+Inquiry
Cat.#:Map2k1-1350MTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Map2k1, His & GST tagged
+Inquiry
Cat.#:MAP2K1-483MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K1, Gly & Pro tagged
+Inquiry
Cat.#:Map2k1-666MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k1, GST-tagged
+Inquiry
Cat.#:MAP2K1-3559RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP2K1 Protein
+Inquiry
Cat.#:MAP2K1-2663RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP2K1 Protein, His-tagged
+Inquiry
Cat.#:MAP2K1-1266CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP2K1
+Inquiry
Cat.#:MAP2K1-12591ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAP2K1
+Inquiry
Cat.#:MAP2K1-1033HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
+Inquiry
Cat.#:MAP2K1-1034HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
+Inquiry
Cat.#:MAP2K1-1035HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged
+Inquiry
Cat.#:Map2k1-1032HTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
+Inquiry
Cat.#:MAP2K1-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K1 cell lysate
+Inquiry
Cat.#:Kit-1614Tag:N/A
Source (Host):Species:
Product nameMEK1 Kinase Binding Assay Kit
+Inquiry

Involved Pathway

Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PPM1NA; RASGRP3; HRASA; FGF13A; PRKCB; NTRK1; KCNA3; FGFR3; GNA12; CACNB4
ErbB signaling pathway
BRAF; CBL; PIK3CA; MYCB; PAK3; NRG2; MAPK10; AKT1; CAMK2A; ABL2
Ras signaling pathway
RAP1B; PIK3CA; PLA2G2E; AKT2; SHC1; FGF12; PLA2G10; FGF3; MAPK9; PLA2G5
Rap signaling pathway
CALM2; ITGAL; FGF4; TEK; PRKD1; GNAI3; IGF1; FGF9; MAPK1; FGF18
cGMP-PKG signaling pathway
ATP1B4; PRKCE; MYLK3; OPRD1; PDE5A; PPP1R12A; PIK3CD; PIK3CB; SLC25A5; SLC25A6
cAMP signaling pathway
GNAS; CNGA4; ARAP3; HTR1F; SOX9; BAD; HCN2; RAF1; HTR1A; CNGA1
Chemokine signaling pathway
SHC3; PRKCB; CCL4L2; HRAS; GM10591; CXCL2; PTK2B; GNG11; GNAI2; Cxcl15
HIF- signaling pathway
NPPA; SERPINE1; Trf; ALDOA; VHL; PFKL; LDHA; MKNK1; IGF1R; RPS6KB2
FoxO signaling pathway
PLK4; GADD45B; TGFBR1; RBL2; USP7; BCL6A; ATM; TGFB1; MAP2K1; MAPK12
Sphingolipid signaling pathway
PRKCB; TP53; PLCB4; SMPD2; PPP2R2C; CERS5; RAC1; PRKCG; DEGS1; RAC3
Phospholipase D signaling pathway
GRM5; RHOA; ARF6; PRKCA; PDGFA; RALGDS; SHC2; PIP5K1A; PIK3R3; GNAS
Oocyte meiosis
FBXW11; CUL1B; CAMK2D2; FBXO5; SMC1B; ANAPC5; CDC25C; RPS6KA3A; BTRC; Ar
PIK-Akt signaling pathway
PPP2R1A; IL2RG; IFNA2; RAF1; PPP2R5D; PIK3R2; PRLR; BCL2L1; ITGA7; EPOR
Vascular smooth muscle contraction
KCNMB3; CALM1B; BRAF; MYLK3; RHOA; CYP4A14; KCNMB2; PTGIR; ROCK1; PPP1CAB
Dorso-ventral axis formation
GRB2A; ETS1; CPEB1A; NOTCH1; SPIRE1A; PIWIL1; CPEB3; GRB2B; CPEB2; GRB2
VEGF signaling pathway
AKT2L; PPP3CB; PTGS2B; PPP3CA; SHC2; PIK3R2; PRKCA; PPP3CCB; CDC42; PXN
Osteoclast differentiation
RELA; TGFBR2; SPI1; TNFRSF11B; MAP3K7; IL1B; PLCG2; PIK3R5; FCGR2C; LCP2
Focal adhesion
BRAF; THBS4B; PAK3; ITGB4; ACTN1; Reln; PAK2A; VAV1; COL2A1A; ITGA6
Gap junction
GNAI2; GRM1; MAP2K2; DRD2B; ITPR3; TUBB5; NRAS; PRKACB; CSNK1DA; TUBB2B
Signaling pathways regulating pluripotency of stem cells
MAPK13; FGFR4; NEUROG1; IL6ST; SETDB1; Fzd4; PAX6; INHBA; FZD6; KRAS
Toll-like receptor signaling pathway
TNF; TRAF3; CCL3; IFNA16; MAPK8A; IL-8; CCL5; TLR7; MAPK8; TLR4BA
Natural killer cell mediated cytotoxicity
NRAS; PPP3R1; MAPK1; PRKCG; NCR2; PRKCB; Fasl; IFNA12; NCR1; KIR2DS2
T cell receptor signaling pathway
BCL10; PIK3CG; NFKBIE; CD3D; VAV2; PPP3CC; VAV1; PAK7; CD8B; PRKCQ
B cell receptor signaling pathway
PLEKHA1; VAV3; SYK; CDK7; Cd79a, Cd79b; RASGRP3; CD19; PIK3AP1; MAP4K1; ARPC5
Fc epsilon RI signaling pathway
AKT2; PIK3CB; LCP2; RAC3; RAC2; MAPK12; PIK3CA; PLA2G4C; MAPK11; MAP2K4
Fc gamma R-mediated phagocytosis
WASL; PRKCB; LYN; PIP5K1A; PRKCA; LIMK2; RAF1; LAT; WASF1; PPAP2B
TNF signaling pathway
Ccl12; TNFRSF1B; CASP7; MLKL; IL18R1; PIK3R1; CX3CL1; TRADD; MAP3K7; TNFRSF1A
Long-term potentiation
RPS6KA2; ITPR3; PLCB1; GRIN2A; PPP3CA; RAP1B; PRKACB; CAMK4; PPP1R1A; PPP3CB
Neurotrophin signaling pathway
CALM4; GAB1; BAX; KIDINS220; NFKBIE; SOS1; BRAF; TRAF6; CALML5; PIK3CG
Cholinergic synapse
GNG10; PRKACA; GNGT1; CAMK2D; BCL2; ACHE; GNG12; KCNQ5; SLC5A7; CHRNA3
Serotonergic synapse
HTR1A; HTR3A; ALOX15; GNAI3; MAOB; CYP2C50; CYP2C55; GNB2; CYP2C70; PRKACB
Long-term depression
NRAS; IGF1R; BRAF; PPP2R1A; MAPK1; PLCB2; GNAS; CRH; GUCY1A3; GNAI2
Regulation of actin cytoskeleton
VAV1; PPP1CB; SCINLB; GIT1; PAK2B; HRASA; RAC1A; FGF12A; ROCK2; PAK7
Insulin signaling pathway
INS1; EIF4E1C; CALM4; RHOQ; PDE3B; HK1; PRKAR1AB; PPP1R3C; HRASA; PRKACBA
GnRH signaling pathway
LHB; GRB2B; GNA11; MAP2K1; MAPK12B; PRKCBB; MAPK14A; ELK1; ATF4; PLCB2
Progesterone-mediated oocyte maturation
MAPK13; INS2; GNAI3; MAPK8A; PGR; ADCY1B; PIK3CG; MAPK14A; BUB1; GNAI2A
Estrogen signaling pathway
ATF4; PLCB2; GABBR2; SP1; ESR1; CALM4; ATF6B; HRAS; MAPK3; MMP2
Melanogenesis
GNA11A; CALM2; KRAS; PRKCA; a; FZD3A; MC1R; HRASA; MAP2K2A; ADCY1B
Prolactin signaling pathway
INS1; SRC; FOS; IRF1; INS; SOS1; CCND2; NFKB1; PIK3R3; MAPK12
Thyroid hormone signaling pathway
RXRB; NOTCH4; PLCB2; MED4; RXRG; MED12; AKT2; TP53; PLCE1; GSK3B
Oxytocin signaling pathway
PLA2G4A; CAMK2D; CAMKK1; ACTB; MYLK4; CACNB2; PLA2G4F; PRKAG3; PTGS2; ACTG1
Prion diseases
C5; C1QA; PRKACA; IL1B; HSPA1A; C8G; PRKACB; MAP2K1; STIP1; IL1A
Alcoholism
HDAC9; HIST3H3; GNG12; HIST1H4L; H2AFX; HDAC7; HIST1H2AP; ATF6B; HDAC6; HIST1H2AA
Hepatitis B
MAPK10; IFNA4; MAVS; PRKCB; STAT1; PCNA; FOS; PIK3R5; PTK2B; RB1
Influenza A
HSPA1L; TNF; TNFRSF10D; MAPK9; FDPS; HNRNPUL1; BLA; RNASEL; HSPA6; IL8L1
Pathways in cancer
PRKACG; IKBKB; HSP90AA1; NFKB1; WNT9A; DAPK2; SMO; NCOA4; SUFU; NFKB2
Proteoglycans in cancer
PIK3R5; GPC1; PDPK1; PRKCG; RHOA; LUM; CDC42; Ctsl; PPP1CB; ITGB3
MicroRNAs in cancer
RHOA; Pdgfa&Pdgfb; PRKCG; MAP2K1; MMP16; PLAU; ROCK1; EZH2; ST14; TRP53
Colorectal cancer
FOS; BCL2; RAC3; DCC; RALGDS; KRAS; APPL1; MSH2; PIK3CG; SMAD4
Renal cell carcinoma
MAP2K2; PIK3CB; TCEB2; SOS1; PTPN11; PAK1; PAK3; RAF1; MAPK1; TGFB1
Pancreatic cancer
RELA; RAD51; AKT2; MAPK1; MAPK8; PLD1; PIK3R5; TGFBR1; SMAD4; KRAS
Endometrial cancer
SOS1; CCND1; KRAS; AXIN1; ERBB2; CASP9; GSK3B; MAPK1; ARAF; MLH1
Glioma
PDGFRB; PIK3CB; TRP53; MAP2K2; GRB2; SHC2; AKT1; MAPK1; MDM2; SHC4
Prostate cancer
TGFA; HRAS; SPINK1; PIK3R3; MAP4K1; CPN1; FGFR2; SMARCD1; INS2; Pdgfa&Pdgfb
Thyroid cancer
CCND1; CCDC6; CDH1; RXRB; NTRK1; KRAS; PPARG; MAPK3; NCOA4; MAP2K1
Melanoma
MAPK1; FGF1; HGF; PIK3CG; PDGFRA; FGF14; MET; Fgf15; CDH1; PTEN
Bladder cancer
TYMP; E2F1; DAPK3; MMP2; MAPK1; RASSF1; MMP9; CDH1; RAF1; SRC
Chronic myeloid leukemia
BCR; RAF1; STAT5A; TRP53; TGFB2; MECOM; RUNX1; SHC3; CDK6; PIK3CG
Acute myeloid leukemia
PIM2; RPS6KB2; MAPK3; NRAS; CHUK; PIK3CA; KIT; BRAF; PPARD; RPS6KB1
Non-small cell lung cancer
PLCG2; PIK3R2; RXRB; RB1; PRKCA; AKT1; TRP53; ERBB2; FOXO3; TGFA
Central carbon metabolism in cancer
TP53; HRAS; PFKL; PDGFRA; NRAS; PIK3CA; PGAM1; PGAM2; SLC7A5; ERBB2
Choline metabolism in cancer
MAPK8; CHKB; RAC2; PDGFD; MAP2K2; DGKG; WASF3; RAC1; SLC5A7; SLC22A3

Protein Function

Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SKIV2L2; AKT3A; TTLL4; FYN; NUBPL; PRKG1; ZRANB3; PRKCDA; CAMKK1; CSNK1A1
Function MAP kinase kinase activity
Related Protein MAP2K6; MAP2K1; MAP2K2; MAPKAPK5; MAPK14; MAPK10; MAP3K20; MAP2K2B; SBK3; ALPK2
Function Ras GTPase binding
Related Protein SH3BP4; RAPGEF4; CIB1; RAP1A; MAP2K1; MAPKAP1; SPHK2; RGL3; MLLT4; RAPGEF6
Function mitogen-activated protein kinase kinase kinase binding
Related Protein CDC37; DUSP19; MAPK1; STK38; MAP4K2; MAPK9; TRAF2; MARVELD3; MAPK8IP3; PPEF2
Function protein C-terminus binding
Related Protein FIGN; AP2A1; ID1; FOXN3; CLIC6; SNF8; YWHAB; SHANK3; MLLT4; CITED1
Function protein N-terminus binding
Related Protein KCNIP2; GTF2H2; LACRT; GLRX; ID1; MAP2K1; PDLIM5; ERCC2; NFE2; UNC13A
Function protein binding
Related Protein DCLRE1B; EFS; PARD6B; SEC13; KLK6; NUP98; CEBPA; MED10; FGF1; RNF113A
Function protein kinase activity
Related Protein MAPK8B; PRKACAB; IRAK1; PRKACBB; BMPR2B; TGFBR1; SRPK1B; ZNF143B; PRKCD; PAK2
Function protein serine/threonine kinase activator activity
Related Protein STK4; CALM3; CALM1; PARP16; CALM2; STK3; SPRY2; IGF2; CDK5R1; ALS2
Function protein serine/threonine kinase activity
Related Protein MAPK12; CAMKK1B; EIF2AK3; SIK2A; STK32C; ACVR2AA; BMPR1A; HIPK3; MAP4K4; MELK
Function protein serine/threonine/tyrosine kinase activity
Related Protein TNK2; AURKA; AURKB; CLK2; TESK1; ACVR2B; DYRK1B; RPS6KA1; TESK2; DSTYK
Function protein tyrosine kinase activity
Related Protein TTK; ERBB2; EPHB2; IGF1R; KDRL; EGFRA; EPHB4A; TNK2B; PTK7; KIT
Function receptor signaling protein tyrosine phosphatase activity
Related Protein MAP2K1

Interacting Protein

Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.
BRAF