map2k1
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  • Official Full Name
  • mitogen-activated protein kinase kinase 1
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Cat.#:MAP2K1-175HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1, GST-tagged
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Cat.#:MAP2K1-167HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human v protein, MYC/DDK-tagged
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Cat.#:MAP2K1-2568HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K1, His-tagged
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Cat.#:MAP2K1-299HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His/MBP-tagged
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Cat.#:MAP2K1-300HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His/MBP-tagged
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Cat.#:MAP2K1-343HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAP2K1
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Cat.#:MAP2K1-596HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP2K1, His-tagged
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Cat.#:MAP2K1-62HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MAP2K1 protein, Flag-tagged, Biotinylated
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Cat.#:MAP2K1-639HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His-tagged
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Cat.#:Map2k1-1032MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k1 protein, GST-tagged
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Cat.#:Map2k1-1350MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Map2k1, His & GST tagged
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Cat.#:MAP2K1-483MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K1, Gly & Pro tagged
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Cat.#:Map2k1-666MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k1, GST-tagged
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Cat.#:MAP2K1-3559RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP2K1 Protein
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Cat.#:MAP2K1-2663RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP2K1 Protein, His-tagged
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Cat.#:MAP2K1-1266CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP2K1
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Cat.#:MAP2K1-12591ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAP2K1
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Cat.#:MAP2K1-1033HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
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Cat.#:MAP2K1-1034HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
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Cat.#:MAP2K1-1035HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged
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Cat.#:Map2k1-1032HTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
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Cat.#:MAP2K1-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K1 cell lysate
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Cat.#:Kit-1614Tag:
Source (Host):Species:
Product nameMEK1 Kinase Binding Assay Kit
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Involved Pathway

Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
AKT1; ARR3B; MAPK6; TGFB1A; NFKB1; FGFR1; PDGFA; Fasl; FGF2; PTPRR
ErbB signaling pathway
PIK3R3; BTC; MAP2K4; ERBB2; MAPK8; ARAF; PIK3CB; ERBB4A; KRAS; CAMK2B
Ras signaling pathway
IGF1R; PDGFC; CALM3; GNG12; VEGFC; INS2; REL; NGF; VEGFA; LOC608458
Rap signaling pathway
F2RL3; FARP2; MAPK1; KRAS; ITGB2; MAGI2; Kitl; PDGFB; FGF16; FGF4
cGMP-PKG signaling pathway
PIK3R3; PLCB2; NPR2; GNA12; MYLK; PPP3CC; AKT2; NFATC4; PPP3CA; NFATC2
cAMP signaling pathway
ATP1B4; PDE3A; GRIN3A; RRAS2; HCAR2; GRIA1; PRKACA; CNGA2; ATP2A2; LOC100328615
Chemokine signaling pathway
IKBKB; CDC42; CCR9; CXCL1; Ccl21a; ITK; CCL22; CCL19; CXCR4; PPBP
HIF- signaling pathway
HK1; EGLN1; IFNGR2; EP300; PLCG1; ENO3; MKNK1; ARNT; EIF4E1B; PIK3R2
FoxO signaling pathway
PRKAA1; HOMER1B; MAPK10; RAG1; STK4; G6PC3; FOXO6; FBXO25; MAP2K2B; HOMER1
Sphingolipid signaling pathway
PPP2R3C; KRAS; PRKCA; ABCC1; AKT1; MAP2K2; PLCB2; PIK3R5; MAPK10; MAP3K5
Phospholipase D signaling pathway
FCER1A; PLA2G4C; AKT1; GRM3; TSC2; AGTR1A; PTK2B; PIP5K1C; PDGFC; PLA2G4A
Oocyte meiosis
AURKA; YWHAE1; PPP3R2; SMC1B; CPEB2; MAD2L1; CAMK2B1; ANAPC5; CALM4; MOS
PIK-Akt signaling pathway
KLK1B4; IFNA10; FIGF; RHEB; ITGB5; RAF1; LPAR5; ITGA3; YWHAE; BCL2L1
Vascular smooth muscle contraction
PLA2G4D; MYH11; MLCK2; PPP1R12B; PLA2G1B; PRKACAB; MYL6B; CALM4; PLCB2; GNA11
Dorso-ventral axis formation
PPP1R2P9; FMN2; PIWIL2; SOS1; GRB2; SPIRE2; NOTCH2; PIWIL1; NOTCH1; MAPK3
VEGF signaling pathway
MAPK14B; SH2D2A; MAPKAPK3; RAF1; HSPB1; RAC3B; PRKCG; AKT2L; MAPK12B; PPP3R1B
Osteoclast differentiation
LILRA1; NCF2; IFNG; MAPK9; NFKBIA; SOCS3; RELA; SIRPB1; MAP2K6; MAP2K7
Focal adhesion
RAPGEF1; PXN; MYLK3; FYNA; RAP1AB; ACTB2; PIK3R3A; TNK1; MAPK6; MAPK1
Gap junction
TJP1; PDGFA; GJA1; GRM5; TUBA3E; MAPK1; GJD2; TUBA8; MAP2K1; GNA11A
Signaling pathways regulating pluripotency of stem cells
WNT5A; AKT2; ONECUT1; INHBC; ESX1; WNT9A; NODAL; INHBB; WNT3; GSK3B
Toll-like receptor signaling pathway
AKT3A; PIK3R3; IFNA12; IFNA8; CXCL8B.3; MAPK9; IFNA5; PIK3R3A; NFKBIA; STAT1
Natural killer cell mediated cytotoxicity
BRAF; FYN; VAV2; KLRC4-KLRK1; IFNA14; IFNA5; ICAM2; VAV3; PPP3R1; Casp3
T cell receptor signaling pathway
PAK3; CARD11; PIK3CA; PPP3CC; MAPK11; PDPK1; HRAS; CBLB; CBLC; PTPRC
B cell receptor signaling pathway
NRAS; PRKCB; ITK; PIK3R2; CDK2; CMTM3; PIK3R1; DOK3; TTC6; AKT1
Fc epsilon RI signaling pathway
PIK3R3; MAPK11; MAPK13; PIK3CA; FCER1A; AKT1; VAV2; PIK3CG; PIK3R1; SOS1
Fc gamma R-mediated phagocytosis
MAPK1; FCGR2B; AKT2; PRKCE; PPAP2B; PTPRC; RAC1; PIP5K1A; PIP5K1B; RPS6KB2
TNF signaling pathway
FOS; TNFAIP3; CXCL10; Ccl12; CXCL3; PIK3CA; SOCS3; CREB3L2; PIK3R2; CREB3L3
Long-term potentiation
PLCB3; PPP3R1; PPP1R1A; CALM1; RAP1B; KRAS; CALML3; CAMK2B; PLCB4; PRKACA
Neurotrophin signaling pathway
IRAK1; GRB2; MAPK9; TP53; AKT2; HRAS; PIK3CD; RAC1; PIK3CG; BAD
Cholinergic synapse
SLC5A7; FYN; CAMK2A; GNG3; GNG4; PRKACA; GNA11; CREB3; PLCB3; GNAI3
Serotonergic synapse
Casp3; GNB1; PLA2G4D; CYP2J6; GNG5; ITPR3; GNB3; PLCB1; PLCB4; CYP2C70
Long-term depression
GNA11; NOS1; GNAS; PPP2R1B; GNAI1; IGF1; MAP2K1; PLA2G4C; GUCY1B3; GRID2
Regulation of actin cytoskeleton
PIP5KL1; PPP1CC; ITGA10; ITGA6; RAC1A; KRAS; MYLK3; RAC1B; MAP2K2B; CD14
Insulin signaling pathway
PRKACA; SOCS3; PHKG2; FOXO1; MAP2K2; CALM3B; TRIP10; CALM3; IKBKB; INS2
GnRH signaling pathway
MAP2K2B; MAP2K7; MAP2K6; FSHB; MAPK14A; MAPK14B; PLCB1; PRKACA; MMP14; CALM3
Progesterone-mediated oocyte maturation
CDC25C; FZR1A; MAPK10; MAD2L1; MAD1L1; MAD2L2; GNAI3; ANAPC4; MAPK8; PIK3CG
Estrogen signaling pathway
PIK3R3; PRKCD; CREB3L2; KCNJ5; SRC; PRKACA; ITPR3; CALM4; KCNJ6; AKT2
Melanogenesis
FZD3B; WNT11R; WNT9B; CALML3; RAF1A; Fzd4; PLCB1; PRKACBA; CREB3L1; EDNRBA
Prolactin signaling pathway
NFKB1; MAPK9; SOCS7; MAP2K1; HRAS; PIK3CB; STAT5B; SOCS6; SIRPA; SRC
Thyroid hormone signaling pathway
RXRB; DIO2; MED17; MAP2K2; ATP1A4; MED12; HRAS; SLC16A2; PIK3CA; MTOR
Oxytocin signaling pathway
PRKACB; PRKAA2; CACNG4; NFATC1; CAMK1D; PLA2G4D; MYL9; PPP1CA; CACNB2; PPP3CC
Prion diseases
NCAM2; C1QC; MAP2K1; C6; C5; Hc; IL1B; SOD1; IL1A; BAX
Alcoholism
HIST1H2BD; HIST1H2BH; HDAC2; GNAO1; TH; CAMKK1; GM14482; GNG3; MAP2K1; HIST3H3
Hepatitis B
MMP9; MAPK3; STAT5A; EP300; CASP10; CCNA1; CCND1; IFNB1; HRAS; IFN-a
Influenza A
TRIM25; NXF1; CXCL10; EIF2AK4; EIF2AK3; HLA-DRB3; IFNG; MAPK10; ICAM1; IRAK4
Pathways in cancer
AGTR1B; CBLB; TGFB1; VEGFB; TFG; BCR; MMP1A; NKX3; FN1; NKX3-1
Proteoglycans in cancer
PTPN6; PLAU; TGFB2; ANK1; Fzd4; FGF2; ITGAV; ERBB2; TLR4; WNT7B
MicroRNAs in cancer
FSCN1; PDGFA; WNT3; IRS2; BMI1; TNC; SERPINB5; SOX4; GLS2; PTEN
Colorectal cancer
SMAD2; PIK3R5; AXIN2; CCND1; MAPK3; PIK3CD; TGFBR2; TRP53; MAP2K1; MAPK8
Renal cell carcinoma
PAK7; GRB2; VHL; ARAF; FH; PIK3R2; TGFB3; PDGFB; TGFA; CDC42
Pancreatic cancer
RAC3; RAF1; TRP53; NFKB1; TGFB2; MAPK1; PIK3CB; SMAD4; TGFBR1; RALB
Endometrial cancer
TCF7; NRAS; AKT1; PIK3R3; PIK3R2; APC; TCF7L2; RAF1; PIK3R1; FOXO3
Glioma
MAP2K1; ARAF; GRB2; MAPK3; MDM2; SHC2; PTEN; Pdgfa&Pdgfb; SOS1; PIK3CG
Prostate cancer
MAP2K2; RB1; SMARCD1; GSTP1; ERBB2; SMARCA4; CCNE2; TCF7L2; FGFR2; MAP4K1
Thyroid cancer
LEF1; NCOA4; TFG; HRAS; RET; NTRK1; TCF7L2; CCND1; TPR; MAPK3
Melanoma
BRAF; FGF3; PDGFRA; FGF6; PIK3CB; FGF1; FGF5; TP53; IGF1; ARAF
Bladder cancer
UPK3A; E2F2; ARAF; MMP9; E2F1; RB1; DAPK3; MAPK1; FGFR3; MAP2K1
Chronic myeloid leukemia
GRB2; PIK3CB; BAD; CBL; AKT2; RUNX1; MDM2; STAT5B; PIK3CG; BCR
Acute myeloid leukemia
PIK3R3; CCND1; IKBKG; BAD; CEBPA; RAF1; KIT; PIM1; ARAF; KRAS
Non-small cell lung cancer
PDPK1; RXRA; TRP53; AKT2; ARAF; SOS1; RAF1; PIK3R5; MAPK3; AKT1
Central carbon metabolism in cancer
TP53; PKM; GLS; HK2; PIK3CB; PDHA2; MET; IDH1; PFKM; SLC1A5
Choline metabolism in cancer
PPAP2C; PLA2G4F; WASL; Pdgfa&Pdgfb; PCYT1A; PRKCG; SLC44A1; MAPK3; RAF1; RAC1

Protein Function

Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PRKACBB; WEE1; DGKQ; RUVBL1; MSH5; UBE2J1; ACOT12; FIGNL2; PRKG1A; PSMC3
Function MAP kinase kinase activity
Related Protein MAP2K3; SBK3; MAP2K1; MAPKAPK5; MAPK14; MAP3K9; MAP2K7; LRRK2; MAP2K2B; ALPK2
Function Ras GTPase binding
Related Protein RAP1GAP; MAPKAP1; RASGRP3; MAP2K1; SPHK2; RAPGEF4; RAPGEF6; MLLT4; SH3BP4; PLCE1
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAP4K2; TCF3; PPEF2; MARVELD3; CDC37; TRAF2; TRAF6; STK38; MAPK8IP3; MAP3K11
Function protein C-terminus binding
Related Protein BLOC1S2; PEX26; ITPR1; NPAT; FBLN1; CACNA1B; MED12; SREBF2; PEX10; PEX12
Function protein N-terminus binding
Related Protein RPA2; EXOC4; PPP1CC; DCTN4; MNAT1; TP53; PEX19; LACRT; ACTN4; ACOX1
Function protein binding
Related Protein NOG; APBB1IP; RWDD2B; KL; FOXD3; RCN2; O3far1; C1orf38; PRSS2; ZFHX3
Function protein kinase activity
Related Protein NLK; NIM1; MYO3A; Fert2; STK25A; RIPK4; CAMKK1B; PKN3; PLK1; DCLK1
Function protein serine/threonine kinase activator activity
Related Protein CDK5R1; IGF2; FAM20A; STRADA; CAB39; ALS2; MAP2K2; STK3; STK4; PARP16
Function protein serine/threonine kinase activity
Related Protein MARK2; MAPKAPK2; SQSTM1; CAMK2G1; NEK1; CDC7; RIPK3; STK11; AKT2L; OXSR1A
Function protein serine/threonine/tyrosine kinase activity
Related Protein DYRK2; AKT1; TNK2; PRKAA2; DYRK1A; SGK1; MAP2K1; CLK2; CLK4; PRKCG
Function protein tyrosine kinase activity
Related Protein Fert2; MATK; EPHA4A; FGFR1; KITA; Aatk; NTRK3A; FYN; EPHB4B; ABL1
Function receptor signaling protein tyrosine phosphatase activity
Related Protein MAP2K1

Interacting Protein

Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.
BRAF