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Official Full Name mitogen-activated protein kinase kinase 1
Background The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Synonyms MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Map2k1-3920M Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MAP2K1-1033H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged Sf9 Insect Cell GST
    Human MAP2K1-1034H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
    Human MAP2K1-1035H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged Sf9 Insect Cell His
    Human MAP2K1-167H Recombinant Human v protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K1-175H Recombinant Human MAP2K1, GST-tagged E.coli GST
    Human MAP2K1-2568H Recombinant Human MAP2K1, His-tagged Insect Cell His
    Human MAP2K1-299H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K1-300H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K1-343H Recombinant Human MAP2K1 Mammalian Cell His
    Human MAP2K1-596H Recombinant Human MAP2K1, His-tagged Sf9 Insect Cell His
    Human MAP2K1-62H Recombinant Human MAP2K1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human MAP2K1-639H Recombinant Human MAP2K1 protein, His-tagged E.coli His
    Mouse MAP2K1-001MCL Recombinant Mouse MAP2K1 cell lysate Insect Cell N/A
    Mouse Map2k1-1032H Recombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
    Mouse Map2k1-1032M Recombinant Mouse Map2k1 protein, GST-tagged E.coli GST
    Mouse Map2k1-1350M Recombinant Mouse Map2k1, His & GST tagged Insect Cell His/GST
    Mouse MAP2K1-483M Recombinant Mouse MAP2K1, Gly & Pro tagged Insect Cell His
    Mouse Map2k1-666M Recombinant Mouse Map2k1, GST-tagged E.coli GST
    Rat MAP2K1-3559R Recombinant Rat MAP2K1 Protein Mammalian Cell His
    Rhesus Macaque MAP2K1-2663R Recombinant Rhesus monkey MAP2K1 Protein, His-tagged Mammalian Cell His
    Chicken MAP2K1-1266C Recombinant Chicken MAP2K1 Mammalian Cell His
    Zebrafish MAP2K1-12591Z Recombinant Zebrafish MAP2K1 Mammalian Cell His
    Kit-1614 MEK1 Kinase Binding Assay Kit N/A

    Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF20; MAPK11; BDNF; PAK2A; PPP3CCA; NRAS; FGF19; Fasl; MEF2C; RAC1
    ErbB signaling pathway GRB2B; HRASA; SOS1; PRKCG; ARAF; RPS6KB1; SHC4; NCK1; CDKN1BA; PAK2
    Ras signaling pathway MRAS; FGF16; ABL2; CALML5; RALGDS; FIGF; GNG7; BAD; PIK3CD; PLD1
    Rap signaling pathway PDGFB; FLT4; CALM1; PFN3; F2R; VAV2; FGFR3; MAGI1; FIGF; PLCB4
    cGMP-PKG signaling pathway CREB3L1; ATP1B2; SLC25A6; VDAC2; VDAC1; GUCY1A3; PIK3R5; PPP1CB; NFATC1; ROCK1
    cAMP signaling pathway GABBR2; ATP2A2; NFATC1; FOS; PIK3R1; TNNI3; GPR119; GRIA3; PPP1CA; MC2R
    Chemokine signaling pathway CCL7; CCL28; AMCF-II; Ccl21c; BRAF; MAPK1; CCR8; CCL3L3; GRK7; ARRB2
    HIF- signaling pathway AKT1; IFNGR1; HK1; MKNK1; MAPK1; RPS6KB2; PIK3R1; TCEB2; ANGPT4; Il6ra
    FoxO signaling pathway PIK3R3; BNIP4; GRM1; TGFBR1B; PRKAB1A; PLK4; GADD45G; MAPK8; AKT1; ATG12
    Sphingolipid signaling pathway TRADD; PLCB1; GNA12; SPTLC2; SPHK2; AKT1; RAC1; TRAF2; MAPK13; S1PR2
    Phospholipase D signaling pathway SYK; PDGFRB; PIK3CD; KRAS; PLCB4; PRKCA; PLA2G4C; INS2; PIK3R3; PLA2G4D
    Oocyte meiosis CDC20; ANAPC13; CUL1; ANAPC11; SGOL1; REC8B; Adcy4; ANAPC1; CPEB3; ADCY1B
    PIK-Akt signaling pathway LAMB1; IL4R; ITGA9; GNG8; GNGT2; GNGT1; MET; FGF5; PDGFC; IGF1
    Vascular smooth muscle contraction CACNA1D; ADORA2AB; PPP1CC; PLA2G10; AGTR1A; GNA15.4; CACNA1DA; PRKCB; MYLK4; RHOA
    Dorso-ventral axis formation CPEB1B; NOTCH4; ETV6; PPP1R2P9; CPEB4; SPIRE1A; CPEB3; NOTCH1B; EGFRA; KRAS
    VEGF signaling pathway MAPKAPK2; AKT3A; PRKCG; PTGS2B; NRAS; CDC42L2; PRKCBA; PTGS2; RAF1; PIK3R3
    Osteoclast differentiation FCGR1; MAPK1; TGFB1; NOX1; ITGB3; MAPK11; PIK3CD; AKT1; FHL2; IFNAR2
    Focal adhesion PTEN; FN1A; SRMS; SEPP1; HRASA; COL27A1B; ACTN3B; RHOA; RAC1B; RAC1A
    Signaling pathways regulating pluripotency of stem cells WNT5A; BMI1; WNT7A; ACVR2B; RAF1; NRAS; MYF5; FZD9; MAPK12; OTX1
    Toll-like receptor signaling pathway IRAK4; STAT1B; IFNA3; MAP2K4A; MAP2K6; AKT2; MAP2K4B; CD80; MAPK12A; TAB2
    Natural killer cell mediated cytotoxicity VAV1; VAV2; CD48; NCR2; PIK3CA; NFATC1; Raet1c; KIR3DL1; PIK3R1; IFNA2
    T cell receptor signaling pathway AKT1; MAP2K1; NFATC2; CBL; MAP3K7; HRAS; CD40LG; DEF6A; IKBKB; CD3E; CD3D
    B cell receptor signaling pathway PPP3CA; ARPC1B; STAP1; CARD11; BLK; KRAS; PRKCB; CDK7; BCL10; CTNNB2
    Fc epsilon RI signaling pathway RAC2; AKT2; LYN; PLA2G4B; PIK3R2; MAP2K7; PLCG2; IL5; RAC3; RAF1
    Fc gamma R-mediated phagocytosis PTPRC; FCGR3A; WASF3; INPPL1; PIK3R2; SYK; PLA2G4D; FCGR1A; PIK3CD; ARPC1A
    TNF signaling pathway CXCL1; BCL3; BAG4; MAPK3; MAPK12; MAPK13; PIK3R5; TRAF5; MAP3K7; TNFAIP3
    Long-term potentiation GRIN1; PRKCA; PRKACG; PLCB3; MAP2K2; PRKCG; CAMK2A; CAMK2G; RAP1A; RAP1B
    Neurotrophin signaling pathway TP53; PIK3R1; NFKB1; PIK3R5; BAX; PIK3CA; CAMK4; KRAS; RPS6KA6; IKBKB
    Cholinergic synapse KCNJ4; ATF4; Adcy4; CAMK4; BCL2; CHRM5; CHAT; PLCB2; CREB5; GNG3
    Serotonergic synapse HTR1E; GNG5; ITPR1; ALOX5; CYP2D10; KCND2; ALOX12B; TRPC1; MAP2K1; GNGT1
    Long-term depression ARAF; PRKCB; PLA2G4F; NRAS; GNAI2; PRKG2; PLA2G4A; GRM1; MAP2K1; GNA12
    Regulation of actin cytoskeleton FGFR2; MYL9B; PIP5KL1; ITGA7; F2; MYLPF; PIP5K1BA; EZR; MYL2; ARHGEF1
    Insulin signaling pathway PYGMA; MAPK9; MAP2K2; HK2; PTPRF; RHOQ; PRKAG1; EIF4E2RS1; PIK3R1; INSRB
    GnRH signaling pathway PRKCA; MAPK8B; MAPK11; MAPK12B; EGFRA; GNA15.4; LHB; RAF1B; KRAS; CAMK2B1
    Progesterone-mediated oocyte maturation ANAPC1; MAPK14A; ANAPC5; RPS6KAL; Adcy4; ARAF; PIK3CD; PRKACAB; MAPK11; MAPK8B
    Estrogen signaling pathway Adcy4; ATF4; FOS; GNAO1; HSPA1L; MMP9; PLCB2; SOS1; HSPA1A; MAP2K2
    Melanogenesis CALM1B; FZD1; WNT1; GNA11A; CREB3L3A; LEF1; CALM2; FZD9B; CAMK2G1; RAF1
    Prolactin signaling pathway MAPK8; SRC; ESR1; PIK3R2; SOCS2; NRAS; LHB; INS2; AKT1; SLC2A2
    Thyroid hormone signaling pathway ATP1B3; RCAN2; MTOR; DIO1; TP53; PIK3R2; THRA; ATP1A3; KAT2A; SLCO1C1
    Oxytocin signaling pathway NFATC4; PLA2G4F; PIK3R3; CAMK2G; MYLK2; PIK3CD; CALM3; PPP3CA; GNAQ; CACNB1
    Prion diseases PRKACB; CCL5; HSPA5; NCAM2; LOC100033925; HSPA1A; C5; MAP2K2; IL1A; LAMC1
    Alcoholism GNB5; HIST1H3I; SLC6A3; HIST1H3F; CALM4; GNG12; HIST1H2BP; GNB4; HIST1H4G; HDAC5
    Hepatitis B MAPK3; TICAM2; Fasl; IL6; IFN-a; HSPG2; STAT4; DDB2; IRF7; EP300
    Pathways in cancer BRAF; GLI2; FGF8; TCF7; PTGS2; ITGB1; WNT3A; IKBKG; STAT1; GNG12
    Proteoglycans in cancer FZD10; FN1; SOS1; PPP1R12A; ROCK2; DROSHA; FAS; MRAS; WNT3; CAMK2A
    MicroRNAs in cancer BRCA1; BMI1; SLC7A1; WNT3A; SOS1; CD44; TRP63; CDCA5; TPM1; MET
    Colorectal cancer AKT2; Casp3; BAD; BIRC5; PIK3CD; RALGDS; PIK3CA; MAPK1; RHOA; MLH1
    Renal cell carcinoma VHL; AKT1; KRAS; SLC2A1; EGLN1; PIK3CB; ARNT2; TCEB2; NRAS; MET
    Pancreatic cancer MAPK10; RELA; BCL2L1; RAC1; RAC2; ARHGEF6; BRCA2; PIK3CA; RAC3; PIK3R3
    Endometrial cancer TCF7; PIK3CA; APC; CTNNA3; PIK3R1; ARAF; CCND1; GRB2; MAPK1; ELK1
    Prostate cancer MAP2K1; AKT1; Pdgfa&Pdgfb; PDGFA; TCF7; AKT2; NKX3-1; ACTL6B; CASP9; RB1
    Thyroid cancer RXRG; CCDC6; MAP2K1; HRAS; RXRB; MAP2K2; TP53; BRAF; PPARG; CCND1
    Bladder cancer MMP1; NRAS; E2F1; TRP53; DAPK3; KRAS; TP53; CDH1; SRC; BRAF
    Chronic myeloid leukemia BCR; NFKB1; BAD; AKT2; TGFB3; BCL2L1; SHC2; NRAS; TP53; PIK3R1
    Acute myeloid leukemia STAT3; RELA; KRAS; SFPI1; ZBTB16; PIK3CB; MTOR; BAD; AKT3; PIK3R2
    Non-small cell lung cancer RXRA; CCND1; PIK3R1; PIK3CA; KRAS; PIK3CD; PIK3CG; HRAS; ERBB2; GRB2
    Central carbon metabolism in cancer MAP2K2; FGFR3; MAPK3; IDH1; PDHB; PIK3R5; RET; SLC16A3; AKT2; HK1
    Choline metabolism in cancer EGF; PDPK1; PDGFB; PLCG1; PLA2G4A; PIK3R1; PDGFA; NRAS; PIK3CG; RALGDS

    Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activity MAP3K14; MAP2K2A; PAK3; MAP2K2; ALPK2; MAP2K2B; MAP2K1; MAP3K9; MAPKAPK5; MAP2K3
    mitogen-activated protein kinase kinase kinase binding STK38; TRAF2; CDC42; MAP3K11; MAPK1; TRAF6; MAPK9; MAP4K2; MARVELD3; MAP2K1
    protein C-terminus binding ATXN2; MAP2K1; PDZD3; VTA1; SAE1; KPNA3; PHB2; PABPC1; SDC1; AXIN1
    protein N-terminus binding HESX1; DCTN4; VWF; UNC13A; HDAC1; MNAT1; ATM; STX1A; PEX19; RND2
    protein binding PSPC1; DNASE1; HNRNPL; TBXAS1; RUFY3; TMEM203; ARL6IP1; SHOX; TGOLN2; TAF15
    protein kinase activity IKBKAP; PKN1B; FGFR1B; NRBP2; TAOK1; PTK2BB; GRK1A; CSNK1G2B; MAP2K4B; TLK1B
    protein serine/threonine kinase activator activity STRADA; CALM3; FAM20A; IGF2; CAB39; ALS2; SPRY2; STK4; CALM1; MAP2K2
    protein serine/threonine kinase activity PKN1B; LIMK2; DAPK3; SNRK; EIF2AK2; KSR2; PLK2; BMPR2A; NLK; MAP3K10
    protein serine/threonine/tyrosine kinase activity PRKAA2; AURKC; ACVR2B; RPS6KB1; TESK2; DSTYK; RPS6KA2; AKT1; TNK2; PRKCG
    protein tyrosine kinase activity KITA; FGFR3; ROS1; EK1; TTK; AXL; ZAP70; FGR; IGF1RA; MAP2K6
    receptor signaling protein tyrosine phosphatase activity MAP2K1

    Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.


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