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Recombinant Full Length Human MAP2K1 Protein, C-Flag-tagged

Cat.No. : MAP2K1-234HFL
Product Overview : Recombinant Full Length Human MAP2K1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 43.3 kDa
AA Sequence : MPKKKPTPIQLNPAPDGSAVNGTSS AETNLEALQKKLEELELDEQQRKRL EAFLTQKQKVGELKDDDFEK ISELGAGNGGVVFKVSHKSSGLVMA RKLIHLEIKPAIRNQIIRELQVLHE CNSPYIVGFYGAFYSDGEIS ICMEHMDGGSLDQVLKKAGRIPEQI LGKVSIAVIKGLTYLREKHKIMHRD VKPSNILVNSRGEIKLCDFG VSGQLIDSMANSFVGTRSYMSPERL QGTHYSVQSDIWSMGLSLVEMAVGR YPIPPPDAKELELMFGCQVE GDAAETPPRPRTPGRPLSSYGMDSR PPMAIFELLDYIVNEPPPKLPSGVF SLEFQDFVNKCLIKNPAERA
DLKQLMVHAFIKRSDAEEVDFAGWL CSTIGLNQPSTPTHAAGVTRTRPLE QKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protein Kinase
Protein Pathways : Acute myeloid leukemia, B cell receptor signaling pathway, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Oocyte meiosis, Pancreatic cancer, Pathways in cancer, Prion diseases, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Thyroid cancer, Toll-like receptor signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway
Gene Name : MAP2K1 mitogen-activated protein kinase kinase 1 [ Homo sapiens (human) ]
Official Symbol : MAP2K1
Synonyms : MEL; CFC3; MEK1; MKK1; MAPKK1; PRKMK1
Gene ID : 5604
mRNA Refseq : NM_002755.4
Protein Refseq : NP_002746.1
MIM : 176872
UniProt ID : Q02750

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there ongoing clinical trials targeting MAP2K1? 01/12/2023

Yes, there are clinical trials exploring the efficacy and safety of MAP2K1 inhibitors in various cancers and other diseases.

Are there diagnostic tests specifically targeting MAP2K1 in clinical practice? 01/10/2023

Some diagnostic tests may analyze MAP2K1 mutations, especially in the context of cancer, to inform treatment decisions.

What diagnostic applications does MAP2K1 have in cancer detection? 09/30/2019

MAP2K1 mutations can serve as biomarkers in cancer diagnostics, aiding in the identification and classification of tumors.

How does MAP2K1 contribute to drug resistance in cancer treatment? 06/14/2019

MAP2K1 mutations can be associated with resistance to certain cancer therapies, making it important to understand its role in treatment response.

Are there targeted therapies based on MAP2K1 in cancer treatment? 02/17/2016

Yes, MAP2K1 inhibitors are being explored as targeted therapies in cancer treatment, aiming to block the abnormal signaling associated with MAP2K1 mutations.

Customer Reviews (3)

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Reviews
08/01/2020

    The unmatched performance of the MAP2K1 protein in both ELISA assays and protein electron microscopy structure analysis showcases its versatility and reliability in various experimental settings.

    05/18/2016

      The MAP2K1 protein finds extensive utility in protein electron microscopy structure analysis.

      04/11/2016

        With its exceptional specificity and sensitivity, it enables precise and reliable detection of target molecules, making it a valuable tool in the field of diagnostic and research applications.

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