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Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged

Cat.No. : MAP2K1-1033H
Product Overview : Recombinant full-length human MAP2K1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Cat. No. : MAP2K1-1033H
Description : MAP2K1 is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MAP2K1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MAP2K1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Constitutive activation of MAP2K1 results in cellular transformation. Thus, MAP2K1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer.
Applications : Kinase Assay; Western Blot
Molecular Weight : 72 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 325 nmol/min/mg
Purity : > 95%
Concentration : 0.1 ug/ul
Sequences : Full-length
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Dorso-ventral axis formation; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prion diseases; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton
Functions : ATP binding; MAP kinase kinase activity; Ras GTPase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; receptor signaling protein tyrosine phosphatase activity; transferase activity
Gene Name : MAP2K1 mitogen-activated protein kinase kinase 1 [ Homo sapiens ]
Official Symbol : MAP2K1
Synonyms : MAP2K1; mitogen-activated protein kinase kinase 1; MEK1; MKK1; MAPKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); EC 2.7.12.2; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1
Gene ID : 5604
mRNA Refseq : NM_002755
Protein Refseq : NP_002746
MIM : 176872
UniProt ID : Q02750
Chromosome Location : 15q22.1-q22.33

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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