NOS3 Protein, nitric oxide synthase 3


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Official Full Name nitric oxide synthase 3
Background Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene. Endothelial NOS is a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscle contraction and platelet aggregation. A constitutive Ca2+ dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golgi bodies within cells.
Synonyms NOS3; Nitric oxide synthase 3 (endothelial cell); eNOS; ECNOS; Constitutive NOS; Endothelial NOS; EC-NOS; NOSIII; cNOS; NOS type III; EC; nitric oxide synthase, endothelial; OTTHUMP00000213183; OTTHUMP00000212826; OTTHUMP00000213184; OTTHUMP00000213185
    • Species :
    • Bovine
    • Cattle
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine NOS3-66B Recombinant bovine NOS3 Protein, His-tagged Insect Cell
    Human NOS3-1156H Recombinant Human NOS3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human NOS3-1206HCL Recombinant Human NOS3 cell lysate N/A
    Human NOS3-28567TH Recombinant Human NOS3 Wheat Germ N/A
    Human NOS3-5993H Recombinant Human NOS3 Protein, GST-tagged Wheat Germ GST
    Human NOS3-635H Recombinant Human Nitric Oxide Synthase 3 (Endothelial Cell) Sf9 Insect Cell N/A
    Human NOS3-7856H Recombinant Human NOS3 protein, His-tagged E.coli His
    Mouse NOS3-10787M Recombinant Mouse NOS3 Protein Mammalian Cell His
    Mouse Nos3-7857M Recombinant Mouse Nos3 protein, His-tagged E.coli His
    Rat NOS3-4025R Recombinant Rat NOS3 Protein Mammalian Cell His
    Rat Nos3-7860R Recombinant Rat Nos3 protein, His-tagged E.coli His
    Dog NOS3-7855D Recombinant Dog NOS3 protein, His & T7-tagged E.coli His/T7
    Cattle NOS3-7854C Recombinant Cattle NOS3 protein, His & T7-tagged E.coli His/T7
    Pig NOS3-7858P Recombinant Pig NOS3 protein, His-tagged E.coli His
    Pig NOS3-7859P Recombinant Pig NOS3 protein, His-tagged E.coli His

    NOS3 involved in several pathways and played different roles in them. We selected most pathways NOS3 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arginine biosynthesis GOT2A; OTC; CPS1; NOS2B; GLUD1A; GOT2; GLULC; GLULA; ACY1; GLS2
    Arginine and proline metabolism DAO1; Ckmm; ALDH4A1; ODC1; CKMT1; P4HA3; LAP3; DAO.3; CKMT2B; CNDP2
    Metabolic pathways ALDOCA; ACSS2; TALDO1; CSGALNACT1; AANAT1; MAN1B1; PLCZ1; GBGT1; ATP6V0A2B; ATP6V1C2
    Calcium signaling pathway TACR3; BDKRB1; PLCZ1; P2RX4A; CALML5; ADRA1BB; STIM2; CAMK4; CAMK2G; EDNRA
    cGMP-PKG signaling pathway ATP1A4; INS1; PRKCE; SLC25A4; PIK3CB; RAF1; NPR1; ATF4; MAP2K2; MYLK
    HIF- signaling pathway EP300; PDK1; ANGPT1; TFRC; IGF1; HK3; PRKCB; RBX1; LDHA; GAPDH
    Sphingolipid signaling pathway PRKCZ; PIK3R3; SGMS1; MAP3K5; CERS5; LASS4; LASS1; OPRD1; RHOA; LOC100328615
    PIK-Akt signaling pathway THBS2; IFNA5; MET; FGF18; ITGB7; FN1; CRTC2; GH1; IGF1; TCL1B
    Platelet activation BTK; PIK3R2; GP9; GUCY1A3; PRKACG; MYL12A; PIK3CG; FGB; ROCK1; PIK3R3
    Estrogen signaling pathway SP1; PRKACA; CREB3L2; GNAI3; PRKCD; KCNJ3; PIK3CA; AKT2; KCNJ9; GABBR1
    Oxytocin signaling pathway CALM2; MYL9; CACNB4; PIK3R2; PRKAB2; GNAO1; ACTG1; GNAI3; GNAS; KRAS
    Insulin resistance PRKAB1; PTPN11A; CD36; INS1; PTPRF; SLC27A5; PPP1R3CA; RPS6KA3B; PIK3R3B; PPP2R4

    NOS3 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS3 itself. We selected most functions NOS3 had, and list some proteins which have the same functions with NOS3. You can find most of the proteins on our site.

    Function Related Protein
    NADPH-hemoprotein reductase activity CYP2J6; NOS2A; POR; NOS3; NOS2B; NOS1; NDOR1; NOS2; MTRR
    actin monomer binding MKL1B; TWF1; TMSB; PKNOX2; PRKCE; PFN1; MYL3; TMSB15B; KLHL8; TMSB4X
    arginine binding NOS2; RARS; NOS3; NAGS; NOS1
    cadmium ion binding MT3; P2RX2; NOS3; NOS1; SLC11A2
    calmodulin binding NRGNA; TTN; MYH1B; ATP2B4; CALD1; MYH10; NOS2; TRPV4; KCNN1A; MYO10
    flavin adenine dinucleotide binding AIFM3; GFER; MAOA; MTHFR; ACAD8; DPYD; POR; ACOX2; ACAD11; DLDH
    heme binding GUCY1A3; CAT; CYP19A1A; NOS3; CYP2R1; CYP3A5; CYP2F2; CYP51A1; CYP4A11; CYP3A4
    iron ion binding TPH1; PDF; CYP2C70; ALOX15B; CYP2C54; CYP3A5; CYP2C38; AOX4; HBB-Y; CYP4A12A
    nitric-oxide synthase activity NOS1; NOS3; NOS2; NOS2A; NOS2B
    protein binding PSMD5; TH; ACSF2; CALM3; GPR85; SEPT2; PAGE2; POU2F1; C19orf40; DZIP1
    scaffold protein binding HOMER1; NCK2; NLGN4X; KRT18; CASP8; CACNA1G; SHANK1; TREM2; GRIN2A; NLGN1
    tetrahydrobiopterin binding TH; NOS1; NOS2; NOS3

    NOS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS3.

    NOSTRIN; AKT1; CDC37; tax; MAGEA11

    Piccoli, JCE; Manfredini, V; et al. Association between endothelial nitric oxide synthase gene polymorphism (-786T > C) and interleukin-6 in acute coronary syndrome. HUMAN & EXPERIMENTAL TOXICOLOGY 33:396-402(2014).
    Syeda, F; Hauton, D; et al. How ubiquitous is endothelial NOS?. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 166:207-214(2013).

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