park2
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  • Official Full Name
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • Background
  • The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
  • Synonyms
  • PARK2; PDJ; PRKN; AR-JP; LPRS2; parkin; parkinson protein 2, E3 ubiquitin protein ligase (parkin); E3 ubiquitin-protein ligase parkin; parkin 2; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; OTTHUMP00000017565; OTTHUMP00000017566; OTTHUMP00000017567; E3 ubiquitin ligase; parkinson disease protein 2; parkinson juvenile disease protein 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; EC 6.3.2.-
Cat.#:PARK2-1529HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PARK2, His-tagged
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Cat.#:PARK2-231HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PARK2, GST-tagged
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Cat.#:PARK2-30784THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PARK2
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Cat.#:PARK2-30785THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PARK2
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Cat.#:PARK2-332HTag:N/A
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PARK2 protein
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Cat.#:PARK2-420HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human parkin RBR E3 ubiquitin protein ligase, His-tagged
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Cat.#:PARK2-421HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PARK2 protein, His-tagged, Active
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Cat.#:PARK2-422HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PARK2 protein
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Cat.#:PARK2-5021HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PARK2, His-tagged
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Cat.#:PARK2-12362MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PARK2 Protein
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Cat.#:PARK2-4273RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PARK2 Protein
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Cat.#:PARK2-772CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PARK2 Protein, His-tagged
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Cat.#:PARK2-2405ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PARK2
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Cat.#:PARK2-3433HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PARK2 293 Cell Lysate
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Involved Pathway

PARK2 involved in several pathways and played different roles in them. We selected most pathways PARK2 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
PARK2; UBE2M; RHOBTB2A; UBE2Q2; CUL1; COP1; VHL; FBXW8; SIAH1; ANAPC11
Protein processing in endoplasmic reticulum
DNAJC5; UBE2E1; CAPN2; DERL1; CAPN2A; SKP1; HSP90AA1.2; SSR4; SEC24B; HSP70L
Parkinsons disease
ATP5B; PRKACB; MT-ATP6; VDAC2; NDUFV2; COX7A1; ATP5O; ATP5G3; LRRK2; NDUFC1

Protein Function

PARK2 has several biochemical functions, for example, F-box domain binding, G-protein coupled receptor binding, Hsp70 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARK2 itself. We selected most functions PARK2 had, and list some proteins which have the same functions with PARK2. You can find most of the proteins on our site.
Function
Related Protein
Function F-box domain binding
Related Protein PARK2
Function G-protein coupled receptor binding
Related Protein UCN3L; S1PR1; GNA12A; PPY; GNAI2B; S1PR2; PARK2; UTS2D; FCN1; GNA11B
Function Hsp70 protein binding
Related Protein GPR37; ST13; RPS3; PARK2; PPID; ERN1; C11orf73; CDK1; METTL21A; STIP1
Function PDZ domain binding
Related Protein KCNJ4; PTEN; PARK2; FZD7; DLC; Apba1; SLC26A6; SNTA1; F11R; DLG4
Function SH3 domain binding
Related Protein PTTG1; DNM2; ADAM9; WIPF3; DPYSL3; PLSCR3; CABYR; PTPN12; ENKUR; LYN
Function actin binding
Related Protein SPIRE1A; ABLIM1A; TPMA; MYRIP; ADD3; NF2A; SCIN; NF2B; MYBPC1; PLEKHH2
Function beta-catenin binding
Related Protein SOX9; NUMB; EP300; CD2AP; HDAC6; TRPC4; AXIN1; CXADR; TCF7L1A; C
Function chaperone binding
Related Protein HES1; DNAJA4; DNAJA3B; VWF; TBCC; BIRC5; DNAJB6; ATP1A2; TFRC; DLST
Function cullin family protein binding
Related Protein ANAPC11; RBX1; DCUN1D2B; DCUN1D4; TCHP; DCUN1D1; DCUN1D2A; DCUN1D2; DCUN1D5; CCDC22
Function enzyme binding
Related Protein AKIRIN2; CYP2C8; RAD9; PLCE1; ESR2; USF1; CLSTN2; SLC18A1; TSPAN33; TBP
Function heat shock protein binding
Related Protein DMPK; DNAJA4; DNAJA3; GPR37; DNAJA2L; DNAJA3A; HSPA9; TOMM34; CDC37; HSPA1B
Function histone deacetylase binding
Related Protein TRAF6; ZMYND15; YWHAB; PRDM1; ANKRA2; RBBP4; NRIP1; SIRT2; CAMTA2; SOD3
Function identical protein binding
Related Protein PTS; BAG2; NUFIP1; TARDBP; HGF; IK; TNF; BLOC1S6; PLEKHH2; C10orf88
Function kinase binding
Related Protein BCL10; UBQLN1; CHIA; TENC1; PRDX3; CHP1; HPCA; CDC37; BARD1; DLG4
Function ligase activity
Related Protein UBE2NB; RFFL; TRIM38; RNF40; RBX1; BIRC2; UBE2IA; HECW1; RNF135; SIAH2
Function phospholipase binding
Related Protein LMNB1; PRKCZ; CALM1; PARK2; ARHGAP6; CALM; PTPN11; PDPK1; SERPINB1A; CALM3
Function protein binding
Related Protein CBR2; TDRD9; FBXO9; INSIG2; FAM9A; SH3BP4; LRP2; USP12; PIAS3; MTIF3
Function protein kinase binding
Related Protein TRIB3; BCL10; SUFU; CALM2; CSPG4; TRIM22; MAP3K1; IKBKB; CACNB4; PPME1
Function tubulin binding
Related Protein BIRC5; EML2; STMN1B; STMN2B; RPS3; CENPJ; AGBL5; RITA1; STMN3; AGBL1
Function ubiquitin binding
Related Protein CRY2; HSPB1; FAN1; NSFL1C; UBR5; IWS1; PARK2; UBXN1; DYRK2; SMAD3
Function ubiquitin conjugating enzyme binding
Related Protein RNF19B; RNF180; RNF144B; SIAH2; PARK2; ARIH1; MARCH6; DCUN1D2B; TOLLIP; RNF19A
Function ubiquitin protein ligase activity
Related Protein HLTF; RNF115; G2E3; RNF14; RNF122; UBE2H; UBE2V2; C12orf51; HACE1; RNF24
Function ubiquitin protein ligase activity involved in ERAD pathway
Related Protein TMEM129; RNF185; TRIM25; PARK2; AMFR; STUB1; RNF5; SYVN1
Function ubiquitin protein ligase binding
Related Protein FZD5; VCL; TRP53; CUL3B; SMAD5; TCEB2; ARRB1; NDUFS2; ERBB2; SPOP
Function ubiquitin-protein transferase activity
Related Protein FBXL7; RLIM; MUL1A; PRP19; FBXO30B; UHRF1; FBXL21; TRIM9; MYLIP; FBXL14
Function ubiquitin-specific protease binding
Related Protein PARK7; PARK2; RAD23A; VPS24; CHMP3; DERL1; VCP; AMFR; SART3; SELS
Function zinc ion binding
Related Protein TRIM35-22; C11orf54; PHRF1; CHORDC1; APOBEC3D; SUV39H2; GALT; NR2E1; MATR3; RC3H2

Interacting Protein

PARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARK2.
PINK1; RANBP2