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Recombinant Human PARK2 protein, His-tagged, Active

Cat.No. : PARK2-421H
Product Overview : Recombinant full length Human PARK2 fused with His tag at N-terminal was expressed in Insect cells. Purified using immobilizedmetal affinity chromatography.
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Description : Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the a-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1.
Source : Insect cells
Species : Human
Tag : His
Form : In 50mM Tris/HCl pH7.5, 150mM NaCl, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Mass : 55 kDa
Purity : 91% by SDS-PAGE and Coomassie blue staining
Applications : For use in Enzyme Assays.
Notes : Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade.
Storage : Estimated to be stable for a minimum of 1 year at -70 centigrade from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Concentration : 1.214 mg/ml
Gene Name : PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) [ Homo sapiens ]
Official Symbol : PARK2
Synonyms : PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin); Parkinson disease (autosomal recessive, juvenile) 2, parkin; E3 ubiquitin-protein ligase parkin; AR JP; E3 ubiquitin ligase; parkin; PDJ; parkin 2; parkinson disease protein 2; parkinson juvenile disease protein 2; PRKN; AR-JP; LPRS2;
Gene ID : 5071
mRNA Refseq : NM_004562
Protein Refseq : NP_004553
MIM : 602544
UniProt ID : O60260
Chromosome Location : 6q25.2-q27
Pathway : Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem;
Function : PDZ domain binding; acid-amino acid ligase activity; chaperone binding; kinase binding; ligase activity; metal ion binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any other neurological disorders associated with PARK2 mutations? 05/13/2022

Besides Parkinson's disease, PARK2 mutations have been linked to other neurodegenerative disorders, expanding the clinical implications of studying this protein.

Can PARK2 protein be a target for drug development in Parkinson's disease? 02/27/2022

Yes, drug development efforts are underway to modulate PARK2 activity and enhance its neuroprotective functions as a potential therapeutic approach for Parkinson's disease.

In what ways does PARK2 protein research contribute to our understanding of mitochondrial dynamics in neurodegenerative diseases? 05/29/2020

PARK2 research provides crucial insights into the role of mitochondrial dynamics in neurodegenerative diseases, helping unravel the mechanisms underlying these disorders and paving the way for targeted therapies.

How can genetic testing for PARK2 mutations aid in personalized medicine for Parkinson's patients? 02/21/2020

Genetic testing can help identify individuals with PARK2 mutations, allowing for personalized treatment strategies tailored to their specific genetic profile.

How is PARK2 protein linked to the regulation of inflammation in the brain? 12/31/2019

PARK2 is implicated in controlling inflammation in the brain, and its dysfunction may contribute to neuroinflammatory processes observed in Parkinson's disease.

Customer Reviews (3)

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Reviews
04/18/2020

    Their expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.

    12/02/2016

      Their knowledgeable team is readily available to address any questions or concerns, guaranteeing a smooth experimental process.

      02/25/2016

        the manufacturer of PARK2 protein provides excellent technical support, ensuring prompt assistance and guidance.

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