ptges3
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  • Official Full Name
  • prostaglandin E synthase 3 (cytosolic)
  • Background
  • p23 is a highly conserved ubiquitous protein, known to have an important function as a co-chaperone for the Hsp90 chaperoning system. Studies have revealed that p23 is a small protein (18-25 kDa) with a simple structure. p23 does not have any structural homology with any other known proteins. p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with Hsp70, p54, and p50. p23 is a phospho-protein, which is highly acidic and has an aspartic acid-rich C-terminal domain. Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase, the heme-regulated kinase HRI, Hsf1 transcription factor, aryl hydrocarbon receptor, telomerase, and Hepadnavirus reverse transcriptase. In spite of several years of study, the exact functional significance of p23 is still not clear. p23 is identical to cytosolic prostaglandin E synthase (cPGES), converting PGH2 to PGE2 downstream of COX-1. p23 is also thought to be involved in the adenosine triphosphate-mediated Hsp90 binding of client proteins. Since many Hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis. Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
  • Synonyms
  • PTGES3; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; cPGES; p23; TEBP; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; u
Cat.#:PTGES3-2046HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGES3, His-tagged
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Cat.#:PTGES3-30051THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGES3
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Cat.#:PTGES3-30054THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGES3
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Cat.#:PTGES3-478HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prostaglandin E Synthase 3 (Cytosolic)
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Cat.#:PTGES3-818HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prostaglandin E Synthase 3 (Cytosolic), His-tagged
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Cat.#:PTGES3-13642MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTGES3 Protein
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Cat.#:PTGES3-829CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PTGES3 Protein, His-tagged
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Cat.#:PTGES3-3692RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTGES3 Protein, His-tagged
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Cat.#:PTGES3-4704CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTGES3
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Cat.#:PTGES3-2712HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PTGES3 293 Cell Lysate
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Involved Pathway

PTGES3 involved in several pathways and played different roles in them. We selected most pathways PTGES3 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Attenuation phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AhR pathway
EGFR; JUN; CYP1A1; CYP1B1; AHRR; CDC37; CYP1A2; PTGES3; AHR; AIP
Arachidonic acid metabolism
ALOX5B.3; GPX7; CYP2AD3; PLA2G6; GGT1; PTGES3B; CYP2C50; CBR3; ALOX8; CYP1A1
Attenuation phase
PTGES3; CREBBP; HSBP1B; HSBP1A; HSBP1
C20 prostanoid biosynthesis
PTGES3
Cellular response to heat stress
MAPKAPK2B; HSBP1B; NUP50; HSPH1; HSPA7; DNAJB6; NUPL2; C11orf73; KIAA1967; HSPA14
Cellular responses to stress
ULK1A; AMBRA1A; SUZ12; HIST4H4; WDR45; HIST1H1C; ATG7; TINF2; H1F0; DPF1
HSF1 activation
HSBP1; EEF1A1; PTGES3
HSF1-dependent transactivation
HSBP1B; HSBP1A; HSBP1; PTGES3

Protein Function

PTGES3 has several biochemical functions, for example, prostaglandin-E synthase activity, protein binding, telomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES3 itself. We selected most functions PTGES3 had, and list some proteins which have the same functions with PTGES3. You can find most of the proteins on our site.
Function
Related Protein
Function prostaglandin-E synthase activity
Related Protein PTGES2; PTGES3; PTGESL; PTGES
Function protein binding
Related Protein NDEL1; LSM7; HERPUD1; GRASP; SLC25A6; WDR92; POP5; AXIN2; CCDC103; H3F3A
Function telomerase activity
Related Protein UAP1L1; CTU1; PRIM2; DKC1; PTGES3; CCDC111; TERT
Function unfolded protein binding
Related Protein CLPXA; DNAJA4; DNAJB1A; SSUH2.2; RP2; AIP; HSP90AA1.1; CLGN; GRXCR2; TOMM20

Interacting Protein

PTGES3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES3.
HSP90AA1; HSP90AB1; IRS4; AGO2; vpu; EIF2C2; POLR3A; FBXO24; URI1; GH1

PTGES3 Related Articles

Eymard, F; Pigenet, A; et al. Induction of an Inflammatory and Prodegradative Phenotype in Autologous Fibroblast-like Synoviocytes by the Infrapatellar Fat Pad From Patients With Knee Osteoarthritis. ARTHRITIS & RHEUMATOLOGY 66:2165-2174(2014).
Sanchez, C; Gabay, O; et al. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. OSTEOARTHRITIS AND CARTILAGE 17:473-481(2009).