|Official Full Name||prostaglandin E synthase 3 (cytosolic)|
|Background||p23 is a highly conserved ubiquitous protein, known to have an important function as a co-chaperone for the Hsp90 chaperoning system. Studies have revealed that p23 is a small protein (18-25 kDa) with a simple structure. p23 does not have any structural homology with any other known proteins. p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with Hsp70, p54, and p50. p23 is a phospho-protein, which is highly acidic and has an aspartic acid-rich C-terminal domain. Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase, the heme-regulated kinase HRI, Hsf1 transcription factor, aryl hydrocarbon receptor, telomerase, and Hepadnavirus reverse transcriptase. In spite of several years of study, the exact functional significance of p23 is still not clear. p23 is identical to cytosolic prostaglandin E synthase (cPGES), converting PGH2 to PGE2 downstream of COX-1. p23 is also thought to be involved in the adenosine triphosphate-mediated Hsp90 binding of client proteins. Since many Hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis. Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.|
|Synonyms||PTGES3; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; cPGES; p23; TEBP; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; u|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PTGES3 involved in several pathways and played different roles in them. We selected most pathways PTGES3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|AhR pathway||CYP1A1; CYP1A2; PTGES3; NQO1; AIP; JUND; CDKN1B; JUN; AHR; CDKN1A|
|Arachidonic acid metabolism||CBR1L; CYP2C50; ALOX5A; PTGS2A; CYP2AD2; PLA2G4AA; GPX2; PLA2G1B; ALOX8; PLA2G4B|
|Attenuation phase||HSBP1; HSBP1B; PTGES3; CREBBP; HSBP1A|
|C20 prostanoid biosynthesis||PTGES3|
|Cellular response to heat stress||HSBP1; HSBP1B; NUPL2; ST13; DNAJC2; HSPA14; BAG5; HSPA12B; BAG3; KIAA1967|
|Cellular responses to stress||HIST1H1E; EGLN2; HBXIP; CDKN2B; BMI1A; RAD50; HIF3A; BMI1B; CDKN2A; CBX4|
|HSF1 activation||PTGES3; EEF1A1; HSBP1|
|HSF1-dependent transactivation||HSBP1A; HSBP1; HSBP1B; PTGES3|
PTGES3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES3 itself. We selected most functions PTGES3 had, and list some proteins which have the same functions with PTGES3. You can find most of the proteins on our site.
|prostaglandin-E synthase activity||PTGES; PTGES3; PTGESL; PTGES2|
|protein binding||MAP1LC3B; OBFC1; PDGFB; SPRTN; SLPI; ZFYVE27; AMOTL2; ALPP; VTI1B; LRRC47|
|telomerase activity||PRIM2; CCDC111; CTU1; PTGES3; DKC1; UAP1L1; TERT|
|unfolded protein binding||SPG7; PPIA; H2-KE2; TRAP1; DNAJA3B; NPM1; PDRG1; CCT7; DNAJB11; HSP90AA1.1|
PTGES3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES3.
HSP90AA1; HSP90AB1; IRS4; AGO2; vpu; EIF2C2; POLR3A; FBXO24; URI1; GH1