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Official Full Name prostaglandin E synthase 3 (cytosolic)
Background p23 is a highly conserved ubiquitous protein, known to have an important function as a co-chaperone for the Hsp90 chaperoning system. Studies have revealed that p23 is a small protein (18-25 kDa) with a simple structure. p23 does not have any structural homology with any other known proteins. p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with Hsp70, p54, and p50. p23 is a phospho-protein, which is highly acidic and has an aspartic acid-rich C-terminal domain. Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase, the heme-regulated kinase HRI, Hsf1 transcription factor, aryl hydrocarbon receptor, telomerase, and Hepadnavirus reverse transcriptase. In spite of several years of study, the exact functional significance of p23 is still not clear. p23 is identical to cytosolic prostaglandin E synthase (cPGES), converting PGH2 to PGE2 downstream of COX-1. p23 is also thought to be involved in the adenosine triphosphate-mediated Hsp90 binding of client proteins. Since many Hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis. Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
Synonyms PTGES3; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; cPGES; p23; TEBP; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; u
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PTGES3-2568H Recombinant Human PTGES3 Protein (1-160 aa), His-tagged Yeast His
    Human PTGES3-2046H Recombinant Human PTGES3, His-tagged E.coli His
    Human PTGES3-2712HCL Recombinant Human PTGES3 293 Cell Lysate HEK293 N/A
    Human PTGES3-30051TH Recombinant Human PTGES3 E.coli N/A
    Human PTGES3-30054TH Recombinant Human PTGES3 E.coli N/A
    Human PTGES3-478H Recombinant Human Prostaglandin E Synthase 3 (Cytosolic) E.coli N/A
    Human PTGES3-818H Recombinant Human Prostaglandin E Synthase 3 (Cytosolic), His-tagged E.coli His
    Mouse PTGES3-13642M Recombinant Mouse PTGES3 Protein Mammalian Cell His
    Cynomolgus Monkey PTGES3-829C Recombinant Cynomolgus PTGES3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PTGES3-3692R Recombinant Rhesus monkey PTGES3 Protein, His-tagged Mammalian Cell His
    Chicken PTGES3-4704C Recombinant Chicken PTGES3 Mammalian Cell His

    PTGES3 involved in several pathways and played different roles in them. We selected most pathways PTGES3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism CBR1L; CYP2C50; ALOX5A; PTGS2A; CYP2AD2; PLA2G4AA; GPX2; PLA2G1B; ALOX8; PLA2G4B
    Attenuation phase HSBP1; HSBP1B; PTGES3; CREBBP; HSBP1A
    C20 prostanoid biosynthesis PTGES3
    Cellular response to heat stress HSBP1; HSBP1B; NUPL2; ST13; DNAJC2; HSPA14; BAG5; HSPA12B; BAG3; KIAA1967
    Cellular responses to stress HIST1H1E; EGLN2; HBXIP; CDKN2B; BMI1A; RAD50; HIF3A; BMI1B; CDKN2A; CBX4
    HSF1 activation PTGES3; EEF1A1; HSBP1
    HSF1-dependent transactivation HSBP1A; HSBP1; HSBP1B; PTGES3

    PTGES3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES3 itself. We selected most functions PTGES3 had, and list some proteins which have the same functions with PTGES3. You can find most of the proteins on our site.

    Function Related Protein
    prostaglandin-E synthase activity PTGES; PTGES3; PTGESL; PTGES2
    protein binding MAP1LC3B; OBFC1; PDGFB; SPRTN; SLPI; ZFYVE27; AMOTL2; ALPP; VTI1B; LRRC47
    telomerase activity PRIM2; CCDC111; CTU1; PTGES3; DKC1; UAP1L1; TERT
    unfolded protein binding SPG7; PPIA; H2-KE2; TRAP1; DNAJA3B; NPM1; PDRG1; CCT7; DNAJB11; HSP90AA1.1

    PTGES3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES3.

    HSP90AA1; HSP90AB1; IRS4; AGO2; vpu; EIF2C2; POLR3A; FBXO24; URI1; GH1

    Eymard, F; Pigenet, A; et al. Induction of an Inflammatory and Prodegradative Phenotype in Autologous Fibroblast-like Synoviocytes by the Infrapatellar Fat Pad From Patients With Knee Osteoarthritis. ARTHRITIS & RHEUMATOLOGY 66:2165-2174(2014).
    Sanchez, C; Gabay, O; et al. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. OSTEOARTHRITIS AND CARTILAGE 17:473-481(2009).

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