Recombinant Mouse Ptges3 Protein, Myc/DDK-tagged

• Cat.No.: Ptges3-5221M
• Product Overview: Purified recombinant protein of mouse full-length prostaglandin E synthase 3 (Ptges3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 19.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ptges3 prostaglandin E synthase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Ptges3
• Synonyms: PTGES3; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; sid 3177; p23 cochaperone; hsp90 co-chaperone; telomerase-binding protein p23; telomerase binding protein, p23; progesterone receptor complex p23; cytosolic prostaglandin E2 synthase; p23; Tebp; Ptges; cPGES; sid3177; 5730442A20Rik
• Gene ID: 56351
• mRNA Refseq: NM_019766
• Protein Refseq: NP_062740
• UniProt ID: Q9R0Q7