• Official Full Name
  • ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
  • Background
  • The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are;proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the;mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to;regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that;encode different protein isoforms.
  • Synonyms
  • UCHL3; ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L3; ubiquitin thiolesterase; ubiquitin thioesterase L3; UCH-L3
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Uchl3 Protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL3, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL3
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL3, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL3, His tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Uchl3, His tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Uchl3, His tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UCHL3 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UCHL3 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UCHL3
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UCHL3
Source (Host):Species:Human
Product nameRecombinant Human UCHL3 293 Cell Lysate

Involved Pathway

UCHL3 involved in several pathways and played different roles in them. We selected most pathways UCHL3 participated on our site, such as Proteasome Degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteasome Degradation
TRIM41; UFL1; KLHL21; RNF144B; UBR2; ASB14; ASB9; ASB13; ARIH2; RNF34

Protein Function

UCHL3 has several biochemical functions, for example, peptidase activity, protein binding, ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL3 itself. We selected most functions UCHL3 had, and list some proteins which have the same functions with UCHL3. You can find most of the proteins on our site.
Related Protein
Function peptidase activity
Related Protein USP25; CASP8; FAM108A1; AZU1; UNC5CL; PRSS59.2; PM20D1.2; MMP25; KEX2; PGCP
Function protein binding
Related Protein HIST1H3C; LRRC33; CDK18; AKAP17A; UBE2D1; MYO18A; SNRPG; MLH3; KSR1; RPL19
Function ubiquitin binding
Related Protein OTUB1; IDE; TNFAIP3; OTUB1B; UBE2NB; VPS28; HSPB1; UBR5; FAF1; TRP53INP2
Function ubiquitin-specific protease activity
Related Protein USP33; USP43; USP10; OTUD5; OTUB1; OTULIN; USP38; COPS5; USP5; USP43A

Interacting Protein

UCHL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL3.
UBB; Smad1; SMAD1; COPS6; COPS5; CLPB; USP20; ATXN7L3; POGK; NSG2; pi3p

UCHL3 Related Articles

Sarveswari, S; Vijayakumar, V; et al. Synthesis of 4-Hydroxy-2(1H)-Quinolone Derived Chalcones, Pyrazolines and Their Antimicrobial, In Silico Antimalarial Evaluations. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:43-64(2015).
Hung, FF; To, WP; et al. Water-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties. CHEMISTRY-A EUROPEAN JOURNAL 20:8604-8614(2014).