ACE
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Official Full Name
angiotensin I converting enzyme
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Overview
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010] -
Synonyms
ACE; angiotensin I converting enzyme; DCP; ICH; ACE1; DCP1; CD143; MVCD3; angiotensin-converting enzyme; kininase II; peptidase P; CD143 antigen; testicular ECA; carboxycathepsin; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Assay Kits
- Chicken
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus monkey
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- Insect cells
- Insect Cells
- Mammalian Cell
- Mammalian cells
- N/A
- NS0
- Wheat Germ
- Fc
- GST
- hIgG4
- His
- Avi
- MBP
- S
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ACE involved in several pathways and played different roles in them. We selected most pathways ACE participated on our site, such as ACE Inhibitor Pathway, Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ACE Inhibitor Pathway | CMA1;ATP6AP2;AGTR1;ACE;CYP11B2;CTSG;AGTR2;AGT |
| Chagas disease (American trypanosomiasis) | PPP2R2D;MAP2K4;GNA15;TNF;MAPK9;CCL3L3;IL6;PPP2R2C;PPP2CA |
| Hypertrophic cardiomyopathy (HCM) | ITGB7;DES;PRKAG3;ITGAV;SGCD;ITGB8;IL6;ITGA2B;TGFB3 |
| Metabolism of Angiotensinogen to Angiotensins | ACE;GZMH;CTSG;ATP6AP2;CMA1;CPB2;CPA3;CPB1 |
| Metabolism of proteins | DPH2;DMBT1;EXOC3;ST6GALNAC2;C19orf10;PHC1;O3far1;MAGT1;CALCA |
| Peptide hormone metabolism | SLC30A5;CPA3;CPN1;GRP;CMA1;CGB5;MBOAT4;CPB1;EXOC8 |
| Renin secretion | CALML5;CALM4;ITPR3;ORAI1;GNAI3;CALML3;CALM3;CLCA4;PPP3CC |
| Renin-angiotensin system | AGTR1A;KLK1B1;KLK1B3;KLK2;PREP;CMA1;REN2;KLK1B24;PRCP |
ACE has several biochemical functions, for example, actin binding, bradykinin receptor binding, carboxypeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE itself. We selected most functions ACE had, and list some proteins which have the same functions with ACE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | TPM4;PARK2;WASH;MYO10;EPB41L3B;MYH15;GCET2;CNN3;DIXDC1 |
| bradykinin receptor binding | AGTR1;AGTR1A;ACE |
| carboxypeptidase activity | AGBL4;CNDP1;NAALADL1;CPB1;CPA2;ACE;CNDP2;ACE2;AGBL1 |
| chloride ion binding | ACE;Amy1;AMY2A;NLGN4X;SLC22A6;CTSC |
| drug binding | GSTP2;P2RX1;SMO;CYP4B1;GPR30;PDE10A;FASN;CYP2C9;DHFR |
| endopeptidase activity | KLK1B9;PSMB5;ECE1;MME;F9;PSMB2;RHBDD1;Ren1;TRAPPC12 |
| exopeptidase activity | GGH;ACE;MME |
| metallopeptidase activity | ADAM12;STAMBPA;MMP13A;DPP3;ADAM28;PAPLNB;ADAM23;CNDP1;AGBL4 |
| mitogen-activated protein kinase binding | MAPKAPK2A;ATF7;TPR;CDK5RAP3;ACE;MAPKAPK2B;SIRT1;MAPKAPK2;ABL1 |
| mitogen-activated protein kinase kinase binding | BRAF;RAF1;PIN1;TAOK2;TRIB1;IGBP1;TRIB2;KSR1;MAP3K11 |
| peptidyl-dipeptidase activity | ACE;TMEM27 |
| protein binding | AKAP17A;GPR37L1;TYR;MSH4;ERH;MLLT10;H2-AB1;CNOT7;GALNT2 |
| tripeptidyl-peptidase activity | TPP1;ACE;TPP2 |
| zinc ion binding | TRIM35-1;NR1D4B;CLIP1;MYLIP;WHSC1L1;RORAA;ADH8A;ESRRGA;ZRANB1 |
ACE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE.
CD247
Research Area
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