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Official Full Name angiotensin I converting enzyme
Background This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Synonyms ACE; angiotensin I converting enzyme; DCP; ICH; ACE1; DCP1; CD143; MVCD3; angiotensin-converting enzyme; kininase II; peptidase P; CD143 antigen; testicular ECA; carboxycathepsin; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus monkey
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Insect Cells
    • Mammalian Cell
    • Mammalian cells
    • N/A
    • Wheat Germ
    • Tag :
    • GST
    • hIgG1
    • hIgG4
    • His
    • MBP
    • S
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACE-011H Recombinant Human ACE Protein, His-tagged Insect Cells His
    Human ACE-033H Recombinant Human ACE Protein, His-tagged Insect cells His
    Human ACE-155H Recombinant Human ACE Protein, GST-Tagged Wheat Germ GST
    Human ACE-509H Recombinant Human ACE protein, His & GST-tagged E.coli His/GST
    Human ACE-510H Recombinant Human ACE protein, His-tagged E.coli His
    Human ACE-744H Recombinant Human ACE, His-tagged Mammalian cells His
    Human ACE-8304H Recombinant Human ACE N/A
    Human ACE-9094HCL Recombinant Human ACE 293 Cell Lysate HEK293 N/A
    Mouse Ace-510M Recombinant Mouse Ace Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Ace-511M Recombinant Mouse Ace protein, His & GST-tagged E.coli His/GST
    Mouse Ace-512M Recombinant Mouse Ace protein, His & MBP-tagged E.coli His/MBP
    Mouse Ace-513M Recombinant Mouse Ace protein, His & S-tagged E.coli His/S
    Rat Ace-3458R Recombinant Rat Ace, His-tagged E.Coli or Yeast His
    Rat ACE-449R Recombinant Rat ACE Protein Mammalian Cell His
    Rhesus monkey ACE-1570R Recombinant Rhesus Monkey ACE Protein HEK293 N/A
    Rhesus monkey ACE-1571R Recombinant Rhesus Monkey ACE Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey ACE-1572R Recombinant Rhesus Monkey ACE Protein, hIgG4-tagged HEK293 hIgG4
    Rabbit ACE-3047R Native rabbit ACE N/A N/A
    Chicken ACE-4022C Recombinant Chicken ACE Mammalian Cell His
    Pig ACE-514P Recombinant Pig ACE protein, His & GST-tagged E.coli His/GST
    Kit-2408 Angiotensin I Converting Enzyme (ACE1) Inhibitor Screening Kit N/A
    Kit-2409 Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit N/A

    ace involved in several pathways and played different roles in them. We selected most pathways ace participated on our site, such as ACE Inhibitor Pathway, Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ace were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ACE Inhibitor Pathway AGTR1; CTSG; AGTR2; ATP6AP2; AGT; CMA1; ACE; CYP11B2
    Chagas disease (American trypanosomiasis) PIK3R2; MAPK11; IL10; IRAK1; GNA11; CD3D; CD3E; CCL3L1; IKBKB; TLR4
    Hypertrophic cardiomyopathy (HCM) CACNG8; ITGB7; EMD; LAMA2; TGFB2; Itga10&Itgb1; ITGA6; CACNB4; CACNG3; SGCB
    Metabolism of Angiotensinogen to Angiotensins CTSG; GZMH; ATP6AP2; CPB1; ACE; CPB2; CMA1; CPA3
    Metabolism of proteins PFDN2; SEC23IP; TRAPPC6BL; NSMCE1; SEC63; DNAJB9; FURINB; ODAM; VBP1; SENP1
    Peptide hormone metabolism PCSK2; CPB1; INHA; O3far1; ACE; GRP; CGB5; SLC30A6; GPR119; SLC30A5
    Renin secretion ITPR3; CALM1; CLCA3; PDE3A; CALM4; PDE1A; REN2; GUCY1B3; CLCA4; PRKACB
    Renin-angiotensin system KLK1; KLK1B5; CTSA; CMA1; AGTR1A; REN2; KLK1B9; KLK1B24; THOP1; ANPEP

    ace has several biochemical functions, for example, actin binding, bradykinin receptor binding, carboxypeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ace itself. We selected most functions ace had, and list some proteins which have the same functions with ace. You can find most of the proteins on our site.

    Function Related Protein
    bradykinin receptor binding AGTR1; AGTR1A; ACE
    carboxypeptidase activity NAALAD2; CPD; PGCP; ACE; CNDP2; CPM; AEBP1; NAALADL1; AGBL1; BLMH
    chloride ion binding SLC22A6; ACE; AMY2A; NLGN4X; CTSC; Amy1
    drug binding HTR2C; PYGB; TLR8; CHRNB3; ADH1; CHRNB2; ATP5O; TYMS; CHRM2; FASN
    endopeptidase activity PSMA6A; PSMA6; TRAPPC12; KLK1B9; KLK1B8; HTRA3; PSMA3; PSMB7; MME; MMP12
    exopeptidase activity MME; ACE; GGH
    metallopeptidase activity GM12824; ADAM10B; ADAM10A; COPS5; Adamts19; ADAM10; ANPEPB; ADAMTS12; CLCA5; PAPPAA
    mitogen-activated protein kinase binding ARRB2; ACE; MAPKAPK2A; MICALCL; TPR; PLCB4; MAPK7; TNIP1; DUSP2; NBR1
    mitogen-activated protein kinase kinase binding DLG1; TRIB3; IGBP1; ARRB1; TAOK2; RAF1; ACE; MAPK8IP3; TRIB1; KSR1
    peptidyl-dipeptidase activity ACE; TMEM27
    protein binding VTN; DNAJB11; ARRB1; EIF5A2; KAT6B; CHTOP; NR1D1; HRG; OSBPL1A; CD93
    tripeptidyl-peptidase activity TPP1; TPP2; ACE
    zinc ion binding MARCH6; NEIL3; ADAM10B; SHANK3; APOBEC3B; RNF13; NR2F1A; DHH; PHF20L1; ISL2A

    ace has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ace here. Most of them are supplied by our site. Hope this information will be useful for your research of ace.


    Connolly, A; O'Keeffe, MB; et al. Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers' spent grain protein isolate. FOOD CHEMISTRY 176:64-71(2015).
    Kleekayai, T; Harnedy, PA; et al. Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes. FOOD CHEMISTRY 176:441-447(2015).

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