Recombinant Human ACE Protein, GST-Tagged

• Cat.No.: ACE-155H
• Product Overview: Human ACE partial ORF ( AAH36375, 592 a.a. - 701 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 61.2 kDa
• AA Sequence: MGTEKESPEPDCQKQFQAAVSVIQN LPKNGSYRPSYEEMLRFYSYYKQAT MGPCLVPRPGFWDPIGRYKWDAWNS LGKMSREEAMSAYITEMKLVAQKVI DTVPLGEVAEDMFGYFEPLYQVIPD MPRPPETFLRRVTGWKEQVVNGDVG AVSEPPCLPKEPAPPSPESHSPRDL DSEVFCDSLEQLEPELVWTEQRAAS GGKRDPRNSPVPPTKKEGLRGSPPG PQELDVWLLGTVRALQESMQEVQAR VQSLESMPRPPEQRPQPRPSARPWP LGLPGPALLFFLLWPFVVQWLFRMF RTQKR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [ Homo sapiens ]
• Official Symbol: ACE
• Synonyms: ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; DCP1; angiotensin-converting enzyme; ACE1; CD143; kininase II; peptidase P; CD143 antigen; testicular ECA; carboxycathepsin; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; angiotensin converting enzyme, somatic isoform; DCP; ICH; MVCD3
• Gene ID: 1636
• mRNA Refseq: NM_000789
• Protein Refseq: NP_000780
• MIM: 106180
• UniProt ID: P12821