ADORA3
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Official Full Name
adenosine A3 receptor
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Overview
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADORA3; adenosine A3 receptor; adenosine receptor A3; AD026; A3AR; A3R; AA3R; AA3R_HUMAN; AD 026; ADORA 3; ARA3; bA552M11.5; Gpcr2; RP11 552M11.7; TGPCR1; RP11-552M11.7;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Human
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Ovis aries (Sheep)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ADORA3-371H | Recombinant Human ADORA3 Protein | Wheat Germ | N/A |
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| Human | ADORA3-372H | Recombinant Human ADORA3 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ADORA3-12HCL | Recombinant Human ADORA3 lysate | HEK293 | N/A |
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| Human | ADORA3-968HF | Recombinant Full Length Human ADORA3 Protein | In Vitro Cell Free System | 318 amino acids |
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| Human | ADORA3-26898TH | Recombinant Human ADORA3 | Wheat Germ | N/A | 105 amino acids |
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| Rat | Adora3-3165R | Recombinant Rat Adora3, His-tagged | E.Coli or Yeast | His | 320 |
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| Rat | ADORA3-535R | Recombinant Rat ADORA3 Protein | Mammalian Cell | His |
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| Rat | ADORA3-191R-B | Recombinant Rat ADORA3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ADORA3-191R | Recombinant Rat ADORA3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Bos taurus (Bovine) | RFL19118BF | Recombinant Full Length Bovine Adenosine Receptor A3(Adora3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-317) |
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| Canis lupus familiaris (Dog) (Canis familiaris) | RFL21718CF | Recombinant Full Length Dog Adenosine Receptor A3(Adora3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-314) |
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| Mus musculus (Mouse) | RFL32181MF | Recombinant Full Length Mouse Adenosine Receptor A3(Adora3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-319) |
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| Oryctolagus cuniculus (Rabbit) | RFL-15125OF | Recombinant Full Length Rabbit Adenosine Receptor A3(Adora3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-319) |
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| Ovis aries (Sheep) | RFL-17161OF | Recombinant Full Length Sheep Adenosine Receptor A3(Adora3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-317) |
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| Rattus norvegicus (Rat) | RFL-13297RF | Recombinant Full Length Rat Adenosine Receptor A3(Adora3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-320) |
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| Rhesus Macaque | ADORA3-255R | Recombinant Rhesus monkey ADORA3 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | ADORA3-83R-B | Recombinant Rhesus Macaque ADORA3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | ADORA3-83R | Recombinant Rhesus Macaque ADORA3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Chicken | ADORA3-5727C | Recombinant Chicken ADORA3 | Mammalian Cell | His |
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| Kit-2177 | ADORA3 CHO-K1 β-Arrestin GPCR Assay Kit | N/A |
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| Kit-0978 | ER Alpha Competitor Assay, Red | N/A |
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| Kit-1106 | Enteropeptidase/Enterokinase Activity Fluorometric Assay Kit | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ADORA3 Related Gene Family
- ADORA3 Related Research Area
ADORA3 involved in several pathways and played different roles in them. We selected most pathways ADORA3 participated on our site, such as Adenosine P1 receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADORA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adenosine P1 receptors | ADORA2A;ADORA3;ADORA2B;ADORA1 |
| Class A/1 (Rhodopsin-like receptors) | AGT;EDNRB;TAAR1;NPS;CXCL13;NPFFR2;GPR132;OXGR1A.1;CXCR7B |
| G alpha (i) signalling events | ADORA3;FPR-RS4;OPN1LW1;TAS2R13;TAS2R3;SST;CCL27;APLN;CCL35.2 |
| GPCR downstream signaling | PROK1;LTB4R;NMU;VIP;CCR6;PDE10A;LPAR1;CCL19A.2;TAC2 |
| GPCR ligand binding | GPBAR1;NPSR1;GPR39;ADM2;CCR3;OXER1;GPR55;CYSLTR1;EDNRA |
| GPCRs, Class A Rhodopsin-like | CCR3;GPR3;GPR45;PTGDR2;ACKR4;DRD3;APLNR;CNR2;GPR17 |
| GPCRs, Other | GPR55;VMN1R45;CELSR1;VMN1R46;GPR77;GPR84;VMN1R48;V1RA8;GPR132 |
| Neuroactive ligand-receptor interaction | GABRG2;NPY6R;F2RL3;TAAR12J;IL12;TRY;NMUR1;ADORA2AB;HCRTR2 |
ADORA3 has several biochemical functions, for example, G-protein coupled adenosine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADORA3 itself. We selected most functions ADORA3 had, and list some proteins which have the same functions with ADORA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled adenosine receptor activity | P2RY12;ADORA2A;ADORA2B;ADORA3;ADORA2AB;ADORA2AA;ADORA1 |
ADORA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADORA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADORA3.
ab-meca; ib-meca
- Q&As
- Reviews
Q&As (3)
Ask a questionThere are currently no drugs available that specifically target ADORA3 proteins. However, there are drugs that target other adenosine receptors, such as caffeine (which blocks adenosine receptors), methylxanthines (which block both adenosine A1 and A2A receptors), and antiarrhythmic drugs (which target adenosine A1 receptors in the heart).
ADORA3 proteins, also known as adenosine A3 receptors, are a subtype of adenosine receptors that are found in various tissues throughout the body including the brain, heart, lungs, liver, and immune cells. These receptors are responsible for mediating the effects of adenosine, a signaling molecule that regulates various physiological processes including inflammation, immune function, and cardiovascular function.
One challenge is the potential for side effects, as these receptors are found in multiple tissues throughout the body and have diverse effects on various physiological processes. Therefore, drugs targeting ADORA3 proteins may have off-target effects on other tissues and systems. Additionally, ADORA3-targeting drugs may need to be developed with specific dosing strategies or combinations with other medications to be effective against certain diseases.
Customer Reviews (3)
Write a reviewIts excellent solubility and stability properties have given me confidence in its reliability.
The purity and consistency of this protein have surpassed my expectations, making it an ideal choice for my research.
the technical team has been extremely responsive and knowledgeable, offering valuable insights and solutions to any concerns I had.
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