ADORA3

  • Official Full Name

    adenosine A3 receptor

  • Overview

    This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ADORA3; adenosine A3 receptor; adenosine receptor A3; AD026; A3AR; A3R; AA3R; AA3R_HUMAN; AD 026; ADORA 3; ARA3; bA552M11.5; Gpcr2; RP11 552M11.7; TGPCR1; RP11-552M11.7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Human
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Ovis aries (Sheep)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADORA3-371H Recombinant Human ADORA3 Protein Wheat Germ N/A
Human ADORA3-372H Recombinant Human ADORA3 Protein, GST-tagged Wheat Germ GST
Human ADORA3-12HCL Recombinant Human ADORA3 lysate HEK293 N/A
Human ADORA3-968HF Recombinant Full Length Human ADORA3 Protein In Vitro Cell Free System 318 amino acids
Human ADORA3-26898TH Recombinant Human ADORA3 Wheat Germ N/A 105 amino acids
Rat Adora3-3165R Recombinant Rat Adora3, His-tagged E.Coli or Yeast His 320
Rat ADORA3-535R Recombinant Rat ADORA3 Protein Mammalian Cell His
Rat ADORA3-191R-B Recombinant Rat ADORA3 Protein Pre-coupled Magnetic Beads HEK293
Rat ADORA3-191R Recombinant Rat ADORA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL19118BF Recombinant Full Length Bovine Adenosine Receptor A3(Adora3) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Canis lupus familiaris (Dog) (Canis familiaris) RFL21718CF Recombinant Full Length Dog Adenosine Receptor A3(Adora3) Protein, His-Tagged E.coli expression system His Full Length (1-314)
Mus musculus (Mouse) RFL32181MF Recombinant Full Length Mouse Adenosine Receptor A3(Adora3) Protein, His-Tagged E.coli expression system His Full Length (1-319)
Oryctolagus cuniculus (Rabbit) RFL-15125OF Recombinant Full Length Rabbit Adenosine Receptor A3(Adora3) Protein, His-Tagged E.coli expression system His Full Length (1-319)
Ovis aries (Sheep) RFL-17161OF Recombinant Full Length Sheep Adenosine Receptor A3(Adora3) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Rattus norvegicus (Rat) RFL-13297RF Recombinant Full Length Rat Adenosine Receptor A3(Adora3) Protein, His-Tagged E.coli expression system His Full Length (1-320)
Rhesus Macaque ADORA3-255R Recombinant Rhesus monkey ADORA3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ADORA3-83R-B Recombinant Rhesus Macaque ADORA3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ADORA3-83R Recombinant Rhesus Macaque ADORA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ADORA3-5727C Recombinant Chicken ADORA3 Mammalian Cell His
Kit-2177 ADORA3 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-0978 ER Alpha Competitor Assay, Red N/A
Kit-1106 Enteropeptidase/Enterokinase Activity Fluorometric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ADORA3 involved in several pathways and played different roles in them. We selected most pathways ADORA3 participated on our site, such as Adenosine P1 receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADORA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adenosine P1 receptorsADORA1;ADORA2B;ADORA3;ADORA2A
Class A/1 (Rhodopsin-like receptors)INSL5;PNOCB;GPR37L1;AGT;AMCF-II;SSTR5;CCR6;CCR1;HRH3
G alpha (i) signalling eventsSST1.1;CNR1;CCR3;CCR8;TAS2R16;RLN3A;APPB;LPAR2A;PPY
GPCR downstream signalingPROKR1A;RGS7;SSTR3;CCK;ARHGEF25;DGKQ;GPR68;PNOC;GCGA
GPCR ligand bindingSSTR4;FPR-RS6;OPN1LW2;INSL5;ANXA1;TAS2R3;CCR9;RGS1;CALCA
GPCRs, Class A Rhodopsin-likeGPR12;OPN1LW;CCR8;APLNR;OPN1SW;GPR20;GPR37L1;RRH;CNR1
GPCRs, OtherSSTR2;S1PR1;VMN1R52;CELSR2;ADORA3;GPR176;VMN1R148;VMN1R48;CELSR3
Neuroactive ligand-receptor interactionF2R;GABRP;ADRA2DB;TAAR5;GRM4;P2RY6;PTGER4;HTR2B;NPY4R

ADORA3 has several biochemical functions, for example, G-protein coupled adenosine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADORA3 itself. We selected most functions ADORA3 had, and list some proteins which have the same functions with ADORA3. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled adenosine receptor activityADORA2AA;ADORA3;ADORA2AB;P2RY12;ADORA1;ADORA2A;ADORA2B

ADORA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADORA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADORA3.

ab-meca; ib-meca

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
06/01/2021

    Its excellent solubility and stability properties have given me confidence in its reliability.

    10/17/2018

      The purity and consistency of this protein have surpassed my expectations, making it an ideal choice for my research.

      06/18/2018

        the technical team has been extremely responsive and knowledgeable, offering valuable insights and solutions to any concerns I had.

        Q&As (3)

        Ask a question
        Are there any drugs currently on the market that target ADORA3 proteins? 08/27/2020

        There are currently no drugs available that specifically target ADORA3 proteins. However, there are drugs that target other adenosine receptors, such as caffeine (which blocks adenosine receptors), methylxanthines (which block both adenosine A1 and A2A receptors), and antiarrhythmic drugs (which target adenosine A1 receptors in the heart).

        What are ADORA3 proteins? 11/12/2019

        ADORA3 proteins, also known as adenosine A3 receptors, are a subtype of adenosine receptors that are found in various tissues throughout the body including the brain, heart, lungs, liver, and immune cells. These receptors are responsible for mediating the effects of adenosine, a signaling molecule that regulates various physiological processes including inflammation, immune function, and cardiovascular function.

        What are some challenges associated with developing drugs that target ADORA3 proteins? 02/01/2016

        One challenge is the potential for side effects, as these receptors are found in multiple tissues throughout the body and have diverse effects on various physiological processes. Therefore, drugs targeting ADORA3 proteins may have off-target effects on other tissues and systems. Additionally, ADORA3-targeting drugs may need to be developed with specific dosing strategies or combinations with other medications to be effective against certain diseases.

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