ADSSL1
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Official Full Name
adenylosuccinate synthase like 1
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Background
ADSSL1 is a muscle isozyme of adenylosuccinate synthase (EC 6.3.4.4), which catalyzes the initial reaction in the;conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) (Sun et al., 2005 (PubMed;15786719)). -
Synonyms
ADSSL1; adenylosuccinate synthase like 1; adenylosuccinate synthetase isozyme 1; FLJ38602; basic isozyme; muscle isozyme; Adenylosuccinate synthetase; AdSS 1; ADSS1; AMPSase 1; IMP aspartate ligase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; PURA1_HUMAN; OTTHUMP00000244483; OTTHUMP00000244484; adenylosuccinate synthetase, basic isozyme; adenylosuccinate synthetase, muscle isozyme;
- Involved Pathway
- Protein Function
- Interacting Protein
ADSSL1 involved in several pathways and played different roles in them. We selected most pathways ADSSL1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADSSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alanine, aspartate and glutamate metabolism | ASS1;DDO;ASL2;GLUL;GLS2;GLULA;GLUD1A;GLUD1B;GPT |
Metabolic pathways | LDHC;SDSL;PAH;ALDH2;PPAT;CYP19A1;NDUFV2;UGT2A2;MTHFD1B |
Metabolism | PPARGC1B;ACOT11A;CYP2C18;CRAT;COX6A1;COX18;SUMF2;SREBF2;ADAL |
Metabolism of nucleotides | DCK;DPYS;DPYD;ADSL;GRX2;TM9SF1;DTYMK;NUDT18;NUDT1 |
Purine metabolism | NT5C2A;RRM2B;ADSL;PDE7B;AK2;NME7;POLD1;PDE8A;ADKB |
Purine ribonucleoside monophosphate biosynthesis | ADSL;PAICS;ADSSL1;ADSS |
adenosine ribonucleotides de novo biosynthesis | ATP5L;ADSS;AK7;AK8;ATP5S;ADSSL1 |
purine nucleotides de novo biosynthesis | AK8;AK7;ADSSL1;ATP5S |
ADSSL1 has several biochemical functions, for example, GTP binding, GTPase activity, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADSSL1 itself. We selected most functions ADSSL1 had, and list some proteins which have the same functions with ADSSL1. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | ARL5C;RAB33B;SEPT5B;LGALS6;MTIF2;RASL10A;C9orf86;RAN;RAB13 |
GTPase activity | DIRAS3;RAB39B;TUBA8L2;MSTO1;RAB39A;GTPBP1L;MRAS;RAB34;DDX3X |
actin filament binding | CTNNA3;CTNNA1;DBNL;TLN1;SVIL;MYO6;SHROOM1;MYO10;MYO3A |
adenylosuccinate synthase activity | ADSSL1;ADSSL;ADSS |
magnesium ion binding | CIB3;IDH3G;PPA1;DUT;HPRT1L;OPA1;PPM1AB;SIK3;PRKACB |
phosphate ion binding | SH2B3;PNP;CHST14;GNG12;ADSS;G6PC;SLC34A2;RPH3A;MTHFD2 |
protein homodimerization activity | CBX5;PVRL1A;NKX2;GM5506;XCL1;MYOM3;RAB11FIP4;ZFP365;ABCG1 |
ADSSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADSSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADSSL1.
YWHAZ; AZIN1; LYAR
- Q&As
- Reviews
Q&As (10)
Ask a questionThe subcellular localization of ADSSL1 protein is primarily within mitochondria, facilitated by mitochondrial targeting sequences and import machinery.
Post-translational modifications, such as phosphorylation or acetylation, and regulatory factors like metabolic signals or protein-protein interactions, may modulate the activity or stability of ADSSL1 protein.
ADSSL1 protein can interact with other enzymes involved in purine metabolism, forming complexes that regulate nucleotide synthesis and energy metabolism.
Genetic variations or mutations in the ADSSL1 gene can impact the expression or function of ADSSL1 protein, potentially leading to disorders associated with purine metabolism abnormalities.
ADSSL1 protein plays a critical role in purine nucleotide metabolism, contributing to the deamination and recycling of adenylosuccinate to maintain nucleotide homeostasis.
ADSSL1 protein contains conserved structural domains, including a catalytic domain and nucleotide-binding motifs, that contribute to its enzymatic activity and substrate specificity.
The enzymatic activity of ADSSL1 protein, catalyzing the conversion of adenylosuccinate to AMP, can be measured using enzymatic assays that quantify substrate utilization and product formation.
Experimental approaches such as knockout or overexpression studies have been utilized to investigate the functional significance of ADSSL1 protein, revealing its role in cellular metabolism and energy balance.
ADSSL1 protein exhibits tissue-specific expression, with higher levels observed in skeletal muscle, heart, and brain. Factors involved in its regulation include transcriptional control and signaling pathways.
Dysregulation or dysfunction of ADSSL1 protein can disrupt cellular purine metabolism, leading to imbalances in nucleotide levels and potential contributions to diseases such as neurodegenerative disorders or metabolic syndromes.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in intracellular trafficking. -
Detecting protein-protein interactions in membrane receptor signaling. -
Understanding protein-protein interaction networks in DNA repair processes. -
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