• Official Full Name

    adenylosuccinate synthase like 1

  • Background

    ADSSL1 is a muscle isozyme of adenylosuccinate synthase (EC, which catalyzes the initial reaction in the;conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) (Sun et al., 2005 (PubMed;15786719)).
  • Synonyms

    ADSSL1; adenylosuccinate synthase like 1; adenylosuccinate synthetase isozyme 1; FLJ38602; basic isozyme; muscle isozyme; Adenylosuccinate synthetase; AdSS 1; ADSS1; AMPSase 1; IMP aspartate ligase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; PURA1_HUMAN; OTTHUMP00000244483; OTTHUMP00000244484; adenylosuccinate synthetase, basic isozyme; adenylosuccinate synthetase, muscle isozyme;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Bovine
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • MYC
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human ADSSL1-392H Recombinant Human ADSSL1 Protein, GST-tagged Wheat Germ GST
    Human ADSSL1-393H Recombinant Human ADSSL1 Protein, GST-tagged Wheat Germ GST
    Human ADSSL1-8993HCL Recombinant Human ADSSL1 293 Cell Lysate HEK293 N/A
    Human ADSSL1-4550H Recombinant Human ADSSL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ADSSL1-983HF Recombinant Full Length Human ADSSL1 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse ADSSL1-1392M Recombinant Mouse ADSSL1 Protein Mammalian Cell His
    Mouse Adssl1-3189M Recombinant Mouse Adssl1, His-tagged E.Coli or Yeast His
    Mouse Adssl1-550M Recombinant Mouse Adssl1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse ADSSL1-370M Recombinant Mouse ADSSL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse ADSSL1-370M-B Recombinant Mouse ADSSL1 Protein Pre-coupled Magnetic Beads HEK293
    Bovine ADSSL1-3188B Recombinant Bovine ADSSL1, His-tagged E.Coli or Yeast His
    Zebrafish ADSSL1-12829Z Recombinant Zebrafish ADSSL1 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    ADSSL1 involved in several pathways and played different roles in them. We selected most pathways ADSSL1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADSSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alanine, aspartate and glutamate metabolismASS1;DDO;ASL2;GLUL;GLS2;GLULA;GLUD1A;GLUD1B;GPT
    Metabolism of nucleotidesDCK;DPYS;DPYD;ADSL;GRX2;TM9SF1;DTYMK;NUDT18;NUDT1
    Purine metabolismNT5C2A;RRM2B;ADSL;PDE7B;AK2;NME7;POLD1;PDE8A;ADKB
    Purine ribonucleoside monophosphate biosynthesisADSL;PAICS;ADSSL1;ADSS
    adenosine ribonucleotides de novo biosynthesisATP5L;ADSS;AK7;AK8;ATP5S;ADSSL1
    purine nucleotides de novo biosynthesisAK8;AK7;ADSSL1;ATP5S

    ADSSL1 has several biochemical functions, for example, GTP binding, GTPase activity, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADSSL1 itself. We selected most functions ADSSL1 had, and list some proteins which have the same functions with ADSSL1. You can find most of the proteins on our site.

    Function Related Protein
    actin filament bindingCTNNA3;CTNNA1;DBNL;TLN1;SVIL;MYO6;SHROOM1;MYO10;MYO3A
    adenylosuccinate synthase activityADSSL1;ADSSL;ADSS
    magnesium ion bindingCIB3;IDH3G;PPA1;DUT;HPRT1L;OPA1;PPM1AB;SIK3;PRKACB
    phosphate ion bindingSH2B3;PNP;CHST14;GNG12;ADSS;G6PC;SLC34A2;RPH3A;MTHFD2
    protein homodimerization activityCBX5;PVRL1A;NKX2;GM5506;XCL1;MYOM3;RAB11FIP4;ZFP365;ABCG1

    ADSSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADSSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADSSL1.


    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How is the subcellular localization of ADSSL1 protein controlled, and are there any specific mechanisms or signals involved? 10/31/2022

    The subcellular localization of ADSSL1 protein is primarily within mitochondria, facilitated by mitochondrial targeting sequences and import machinery.

    Are there any known post-translational modifications or regulatory factors that modulate the activity or stability of ADSSL1 protein? 10/17/2022

    Post-translational modifications, such as phosphorylation or acetylation, and regulatory factors like metabolic signals or protein-protein interactions, may modulate the activity or stability of ADSSL1 protein.

    Does ADSSL1 protein interact with other proteins or participate in protein complexes, and if so, what are the functional implications? 03/19/2022

    ADSSL1 protein can interact with other enzymes involved in purine metabolism, forming complexes that regulate nucleotide synthesis and energy metabolism.

    Are there any genetic variations or mutations in the ADSSL1 gene that impact the expression or function of ADSSL1 protein? 12/14/2019

    Genetic variations or mutations in the ADSSL1 gene can impact the expression or function of ADSSL1 protein, potentially leading to disorders associated with purine metabolism abnormalities.

    What is the role of ADSSL1 protein in specific metabolic pathways or cellular processes? 11/19/2018

    ADSSL1 protein plays a critical role in purine nucleotide metabolism, contributing to the deamination and recycling of adenylosuccinate to maintain nucleotide homeostasis.

    Are there any specific structural features or domains of ADSSL1 protein that contribute to its enzymatic activity and substrate specificity? 07/20/2018

    ADSSL1 protein contains conserved structural domains, including a catalytic domain and nucleotide-binding motifs, that contribute to its enzymatic activity and substrate specificity.

    What is the enzymatic activity of ADSSL1 protein, and how is it measured in experimental assays? 02/15/2018

    The enzymatic activity of ADSSL1 protein, catalyzing the conversion of adenylosuccinate to AMP, can be measured using enzymatic assays that quantify substrate utilization and product formation.

    What experimental approaches, such as knockout or overexpression studies, have been employed to investigate the functional significance of ADSSL1 protein? 01/04/2018

    Experimental approaches such as knockout or overexpression studies have been utilized to investigate the functional significance of ADSSL1 protein, revealing its role in cellular metabolism and energy balance.

    What are the tissue-specific expression patterns of ADSSL1 protein and the factors that contribute to its regulation? 01/10/2017

    ADSSL1 protein exhibits tissue-specific expression, with higher levels observed in skeletal muscle, heart, and brain. Factors involved in its regulation include transcriptional control and signaling pathways.

    How does dysregulation or dysfunction of ADSSL1 protein affect cellular metabolism and contribute to disease development? 04/08/2015

    Dysregulation or dysfunction of ADSSL1 protein can disrupt cellular purine metabolism, leading to imbalances in nucleotide levels and potential contributions to diseases such as neurodegenerative disorders or metabolic syndromes.

    Customer Reviews (3)

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      Exploring protein-protein interactions involved in intracellular trafficking. -


        Detecting protein-protein interactions in membrane receptor signaling. -


          Understanding protein-protein interaction networks in DNA repair processes. -

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