Recombinant Human ADSSL1 Protein, GST-tagged
|Product Overview :||Human ADSSL1 full-length ORF ( NP_689541.1, 1 a.a. - 457 a.a.) recombinant protein with GST-tag at N-terminal.|
- Gene Information
- Related Products
|Description :||This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]|
|Source :||Wheat Germ|
|Molecular Mass :||76.6 kDa|
|AA Sequence :||MSGTRASNDRPPGAGGVKRGRLQQE AAATGSRVTVVLGAQWGDEGKGKVV DLLATDADIISRCQGGNNAGHTVVV DGKEYDFHLLPSGIINTKAVSFIGN GVVIHLPGLFEEAEKNEKKGLKDWE KRLIISDRAHLVFDFHQAVDGLQEV QRQAQEGKNIGTTKKGIGPTYSSKA ARTGLRICDLLSDFDEFSSRFKNLA HQHQSMFPTLEIDIEGQLKRLKGFA ERIRPMVRDGVYFMYEALHGPPKKI LVEGANAALLDIDFGTYPFVTSSNC TVGGVCTGLGIPPQNIGDVYGVVKA YTTRVGIGAFPTEQINEIGGLLQTR GHEWGVTTGRKRRCGWLDLMILRYA HMVNGFTALALTKLDILDVLGEVKV GVSYKLNGKRIPYFPANQEMLQKVE VEYETLPGWKADTTGARRWEDLPPQ AQNYIRFVENHVGVAVKWVGVGKSR ESMIQLF|
|Applications :||Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
|Notes :||Best use within three months from the date of receipt of this protein.|
|Storage :||Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.|
|Gene Name :||ADSSL1 adenylosuccinate synthase like 1 [ Homo sapiens ]|
|Official Symbol :||ADSSL1|
|Synonyms :||ADSSL1; adenylosuccinate synthase like 1; adenylosuccinate synthetase isozyme 1; FLJ38602; adSS 1; AMPSase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; adenylosuccinate synthetase, basic isozyme; adenylosuccinate synthetase, muscle isozyme;|
|Gene ID :||122622|
|mRNA Refseq :||NM_152328|
|Protein Refseq :||NP_689541|
|UniProt ID :||Q8N142|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
The subcellular localization of ADSSL1 protein is primarily within mitochondria, facilitated by mitochondrial targeting sequences and import machinery.
Post-translational modifications, such as phosphorylation or acetylation, and regulatory factors like metabolic signals or protein-protein interactions, may modulate the activity or stability of ADSSL1 protein.
ADSSL1 protein can interact with other enzymes involved in purine metabolism, forming complexes that regulate nucleotide synthesis and energy metabolism.
Genetic variations or mutations in the ADSSL1 gene can impact the expression or function of ADSSL1 protein, potentially leading to disorders associated with purine metabolism abnormalities.
ADSSL1 protein plays a critical role in purine nucleotide metabolism, contributing to the deamination and recycling of adenylosuccinate to maintain nucleotide homeostasis.
ADSSL1 protein contains conserved structural domains, including a catalytic domain and nucleotide-binding motifs, that contribute to its enzymatic activity and substrate specificity.
The enzymatic activity of ADSSL1 protein, catalyzing the conversion of adenylosuccinate to AMP, can be measured using enzymatic assays that quantify substrate utilization and product formation.
Experimental approaches such as knockout or overexpression studies have been utilized to investigate the functional significance of ADSSL1 protein, revealing its role in cellular metabolism and energy balance.
ADSSL1 protein exhibits tissue-specific expression, with higher levels observed in skeletal muscle, heart, and brain. Factors involved in its regulation include transcriptional control and signaling pathways.
Dysregulation or dysfunction of ADSSL1 protein can disrupt cellular purine metabolism, leading to imbalances in nucleotide levels and potential contributions to diseases such as neurodegenerative disorders or metabolic syndromes.
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Exploring protein-protein interactions involved in intracellular trafficking. -
Detecting protein-protein interactions in membrane receptor signaling. -
Understanding protein-protein interaction networks in DNA repair processes. -
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