• Official Full Name

    RAC-alpha serine/threonine-protein kinase

  • Overview

    Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
  • Synonyms

    AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Protein Modification
  • Rabbit
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • 6xHis
  • GST
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST|His
  • His (Fc)
  • Avi
  • Strep
  • His|MBP
  • His|Strep
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKT1-1363H Active Recombinant Human AKT1, GST-tagged Sf9 Insect Cell GST Full length
Human AKT1-420H Active Recombinant Human AKT1 Protein, GST-His tagged Insect Cell GST/His
Human AKT1-421H Active Recombinant Human AKT1 Protein, His-tagged Insect Cell His
Human AKT1-101H Active Recombinant Human AKT1, GST-tagged Sf9 Insect Cell GST
Human AKT1-16HFL Active Recombinant Full Length Human AKT1 Protein, N-His-tagged Sf21 His Full Length
Human AKT1-13HFL Recombinant Human AKT1 Protein, Full Length, N-His tagged Insect cells N-His Full Length
Human AKT1-17HFL Unactive Recombinant Full Length Human AKT1 Protein, N-His-tagged Sf21 His Full Length
Human AKT1-15H Active Recombinant Human AKT1(S473D)(118-end) Mutation Protein, N-His-tagged Sf21 His 118-end
Human AKT1-786H Recombinant Human AKT1, His tagged Insect Cell His
Human AKT1-56H Recombinant Human AKT1, Actived Sf9 Insect Cell N/A
Human AKT1-14H Recombinant Human AKT1 Protein, His-tagged Insect Cell His
Human AKT1-259H Recombinant Human AKT1 protein, His-tagged Insect Cells His Met1-Ala480
Human AKT1-50H Recombinant Human AKT1 protein, GST-tagged Insect Cell GST
Human AKT1-2521H Recombinant Human AKT1, GST-tagged, Active E.coli GST
Human AKT1-47H Recombinant Human AKT1 protein, His-tagged E.coli His
Human AKT1-30H Recombinant Human AKT1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human AKT1-3920H Recombinant Human AKT1 protein, GST-tagged E.coli GST 1-224aa
Human AKT1-57H Recombinant Human AKT1, Inactived Sf9 Insect Cell N/A
Human AKT1-155H Recombinant Human AKT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AKT1-307H Recombinant Human AKT1 protein, His/MBP-tagged E.coli His/MBP 13-253 aa
Human AKT1-156H Recombinant Human AKT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AKT1-1516H Recombinant Human AKT1 protein E.coli N/A
Human AKT1-422H Recombinant Human AKT1 Protein, GST-tagged Wheat Germ GST
Human AKT1-677HCL Recombinant Human AKT1 cell lysate Insect Cell N/A
Human AKT1-33HFL Recombinant Human AKT1 Protein, Full Length, N-His tagged N-His Full Length
Human AKT1-001H Recombinant Human AKT1 Protein, His-GST-tagged E.coli 6xHis-GST
Human AKT1-427H Recombinant Human AKT1 Protein, His-tagged E.coli His Ser122~Thr443
Human AKT1-336H Recombinant Human AKT1 protein, His/Strep-tagged HEK293 His/Strep 480
Human AKT1-96HFL Recombinant Full Length Human AKT1 Protein, C-Flag-tagged Mammalian cells Flag
Human AKT1-014H Recombinant Human AKT1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human AKT1-2689H Recombinant Human AKT1 protein, His-tagged E.coli His 293 - 405 aa
Human AKT1-2503H Recombinant Human AKT1 protein, GST-tagged E.coli GST 1-480aa
Human AKT1-03H Recombinant Human AKT1 Over-expression Lysate, C-Myc/DDK tagged HEK293T C-Myc/DDK
Human AKT1-4200H Recombinant Human AKT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKT1-786HAF555 Recombinant Human AKT1 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cell His 491
Human AKT1-1532HF Recombinant Full Length Human AKT1 Protein, GST-tagged In Vitro Cell Free System GST 480 amino acids
Human AKT1-0081H Recombinant Human AKT1 Protein (M1-A480), GST tagged Insect Cell GST M1-A480
Human AKT1-5186H Recombinant Human AKT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKT1-786HAF647 Recombinant Human AKT1 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cell His 491
Human AKT1-306H Recombinant Human AKT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AKT1-306H-B Recombinant Human AKT1 Protein Pre-coupled Magnetic Beads HEK293
Human AKT1-786HAF488 Recombinant Human AKT1 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cell His 491
Human AKT1-786HF Recombinant Human AKT1 Protein, His-tagged, FITC conjugated Insect Cell His 491
Human Akt1-810H Recombinant Human Akt1 Protein, His and Strep-tagged HEK293 His and Strep 480
Human CAB-2492MH Mouse Anti-Human AKT1 Monoclonal Antibody, DyLight 649 Mouse N/A
Human AKT1-0080H Recombinant Human AKT1 Protein (M1-A480), Tag Free Insect Cell No tag M1-A480
Human CPBTT-30930RH Rabbit Anti-Human AKT Polyclonal Antibody Rabbit N/A
Human AKT1-0535H Recombinant Human AKT1 Protein (Met1-Ala480), C-His-tagged E.coli C-His Met1-Ala480
Mouse AKT1-1507M Recombinant Mouse AKT1 Protein Mammalian Cell His
Mouse AKT1-443M Recombinant Mouse AKT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Akt1-566M Recombinant Mouse Akt1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse AKT1-443M-B Recombinant Mouse AKT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Akt1-2840M Recombinant Mouse Phosphorylated Akt1 Protein, His-tagged Protein Modification N-His Met458-Tyr474 with phosphoserine at 473 site.
Rat AKT1-605R Recombinant Rat AKT1 Protein Mammalian Cell His
Rat AKT1-261R Recombinant Rat AKT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AKT1-261R-B Recombinant Rat AKT1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AKT1-296R Recombinant Rhesus monkey AKT1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKT1-124R-B Recombinant Rhesus Macaque AKT1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AKT1-124R Recombinant Rhesus Macaque AKT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish AKT1-8342Z Recombinant Zebrafish AKT1 Mammalian Cell His
Chicken AKT1-6612C Recombinant Chicken AKT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • AKT1 Related Signal Pathway

AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayPAK3;PLA2G3;PDGFRA;GNG5;GNG8;GAB1;KLK1B4;CALML3;GNB2
Rap signaling pathwayFGF8;VEGFC;IGF1;PRKCA;INSR;FGF3;Pdgfa&Pdgfb;PRKCI;FGF2
Chemokine signaling pathwayPTK2;CCL3L3;AKT2;KRAS;CCR1;XCL1;CCR3;GNGT2;CCL25
HIF- signaling pathwayVEGFA;MKNK1;Trf;INS2;ANGPT2;NOX1;EGLN1;EIF4E1B;GM5506
Sphingolipid signaling pathwayMS4A2;CERS5;FCER1A;AKT1;PPP2R3C;SPHK1;MAPK13;BCL2;GNAI3
Phospholipase D signaling pathwayPLA2G4D;AVP;TSC2;MTOR;KITLG;GAB2;CXCR1;PLD2;LPAR6
PIK-Akt signaling pathwayGNG5;IL2RB;PCK1;IFNA4;CREB3L3;GYS1;EIF4E1B;ITGA2;IFNA13
Adrenergic signaling in cardiomyocytesATP1A2;PPP2R2CA;PPP2R5C;MAPK12;CALM3;AGTR1;TPM4A;ATP2B4;SLC14A2
Osteoclast differentiationSYK;PPP3CB;NCF1;LILRA1;IL1A;SOCS1;TGFB2;NOX3;ACP5
Signaling pathways regulating pluripotency of stem cellsDLX5;WNT11;MAPK12;SMAD2;FZD7;LEFTY2;WNT3A;ACVR1B;INHBE
Toll-like receptor signaling pathwayMAP2K2B;IFNA4;MAP2K3;IFNA16;SPP1;IL-8;CD14;STAT1A;IFNA2
Jak-STAT signaling pathwayIFNA5;AKT2L;GM-CSF;Il6ra;IFNA1;IL12RB1;GH2;PIK3CG;IL28RA
T cell receptor signaling pathwayNFKBIB;PAK3;TEC;PIK3R3;ICOS;NFATC2;GRB2;CBLB;PPP3R1
B cell receptor signaling pathwayPPP3CA;CD81;NFATC2;ACTR3;VAV1;LAT2;NRAS;HDAC5;RAP2A
Fc epsilon RI signaling pathwayHRAS;RAC1;GRB2;FYN;VAV1;PIK3CG;PIK3CA;LYN;MAPK9
Fc gamma R-mediated phagocytosisPPAP2C;PLA2G4F;PTPRC;NCF1;WASF2;ASAP2;FCGR1;PIK3R3;SYK
Neurotrophin signaling pathwayMAPK1;GAB1;PDPK1;ARHGDIB;RPS6KA3;MAP2K2;Fasl;NFKB1;PIK3R1
Progesterone-mediated oocyte maturationCPEB1A;PRKACG;PLK1;ARAF;BUB1;ANAPC1;RPS6KA3B;IGF1RB;HSP90AA1.1
Estrogen signaling pathwayHRAS;MAP2K2;MAPK1;SHC1;MAPK3;PIK3CB;HSPA1B;AKT1;MMP9
Prolactin signaling pathwayTNFSF11;PPIB;SOCS1;INS2;RAF1;FOS;SOCS7;MAP2K2;IRF1
Thyroid hormone signaling pathwayPLCG1;ACTB;RAF1;PLN;PIK3CG;SIN3A;SRC;NCOA1;BAD
Regulation of lipolysis in adipocytesPRKG2;TSHB;PRKACG;PIK3CB;AKT1;GNAI2;PIK3CD;PIK3R2;IRS2
Non-alcoholic fatty liver disease (NAFLD)NDUFA5;IKBKB;FASLG;SDHA;COX5A;INS1;MAP3K11;CDC42;RAC1
Carbohydrate digestion and absorptionPIK3R5;AKT2;HK2;ATP1B2;TAS1R2;ATP1A4;HK3;ATP1A3;G6PC2
Chagas disease (American trypanosomiasis)MAPK12;GNAI3;TLR4;PIK3R1;RELA;PPP2CB;GNA11;MAPK11;FAS
Epstein-Barr virus infectionRBPJ;YWHAZ;SNW1;RELA;HSPB2;TNFAIP3;CD58;CD38;GTF2E1
Pathways in cancerFZD1;ITGA3;MSH2;RB1;FGF14;CASP9;Flt3l;BIRC2;ABL1
Colorectal cancerTGFB1;PIK3R1;PIK3CG;DCC;MLH1;AKT2;TP53;TGFBR1;MAPK1
Renal cell carcinomaPAK7;MAPK1;PIK3R1;MAP2K2;VHL;NRAS;TCEB1;FH1;PIK3R5
Chronic myeloid leukemiaARAF;TGFB1;SMAD4;PIK3CA;PIK3R3;RUNX1;RAF1;IKBKG;SHC4
Acute myeloid leukemiaPIM2;RUNX1T1;PIM1;AKT3;STAT5A;MYC;KRAS;STAT5B;RARA
Non-small cell lung cancerBAD;PRKCB;MAP2K2;CCND1;PIK3CD;PDPK1;PIK3CA;RASSF5;KRAS
Central carbon metabolism in cancerLDHA;HIF1A;HK3;NTRK3;SLC7A5;FLT3;PDHB;PGAM2;RET
Choline metabolism in cancerMAP2K2;PIP5K1A;RPS6KB2;PIK3R5;DGKQ;PLCG1;PLD2;PRKCB;CHKA

AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.

Function Related Protein
14-3-3 protein bindingTSC2;ZFP36;AKT1;HDAC7;PRKCZ;DDIT4;YWHAQ;ARRB2;AANAT
enzyme bindingHSPA8;LGALS9;PRTN3;HNRNPUL1;ESR1;BACE1;TRP53;TULP3;C2orf56
identical protein bindingSIRT1;PCBD1;IIGP1;CD28;LCK;TPCN1;BAX;TOPBP1;SYP
nitric-oxide synthase regulator activityCALM2;CALM3;HSP90AB1;HSP90AA1.1;CALM1;HSP90AA1;ESR1;AKT1
phosphatidylinositol-3,4,5-trisphosphate bindingOGT;PARD3;GBF1;RACGAP1;CYTH3;NRGN;ASAP1;ARAP2;ARAP3
phosphatidylinositol-3,4-bisphosphate bindingRAG2;NCF1;COMMD1;D6WSU116E;ARAP3;PLEKHA1;MAPKAP1;SESTD1;FAM21C
protein bindingFXYD6;FGF13;ATF7;WWP1;GRIN1;THAP7;CD8B1;TNIP2;ARMC9
protein kinase C bindingPARD3;DACT2;HDAC7A;TRPV4;C1QBP;PLEK;AVPR1B;SQSTM1;PKP2
protein phosphatase 2A bindingAKT1;SHC1;RPS6KB1;TRP53;CTTNBP2NL;ENSA;SMG7;IGBP1;FOXO1
protein serine/threonine kinase activityPRKD1;CAMKK1B;NEK7;PBK;ADCK1;VRK1;STK32B;CPNE3;CDK11A
protein serine/threonine/tyrosine kinase activityRPS6KA2;AKT1;TESK2;AURKB;PRKCG;AURKA;DYRK3;MAP2K2;TTK

AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.


Gene Family


Research Area

Related articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (13)

Ask a question
Are there any drugs or agents that specifically target AKT1? 03/14/2023

Yes, several drugs and agents have been developed to specifically target AKT1. These include small molecule inhibitors that directly target the kinase activity of AKT1. Examples of AKT1 inhibitors currently under investigation or in clinical trials include MK-2206, ipatasertib, and capivasertib. These inhibitors aim to block the activation of AKT1 and disrupt its downstream signaling pathways.

Are there any inhibitors of AKT1 protein? 09/11/2022

Yes, there are inhibitors that specifically target the activity of AKT1 protein. Small molecule inhibitors, such as MK-2206 and GSK690693, have been developed to block AKT1 activation and downstream signaling. These inhibitors are being studied as potential therapeutic agents for cancer treatment. Additionally, certain natural compounds, including resveratrol and curcumin, have been reported to inhibit AKT1 activity and exhibit anti-tumor effects.

Are there any diseases associated with AKT1 protein mutations? 01/29/2022

Mutations in AKT1 have been implicated in certain diseases. For example, somatic mutations in AKT1 have been found in a subset of human cancers, such as breast, ovarian, and colorectal cancers. These mutations can lead to constitutive activation of AKT1, contributing to tumor development. Moreover, germline mutations in AKT1 have been linked to a rare genetic disorder called Proteus syndrome, characterized by asymmetric and progressive overgrowth of various tissues.

Can AKT1 be targeted in combination with other therapies for cancer treatment? 07/15/2021

Yes, combining AKT1 inhibitors with other therapies is being investigated as a potential strategy for cancer treatment. AKT1 inhibition can enhance the efficacy of conventional chemotherapy agents or targeted therapies. For example, combining AKT1 inhibitors with inhibitors of the phosphoinositide 3-kinase (PI3K)/mTOR pathway, which upstream regulates AKT1, could provide a more comprehensive blockade of the pathway. Additionally, AKT1 inhibitors have also been tested in combination with immune checkpoint inhibitors to enhance immune response against tumors. Such combination approaches aim to improve treatment outcomes and overcome drug resistance mechanisms.

What are the potential downstream targets of AKT1 signaling? 05/14/2021

AKT1 signaling regulates numerous downstream targets involved in diverse cellular processes. Some of the well-known targets include the mammalian target of rapamycin (mTOR), which plays a role in protein synthesis and cell growth, and the pro-apoptotic protein Bad, which AKT1 phosphorylates to prevent apoptosis. AKT1 also phosphorylates and inactivates the transcription factor Forkhead box protein O (FOXO), which regulates genes involved in apoptosis, cell cycle arrest, and oxidative stress response. Other downstream targets of AKT1 include glycogen synthase kinase 3 (GSK3), nuclear factor-kappa B (NF-kB), and endothelial nitric oxide synthase (eNOS), among others.

Can AKT1 protein be a potential therapeutic target for other conditions apart from cancer? 04/18/2021

Yes, AKT1 protein has the potential to be a therapeutic target for conditions beyond cancer. Due to its role in insulin signaling and glucose metabolism, targeting AKT1 activity could be beneficial in treating metabolic disorders such as type 2 diabetes. Strategies aimed at increasing AKT1 activity and sensitivity to insulin are being explored.

Can AKT1 mutations be targeted for therapeutic purposes? 11/16/2020

Targeting AKT1 mutations is an active area of research for therapeutic development. Due to the involvement of AKT1 in cancer progression, efforts are being made to develop specific inhibitors that can selectively target mutant AKT1 forms. Clinical trials are being conducted to investigate the efficacy of AKT inhibitors in patients harboring AKT1 mutations in various cancers. However, further research is still needed to fully understand the implications and potential therapeutic strategies for AKT1 mutations.

What are the functions of AKT1 protein? 07/12/2019

AKT1 protein is involved in numerous cellular processes. Some of its key functions include promoting cell survival by inhibiting apoptosis (programmed cell death), regulating cell growth and proliferation, and participating in glucose metabolism. It is also involved in the regulation of protein synthesis, cell cycle progression, DNA repair, and cellular migration.

Are there any natural compounds or dietary factors that can modulate AKT1 activity? 02/19/2019

Yes, certain natural compounds and dietary factors have been found to modulate AKT1 activity. For example, resveratrol, a polyphenol found in grapes and red wine, has been shown to inhibit AKT1 signaling and induce apoptosis in cancer cells. Curcumin, a compound found in turmeric, has also been reported to inhibit AKT1 activation and suppress tumor growth.

How is AKT1 protein activated? 11/19/2018

AKT1 protein is activated by a process called phosphorylation. When growth factor receptors, such as insulin receptors or receptor tyrosine kinases, are stimulated by their ligands, it triggers the activation of phosphoinositide 3-kinase (PI3K). PI3K then converts phosphatidylinositol 4,5-bisphosphate (PIP2) into phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 acts as a second messenger and recruits AKT1 to the cell membrane.

Can AKT1 mutations contribute to drug resistance in cancer treatment? 02/06/2018

Yes, AKT1 mutations can contribute to drug resistance in cancer treatment. Mutations in AKT1 can lead to constitutive activation of its signaling pathway, rendering cancer cells resistant to targeted therapies that rely on inhibiting AKT1. For example, tumors with activating mutations in AKT1 may not respond to AKT1 inhibitors. Additionally, mutations in AKT1 or its upstream regulators such as PI3K can bypass the inhibitory effects of targeted therapies.

How is AKT1 protein regulated? 12/30/2016

The activity of AKT1 protein is regulated through various mechanisms. In addition to phosphorylation, which activates AKT1, there are several factors that can modulate its activity. One important regulator is phosphatase and tensin homolog (PTEN), which dephosphorylates PIP3 and limits AKT1 activation. Other regulatory proteins, such as protein phosphatase 2A (PP2A) and protein kinase C (PKC), can also influence AKT1 activity by dephosphorylating or phosphorylating AKT1, respectively.

Are there any diseases or conditions linked to dysregulation of AKT1 protein? 11/27/2016

Dysregulation of AKT1 has been associated with various diseases and conditions. Apart from its prominent role in cancer, altered AKT1 signaling has been implicated in metabolic disorders such as diabetes and obesity. Reduced AKT1 activity is observed in insulin resistance, whereby insulin stimulation of AKT1-mediated glucose uptake is impaired. AKT1 dysregulation has also been linked to neurological disorders, including Alzheimer's disease and schizophrenia. Abnormal AKT1 signaling has been implicated in synaptic dysfunction, neuronal survival, and cognitive impairment associated with these conditions. Further research is needed to fully understand the mechanisms and implications of AKT1 dysregulation in these diseases.

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