AKT1

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AKT1

Official Full Name RAC-alpha serine/threonine-protein kinase
Background Akt(protein kinase B, PKB) is a serine/threonine protein kinase. Akt is activated by PI3 kinase, which is itself activated by tyrosine kinase (Thr308, Ser473). Akt/PKB controls vital cellular functions such as cell survival/apoptosis, cell cycle progression and glucose metabolism. It also acts down-stream from growth factors and hormones. Akt/PKB can inhibit cell cycle arrest by phosphorylating p21. Also, Akt/PKB may potentiate cell cycle progression through increased translation of cyclin D. Akt/PKB directly affects the apoptosis pathway by, for example, targeting the pro-apoptotic Bcl-2 related protein, BAD. It also can phosphorylate three kinases upstream of SAPK. The SAPK system consists of two groups of kinases, and JNK and p38 MAP kinase pathways. The SAPK pathway is an important target for Akt/PKB regulation to promote cell survival. Akt/PKB is able to regulate cell survival through transcriptional factors(Forkhead, nuclear factor-kB(NF-kB), Murine double minute 2(Mdm2)) that are responsible for pro- as well as anti-apoptotic genes. One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3(GSK3), which has been associated with the control of many cellular processes, including glycogen and protein synthesis, and the modulation of transcription factor activity. The involvement of Akt in disease processes like malignancy, neurodegeneration and abnormal glucose metabolism has also been demonstrated.
Synonyms AKT 1; AKT 2; AKT 3; AKT1; AKT2; AKT3; C AKT; CAKT; DKFZP434N0250; v-akt murine thymoma viral oncogene homolog 1; Murine thymoma viral (v akt) homolog 2; murine thymoma viral (v akt) oncogene homolog 1; Murine thymoma viral (vakt) oncogene homolog 1; PKB Akt; PKB alpha; PKB; PKB beta; PKBalpha; PKBBETA; PKBG; PRKBA; PRKBB; PRKBG; Protein kinase Akt 2; Protein kinase Akt 3; Protein kinase B; Protein kinase B beta; Protein kinase B gamma; RAC alpha; RAC alpha serine/threonine protein kinase; RAC; RAC beta; RAC beta serine/threonine protein kinase; RAC gamma; RAC gamma serine/threonine protein kinase; RAC PK alpha; RAC PK beta; RAC PK gamma; Rac protein kinase alpha; Rac protein kinase beta; RAC Serine/Threonine Protein Kinase; Serine threonine protein kinase Akt 3; STK 2; STK2; V AKT Murine Thymoma Viral Oncogene Homolog 1; v akt murine thymoma viral oncogene homolog 2; v akt murine thymoma viral oncogene homolog 3; VAKT Murine Thymona Viral Oncogene 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Rabbit
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • 6xHis-GST
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • MBP
    • Strep
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKT1-001H Recombinant Human AKT1 Protein, His-GST-tagged E.coli 6xHis-GST
    Human AKT1-014H Recombinant Human AKT1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human AKT1-101H Recombinant Human AKT1, GST-tagged Sf9 Insect Cell GST
    Human AKT1-1363H Recombinant Human AKT1 (Active), GST-tagged Sf9 Insect Cell GST
    Human AKT1-14H Recombinant Human AKT1 Protein, His-tagged Insect Cell His
    Human AKT1-1516H Recombinant Human AKT1 protein E.coli N/A
    Human AKT1-155H Recombinant Human AKT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1-156H Recombinant Human AKT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1-2521H Recombinant Human AKT1, GST-tagged, Active E.coli GST
    Human AKT1-259H Recombinant Human AKT1 protein, His-tagged Insect Cell His
    Human AKT1-307H Recombinant Human AKT1 protein, His/MBP-tagged E.coli His/MBP
    Human AKT1-30H Recombinant Human AKT1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human AKT1-336H Recombinant Human AKT1 protein, His/Strep-tagged HEK293 His/Strep
    Human AKT1-3920H Recombinant Human AKT1 protein, GST-tagged E.coli GST
    Human AKT1-4200H Recombinant Human AKT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKT1-420H Recombinant Human AKT1 Protein, GST-His tagged Insect Cell GST/His
    Human AKT1-421H Recombinant Human AKT1 Protein, His-tagged Insect Cell His
    Human AKT1-422H Recombinant Human AKT1 Protein, GST-tagged Wheat Germ GST
    Human AKT1-427H Recombinant Human AKT1 Protein, His-tagged E.coli His
    Human AKT1-47H Recombinant Human AKT1 protein, His-tagged E.coli His
    Human AKT1-50H Recombinant Human AKT1 protein, GST-tagged Insect Cell GST
    Human AKT1-5186H Recombinant Human AKT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKT1-56H Recombinant Human AKT1, Actived Sf9 Insect Cell N/A
    Human AKT1-57H Recombinant Human AKT1, Inactived Sf9 Insect Cell N/A
    Human AKT1-677HCL Recombinant Human AKT1 cell lysate Insect Cell N/A
    Human AKT1-786H Recombinant Human AKT1, His tagged Insect Cell His
    Human CAB-2492MH Mouse Anti-Human AKT1 Monoclonal Antibody, DyLight 649 Mouse N/A
    Human CPBTT-30930RH Rabbit Anti-Human AKT Polyclonal Antibody Rabbit N/A
    Mouse AKT1-1507M Recombinant Mouse AKT1 Protein Mammalian Cell His
    Mouse Akt1-566M Recombinant Mouse Akt1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat AKT1-605R Recombinant Rat AKT1 Protein Mammalian Cell His
    Rhesus Macaque AKT1-296R Recombinant Rhesus monkey AKT1 Protein, His-tagged Mammalian Cell His
    Chicken AKT1-6612C Recombinant Chicken AKT1 Mammalian Cell His
    Zebrafish AKT1-8342Z Recombinant Zebrafish AKT1 Mammalian Cell His

    AKT1 involved in several pathways and played different roles in them. We selected most pathways AKT1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNB2; MAPK10; DDIT3; DUSP3; FGF6B; TGFBR1; MAPK8IP2; AKT2; SRFA; ELK1
    ErbB signaling pathway NCK1; BRAF; ERBB2; EGFRA; MAP2K4B; CAMK2B; PRKCBB; PAK2; PIK3R3; SHC1
    Ras signaling pathway BCL2L1; SHC3; VEGFB; FGF2; FLT4; MAPK3; RASAL1; TEK; PLA1A; FGF9
    Rap signaling pathway MAPK1; PLCE1; PLCB1; ITGB3; FGF20; PRKCA; RRAS; GNAI1; FARP2; PIK3R5
    cGMP-PKG signaling pathway PIK3R5; NPR1; AGTR1A; PRKG1; CALM3; PIK3CD; GNAI1; ATP2A2; ROCK2; PDE3A
    cAMP signaling pathway NPY1R; VAV3; BDNF; BRAF; PIK3CA; GRIA2; FOS; ROCK1; ATP2A2; SLC9A1
    Chemokine signaling pathway RAP1A; CCL27; NCF1; CCL28; RASGRP2; GRK5; GNG11; PRKACG; CCL4L1; PRKCZ
    HIF- signaling pathway ANGPT4; PDK1; ANGPT2; GM5506; GAPDH; ALDOA; ENO1; NPPA; PIK3R5; PDHB
    FoxO signaling pathway BNIP4; HRASB; TGFB3; ATG12; HOMER2; MAPK12B; MAPK14B; STK4; TGFBR1B; PRKAG1
    Sphingolipid signaling pathway ASAH2; S1PR4; PIK3CA; SGMS1; SPTLC2; MS4A2; PIK3CD; PPP2R3A; NRAS; NOS3
    Phospholipase D signaling pathway SYK; CXCR1; PIP5K1A; GRM5; LPAR4; PPAP2C; GNAS; PLCB1; CYTH4; PLCB2
    mTOR signaling pathway RPS6KA3B; AKT1; STRADA; TSC1A; RRAGC; RRAGCB; RPS6KA3; RPS6KB1B; EIF4E2RS1; RRAGCA
    PIK-Akt signaling pathway PKN1; IFNA7; GH2; GNG3; CCNE1; IFNB1; RELA; PIK3CA; IL7; LAMC2
    AMPK signaling pathway ADIPOR2; ADIPOR1; G6PC; RAB2A; CAB39; PPP2R2B; PFKFB3; PIK3R1; AKT1; PPARGC1A
    Apoptosis FAS; AKT2L; PIK3CG; DAPK3; HMGB2; PIK3R3; CAPN1B; TRADD; HDR; CASP2
    Adrenergic signaling in cardiomyocytes CACNA2D4; TPM1; ATP1A4; CACNB3; PRKACG; ADRB3A; ADRB1; AKT2L; PIK3R3; MAPK12A
    VEGF signaling pathway PRKCBA; RAC3; PTGS2B; PPP3CB; VEGFAA; PRKCG; SRC; PIK3R5; PIK3CD; PRKCB
    Osteoclast differentiation CSF1R; FOSL1; GAB2; SIRPA; FCGR3; SQSTM1; TRAF2; PIK3R3; PIK3CB; NCF4
    Focal adhesion BCL2A; ROCK2A; MYLPFB; COL27A1B; ROCK2B; BRAF; MYL10; MYLPFA; LAMA1; PDGFRA
    Tight junction CLDN16; PRKCA; PRKCBA; ACTB1; CLDN7A; MYH11; ACTN2B; CDC42L; MYH7; ACTG1
    Signaling pathways regulating pluripotency of stem cells FZD2; MYF5; SMAD9; SMAD4; SOX2; NEUROG1; NRAS; MAPK12; WNT5A; MAP2K1
    Platelet activation PRKACA; SNAP23; GNAS; ITGB3; GNAI3; FYN; ITPR3; ROCK1; ARHGEF1; PLCB1
    Toll-like receptor signaling pathway CASP8; Ifna11; TBK1; PIK3CA; NFKBIA; IFNA17; MAP2K4; AKT1; IFNA12; RAC1B
    Jak-STAT signaling pathway IFNA4; OSM; GRB2; STAT5B; IL21R.1; LIFR; IFNA1; AKT2; IL6R; GHR
    T cell receptor signaling pathway IKBKG; NFATC2; GRAPA; CARD11; CBLB; PAK2; CD40LG; NFKBIE; PIK3R3; PIK3R1
    B cell receptor signaling pathway HDAC5; DOK1; SYK; BLK; RASGRP3; CD81; PTPN18; DUSP4; VAV1; BTK
    Fc epsilon RI signaling pathway PLA2G4C; PLCG1; FYN; PRKCA; VAV2; IL3; MAPK8; PIK3R2; MAPK12; GRB2
    Fc gamma R-mediated phagocytosis GSN; PLA2G4A; VASP; LAT; PRKCD; PLD2; PRKCA; PIP5K1C; DOCK2; ASAP2
    TNF signaling pathway ICAM1; LTA; VCAM1; RPS6KA5; MAP2K7; BIRC3; MAP3K5; CREB5; TRADD; MAPK11
    Neurotrophin signaling pathway HRAS; PDPK1; PIK3CA; PIK3CD; CALM2; MAPK9; MAPK1; ABL1; RIPK2; ZNF274
    Cholinergic synapse PRKCG; CREB5; GNG2; JAK2; GNB3; CREB3; KCNQ5; KCNQ4; KCNJ3; CAMK2B
    Dopaminergic synapse PRKACA; DRD2; GNB4; PRKCG; GNAL; GRIA1; AKT1; PLCB1; CAMK2B; PPP1CC
    Insulin signaling pathway FBP1A; PPP1R3C; RPS6; INPP5K; PDE3B; CALM3; HRASB; CALML3; PYGMA; FOXO1
    Progesterone-mediated oocyte maturation PRKACA; FZR1A; MAD2L1; GNAIA; AKT3A; CCNA2; ADCY1B; BRAF; FZR1; IGF1
    Estrogen signaling pathway HSP90B1; HSPA1L; ATF4; SHC2; FKBP5; PIK3CA; GNAI3; SP1; MAP2K2; NOS3
    Prolactin signaling pathway STAT3; PIK3CA; PRLR; RAF1; MAP2K1; SRC; SOCS1; FOS; SOCS5; PIK3R1
    Thyroid hormone signaling pathway NOTCH3; PRKCG; PIK3R1; BAD; MED4; PLCD4; RHEB; ATP2A2; HIF1A; SLCO1C1
    Adipocytokine signaling pathway NFKBIB; RELA; PRKAA1; SOCS3; CAMKK1; ADIPOR1; PRKAG1; JAK2A; G6PC; TNFRSF1A
    Regulation of lipolysis in adipocytes FABP4; PIK3CB; IRS2; GNAI2; PRKG2; AQP7; PIK3CA; IRS1; PIK3CD; Adcy4
    Insulin resistance NFKBIAB; PPARGC1B; PTENA; INS; PRKAG2A; MAPK9; OGT; PYGMA; PPP1CAA; SOCS3
    Non-alcoholic fatty liver disease (NAFLD) COX7B; NDUFA11; NDUFS4; KCNA3; NDUFS2; PRKAA2; SDHD; MAP3K11; XBP1; RAC1
    Carbohydrate digestion and absorption Amy1; TAS1R2; G6PC2; SLC2A5; AMY2A3; AKT2; ATP1B2; PIK3CB; PIK3R2; PIK3R5
    Chagas disease (American trypanosomiasis) RELA; TICAM1; PIK3CD; IKBKB; MAPK3; MAPK1; MAPK12; IL-8; SERPINE1; LOC100033925
    Toxoplasmosis HLA-DRB1; MAP2K3; IFNG; LAMA4; H2-AA; LAMC2; PPIF; LAMA5; RELA; XIAP
    Tuberculosis Casp3; MRC2; HSPA9; PPP3R2; PIK3C3; IFNG; ATP6V0D1; HLA-DRB1; CLEC4M; IL1B
    Hepatitis C IFNA1; CLDN22; EIF2AK4; MAPK8; Ifna15; HRAS; PIK3R3; TYK2; PIK3R2; TNFRSF1A
    Hepatitis B IFNA2; MAPK10; Ifna11; TGFB1; IKBKG; IFNA4; OSTN; MAP3K1; STAT2; IFNA1
    Measles OAS2; STAT1; HSPA2; TRAF6; IFNA21; IL13; OAS3; TACR1; STAT2; MAP3K7
    Influenza A RELA; PRSS3; RSAD2; IFNA3; HLA-DRA; IL8L1; TNFRSF1A; IFNA13; NLRX1; PIK3R1
    HTLV-I infection WNT8B; RAN; RB1; MSX2; APC; TERT; RANBP3; CANX; FOSL1; TBPL1
    Epstein-Barr virus infection GSK3B; H2-Q10; ENTPD1; YWHAH; POLR2C; POLR3E; IKBKG; TRAF2; SND1; NUP214
    Pathways in cancer MMP9; GNG7; KRAS; PTGER3; GLI2; GSK3B; MSH3; ITGA2; ARHGEF1; LPAR2
    Proteoglycans in cancer GRB2; FZD3; RPS6; PIK3R2; CAV2; CAV1; SMO; EZR; CAV3; ERBB3
    Colorectal cancer TGFBR1; GSK3B; PIK3R1; MSH2; TGFB1; Casp3; PIK3CG; PIK3CD; MAPK1; PIK3R2
    Renal cell carcinoma PAK1; PIK3R3; MAPK1; HIF1A; PAK6; KRAS; AKT2; VHL; TGFB1; BRAF
    Pancreatic cancer CDC42; MAPK3; TGFB1; ARHGEF6; SMAD3; CCND1; MAPK9; MAPK8; NFKB1; ERBB2
    Endometrial cancer CCND1; CTNNA2; TRP53; GRB2; PTEN; ILK; PIK3CA; PIK3CB; MAP2K2; AKT1
    Glioma CAMK2B; PRKCG; PIK3R5; MAP2K1; TGFA; NRAS; Pdgfa&Pdgfb; SHC3; SOS1; SHC4
    Prostate cancer HRAS; TCF7; PIK3R1; HSP90B1; PDGFRB; KRAS; INSRR; NDRG1; MDM2; PIK3CG
    Melanoma PTEN; CCND1; FGF11; FGF14; PIK3CG; PIK3CA; ARAF; PDGFD; TP53; CDH1
    Chronic myeloid leukemia BRAF; BAD; MDM2; NRAS; PIK3R3; MAPK3; CCND1; HDAC2; TGFBR2; SHC1
    Acute myeloid leukemia AKT1; MTOR; KRAS; HRAS; PIK3R2; RPS6KB2; NRAS; PIK3CG; TCF7; CEBPA
    Small cell lung cancer BIRC7; TRAF3; CYCS; CKS2; CCNE1; PIK3CA; TRAF4; ITGA6; ITGAV; SKP2
    Non-small cell lung cancer AKT1; RXRG; PLCG1; CCND1; PRKCA; BAD; RASSF1; MAP2K1; FHIT; RXRB
    Central carbon metabolism in cancer PKM2; SIRT6; SLC2A1; PIK3R3; HIF1A; FGFR2; PGAM1; HRAS; MAPK3; PIK3CD
    Choline metabolism in cancer TSC2; WASL; PPAP2C; SLC22A2; MAPK8; PLA2G4B; PLD1; PRKCB; RAC3; PLA2G4A

    AKT1 has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1 itself. We selected most functions AKT1 had, and list some proteins which have the same functions with AKT1. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding PPP1R12A; ZFP36; KCNH1; AKT1; TSC2; HDAC7A; AANAT; IRS2; DDIT4; PRKCZ
    ATP binding KIF1C; CAMK1GB; MYH7; IGF1R; PAICS; CKMT2; FASTK; MYH3; KIF3CB; DAPK3
    enzyme binding ZFHX3; PLAUR; UGT1A9; SELS; CCND1; NOP14; MLEC; CD40; APOA5; NOTCH1
    identical protein binding PTS; DYNLT1A; ATG101; MAP1S; STAT6; PRPS2; NELL2; PSME3; CCDC109A; AHI1
    kinase activity CAMK2A; MARCKSA; NADKD1; HIPK2; CSF1RA; KITA; MAPK14B; CDK14; MAP3K4; BMPR1AB
    nitric-oxide synthase regulator activity AKT1; CALM2; HSP90AA1; HSP90AB1; CALM1; ESR1; CALM3; HSP90AA1.1
    phosphatidylinositol-3,4,5-trisphosphate binding ARAP2; MAPKAP1; RAG2; OGT; PARD3; FERMT2; ARAP3; FAM21C; NRGN; AKT1
    phosphatidylinositol-3,4-bisphosphate binding MYO1G; ZFYVE1; PLEK; ARAP3; PHLDA3; SESTD1; D6WSU116E; RAG2; AKT1; ANXA8
    protein binding TPSB2; FAM3C; Serpina1b; ITSN2; CREBBP; BEND7; COX8A; C4orf19; EIF5; SF3B4
    protein kinase C binding SDC4; AVPR1A; GNB2L1; SDPR; TOP2B; FLNA; IRS1; PAWR; FEZ1; TWF2
    protein kinase activity MAP2K4B; SYK; PRKACAB; MAP4K1; POMK; VSIG8B; CSF1RA; FGFR1B; SRC; MAP3K12
    protein phosphatase 2A binding CTTNBP2NL; PTPN1; STRN; EIF4EBP1; IGBP1; MASTL; MAPT; RPS6KB1; ENSAA; ANKLE2
    protein serine/threonine kinase activity EIF2AK2; ROCK2B; PDIK1L; ACVR2AA; PRKCB; CHEK1; AKT2L; PINK1; ERN1; CSNK1G1
    protein serine/threonine/tyrosine kinase activity AURKC; RPS6KB1; CLK3; MAP2K1; DYRK1AA; CLK1; PRKAA2; DSTYK; AURKA; DYRK1A

    AKT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1.

    MDM2; N/A; PPP2CA

    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
    Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).

    TGF

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