ANGPT1
-
Official Full Name
Angiopoietin 1 -
Overview
Angiopoietin-1 is a 498 amino acid secreted protein that undergoes post-translational glycosylation. It contains 1 fibrinogen C-terminal domain. Angiopoietin-1 is found to bind and activate TIE2 receptors by inducing its tyrosine phosphorylation. It is implicated in endothelial developmental processes later and is distinct from that of VEGF. Angiopoietin-1 appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Moreover, it mediates blood vessel maturation/stability. Angiopoietin-1 may also play an important role in early development of the heart. It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart. -
Synonyms
ANGPT1;AGP1;AGPT;ANG1;ANG-1
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Chicken
- Mouse
- Dog
- Rat
- Zebrafish
- Rat/Human
- Pig
- E.coli
- Mammalian cells
- HELA
- CHO
- HeLa
- Insect Cell
- HEK293
- Wheat Germ
- Mammalian Cell
- COS
- Insect cells
- Yeast
- In Vitro Cell Free System
- His
- Flag
- Non
- Myc
- GST
- FLAG
- Fc
- His&Fc&Avi
Involved Pathway
ANGPT1 involved in several pathways and played different roles in them. We selected most pathways ANGPT1 participated on our site, such as Ras signaling pathway,Rap signaling pathway,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | LPAR4,FGF3,PIK3CA,Itgam&Itgb2,CDH1,CALML5,PRKCB,RAP1A,LPAR3,VASP |
| PIK-Akt signaling pathway | GHR,IFNA17,IFNB1,COL6A6,FGF19,INS2,GNG11,COL4A1,PKN3,EIF4E2 |
| HIF- signaling pathway | NOS3,MAPK3,IGF1,SLC2A1,GM5506,MAP2K1,IFNG,PIK3R1,PIK3R2,PLCG2 |
| Ras signaling pathway | PLA2G4C,PIK3R1,GRIN1,MAPK10,PAK7,GNG2,PTPN11,PLA2G2D,FASLG,PDGFB |
| Rheumatoid arthritis | CCL20,HLA-DPB1,CXCL5,CCL3L1,HLA-DPA1,CD86,IL1A,MMP1A,ATP6V0B,TNFSF13 |
Protein Function
ANGPT1 has several biochemical functions, for example, protein binding,receptor tyrosine kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPT1 itself. We selected most functions ANGPT1 had, and list some proteins which have the same functions with ANGPT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor tyrosine kinase binding | GAS6,FIZ1,PTPN14,Flt3l,PTPN2,PITPNM3,TOB1,PIK3R2,ZFP259,TP53 |
| protein binding | RFWD3,GPA33,PRKD1,HEBP2,SPRR3,ST13,COQ9,PRKCE,EDARADD,PRR16 |
Interacting Protein
ANGPT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPT1.
daap-5;TEK
Resources
Research Area
Cancer Drug TargetsInflammatory Mediators
Angiopoietins, Angiopoietin-like Proteins, and Receptors
Angiopoietin
Related Services
Related Products
References
- Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
- Scotti, L; Abramovich, D; et al. Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS). MOLECULAR AND CELLULAR ENDOCRINOLOGY 365:223-230(2013).
