angpt1

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angpt1

Official Full Name Angiopoietin 1
Background Angiopoietin-1 is a 498 amino acid secreted protein that undergoes post-translational glycosylation. It contains 1 fibrinogen C-terminal domain. Angiopoietin-1 is found to bind and activate TIE2 receptors by inducing its tyrosine phosphorylation. It is implicated in endothelial developmental processes later and is distinct from that of VEGF. Angiopoietin-1 appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Moreover, it mediates blood vessel maturation/stability. Angiopoietin-1 may also play an important role in early development of the heart. It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.
Synonyms ANGPT1; AGP1; AGPT; ANG1; ANG-1
    • Species :
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Human
    • Mouse
    • Rat
    • Rat and Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • COS
    • E.coli
    • HEK293
    • HeLa
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • Flag
    • GST
    • His
    • HlgG1 Fc
    • MYC
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat Angpt1-539R Recombinant Rat Angpt1 protein, His-tagged Yeast His
    Human ANGPT1-1065H Recombinant Human ANGPT1 Protein (Met1-Leu261 and Arg277-Phe498), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Cynomolgus ANGPT1-1066C Recombinant Cynomolgus ANGPT1 Protein (Arg277-Phe498), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Human Ang-1-3455H Recombinant Human Ang-1 HeLa N/A
    Human ANGPT1-115H Recombinant Human Angiopoietin 1, Myc-tagged Insect Cell MYC
    Human ANGPT1-157H Recombinant Human ANGPT1 Protein, His-tagged, Biotinylated NS0 His
    Human ANGPT1-2518H Recombinant Human Angiopoietin 1 NS0 N/A
    Human ANGPT1-256H Recombinant Human ANGPT1 protein, GST-tagged Wheat Germ GST
    Human ANGPT1-27316TH Recombinant Human ANGPT1 E.coli N/A
    Human ANGPT1-27317TH Recombinant Human ANGPT1, FLAG-tagged E.coli Flag
    Human ANGPT1-3455H Recombinant Human ANGPT1 protein, His-tagged HELA His
    Human ANGPT1-35H Recombinant Human ANGPT1/COMP protein, FLAG-tagged HEK293 FLAG
    Human ANGPT1-434H Recombinant Human Angiopoietin 1, FLAG-tagged CHO Flag
    Human ANGPT1-525H Recombinant Human ANGPT1 protein, His-tagged E.coli His
    Human ANGPT1-526H Recombinant Human ANGPT1 protein, His-tagged E.coli His
    Human ANGPT1-6881H Recombinant Human Angiopoietin 1 E.coli N/A
    Human ANGPT1-8863HCL Recombinant Human ANGPT1 293 Cell Lysate HEK293 N/A
    Mouse Angpt1-4964M Recombinant Mouse Angpt1 protein COS N/A
    Mouse Angpt1-527M Recombinant Mouse Angpt1 protein, His-tagged E.coli His
    Mouse Angpt1-528M Recombinant Mouse Angpt1 protein, His-tagged E.coli His
    Mouse Angpt1-857M Recombinant Mouse Angpt1 Protein, His-tagged HEK293 His
    Rat Angpt1-529R Recombinant Rat Angpt1 protein, His-tagged E.coli His
    Rat ANGPT1-668R Recombinant Rat ANGPT1 Protein Mammalian Cell His
    Cynomolgus Monkey ANGPT1-1171C Recombinant Cynomolgus ANGPT1 Protein, His-tagged HEK293 His
    Rhesus Macaque ANGPT1-324R Recombinant Rhesus monkey ANGPT1 Protein, His-tagged Mammalian Cell His
    Dog ANGPT1-523D Recombinant Dog ANGPT1 protein, His-tagged E.coli His
    Dog ANGPT1-524D Recombinant Dog ANGPT1 protein, His-tagged E.coli His
    Chicken ANGPT1-4313C Recombinant Chicken ANGPT1 Mammalian Cell His
    Zebrafish ANGPT1-9324Z Recombinant Zebrafish ANGPT1 Mammalian Cell His
    Rat and Human COMP-Ang1-01 Recombinant Comp(Rat) and ANGPT1(Human), Flag-tagged CHO N/A

    angpt1 involved in several pathways and played different roles in them. We selected most pathways angpt1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with angpt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway SHC4; FGF12; FGF6; FGFR2; CALM1; SHOC2; GNG5; MAPK10; VEGFB; NFKB1
    Rap signaling pathway ARAP3; RAC3; KIT; PFN1; VEGFC; FGF18; PDGFRA; FGF11; RAF1; RALGDS
    HIF- signaling pathway Trf; MTOR; HK1; AKT2; TF; EIF4E1B; VHL; ENO3; MAP2K2; ENO2
    PIK-Akt signaling pathway GH2; IL2RB; IL7R; ANGPT1; MET; SOS1; STK11; HSP90AB1; IGF1; IFNA10
    Rheumatoid arthritis FLT1; ATP6V1G2; IL6; ANGPT1; ATP6V0E; TLR2; TNF; ATP6V1F; IL11; GM-CSF

    angpt1 has several biochemical functions, for example, protein binding, receptor tyrosine kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by angpt1 itself. We selected most functions angpt1 had, and list some proteins which have the same functions with angpt1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SNX1; NAP1L4; RNF168; POLE4; PPP4R4; FBXO5; NAA50; APPB; SPATA22; IL-8
    receptor tyrosine kinase binding ANGPT4; ANXA5; PTPN2; PTPN1; CPNE3; TP53; FLT3LG; ARHGEF16; PLCG1; NRG1

    angpt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with angpt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of angpt1.

    daap-5; TEK

    Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
    Scotti, L; Abramovich, D; et al. Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS). MOLECULAR AND CELLULAR ENDOCRINOLOGY 365:223-230(2013).

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