Active Recombinant Human ANGPT1 Protein

• Cat.No.: ANGPT1-003H
• Product Overview: The mature recombinant human Ang-1 protein containing 479aa (S20-F498) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 20-498 a.a.
• Description: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema.
• Bio-activity: Measured by its ability to inhibit serum deprivation induced apoptosis in HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 10-40 ng/mL.
• Molecular Mass: 56 kDa
• Product-Related Proteins: 20-498
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: ANGPT1 angiopoietin 1 [ Homo sapiens (human) ]
• Official Symbol: ANGPT1
• Synonyms: ANGPT1; angiopoietin 1; AGP1; AGPT; ANG1; HAE5; angiopoietin-1; Names; ANG-1
• Gene ID: 284
• mRNA Refseq: NM_001146
• Protein Refseq: NP_001137
• MIM: 601667
• UniProt ID: Q15389