APOC2 Protein

September 27-30, 2022

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APOC2

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APOC2

Official Full Name apolipoprotein C-II
Background This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
Synonyms APOC2; apolipoprotein C-II; APO-CII; APOC-II; apolipoprotein C2;
    • Species :
    • Cynomolgus Monkey
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human Plasma
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • His-SUMO
    • MYC/DDK
    • N/A
    • N-His
    • N-His&GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APOC2-4773H Human Apolipoprotein C-II N/A
    Human APOC2-705H Recombinant Human APOC2 protein, GST-tagged Wheat Germ GST
    Human APOC2-916H Recombinant Human APOC2 Protein, His-tagged E.coli His
    Mouse APOC2-1788M Recombinant Mouse APOC2 Protein Mammalian Cell His
    Mouse Apoc2-2087M Recombinant Mouse Apoc2 protein, His & GST-tagged E.coli His/GST
    Cynomolgus Monkey APOC2-304C Recombinant Cynomolgus APOC2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque APOC2-367R Recombinant Rhesus monkey APOC2 Protein, His-tagged Mammalian Cell His
    Horse APOC2-2085H Recombinant Horse APOC2 protein, His & T7-tagged E.coli His/T7
    Guinea pig Apoc2-2086G Recombinant Guinea pig Apoc2 protein, His & GST-tagged E.coli His/GST
    Guinea pig Apoc2-3569C Recombinant Cavia porcellus (Guinea pig) Apoc2, GST-tagged E.Coli or Yeast GST
    Human APOC2-8783HCL Recombinant Human APOC2 293 Cell Lysate HEK293 N/A
    Human APOC2-221H Recombinant Human APOC2 Protein, His&GST-tagged E.coli N-His&GST
    Rat Apoc2-222R Recombinant Rat Apoc2 Protein, His-tagged E.coli N-His
    Human APOC2-2538H Recombinant Human APOC2 protein, His-SUMO-tagged E.coli His-SUMO
    Human APOC2-1776H Recombinant Human APOC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human APOC2-27331TH Native Human APOC2 protein Human Plasma N/A
    Human APOC2-27332TH Native Human APOC2 N/A
    Human APOC2-4904H Native Human Apolipoprotein CII Human Plasma N/A
    Mouse Apoc2-817M Recombinant Mouse Apoc2 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    APOC2 involved in several pathways and played different roles in them. We selected most pathways APOC2 participated on our site, such as Chylomicron-mediated lipid transport, HDL-mediated lipid transport, Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chylomicron-mediated lipid transport APOA5; MTP; APOA4B.1; APOC2; APOEA; APOA4A; APOEB; APOBB.1; APOA4B.2; APOA1B
    HDL-mediated lipid transport AMN; ABCA1; BMP1A; CETP; APOC2; Alb; APOA1B
    Lipid digestion, mobilization, and transport FABP12; APOEA; CLPS; MTP; APOEB; APOA4A; FABP9; APOC2; APOBB.1; FABP1B.1
    Lipoprotein metabolism APOEB; APOEA; APOF; Alb; APOA1B; APOA5; APOA4A; LPA; APOA4B.1; ABCA1
    Metabolism PPM1K; ATP5H; TACO1; ACOT8; CYP27A1; CPNE7; SULT4A1; SLC25A21; PPM1LA; PFKLB
    Metabolism of lipids and lipoproteins CPNE3; SACM1LB; AWAT1; CYP2N13; PPM1LA; CYP2Y3; ARV1; CLPS; CYP2AD3; FABP9
    Retinoid metabolism and transport BCO2L; LRP12; APOA4B.1; CLPS; AKR1C21; BCO2A; APOM; APOA4B.2; APOA4A; BCO2
    Signal Transduction APLNR; OTULINB; TAX1BP1; ARHGEF25; TLE3B; NOXA1; APOA4B.2; DEPDC1B; HECW1; MYO9B

    APOC2 has several biochemical functions, for example, lipase inhibitor activity, lipid binding, lipoprotein lipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC2 itself. We selected most functions APOC2 had, and list some proteins which have the same functions with APOC2. You can find most of the proteins on our site.

    Function Related Protein
    lipase inhibitor activity APOC2; APOA1; APOC3; FAF2; APOC1; APOA2
    lipid binding RASGRP1; MARK2; BPIFB2; CADPS; PSAP; LPAR3; HDLBP; SNX10A; CETP; FAM123A
    lipoprotein lipase activator activity APOH; APOC2; APOA5
    phospholipase activator activity ARHGAP6; CCL8; APOC2; PDPK1; CCL3; CCL5; GM2A
    phospholipase binding APOC2; DGKQ; SERPINB1A; Pla2r1; WAS; PTPN11; NEFL; PARK2; CALM3; CALM2
    protein homodimerization activity NAMPT; ACCS; B4GALT1; TRIM9; VPS24; ZBTB4; NR4A3; UGT1A6B; TSG101; JAM3

    APOC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC2.

    d-mannose; APOE; APOA2; ALB; APOB

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