atp1b1

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atp1b1

Official Full Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Background The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
Synonyms ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide; ATP1B; sodium/potassium-transporting ATPase subunit beta-1; adenosinetriphosphatase; Na, K-ATPase beta-1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; sodium/potassium-dependent ATPase beta-1 su
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP1B1-10007H Recombinant Human ATP1B1, GST-tagged E.coli GST
    Human ATP1B1-2279H Recombinant Human ATP1B1 protein, His-tagged E.coli His
    Human ATP1B1-246H Recombinant Human ATP1B1, His tagged Human Cell Fc
    Human ATP1B1-919HCL Recombinant Human ATP1B1 cell lysate Human Cell N/A
    Human ATP1B1-965H Recombinant Human ATP1B1 protein, GST-tagged Wheat Germ GST
    Mouse ATP1B1-2116M Recombinant Mouse ATP1B1 Protein Mammalian Cell His
    Mouse ATP1b1-3766M Recombinant Mouse ATP1b1, His-tagged E.coli His
    Mouse Atp1b1-462M Recombinant Mouse Atp1b1 Protein, His-tagged E.coli His
    Rat ATP1B1-856R Recombinant Rat ATP1B1 Protein Mammalian Cell His
    Cynomolgus Monkey ATP1B1-321C Recombinant Cynomolgus ATP1B1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ATP1B1-449R Recombinant Rhesus monkey ATP1B1 Protein, His-tagged Mammalian Cell His
    Chicken ATP1B1-7069C Recombinant Chicken ATP1B1 Mammalian Cell His

    atp1b1 involved in several pathways and played different roles in them. We selected most pathways atp1b1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with atp1b1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway GNAI2; PIK3R3; PPP3CA; PLCB3; ATP1B4; ATP1B3; SLC25A6; PPP3R2; ATP2B4; PIK3CA
    cAMP signaling pathway GNAI3; GABBR1; RRAS2; PDE4D; PTCH1; RELA; GRIN3B; PDE4C; NFKBIA; GLP1R
    Cardiac muscle contraction CACNB2; CACNB1; COX5B2; TNNC1; CACNG8; COX5B; COX7A2L; TPM1; SLC8A1; COX4I2
    Adrenergic signaling in cardiomyocytes CALML5; PIK3R3B; PPP2R2B; CALML3; MYL2; PIK3CG; CALM2A; CACNB4; ADRA1D; ATP1A3
    Insulin secretion INS1; PRKACG; CAMK2D; GLP1R; CREB5; ATP1A1; CAMK2G; KCNN3; TRPM4; STX1A
    Thyroid hormone synthesis ATF4; CANX; GPX3; PLCB4; ATP1A1; GSR; ATP1A4; ATP1B3; TSHB; ATP1B1
    Thyroid hormone signaling pathway PRKCG; MED12L; RCAN2; PIK3CB; ITGAV; PRKCB; ATP1A1; PDPK1; PLCG2; ATP1B2
    Aldosterone-regulated sodium reabsorption ALPHA-ENAC; SCNN1G; PDPK1; INS; PIK3CD; ATP1A3; PRKCB; NR3C2; SLC9A3R2; ATP1A1
    Endocrine and other factor-regulated calcium reabsorption ATP2B1; BDKRB2; ATP1B3; ATP1A4; KLK1B9; PRKCA; KLK1B24; GNAQ; DNM2; DNM3
    Proximal tubule bicarbonate reclamation SLC25A10; PCK2; ATP1B1; PCK1; ATP1B2; ATP1A3; AQP1; ATP1A4; GLUD2; GLS
    Salivary secretion CALM2; STATH; PRKCA; GNAS; BST1; CAP18; Adcy4; PRKCB; LYZ; CST5
    Gastric acid secretion ATP1A1; KCNK10; MYLK; KCNQ1; ATP1B2; PRKACG; CA2; ITPR1; MYLK2; GNAS
    Pancreatic secretion PLA2G1B; CPA1; CLCA5; KCNQ1; CA2; PRSS3; CLCA4; Adcy4; RAB3D; Slc4a2
    Carbohydrate digestion and absorption TAS1R3; AMY2A5; PIK3R2; AMY2A3; Amy1; AMY1A; PIK3CB; G6PC; PIK3R1; PIK3CD
    Protein digestion and absorption SLC8A1; SLC15A1; ATP1B3; CPA1; LOC780933; CELA2B; SLC7A7; SLC3A1; CPB2; PGA5
    Bile secretion CYP3A4; CA2; ABCB1; GNAS; ABCB1A; NCEH1; ATP1A1; NR0B2; CYP7A1; SLC4A4
    Mineral absorption MT1H; SLC11A1; FXYD2; ATP7A; FTH1; MT1F; ATP1B2; SLC5A1; HMOX1; MT1

    atp1b1 has several biochemical functions, for example, contributes_to ATP binding, ATPase activator activity, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by atp1b1 itself. We selected most functions atp1b1 had, and list some proteins which have the same functions with atp1b1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ATP binding ATP1B1; ATP1A2; MSH6; SFRP5; ATP5D; MSH2; ABCG8
    ATPase activator activity RAB4A; DNAJC15; AHSA1; AHSA2; TOR1AIP1; DNAJC24; ATP1B2; ATP1B3; DNAJC19; TOR1AIP2
    contributes_to ATPase activity ATP5L; ATP5I; RFC3; ATP5E; ATP5O; ATP5J; ATP5B; RUVBL2; ATP5J2; ATP1A2
    ATPase binding ATP6V0A2B; TCIRG1; DRD1; ATP6V0A1A; ATPIF1A; ATXN3; SELS; SVIP; ATP6V1G1; PEX19
    MHC class II protein complex binding CD81; CD74; MS4A1; ATP1B1; HSP90AA1; PKM; HLA-DRA; HLA-DOA; YWHAE; HLA-DOB
    contributes_to drug binding ATP1B1; ATP1A2; PGGT1B
    contributes_to potassium ion binding ATP1A2; ATP1B1
    protein C-terminus binding PRDX3; CACNA1B; PABPC1; CD2AP; PHB; FIGN; CTGF; TJP2; PDZD3; NIPBL
    protein binding WBSCR27; SEMA4A; IFRD2; SREBF1; LLGL1; IL23R; TNNI3; TMED10; INPP5K; POLR1B
    contributes_to sodium ion binding ATP1A2; ATP1B1
    contributes_to sodium:potassium-exchanging ATPase activity ATP1B2; ATP1B3; ATP1B1; ATP1A2; ATP1A1

    atp1b1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atp1b1 here. Most of them are supplied by our site. Hope this information will be useful for your research of atp1b1.

    SLC4A1; MLC1; NR3C1; SMAD2; DDAH2; CRIP2; PSME1; EZH2; RIF1; TRMT2A; KMT2B; ouabain

    Willmsa, K; Shoemaker, CB; et al. Cloning and expression of a Na+, K+-ATPase alpha-subunit from Taenia solium (TNaK1 alpha). MOLECULAR AND BIOCHEMICAL PARASITOLOGY 138:79-82(2004).
    Therien, AG; Goldshleger, R; et al. Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase. JOURNAL OF BIOLOGICAL CHEMISTRY 272:32628-32634(1997).

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