ATP1B1

  • Official Full Name

    ATPase, Na+/K+ transporting, beta 1 polypeptide

  • Overview

    The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
  • Synonyms

    ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide; ATP1B; sodium/potassium-transporting ATPase subunit beta-1; adenosinetriphosphatase; Na, K-ATPase beta-1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; sodium/potassium-dependent ATPase beta-1 su;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Anguilla anguilla (European freshwater eel) (Muraena anguilla)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Cynomolgus Monkey
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Tetronarce californica (Pacific electric ray) (Torpedo californica)
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP1B1-965H Recombinant Human ATP1B1 protein, GST-tagged Wheat Germ GST
Human ATP1B1-246H Recombinant Human ATP1B1, His tagged Human Cell Fc
Human ATP1B1-10007H Recombinant Human ATP1B1, GST-tagged E.coli GST 59-303a.a.
Human ATP1B1-2279H Recombinant Human ATP1B1 protein, His-tagged E.coli His
Human ATP1B1-919HCL Recombinant Human ATP1B1 cell lysate Human Cell N/A
Human ATP1B1-1131HF Recombinant Full Length Human ATP1B1 Protein, GST-tagged In Vitro Cell Free System GST 303 amino acids
Human ATP1B1-17H Active Recombinant Human ATP1B1 Protein (63-303aa), C-His tagged Insect Cell C-His 63-303aa
Mouse ATP1B1-2116M Recombinant Mouse ATP1B1 Protein Mammalian Cell His
Mouse ATP1b1-3766M Recombinant Mouse ATP1b1, His-tagged E.coli His 304
Mouse Atp1b1-1309M Recombinant Mouse Atp1b1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-304aa
Mouse Atp1b1-462M Recombinant Mouse Atp1b1 Protein, His-tagged E.coli His Thr53~Ser304
Mouse ATP1B1-850M Recombinant Mouse ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATP1B1-850M-B Recombinant Mouse ATP1B1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP1B1-856R Recombinant Rat ATP1B1 Protein Mammalian Cell His
Rat ATP1B1-512R-B Recombinant Rat ATP1B1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP1B1-512R Recombinant Rat ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Anguilla anguilla (European freshwater eel) (Muraena anguilla) RFL-36303AF Recombinant Full Length Anguilla Anguilla Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Canis lupus familiaris (Dog) (Canis familiaris) RFL-11841CF Recombinant Full Length Dog Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Cynomolgus Monkey ATP1B1-321C Recombinant Cynomolgus ATP1B1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ATP1B1-71C-B Recombinant Cynomolgus Monkey ATP1B1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ATP1B1-71C Recombinant Cynomolgus Monkey ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Gallus gallus (Chicken) RFL-33534GF Recombinant Full Length Chicken Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-305)
Homo sapiens (Human) RFL-7504HF Recombinant Full Length Human Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Mus musculus (Mouse) RFL-1006MF Recombinant Full Length Mouse Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-304)
Ovis aries (Sheep) RFL-7919OF Recombinant Full Length Sheep Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Pan troglodytes (Chimpanzee) RFL-36188PF Recombinant Full Length Pan Troglodytes Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Rattus norvegicus (Rat) RFL-15257RF Recombinant Full Length Rat Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-304)
Rhesus Macaque ATP1B1-449R Recombinant Rhesus monkey ATP1B1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP1B1-278R-B Recombinant Rhesus Macaque ATP1B1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP1B1-278R Recombinant Rhesus Macaque ATP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL-11617SF Recombinant Full Length Pig Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-303)
Tetronarce californica (Pacific electric ray) (Torpedo californica) RFL-19609TF Recombinant Full Length Torpedo Californica Sodium/Potassium-Transporting Atpase Subunit Beta-1(Atp1B1) Protein, His-Tagged E.coli expression system His Full Length (1-305)
Chicken ATP1B1-7069C Recombinant Chicken ATP1B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP1B1 Related Articles

ATP1B1 involved in several pathways and played different roles in them. We selected most pathways ATP1B1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwaySLC25A5;PDE2A;GNAI1;PIK3R5;ROCK1;CALML5;PPP3R2;ITPR1;GTF2IRD1
cAMP signaling pathwayRRAS;PLD1;MAPK8;FFAR2;ATP1A3;GRIA4;ATP1B1;RRAS2;PRKACG
Cardiac muscle contractionATP1A2A;CACNG7;CACNA2D2;CACNB4A;ATP1B1B;TMEM8C;SLC9A1;COX7A3;ACTC1B
Adrenergic signaling in cardiomyocytesADRB2B;CACNA1SB;PPP2R2C;PPP2R1B;CALM3;ADCY1B;PIK3CG;MAPK1;SLC9A1
Insulin secretionPDX1;SLC2A1;INS1;VAMP2;PRKACA;CREB3L1;ATP1A3;STX1A;CAMK2G
Thyroid hormone synthesisTPO;HSPA5;CREB3L3;IYD;CREB3L1;HSP90B1;TTF2;PLCB1;CREB5
Thyroid hormone signaling pathwayPIK3CA;PLCB1;PLCE1;SLC9A1;TSC2;DIO1;MAPK3;SLC16A2;RCAN2
Aldosterone-regulated sodium reabsorptionINS;PIK3R5;INSR;SLC9A3R2;PRKCB;INS2;ATP1A1;ATP1B1;NR3C2
Endocrine and other factor-regulated calcium reabsorptionDNM2;SLC8A1;ATP2B1;KLK1B3;DNM3;KLK1B24;ATP1A4;PRKCA;GNAS
Proximal tubule bicarbonate reclamationFXYD2;GLUD2;SLC38A3;AQP1;ATP1A2;ATP1B4;GLUD1;PCK1;GLS
Salivary secretionPLCB2;TRPV6;PRH1;VAMP2;PMAP-36;MUC7;Adcy4;PRKACG;DMBT1
Gastric acid secretionPLCB2;ATP1A3;GNAI3;ATP1A2;MYLK2;GNAQ;PLCB1;ITPR1;MYLK
Pancreatic secretionPLA2G10;CELA2B;ATP2A1;PLA2G12A;ATP1A2;SLC26A3;PLA2G2D;CLCA2;ATP1B3
Carbohydrate digestion and absorptionPIK3CB;PRKCB;GNAT3;G6PC2;PIK3R1;AMY2A;AMY1B;PIK3R2;PIK3CG
Protein digestion and absorptionATP1B1;LOC780933;ATP1B4;CTRL;MEP1A;PGA4;CELA3A;COL18A1;SLC1A5
Bile secretionFAM84B;ADCY9;ATP1A4;SLCO1A2;SLC10A2;SLCO1A5;ABCC2;AQP4;CA2
Mineral absorptionSLC11A1;STEAP2;SLC9A3;SLC26A9;FTL;ATP1A3;TRPV6;ATP1B1;SLC40A1

ATP1B1 has several biochemical functions, for example, contributes_to ATP binding, ATPase activator activity, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B1 itself. We selected most functions ATP1B1 had, and list some proteins which have the same functions with ATP1B1. You can find most of the proteins on our site.

Function Related Protein
contributes_to ATP bindingMSH2;ATP5D;ATP1A2;MSH6;ABCG8;SFRP5;ATP1B1
ATPase activator activityRAB4A;AHSA1;DNAJC24;ATP1B1;MYBPC3;DNAJC10;TOR1AIP1;ATP1B3;DNAJC19
contributes_to ATPase activityATP6V1H;ATP5J2;ATP5B;ATP5L;ATP1B1;MSH2;SFRP5;ATP5D;ATP5E
ATPase bindingATP6V0A1A;NKAIN1;FXYD1;UBXN1;NOP58;DNAJC10;ATP6V1E1;NUFIP1;SYVN1
MHC class II protein complex bindingANXA11;PKM2;HSP90AA1;HLA-DMA;MS4A1;HLA-DMB;HLA-DOA;CD74;HLA-DRA
contributes_to drug bindingATP1A2;PGGT1B;ATP1B1
contributes_to potassium ion bindingATP1A2;ATP1B1
protein C-terminus bindingLIG4;BLOC1S2;VPS36;SLC9A3R2;CSK;FIGN;YWHAB;PABPC1;SHANK1
protein bindingCDC42;TDG;LXN;PAGE1;KCNH7;ANKMY2;LRFN2;SORBS2;TGFB3
contributes_to sodium ion bindingATP1A2;ATP1B1
contributes_to sodium:potassium-exchanging ATPase activityATP1B3;ATP1A1;ATP1B1;ATP1B2;ATP1A2

ATP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B1.

SLC4A1; MLC1; NR3C1; SMAD2; DDAH2; CRIP2; PSME1; EZH2; RIF1; TRMT2A; KMT2B; ouabain

Willmsa, K; Shoemaker, CB; et al. Cloning and expression of a Na+, K+-ATPase alpha-subunit from Taenia solium (TNaK1 alpha). MOLECULAR AND BIOCHEMICAL PARASITOLOGY 138:79-82(2004).
Therien, AG; Goldshleger, R; et al. Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase. JOURNAL OF BIOLOGICAL CHEMISTRY 272:32628-32634(1997).
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