BAG3

  • Official Full Name

    BCL2-associated athanogene 3

  • Overview

    BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
  • Synonyms

    BAG3; BCL2-associated athanogene 3; BIS; MFM6; BAG-3; CAIR-1; BAG family molecular chaperone regulator 3; docking protein CAIR-1; BCL2-binding athanogene 3; bcl-2-binding protein Bis;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BAG3-1824H Recombinant Human BCL2-associated Athanogene 3, His tagged E.coli His
Human BAG3-26064TH Recombinant Human BAG3, His-tagged E.coli His
Human BAG3-10125H Recombinant Human BAG3, His-tagged E.coli His 275-575a.a.
Human BAG3-054H Recombinant Human BAG3 protein, GST-tagged Wheat Germ GST
Human BAG3-56HCL Recombinant Human BAG3 lysate HEK293 N/A
Human BAG3-16H Recombinant Human BAG3 Protein, His-tagged E.coli His
Human BAG3-2138H Recombinant Human BAG3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BAG3-343HFL Recombinant Full Length Human BAG3 Protein, C-Flag-tagged Mammalian cells Flag
Human BAG3-420H-B Recombinant Human BAG3 Protein Pre-coupled Magnetic Beads HEK293
Human BAG3-01H Recombinant Human BAG3, His tagged E.coli His 595
Human BAG3-097H Recombinant Human BAG3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human BAG3-420H Recombinant Human BAG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BAG3-293H Recombinant Human BAG3 Protein, His-tagged E.coli N-His Gly421-Ala498
Human BAG3-0227H Recombinant Human BAG3 Protein (Gly421-Ala498), N-GST-tagged E.coli N-GST Gly421-Ala498
Human BAG3-1774HF Recombinant Full Length Human BAG3 Protein, GST-tagged In Vitro Cell Free System GST 575 amino acids
Mouse BAG3-2272M Recombinant Mouse BAG3 Protein Mammalian Cell His
Mouse Bag3-34M Recombinant Mouse Bag3 protein, His/SUMO-tagged E.coli His/SUMO 2-577aa
Mouse Bag3-33M Recombinant Mouse Bag3 protein, His-tagged Yeast His
Mouse Bag3-1817M Recombinant Mouse Bag3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse BAG3-952M-B Recombinant Mouse BAG3 Protein Pre-coupled Magnetic Beads HEK293
Mouse BAG3-952M Recombinant Mouse BAG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BAG3-507R Recombinant Rhesus monkey BAG3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BAG3-335R-B Recombinant Rhesus Macaque BAG3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BAG3-335R Recombinant Rhesus Macaque BAG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish BAG3-969Z Recombinant Zebrafish BAG3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

BAG3 involved in several pathways and played different roles in them. We selected most pathways BAG3 participated on our site, such as Apoptosis Modulation and Signaling, Cellular response to heat stress, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Apoptosis Modulation and SignalingDAXX;HN1;DIABLO;CRADD;CASP2;BOK;HRK;BIK;CDKN2A
Cellular response to heat stressDNAJB6;DNAJC2;HSPA13;DNAJC7;C11orf73;RPS19BP1;KIAA1967;NUP35;BAG3
Cellular responses to stressKAT5;HIST1H1D;ERF;HMGA1B;ATG7;DYNLL2;TERF1;ULK1A;HSPA12B
Regulation of HSF1-mediated heat shock responseC11orf73;HSPA7;DNAJC7;HSPA13;HSPA12B;HSPA14;BAG3;ST13;KIAA1967

BAG3 has several biochemical functions, for example, chaperone binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG3 itself. We selected most functions BAG3 had, and list some proteins which have the same functions with BAG3. You can find most of the proteins on our site.

Function Related Protein
chaperone bindingDNAJA3A;RNF207;HSP104;PFDN4;AMFR;DNAJB5;HSPA5;DNAJA4;TRP53
protein bindingPHF1;MAPK1;LGALSL;GSN;WBSCR27;RSPO2;CD200R3;PGR;RNF220
protein complex bindingPCSK2;HADHA;NOG;TAB1;MLKL;RAD18;NDUFA4;HNF1B;CYFIP1

BAG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG3.

HSPB8; HSPB1; DAZAP2; STUB1; PDE9A

Research Area

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How to quantitatively detect the expression level of BAG3 protein? 12/27/2019

The expression level of BAG3 protein can be quantitatively detected by Western blot, immunohistochemistry, real-time PCR and other technical methods.

What is the role of BAG3 protein in cardiomyopathy? 05/25/2019

This protein is involved in biological processes such as cardiomyocyte survival and metabolism, and plays an important role in the occurrence and progression of cardiomyopathy.

How can BAG3 protein be used to develop treatments for cardiomyopathy? 05/08/2019

The specific regulatory mechanism of BAG3 protein can be explored to develop therapeutic strategies for its function, such as bioengineering drugs or cell gene therapy.

How about the BAG3 protein in amyotrophic lateral sclerosis? 04/24/2019

BAG3 protein plays an important role in regulating muscle cell life activities, metabolic processes and protein synthesis, and plays an important role in the occurrence and development of amyotrophic lateral sclerosis.

What is the relationship between BAG3 protein and the autophagy process? 04/01/2019

BAG3 protein plays an important role in the autophagy process, such as participating in the formation of autophagy membranes and inhibiting specific steps of autophagy pathways, affecting the occurrence and development of autophagy processes.

How to develop tumor therapeutics for BAG3 protein? 01/13/2019

It is possible to develop specific targeted drugs for BAG3 protein, interfere with the binding of BAG3 protein to other apoptosis-regulatory proteins, etc., to affect the growth and metastasis of tumor cells.

Customer Reviews (3)

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Reviews
09/14/2021

    With its wide applicability, it can play a key role in many fields of research and promote the progress of science.

    03/20/2021

      The short half-life and high clearance properties of this recombinant protein make it a higher potential in drug research and development, which is expected to become a new generation of therapeutic drugs.

      11/06/2020

        It's the most biologically active protein I've ever seen, and the purity of its production is impressive.

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