Recombinant Active Human BMP8B Protein, His-tagged(N-ter)

• Cat.No.: BMP8B-19H
• Product Overview: Recombinant Active Human BMP8B Protein with His tag (N-ter) was expressed in E. coli.

Specification

• Description: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
• Source: E. coli
• Species: Human
• Tag: His
• Form: Powder
• Bio-activity: Determined by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is < 21.8 ng/mL.
• AA Sequence: AVRPLRRRQPKKSNELPQANRLPGI FDDVHGSHGRQVCRRHELYVSFQDL GWLDWVIAPQGYSAYYCEGECSFPL DSCMNATNHAILQSLVHLMMPDAVP KACCAPTKLSATSVLYYDSSNNVIL RKHRNMVVKACGCH
• Endotoxin: Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
• Purity: > 98% (by SDS-PAGE)
• Applications: SDS-PAGE
• Notes: For laboratory research only, not for drug, diagnostic or other use.
• Storage: Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
• Storage Buffer: 20 mM Sodium citrate (pH 3.5) and 0.2 M NaCl.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.

Gene Information

• Gene Name: BMP8B bone morphogenetic protein 8b [ Homo sapiens ]
• Official Symbol: BMP8B
• Synonyms: BMP8B; bone morphogenetic protein 8b; BMP8, bone morphogenetic protein 8 (osteogenic protein 2); bone morphogenetic protein 8B; OP 2; osteogenic protein 2; BMP-8; BMP-8B; bone morphogenetic protein 8 (osteogenic protein 2); dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); OP2; BMP8; MGC131757
• Gene ID: 656
• mRNA Refseq: NM_001720
• Protein Refseq: NP_001711
• MIM: 602284
• UniProt ID: P34820

Reviews

07/06/2021

The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.

09/16/2019

This enables researchers to confidently incorporate BMP8B into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.

04/09/2016

the high-quality BMP8B protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.

Q&As

Are there any clinical implications of BMP8B in obesity treatment?

Research suggests that BMP8B could be a potential target for obesity treatment due to its involvement in metabolic regulation, but more studies are needed to fully understand its therapeutic potential.

How is BMP8B linked to cardiovascular health?

BMP8B has been implicated in cardiovascular health, with studies suggesting its involvement in vascular smooth muscle cell function and potential implications for cardiovascular diseases.

Does BMP8B play a role in cancer development or progression?

The role of BMP8B in cancer is still under investigation. Some studies suggest it may influence cancer cell behavior, but the exact mechanisms are not fully understood.

Are there any known side effects associated with manipulating BMP8B levels?

The potential side effects of manipulating BMP8B levels are not yet fully elucidated, and this is an area of active research.

How does BMP8B contribute to fertility?

BMP8B has been associated with female fertility, and studies indicate its involvement in the regulation of ovulation and the menstrual cycle.